TDR Targets

Basic information

Technical information

TDR Targets ID: 685982
Name: N-(2,5-dimethylphenyl)-N'-(thiophen-2-ylmethy l)oxamide
MW: 288.365 | Formula: C15H16N2O2S
H donors: 2 H acceptors: 2 LogP: 2.75 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(c(c1)NC(=O)C(=O)NCc1cccs1)C
InChi: 1S/C15H16N2O2S/c1-10-5-6-11(2)13(8-10)17-15(19)14(18)16-9-12-4-3-7-20-12/h3-8H,9H2,1-2H3,(H,16,18)(H,17,19)
InChiKey: QOJRUFJMPKCLSO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2,5-dimethylphenyl)-N'-(2-thienylmethyl)oxamide
N-(2,5-dimethylphenyl)-N'-(thiophen-2-ylmethyl)ethanediamide
ZINC04583808

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	ap endonuclease	0.0021	0.0665	0.2556
Loa Loa (eye worm)	MH1 domain-containing protein	0.0009	0.0206	0.0389
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0665	0.5
Schistosoma mansoni	smad	0.0009	0.0206	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0005	0.004	0.0075
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0665	0.1253
Loa Loa (eye worm)	MH2 domain-containing protein	0.0009	0.0206	0.0389
Loa Loa (eye worm)	hypothetical protein	0.004	0.1425	0.2687
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0118	0.0818
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.1425	0.2687
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.004	0.1425	0.1424
Loa Loa (eye worm)	TAR-binding protein	0.007	0.2601	0.4904
Loa Loa (eye worm)	MH2 domain-containing protein	0.0139	0.5303	1
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.1425	1
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0001	0.0002
Onchocerca volvulus	Putative neutral sphingomyelinase	0.0004	0.0001	0.0009
Brugia malayi	MH2 domain containing protein	0.0009	0.0206	0.0389
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0217	0.0408
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0009	0.0206	0.0792
Loa Loa (eye worm)	hypothetical protein	0.004	0.1425	0.2687
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0001	0.0002
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.1088	0.2052
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0118	0.0818
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.1425	0.5478
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0665	0.2556
Brugia malayi	MH2 domain containing protein	0.0009	0.0206	0.0389
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0118	0.0818
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0004	0.0001	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0001	0.0002
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0001	0.0002
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0118	0.0818
Loa Loa (eye worm)	CCR4-NOT transcription complex subunit 6 family protein	0.0004	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0001	0.0002
Schistosoma mansoni	cpg binding protein	0.0034	0.116	0.4459
Schistosoma mansoni	synaptojanin	0.0004	0.0001	0.0005
Echinococcus granulosus	tar DNA binding protein	0.007	0.2601	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0665	0.466
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.1832	0.7043
Brugia malayi	RNA binding protein	0.007	0.2601	0.4904
Brugia malayi	MH1 domain containing protein	0.0005	0.004	0.0075
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0001	0.0002
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0118	0.0818
Toxoplasma gondii	ABC1 family protein	0.004	0.1425	0.6444
Mycobacterium ulcerans	lipase LipD	0.004	0.1425	1
Echinococcus granulosus	traf and tnf receptor associated protein	0.0004	0.0001	0.0005
Echinococcus multilocularis	smad	0.0009	0.0206	0.0792
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0118	0.0818
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.1425	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0665	1
Toxoplasma gondii	exonuclease III APE	0.0021	0.0665	0.3003
Mycobacterium tuberculosis	Probable lipase LipD	0.004	0.1425	0.1424
Brugia malayi	MH1 domain containing protein	0.0009	0.0206	0.0389
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.1425	1
Trichomonas vaginalis	helicase, putative	0.0007	0.0118	0.0818
Onchocerca volvulus		0.0004	0.0001	0.0009
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0001	0.0002
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.1832	0.7043
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0118	0.0818
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0665	0.466
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0222	0.0418
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0118	0.0818
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.1425	0.5478
Echinococcus multilocularis	traf and tnf receptor associated protein	0.0004	0.0001	0.0005
Schistosoma mansoni	cpg binding protein	0.0034	0.116	0.4459
Schistosoma mansoni	tar DNA-binding protein	0.007	0.2601	1
Mycobacterium leprae	conserved hypothetical protein	0.004	0.1425	0.5
Echinococcus multilocularis	cpg binding protein	0.0034	0.116	0.4459
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0665	1
Leishmania major	hypothetical protein, conserved	0.004	0.1425	1
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0206	0.0792
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0145	0.0558
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0009	0.0206	0.0792
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.1425	0.2687
Echinococcus granulosus	cpg binding protein	0.0034	0.116	0.4459
Schistosoma mansoni	cpg binding protein	0.0032	0.1088	0.4184
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.0665	0.0663
Mycobacterium tuberculosis	Probable esterase LipL	0.004	0.1425	0.1424
Echinococcus granulosus	Smad4	0.0009	0.0206	0.0792
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0118	0.0818
Schistosoma mansoni	neutral sphingomyelinase	0.0004	0.0001	0.0005
Schistosoma mansoni	Smad4	0.0009	0.0206	0.0792
Loa Loa (eye worm)	hypothetical protein	0.004	0.1425	0.2687
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0001	0.0002
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.1425	0.5478
Mycobacterium tuberculosis	Probable hydrolase	0.004	0.1425	0.1424
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.1425	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0145	0.0558
Echinococcus multilocularis	CCR4 NOT transcription complex subunit 6	0.0004	0.0001	0.0005
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0665	0.466
Echinococcus granulosus	synaptojanin 1	0.0004	0.0001	0.0005
Echinococcus granulosus	smad	0.0009	0.0206	0.0792
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0004	0.0001	0.0005
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0145	0.0558
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.004	0.1425	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0118	0.0818
