Detailed information for compound 685797

Basic information

Technical information
  • TDR Targets ID: 685797
  • Name: 1-(4-ethoxyphenyl)sulfonyl-N,N-diethyl-3,5-di methylpyrazole-4-sulfonamide
  • MW: 415.528 | Formula: C17H25N3O5S2
  • H donors: 0 H acceptors: 5 LogP: 2.48 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)S(=O)(=O)n1nc(c(c1C)S(=O)(=O)N(CC)CC)C
  • InChi: 1S/C17H25N3O5S2/c1-6-19(7-2)27(23,24)17-13(4)18-20(14(17)5)26(21,22)16-11-9-15(10-12-16)25-8-3/h9-12H,6-8H2,1-5H3
  • InChiKey: PSLONLVNMDHZDH-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(4-ethoxyphenyl)sulfonyl-N,N-diethyl-3,5-dimethyl-pyrazole-4-sulfonamide
  • 1-(4-ethoxyphenyl)sulfonyl-N,N-diethyl-3,5-dimethyl-4-pyrazolesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni gabp alpha 0.0152 0.1755 0.2847
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0641 0.8668 1
Echinococcus multilocularis survival motor neuron protein 1 0.0255 0.3206 0.3201
Loa Loa (eye worm) hypothetical protein 0.0114 0.1215 0.1815
Loa Loa (eye worm) hypothetical protein 0.0032 0.0057 0.0086
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0147 0.014
Onchocerca volvulus Huntingtin homolog 0.0131 0.1457 0.4484
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0254
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0082 0.0122
Onchocerca volvulus 0.0108 0.1121 0.3445
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0303 0.3891 0.4137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.163 0.2644
Loa Loa (eye worm) animal heme peroxidase 0.004 0.017 0.0254
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0077 0.0104
Onchocerca volvulus 0.0052 0.0334 0.1011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0144 0.163 0.2428
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0114 0.1215 0.1806
Schistosoma mansoni hypothetical protein 0.0034 0.0077 0.0113
Schistosoma mansoni tar DNA-binding protein 0.007 0.0585 0.0941
Loa Loa (eye worm) hypothetical protein 0.0114 0.1215 0.1815
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0641 0.8668 1
Echinococcus multilocularis geminin 0.0191 0.23 0.2294
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0057 0.0081
Brugia malayi Animal haem peroxidase family protein 0.004 0.017 0.0243
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0077 0.0069
Onchocerca volvulus Dual oxidase homolog 0.004 0.017 0.0503
Plasmodium vivax hypothetical protein, conserved 0.0114 0.1215 1
Brugia malayi MH2 domain containing protein 0.0034 0.0082 0.0111
Echinococcus multilocularis beta LACTamase domain containing family member 0.0114 0.1215 0.1208
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.1215 0.1967
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0082 0.0074
Brugia malayi MH1 domain containing protein 0.0034 0.0082 0.0111
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0077 0.0069
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0254
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0254
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0082 0.0074
Onchocerca volvulus 0.0114 0.1215 0.3735
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0144 0.163 0.2436
Loa Loa (eye worm) hypothetical protein 0.0114 0.1215 0.1815
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.111 0.1659
Echinococcus granulosus peroxidasin 0.004 0.017 0.0163
Brugia malayi Fli-1 protein 0.0463 0.6145 0.9182
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0254
Echinococcus multilocularis thyroid hormone receptor alpha 0.0286 0.3648 0.3643
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0147 0.014
Schistosoma mansoni hypothetical protein 0.0034 0.0077 0.0113
Schistosoma mansoni peroxidasin 0.004 0.017 0.0265
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.2797 0.4181
Schistosoma mansoni hypothetical protein 0.0039 0.0147 0.0228
Echinococcus granulosus tar DNA binding protein 0.007 0.0585 0.0578
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.1215 0.0437
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.111 0.165
Echinococcus multilocularis Smad4 0.0034 0.0082 0.0074
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0082 0.0122
Brugia malayi MH1 domain containing protein 0.0034 0.0082 0.0111
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0303 0.3891 0.3871
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0254
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0254
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0057 0.005
Loa Loa (eye worm) beta-lactamase 0.0114 0.1215 0.1815
Brugia malayi Animal haem peroxidase family protein 0.004 0.017 0.0243
Brugia malayi MH2 domain containing protein 0.0501 0.6691 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.1215 0.1815
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0632 0.0934
Mycobacterium tuberculosis Conserved protein 0.0114 0.1215 0.0739
Echinococcus multilocularis smad 0.0034 0.0082 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.1215 0.0437
Mycobacterium tuberculosis Conserved protein 0.0114 0.1215 0.0739
