Detailed information for compound 68606

Basic information

Technical information
  • TDR Targets ID: 68606
  • Name: 1-adamantylmethyl-[5-cyano-5-(3,4-dimethoxyph enyl)-6-methylhept-2-ynyl]-methylazanium chlo ride
  • MW: 485.101 | Formula: C29H41ClN2O2
  • H donors: 0 H acceptors: 1 LogP: 6.97 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(c1ccc(c(c1)OC)OC)(C(C)C)CC#CCN(CC12CC3CC(C2)CC(C1)C3)C.Cl
  • InChi: 1S/C29H40N2O2.ClH/c1-21(2)29(19-30,25-8-9-26(32-4)27(15-25)33-5)10-6-7-11-31(3)20-28-16-22-12-23(17-28)14-24(13-22)18-28;/h8-9,15,21-24H,10-14,16-18,20H2,1-5H3;1H
  • InChiKey: JWOZELPDPKGKJU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-adamantylmethyl-[5-cyano-5-(3,4-dimethoxyphenyl)-6-methyl-hept-2-ynyl]-methyl-ammonium chloride
  • 1-adamantylmethyl-[5-cyano-5-(3,4-dimethoxyphenyl)-6-methylhept-2-ynyl]-methylammonium chloride
  • 1-adamantylmethyl-[5-cyano-5-(3,4-dimethoxyphenyl)-6-methyl-hept-2-ynyl]-methyl-azanium chloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus methyltransferase protein 5 0.0053 0.0049 0.0049
Brugia malayi hypothetical protein 0.0024 0.0007 0.0007
Echinococcus granulosus tissue type plasminogen activator 0.0051 0.0045 0.0045
Brugia malayi CUB domain containing protein 0.0024 0.0007 0.0007
Plasmodium vivax plasmepsin IV, putative 0.0035 0.0022 0.0388
Loa Loa (eye worm) hypothetical protein 0.0039 0.0028 0.0028
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0067 0.0068 0.0959
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0311 0.0417 1
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0067 0.0068 0.1071
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0031 0.005
Plasmodium falciparum cysteine repeat modular protein 1 0.0051 0.0045 0.0814
Schistosoma mansoni chromatin regulatory protein sir2 0.0451 0.0618 0.0618
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0022 0.0022
Echinococcus granulosus serine/threonine protein kinase 0.0022 0.0005 0.0005
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.0024 0.0007 0.0009
Echinococcus granulosus growth factor receptor bound protein 2 0.0138 0.017 0.017
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1718 0.2432 0.2432
Echinococcus granulosus c4b binding protein beta chain 0.0039 0.0028 0.0028
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0451 0.0618 0.0618
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Mycobacterium ulcerans Sir2-like regulatory protein 0.0067 0.0068 0.0159
Echinococcus granulosus Furin 1 0.1718 0.2432 0.2432
Brugia malayi von Willebrand factor type A domain containing protein 0.0022 0.0005 0.0005
Schistosoma mansoni dock 0.0041 0.0031 0.0031
Entamoeba histolytica hypothetical protein, conserved 0.0022 0.0005 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.1407 0.1987 0.3249
Brugia malayi pregnancy-associated plasma protein-A 0.0039 0.0028 0.0028
Brugia malayi aspartic protease BmAsp-2, identical 0.0035 0.0022 0.0022
Echinococcus granulosus cubilin 0.0024 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0041 0.0031 0.0031
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0022 0.0005 0.0055
Brugia malayi transcriptional regulator, Sir2 family protein 0.0451 0.0618 0.0618
Plasmodium falciparum subtilisin-like protease 1 0.0311 0.0417 0.7819
Brugia malayi Carm1-pending protein 0.0053 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0051 0.0045 0.0045
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Onchocerca volvulus Putative endochitinase 0.0073 0.0077 0.1457
Loa Loa (eye worm) hypothetical protein 0.7006 1 1
Brugia malayi hypothetical protein 0.0039 0.0028 0.0028
Schistosoma mansoni DNA repair endonuclease xp-f / mei-9 / rad1 0.0038 0.0027 0.0027
Brugia malayi celfurPC protein 0.5599 0.7986 0.7986
Onchocerca volvulus 0.0024 0.0007 0.0045
Leishmania major chitinase 0.0073 0.0077 0.0567
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0311 0.0417 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0007
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0022 0.0022
Brugia malayi Protein kinase domain containing protein 0.0096 0.011 0.011
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0053 0.0049 0.0049
Echinococcus granulosus protein arginine methyltransferase 0.0095 0.0108 0.0108
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Plasmodium vivax LCCL domain-containing protein 0.0041 0.0031 0.0543
Onchocerca volvulus 0.0039 0.0028 0.0466
Echinococcus granulosus discoidin domain containing receptor 2 0.0041 0.0031 0.0031