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0118	0.0818
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.1425	0.5478
Schistosoma mansoni	tar DNA-binding protein	0.007	0.2601	1
Mycobacterium ulcerans	esterase/lipase LipP	0.004	0.1425	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.1832	0.3454
Mycobacterium leprae	Probable lipase LipE	0.004	0.1425	0.5
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0001	0.0002
Loa Loa (eye worm)	beta-lactamase	0.004	0.1425	0.2687
Schistosoma mansoni	tar DNA-binding protein	0.007	0.2601	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.2494	0.9592
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.1425	1
Onchocerca volvulus		0.004	0.1425	1
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0001	0.0002
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0001	0.0002
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0665	0.2556
Onchocerca volvulus		0.0004	0.0001	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0001	0.0002
Echinococcus granulosus	neutral sphingomyelinase	0.0004	0.0001	0.0005
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.221	1
Mycobacterium tuberculosis	Conserved protein	0.004	0.1425	0.1424
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0222	0.0852
Schistosoma mansoni	synaptojanin	0.0004	0.0001	0.0005
Brugia malayi	RNA recognition motif domain containing protein	0.007	0.2601	0.4904
Onchocerca volvulus		0.0032	0.1088	0.7636
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0222	0.0852
Loa Loa (eye worm)	nuclear factor I	0.0005	0.004	0.0075
Plasmodium vivax	hypothetical protein, conserved	0.004	0.1425	1
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0001	0.0002
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0206	0.0792
Brugia malayi	CCR4	0.0004	0.0001	0.0002
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0118	0.0818
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0665	0.466
Brugia malayi	beta-lactamase family protein	0.004	0.1425	0.2687
Echinococcus granulosus	CCR4 NOT transcription complex subunit 6	0.0004	0.0001	0.0005
Brugia malayi	beta-lactamase	0.004	0.1425	0.2687
Mycobacterium tuberculosis	Conserved protein	0.004	0.1425	0.1424
Loa Loa (eye worm)	hypothetical protein	0.004	0.1425	0.2687
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0001	0.0002
Echinococcus multilocularis	tar DNA binding protein	0.007	0.2601	1
Mycobacterium ulcerans	beta-lactamase	0.004	0.1425	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0665	0.466
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.1425	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.1425	0.2687
Schistosoma mansoni	ap endonuclease	0.0021	0.0665	0.2556
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0001	0.0002
Echinococcus multilocularis	Smad4	0.0009	0.0206	0.0792
Echinococcus granulosus	mothers against decapentaplegic 5	0.0009	0.0206	0.0792
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.1832	0.7043
Schistosoma mansoni	cript-related	0.0004	0.0001	0.0005
Echinococcus multilocularis	synaptojanin 1	0.0004	0.0001	0.0005
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.1832	0.7043
Brugia malayi	MH2 domain containing protein	0.0139	0.5303	1
Brugia malayi	MH1 domain containing protein	0.0009	0.0206	0.0389
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.1832	0.7043
Brugia malayi	TAR-binding protein	0.007	0.2601	0.4904
Mycobacterium tuberculosis	Conserved protein	0.004	0.1425	0.1424
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0206	0.0792
Mycobacterium ulcerans	hypothetical protein	0.004	0.1425	1
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0009	0.0206	0.0792
Brugia malayi	beta-lactamase family protein	0.004	0.1425	0.2687
Loa Loa (eye worm)	RNA binding protein	0.007	0.2601	0.4904
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0005	0.0013	0.0051
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.1425	1
Schistosoma mansoni	ocrl type II inositol 5-phosphatase	0.0004	0.0001	0.0005
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.007	0.2601	0.4904
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0001	0.0002
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0021	0.0665	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0118	0.0818
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.1832	0.3454
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0665	0.466
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.1832	0.7043
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0145	0.0558
Mycobacterium tuberculosis	Probable lipase LipE	0.004	0.1425	0.1424
Brugia malayi	Smad1	0.0009	0.0206	0.0389
Echinococcus multilocularis	inositol polyphosphate 5 phosphatase OCRL 1	0.0004	0.0001	0.0005
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0021	0.0665	1
Schistosoma mansoni	nocturnin	0.0004	0.0001	0.0005
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.004	0.1425	0.1424
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0145	0.0558
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0118	0.0818
Brugia malayi	CXXC zinc finger family protein	0.0032	0.1088	0.2052
Onchocerca volvulus		0.004	0.1425	1
Schistosoma mansoni	carbon catabolite repressor protein	0.0004	0.0001	0.0005
Schistosoma mansoni	hypothetical protein	0.0004	0.0001	0.0005
Loa Loa (eye worm)	transcription factor SMAD2	0.0139	0.5303	1
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0009	0.0206	0.0792
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0118	0.0818
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0001	0.0002
Onchocerca volvulus		0.004	0.1425	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0665	0.466
Schistosoma mansoni	tar DNA-binding protein	0.007	0.2601	1
Trichomonas vaginalis	esterase, putative	0.004	0.1425	1
Brugia malayi	MH1 domain containing protein	0.0005	0.004	0.0075
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0118	0.0818
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.1832	0.7043
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.004	0.1425	0.1424
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0665	0.1253
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0118	0.0818
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.1425	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.1425	0.2687
Echinococcus multilocularis	deoxyribonuclease 1 2	0.0004	0.0001	0.0005
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0001	0.0002
Schistosoma mansoni	tar DNA-binding protein	0.007	0.2601	1
Echinococcus multilocularis	neutral sphingomyelinase	0.0004	0.0001	0.0005
Loa Loa (eye worm)	Smad1	0.0009	0.0206	0.0389
Echinococcus granulosus	inositol polyphosphate 5 phosphatase OCRL 1	0.0004	0.0001	0.0005

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 685982