Onchocerca volvulus Peroxidase homolog 0.004 0.017 0.0503
Trichomonas vaginalis set domain proteins, putative 0.0257 0.3239 1
Schistosoma mansoni thyroid hormone receptor 0.0286 0.3648 0.5932
Mycobacterium tuberculosis Probable lipase LipE 0.0114 0.1215 0.0739
Onchocerca volvulus Peroxidase homolog 0.004 0.017 0.0503
Loa Loa (eye worm) hypothetical protein 0.0108 0.1121 0.1675
Loa Loa (eye worm) blistered cuticle protein 3 0.004 0.017 0.0254
Schistosoma mansoni tar DNA-binding protein 0.007 0.0585 0.0941
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0585 0.0874
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0303 0.3891 0.3871
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.163 0.2644
Brugia malayi Ets-domain containing protein 0.0152 0.1755 0.2614
Trypanosoma brucei hypothetical protein, conserved 0.0114 0.1215 0.0437
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.163 0.1624
Mycobacterium ulcerans lipase LipD 0.0114 0.1215 0.1803
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0519 0.0512
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.163 0.1624
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0519 0.0834
Onchocerca volvulus 0.0257 0.3239 1
Loa Loa (eye worm) animal heme peroxidase 0.004 0.017 0.0254
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0265 0.3347 0.3342
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0641 0.8668 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0082 0.0121
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0585 0.0864
Schistosoma mansoni ets-related 0.0463 0.6145 1
Schistosoma mansoni thyroid hormone receptor 0.0286 0.3648 0.5932
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0077 0.0069
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0254
Echinococcus granulosus geminin 0.0191 0.23 0.2294
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0114 0.1215 0.1803
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0114 0.1215 0.0739
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0254
Onchocerca volvulus Huntingtin homolog 0.0131 0.1457 0.4484
Schistosoma mansoni hypothetical protein 0.0034 0.0077 0.0113
Entamoeba histolytica hypothetical protein 0.0039 0.0147 0.5
Mycobacterium ulcerans hypothetical protein 0.0338 0.4376 1
Schistosoma mansoni smad 0.0034 0.0082 0.0121
Schistosoma mansoni tar DNA-binding protein 0.007 0.0585 0.0941
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0114 0.1215 0.0739
Mycobacterium ulcerans hypothetical protein 0.0114 0.1215 0.1803
Schistosoma mansoni peroxidasin 0.004 0.017 0.0265
Entamoeba histolytica hypothetical protein 0.0039 0.0147 0.5
Brugia malayi hypothetical protein 0.0131 0.1457 0.2168
Onchocerca volvulus Peroxidasin homolog 0.004 0.017 0.0503
Brugia malayi Animal haem peroxidase family protein 0.004 0.017 0.0243
Brugia malayi Ets-domain containing protein 0.0152 0.1755 0.2614
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0254
Schistosoma mansoni hypothetical protein 0.0265 0.3347 0.5441
Onchocerca volvulus Peroxidasin homolog 0.004 0.017 0.0503
Echinococcus multilocularis GPCR, family 2 0.0034 0.0077 0.0069
Entamoeba histolytica hypothetical protein 0.0039 0.0147 0.5
Echinococcus multilocularis tumor protein p63 0.0735 1 1
Echinococcus granulosus Smad4 0.0034 0.0082 0.0074
Brugia malayi Blistered cuticle protein 3 0.004 0.017 0.0243
Echinococcus multilocularis tar DNA binding protein 0.007 0.0585 0.0578
Loa Loa (eye worm) hypothetical protein 0.0131 0.1457 0.2177
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.011 0.1153 0.0358
Leishmania major mitochondrial DNA polymerase beta 0.0641 0.8668 1
Brugia malayi RNA binding protein 0.007 0.0585 0.0864
Toxoplasma gondii hypothetical protein 0.0103 0.1061 0.8675
Onchocerca volvulus 0.0032 0.0057 0.0154
Loa Loa (eye worm) animal heme peroxidase 0.004 0.017 0.0254
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0254
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.163 0.1624
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.004 0.0033
Schistosoma mansoni smad1 5 8 and 0.0034 0.0082 0.0121
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0519 0.0512
Onchocerca volvulus 0.004 0.017 0.0503
Mycobacterium leprae Probable lipase LipE 0.0114 0.1215 0.5
Loa Loa (eye worm) RNA binding protein 0.007 0.0585 0.0874
Schistosoma mansoni hypothetical protein 0.0073 0.0632 0.1017
Toxoplasma gondii ABC1 family protein 0.0114 0.1215 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0632 0.0944
Brugia malayi Pre-SET motif family protein 0.0032 0.0057 0.0075
Schistosoma mansoni hypothetical protein 0.0191 0.23 0.3736
Brugia malayi hypothetical protein 0.004 0.017 0.0243
Brugia malayi beta-lactamase 0.0114 0.1215 0.1806
Echinococcus granulosus GA binding protein alpha chain 0.0152 0.1755 0.1749
Echinococcus granulosus smad 0.0034 0.0082 0.0074
Loa Loa (eye worm) hypothetical protein 0.0255 0.3206 0.4791
Mycobacterium tuberculosis Probable esterase LipL 0.0114 0.1215 0.0739
Loa Loa (eye worm) fli-1 protein 0.0463 0.6145 0.9183
Mycobacterium tuberculosis Possible penicillin-binding protein 0.073 0.9925 1