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Schistosoma mansoni tyrosine kinase 0.0659 0.0916 0.0916
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0031 0.005
Trypanosoma cruzi UDP-galactopyranose mutase 0.007 0.0072 0.1144
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1407 0.1987 0.3249
Brugia malayi Kelch motif family protein 0.0024 0.0007 0.0007
Echinococcus multilocularis C type lectin domian containing protein 0.0039 0.0028 0.0035
Echinococcus multilocularis Tolloid protein 1 0.0024 0.0007 0.0009
Brugia malayi hypothetical protein 0.0039 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0022 0.0005 0.0005
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0005 0.0073
Giardia lamblia Sirtuin type 2 0.0067 0.0068 0.0181
Entamoeba histolytica hypothetical protein, conserved 0.0067 0.0068 0.1095
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0451 0.0618 0.0774
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1718 0.2432 0.3977
Trypanosoma cruzi DNA repair protein, putative 0.0023 0.0006 0.0066
Trypanosoma cruzi subtilisin peptidase 0.0311 0.0417 0.6748
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0022 0.0005 0.0055
Plasmodium falciparum plasmepsin IX 0.0035 0.0022 0.0388
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0022 0.0022
Trypanosoma brucei rac serine-threonine kinase, putative 0.0041 0.0032 0.0144
Entamoeba histolytica elongation factor-2 kinase, putative 0.0022 0.0005 0.0075
Echinococcus multilocularis nervana 2 0.002 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.2715 0.3859 0.3859
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0022 0.0022
Plasmodium vivax aspartyl protease, putative 0.0035 0.0022 0.0388
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0095 0.0108 0.0108
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0032 0.0018 0.0018
Onchocerca volvulus 0.0032 0.0018 0.0276
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0311 0.0417 0.0417
Plasmodium vivax ERCC1 nucleotide excision repair protein, putative 0.0054 0.0049 0.0899
Entamoeba histolytica protein kinase 2, putative 0.002 0.0002 0.0027
Plasmodium vivax subtilisin-like serine protease, putative 0.0311 0.0417 0.7819
Schistosoma mansoni chromatin regulatory protein sir2 0.0067 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Echinococcus granulosus lysine specific histone demethylase 1A 0.0343 0.0463 0.0463
Loa Loa (eye worm) hypothetical protein 0.0148 0.0184 0.0184
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.007 0.0072 0.0072
Echinococcus multilocularis protein will die slowly 0.0136 0.0167 0.0209
Giardia lamblia hypothetical protein 0.0029 0.0014 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0311 0.0417 0.0683
Toxoplasma gondii histone deacetylase SIR2 0.0067 0.0068 0.1316
Trichomonas vaginalis WD repeat domain, putative 0.0136 0.0167 0.0273
Onchocerca volvulus Putative endochitinase 0.0073 0.0077 0.1457
Onchocerca volvulus Putative endochitinase 0.0073 0.0077 0.1457
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0343 0.0463 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.1407 0.1987 0.3249
Mycobacterium leprae Possible secreted protease 0.0311 0.0417 1
Onchocerca volvulus 0.0096 0.011 0.2099
Loa Loa (eye worm) hypothetical protein 0.0051 0.0045 0.0045
Echinococcus multilocularis DNA excision repair protein ERCC 1 0.0054 0.0049 0.0062
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.007 0.0072 0.141
Brugia malayi transcriptional regulator, Sir2 family protein 0.0067 0.0068 0.0068
Brugia malayi Zona pellucida-like domain containing protein 0.0022 0.0005 0.0005
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0335 0.0452 0.7306
Leishmania major subtilisin-like serine peptidase 0.0311 0.0417 0.6502
Loa Loa (eye worm) hypothetical protein 0.0039 0.0028 0.0028
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0138 0.017 0.017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4291 0.6114 1
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0053 0.0049 0.0061
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0067 0.0068 0.0181
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0053 0.0049 0.0764
Brugia malayi SWIRM domain containing protein 0.0372 0.0505 0.0505
Plasmodium falciparum plasmepsin V 0.0392 0.0533 1
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0067 0.0068 0.0396
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0343 0.0463 0.058
Echinococcus multilocularis Furin 1 0.1718 0.2432 0.3045
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Loa Loa (eye worm) hypothetical protein 0.0063 0.0062 0.0062
Brugia malayi hypothetical protein 0.0035 0.0022 0.0022
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0051 0.0045 0.0814
Echinococcus multilocularis discoidin domain containing receptor 2 0.0041 0.0031 0.0038
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0005 0.0005
Plasmodium vivax aspartyl protease, putative 0.0035 0.0022 0.0388
Plasmodium falciparum LCCL domain-containing protein 0.0041 0.0031 0.0543
Onchocerca volvulus 0.0035 0.0022 0.0354
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0148 0.0184 0.2963
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0039 0.0029 0.0029
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0148 0.0184 0.2963
Loa Loa (eye worm) hypothetical protein 0.0034 0.0021 0.0021
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0024 0.0007 0.0007
Giardia lamblia Hypothetical protein 0.0451 0.0618 0.1687
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Loa Loa (eye worm) transcriptional regulator 0.0451 0.0618 0.0618
Echinococcus granulosus nervana 2 0.002 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0014 0.0023
Loa Loa (eye worm) hypothetical protein 0.0035 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0311 0.0417 0.0683
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.4291 0.6114 0.7655
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0022 0.0005 0.0047
Brugia malayi endochitinase 0.0073 0.0077 0.0077
Trichomonas vaginalis AGC family protein kinase 0.0041 0.0032 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0031 0.005
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0024 0.0007 0.0007
Entamoeba histolytica protein kinase, putative 0.0039 0.0029 0.0463
Loa Loa (eye worm) hypothetical protein 0.0343 0.0463 0.0463
Brugia malayi p70 ribosomal S6 kinase beta 0.0039 0.0029 0.0029
Echinococcus multilocularis 0.5599 0.7986 1
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.007 0.0072 0.1326
Echinococcus granulosus C type lectin domian containing protein 0.0039 0.0028 0.0028
Onchocerca volvulus 0.0035 0.0022 0.0354
Echinococcus multilocularis nervana 2 0.002 0.0001 0.0001
Echinococcus multilocularis 0.007 0.0072 0.009
Entamoeba histolytica SWIRM domain protein 0.0029 0.0014 0.0226
Brugia malayi neuroendocrine convertase 1 precursor 0.4433 0.6318 0.6318
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0095 0.0108 0.2157
Brugia malayi aspartic protease BmAsp-1, identical 0.0035 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.1407 0.1987 0.3249
Brugia malayi Zona pellucida-like domain containing protein 0.0022 0.0005 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0067 0.0068 0.1241
Echinococcus granulosus CUB 0.0024 0.0007 0.0007
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0095 0.0108 0.0177
Onchocerca volvulus 0.0039 0.0028 0.0466
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0005 0.0073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0022 0.0022
Echinococcus multilocularis MAM 0.0096 0.011 0.0137
Loa Loa (eye worm) transcriptional regulator 0.0067 0.0068 0.0068
Echinococcus multilocularis protoporphyrinogen oxidase 0.007 0.0072 0.009
Onchocerca volvulus 0.0024 0.0007 0.0045
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0035 0.0022 0.0022
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1718 0.2432 0.3977
Trypanosoma brucei subtilisin peptidase 0.0311 0.0417 0.23
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0067 0.0068 0.0111
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.007 0.0072 0.0286
Leishmania major sir2-family protein-like protein 0.0067 0.0068 0.0396
Trichomonas vaginalis AGC family protein kinase 0.0041 0.0032 0.0052
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Echinococcus multilocularis discoidin domain containing receptor 2 0.0041 0.0031 0.0038
Loa Loa (eye worm) cuticular endochitinase 0.0073 0.0077 0.0077
Toxoplasma gondii ERCC4 domain-containing protein 0.0038 0.0027 0.0471
Loa Loa (eye worm) hypothetical protein 0.0372 0.0505 0.0505
Loa Loa (eye worm) hypothetical protein 0.0103 0.012 0.012
Echinococcus granulosus collagen alpha 1VII chain 0.0022 0.0005 0.0005
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0041 0.0031 0.005
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0041 0.0031 0.0038
Schistosoma mansoni atypical protein kinase C 0.0026 0.0009 0.0009
Echinococcus granulosus furin 0.7006 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0014 0.0023
Trypanosoma cruzi DNA repair protein, putative 0.0023 0.0006 0.0066