Brugia malayi Smad1 0.0034 0.0082 0.0111
Brugia malayi MH2 domain containing protein 0.0034 0.0082 0.0111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0057 0.0081
Brugia malayi hypothetical protein 0.0255 0.3206 0.4785
Loa Loa (eye worm) transcription factor SMAD2 0.0501 0.6691 1
Mycobacterium leprae conserved hypothetical protein 0.0114 0.1215 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0114 0.1215 0.1815
Schistosoma mansoni Smad4 0.0034 0.0082 0.0121
Brugia malayi Pre-SET motif family protein 0.0226 0.2797 0.4174
Mycobacterium tuberculosis Conserved protein 0.0114 0.1215 0.0739
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0519 0.3992
Brugia malayi Animal haem peroxidase family protein 0.004 0.017 0.0243
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.1215 0.1967
Onchocerca volvulus 0.004 0.017 0.0503
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0007 0.0011
Entamoeba histolytica hypothetical protein 0.0039 0.0147 0.5
Schistosoma mansoni smad1 5 8 and 0.0034 0.0082 0.0121
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0254
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0057 0.005
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0077 0.0069
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0057 0.0081
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0147 0.0228
Leishmania major hypothetical protein, conserved 0.0114 0.1215 0.0853
Echinococcus granulosus beta LACTamase domain containing family member 0.0114 0.1215 0.1208
Loa Loa (eye worm) TAR-binding protein 0.007 0.0585 0.0874
Echinococcus granulosus GPCR family 2 0.0034 0.0077 0.0069
Echinococcus multilocularis GA binding protein alpha chain 0.0152 0.1755 0.1749
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0082 0.0074
Brugia malayi beta-lactamase family protein 0.0114 0.1215 0.1806
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0265 0.3347 0.3342
Onchocerca volvulus 0.004 0.017 0.0503
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.111 0.165
Onchocerca volvulus Chorion peroxidase homolog 0.004 0.017 0.0503
Schistosoma mansoni hypothetical protein 0.0191 0.23 0.3736
Loa Loa (eye worm) hypothetical protein 0.0107 0.111 0.1659
Onchocerca volvulus 0.0114 0.1215 0.3735
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0254
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0077 0.0104
Brugia malayi hypothetical protein 0.0039 0.0147 0.0209
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0077 0.0115
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.163 0.2644
Brugia malayi Animal haem peroxidase family protein 0.004 0.017 0.0243
Mycobacterium tuberculosis Probable hydrolase 0.0114 0.1215 0.0739
Schistosoma mansoni hypothetical protein 0.0034 0.0077 0.0113
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0519 0.0834
Echinococcus multilocularis peroxidasin 0.004 0.017 0.0163
Loa Loa (eye worm) MH2 domain-containing protein 0.0501 0.6691 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0011
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0057 0.005
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0254
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0082 0.0074
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0152 0.1755 0.2622
Schistosoma mansoni tar DNA-binding protein 0.007 0.0585 0.0941
Schistosoma mansoni survival motor neuron protein 0.0052 0.0334 0.0532
Brugia malayi Peroxidasin 0.004 0.017 0.0243
Loa Loa (eye worm) hypothetical protein 0.0114 0.1215 0.1815
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.163 0.1624
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0334 0.0489
Loa Loa (eye worm) Smad1 0.0034 0.0082 0.0122
Loa Loa (eye worm) hypothetical protein 0.004 0.017 0.0254
Loa Loa (eye worm) animal heme peroxidase 0.004 0.017 0.0254
Echinococcus granulosus survival motor neuron protein 1 0.0255 0.3206 0.3201
Mycobacterium tuberculosis Probable lipase LipD 0.0114 0.1215 0.0739
Loa Loa (eye worm) hypothetical protein 0.013 0.1442 0.2155
Brugia malayi TAR-binding protein 0.007 0.0585 0.0864
Schistosoma mansoni cellular tumor antigen P53 0.0108 0.1121 0.1814
Loa Loa (eye worm) hypothetical protein 0.0034 0.0077 0.0115
Schistosoma mansoni smad1 5 8 and 0.0034 0.0082 0.0121
Mycobacterium ulcerans beta-lactamase 0.0114 0.1215 0.1803
Mycobacterium tuberculosis Conserved hypothetical protein 0.0338 0.4376 0.41
Loa Loa (eye worm) hypothetical protein 0.0114 0.1215 0.1815
Brugia malayi beta-lactamase family protein 0.0114 0.1215 0.1806
Onchocerca volvulus 0.0114 0.1215 0.3735
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0114 0.1215 0.0739
Loa Loa (eye worm) hypothetical protein 0.0131 0.1457 0.2177
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0057 0.0081
Schistosoma mansoni hypothetical protein 0.0052 0.0334 0.0532
Schistosoma mansoni tar DNA-binding protein 0.007 0.0585 0.0941
Mycobacterium ulcerans esterase/lipase LipP 0.0114 0.1215 0.1803

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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