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.126 0.1776 0.1776
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0045 0.0703
Toxoplasma gondii histone lysine-specific demethylase 0.007 0.0072 0.141
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0095 0.0108 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.1407 0.1987 0.3249
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0067 0.0068 0.0111
Schistosoma mansoni hypothetical protein 0.0136 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0035 0.0022 0.0022
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0067 0.0068 0.0111
Schistosoma mansoni site-1 peptidase (S08 family) 0.0311 0.0417 0.0417
Echinococcus granulosus serine threonine protein kinase nrc 0.002 0.0002 0.0002
Onchocerca volvulus 0.0024 0.0007 0.0045
Brugia malayi Protein arginine N-methyltransferase 0.0053 0.0049 0.0049
Toxoplasma gondii subtilisin SUB10 0.0311 0.0417 0.862
Schistosoma mansoni hypothetical protein 0.1407 0.1987 0.1987
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0031 0.005
Loa Loa (eye worm) CUTiclin-Like family member 0.0022 0.0005 0.0005
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0311 0.0417 0.0417
Giardia lamblia High cysteine membrane protein Group 2 0.2572 0.3654 1
Echinococcus granulosus neuroendocrine convertase 2 0.4433 0.6318 0.6318
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0335 0.0452 0.7306
Onchocerca volvulus 0.0039 0.0028 0.0466
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0148 0.0184 0.0997
Toxoplasma gondii aspartyl protease ASP5 0.0357 0.0484 1
Schistosoma mansoni hypothetical protein 0.0024 0.0007 0.0007
Leishmania major silent information regulator 2, putative 0.0451 0.0618 1
Trichomonas vaginalis conserved hypothetical protein 0.1407 0.1987 0.3249
Schistosoma mansoni chromatin regulatory protein sir2 0.0451 0.0618 0.0618
Plasmodium falciparum protoporphyrinogen oxidase 0.007 0.0072 0.1326
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.002 0.0002 0.0002
Echinococcus multilocularis protein arginine methyltransferase 0.0095 0.0108 0.0135
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0067 0.0068 0.1071
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Toxoplasma gondii kringle domain-containing protein 0.0051 0.0045 0.0843
Loa Loa (eye worm) hypothetical protein 0.0039 0.0028 0.0028
Entamoeba histolytica hypothetical protein 0.0148 0.0184 0.2982
Schistosoma mansoni amine oxidase 0.007 0.0072 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0311 0.0417 0.0683
Echinococcus granulosus protein will die slowly 0.0136 0.0167 0.0167
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0035 0.0022 0.0028
Onchocerca volvulus 0.0311 0.0417 0.8256
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0011 0.0011
Toxoplasma gondii subtilisin SUB5 0.0311 0.0417 0.862
Trichomonas vaginalis excision repair cross-complementing 1 ercc1, putative 0.0054 0.0049 0.0081
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0007
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0067 0.0068 0.0111
Schistosoma mansoni hypothetical protein 0.0053 0.0049 0.0049
Schistosoma mansoni septate junction protein 0.005 0.0044 0.0044
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Loa Loa (eye worm) proprotein convertase 2 0.1718 0.2432 0.2432
Mycobacterium ulcerans protoporphyrinogen oxidase 0.007 0.0072 0.0286
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0022 0.0022
Plasmodium falciparum plasmepsin VII 0.0035 0.0022 0.0388
Onchocerca volvulus 0.0039 0.0028 0.0466
Schistosoma mansoni furin-1 (S08 family) 0.3026 0.4304 0.4304
Trypanosoma brucei RNA helicase, putative 0.1274 0.1796 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.007 0.0072 0.1326
Schistosoma mansoni discoidin domain receptor 0.0041 0.0031 0.0031
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0022 0.0005 0.0005
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0022 0.0005 0.0006
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0031 0.0031
Plasmodium falciparum plasmepsin III 0.0035 0.0022 0.0388
Schistosoma mansoni chromatin regulatory protein sir2 0.0067 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0078 0.0085 0.0085
Echinococcus multilocularis tissue type plasminogen activator 0.0051 0.0045 0.0056
Loa Loa (eye worm) WD40 repeat protein 0.0136 0.0167 0.0167
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.4291 0.6114 0.6114
Brugia malayi endochitinase 0.0073 0.0077 0.0077
Plasmodium vivax protoporphyrinogen oxidase, putative 0.007 0.0072 0.1326
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0067 0.0068 0.0111
Plasmodium vivax plasmepsin V, putative 0.0392 0.0533 1
Echinococcus multilocularis rac serine:threonine kinase 0.0022 0.0005 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0041 0.0032 0.0052
Plasmodium falciparum plasmepsin VIII, putative 0.0035 0.0022 0.0388
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Loa Loa (eye worm) TK/EGFR protein kinase 0.0659 0.0916 0.0916
Loa Loa (eye worm) endoprotease bli-4 0.7006 1 1
Trichomonas vaginalis hypothetical protein 0.0041 0.0031 0.005
Plasmodium vivax thrombospondin-related anonymous protein 0.0022 0.0005 0.0055
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.002 0.0002 0.0002
Toxoplasma gondii F5/8 type C domain-containing protein 0.0041 0.0031 0.0542
Echinococcus multilocularis CUB 0.0024 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.0024 0.0007 0.0007
Plasmodium falciparum plasmepsin II 0.0035 0.0022 0.0388
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0451 0.0618 0.1011
Loa Loa (eye worm) hypothetical protein 0.0041 0.0031 0.0031
Toxoplasma gondii subtilisin SUB11 0.0311 0.0417 0.862
Toxoplasma gondii subtilisin SUB12 0.0311 0.0417 0.862
Toxoplasma gondii subtilisin SUB4 0.0311 0.0417 0.862
Plasmodium falciparum subtilisin-like protease 2 0.0311 0.0417 0.7819
Leishmania major arginine N-methyltransferase-like protein 0.0095 0.0108 0.1099
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0022 0.0005 0.0005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0022 0.0022
Plasmodium vivax aspartyl proteinase, putative 0.0035 0.0022 0.0388
Trichomonas vaginalis conserved hypothetical protein 0.1407 0.1987 0.3249
Schistosoma mansoni btb and poz domain-containing protein 0.0041 0.0031 0.0031
Entamoeba histolytica DNA excision repair protein, putative 0.0054 0.0049 0.08
Echinococcus granulosus protein kinase c iota type 0.0026 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.1407 0.1987 0.3249
Onchocerca volvulus 0.0041 0.0031 0.0519
Schistosoma mansoni hypothetical protein 0.0024 0.0007 0.0007
Toxoplasma gondii F5/8 type C domain-containing protein 0.0041 0.0031 0.0542
Brugia malayi Protein kinase domain containing protein 0.0051 0.0045 0.0045
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0022 0.0005 0.0008
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0053 0.0049 0.0764
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0067 0.0068 0.0085
Loa Loa (eye worm) transcriptional regulator 0.0067 0.0068 0.0068
Onchocerca volvulus 0.0041 0.0031 0.0519
Plasmodium falciparum plasmepsin X 0.0035 0.0022 0.0388
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0011 0.0011
Toxoplasma gondii aspartyl protease 0.0035 0.0022 0.0369
Brugia malayi von Willebrand factor type A domain containing protein 0.0022 0.0005 0.0005
Entamoeba histolytica hypothetical protein 0.0029 0.0014 0.0226
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0029 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0096 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0024 0.0007 0.0007
Brugia malayi Calcium binding EGF domain containing protein 0.0034 0.0021 0.0021
Entamoeba histolytica PH domain containing protein kinase, putative 0.0074 0.0078 0.1261
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0035 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0067 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0067 0.0068 0.1241
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0031 0.005
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0311 0.0417 0.6748
Onchocerca volvulus 0.0136 0.0167 0.324
Plasmodium vivax hypothetical protein, conserved 0.007 0.0072 0.1326
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0053 0.0049 0.024
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0024 0.0007 0.0007
Toxoplasma gondii histone deacetylase SIR2-like 0.0067 0.0068 0.1316
Toxoplasma gondii SWIRM domain-containing protein 0.0029 0.0014 0.0195
Giardia lamblia Furin precursor putative serine protease 0.1407 0.1987 0.5434
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0053 0.0049 0.0066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1718 0.2432 0.3977
Brugia malayi Lectin C-type domain containing protein 0.0024 0.0007 0.0007
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.007 0.0072 0.1075
Loa Loa (eye worm) CUTiclin family member 0.0022 0.0005 0.0005
Onchocerca volvulus 0.0039 0.0028 0.0466
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0095 0.0108 0.0108
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0311 0.0417 1
Loa Loa (eye worm) CUB domain-containing protein 0.0024 0.0007 0.0007
Loa Loa (eye worm) aspartyl protease 6 0.0035 0.0022 0.0022
Brugia malayi Nematode astacin protease protein 30 0.0024 0.0007 0.0007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Echinococcus granulosus protein arginine N methyltransferase 8 0.0095 0.0108 0.0108
Brugia malayi Suppressor of lurcher protein 1 precursor 0.0024 0.0007 0.0007
Echinococcus multilocularis protein kinase c iota type 0.0026 0.0009 0.0011
Brugia malayi von Willebrand factor type A domain containing protein 0.0022 0.0005 0.0005
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0067 0.0068 0.0085
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0311 0.0417 1
Onchocerca volvulus 0.0039 0.0028 0.0466
Loa Loa (eye worm) hypothetical protein 0.0039 0.0028 0.0028
Brugia malayi proprotein convertase 2 0.4433 0.6318 0.6318
Brugia malayi CUB domain containing protein 0.0024 0.0007 0.0007
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0053 0.0049 0.0764
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0053 0.0049 0.008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0031 0.005
Brugia malayi Probable ATP-dependent helicase DHX35 0.0032 0.0019 0.0019
Plasmodium vivax aspartyl protease, putative 0.0035 0.0022 0.0388
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0041 0.0031 0.005
Brugia malayi CUB domain containing protein 0.0024 0.0007 0.0007
Toxoplasma gondii PA14 domain-containing protein 0.0041 0.0031 0.0542
Entamoeba histolytica chitinase, putative 0.0073 0.0077 0.1254
Echinococcus granulosus protein arginine N methyltransferase 7 0.0053 0.0049 0.0049
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0067 0.0068 0.0346
Mycobacterium tuberculosis Possible oxidoreductase 0.007 0.0072 0.1075
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0095 0.0108 0.0135
Brugia malayi Kringle domain containing protein 0.0051 0.0045 0.0045
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0451 0.0618 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.0005 0.0005
Plasmodium falciparum thrombospondin-related anonymous protein 0.0022 0.0005 0.0055
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0067 0.0068 0.0068
Brugia malayi hypothetical protein 0.0039 0.0028 0.0028
Echinococcus granulosus cubilin 0.0024 0.0007 0.0007
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0311 0.0417 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.007 0.0072 0.1075
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0451 0.0618 1
Onchocerca volvulus 0.0039 0.0028 0.0466
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0067 0.0068 0.1241
Schistosoma mansoni hypothetical protein 0.1274 0.1796 0.1796
Plasmodium falciparum DNA repair endonuclease, putative 0.0034 0.0021 0.0355
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0311 0.0417 0.0417
Plasmodium vivax apical sushi protein, putative 0.0039 0.0028 0.0494
Schistosoma mansoni hypothetical protein 0.0022 0.0005 0.0005
Brugia malayi Protein kinase domain containing protein 0.0041 0.0031 0.0031
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1718 0.2432 0.3977
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.007 0.0072 0.1326
Mycobacterium ulcerans NAD-dependent deacetylase 0.0067 0.0068 0.0159
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Loa Loa (eye worm) hypothetical protein 0.0039 0.0028 0.0028
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0024 0.0007 0.0007
Plasmodium falciparum apical sushi protein 0.0039 0.0028 0.0494
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0451 0.0618 0.1011
Loa Loa (eye worm) hypothetical protein 0.0343 0.0463 0.0463
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0022 0.0005 0.0005
Brugia malayi Subtilase family protein 0.0311 0.0417 0.0417
Schistosoma mansoni memapsin-2 (A01 family) 0.0035 0.0022 0.0022
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.007 0.0072 0.0286
Loa Loa (eye worm) hypothetical protein 0.007 0.0072 0.0072
Echinococcus granulosus discoidin domain receptor 0.0041 0.0031 0.0031
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0053 0.0049 0.0049
Mycobacterium ulcerans monoamine oxidase 0.007 0.0072 0.0286
Loa Loa (eye worm) hypothetical protein 0.0039 0.0028 0.0028
Onchocerca volvulus 0.0024 0.0007 0.0045
Entamoeba histolytica protein kinase, putative 0.0041 0.0032 0.051
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0031 0.005
Trichomonas vaginalis nuclease Rad1 0.0038 0.0027 0.0044
Leishmania major UDP-galactopyranose mutase 0.007 0.0072 0.0474
Loa Loa (eye worm) hypothetical protein 0.0096 0.011 0.011
Entamoeba histolytica protein kinase, putative 0.0041 0.0032 0.051
Schistosoma mansoni excision repair cross-complementing 1 ercc1 0.0054 0.0049 0.0049
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0229 0.03 0.03
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0113 0.0113
Onchocerca volvulus 0.0039 0.0028 0.0466
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0022 0.0022
Trypanosoma brucei SIR2-like protein 4, putative 0.0067 0.0068 0.0346
Brugia malayi GCC2 and GCC3 family protein 0.0048 0.0042 0.0042
Echinococcus multilocularis cubilin 0.0024 0.0007 0.0009
Echinococcus granulosus protein kinase C gamma type 0.0021 0.0002 0.0002
Plasmodium vivax DNA repair endonuclease, putative 0.0038 0.0027 0.048
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0335 0.0452 0.2492
Brugia malayi transcriptional regulator, Sir2 family protein 0.0067 0.0068 0.0068
Echinococcus granulosus serine:threonine protein kinase N2 0.0072 0.0075 0.0075
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0067 0.0068 0.1095
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0067 0.0068 0.0111
Trichomonas vaginalis AGC family protein kinase 0.0041 0.0032 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0041 0.0032 0.0052
Echinococcus multilocularis c4b binding protein beta chain 0.0039 0.0028 0.0035
Toxoplasma gondii DNA repair protein rad10 subfamily protein 0.0054 0.0049 0.0936
Brugia malayi Furin-like cysteine rich region family protein 0.0659 0.0916 0.0916
Brugia malayi hypothetical protein 0.007 0.0072 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0007 0.0011
Brugia malayi von Willebrand factor type A domain containing protein 0.0022 0.0005 0.0005
Loa Loa (eye worm) ERCC4 domain-containing protein 0.0038 0.0027 0.0027
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0067 0.0068 0.0111
Echinococcus granulosus epidermal growth factor receptor 0.0659 0.0916 0.0916
Trichomonas vaginalis conserved hypothetical protein 0.1407 0.1987 0.3249
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0041 0.0031 0.0038
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0311 0.0417 0.0417
Onchocerca volvulus 0.0372 0.0505 1
Brugia malayi von Willebrand Factor 0.0022 0.0005 0.0005
Echinococcus granulosus nervana 2 0.002 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0007
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1407 0.1987 0.3249
Trichomonas vaginalis conserved hypothetical protein 0.0311 0.0417 0.0683
Plasmodium falciparum subtilisin-like protease 3 0.0311 0.0417 0.7819
Onchocerca volvulus Putative endochitinase 0.0073 0.0077 0.1457
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Echinococcus granulosus membrane bound transcription factor site 1 0.0311 0.0417 0.0417
Echinococcus granulosus Glutaredoxin protein 5 0.002 0.0001 0.0001
Brugia malayi von Willebrand factor type A domain containing protein 0.0022 0.0005 0.0005
Echinococcus multilocularis discoidin domain receptor 0.0041 0.0031 0.0038
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0053 0.0049 0.008
Schistosoma mansoni discoidin domain receptor 0.0041 0.0031 0.0031
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Loa Loa (eye worm) TK/ALK protein kinase 0.0096 0.011 0.011
Trichomonas vaginalis conserved hypothetical protein 0.1407 0.1987 0.3249
Echinococcus multilocularis Glutaredoxin protein 5 0.002 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0024 0.0007 0.0007
Loa Loa (eye worm) sirtuin 4 0.0067 0.0068 0.0068
Loa Loa (eye worm) subtilase 0.0311 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0029 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0039 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0007
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0148 0.0184 0.2982
Mycobacterium tuberculosis Possible chitinase 0.0063 0.0062 0.0813
Toxoplasma gondii F5/8 type C domain-containing protein 0.0041 0.0031 0.0542
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0041 0.0031 0.005
Brugia malayi von Willebrand factor type A domain containing protein 0.0022 0.0005 0.0005
Entamoeba histolytica hypothetical protein, conserved 0.0022 0.0005 0.0075
Onchocerca volvulus 0.0051 0.0045 0.0807
Brugia malayi Protein kinase domain containing protein 0.0041 0.0032 0.0032
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0022 0.0005 0.0055
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0311 0.0417 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0031 0.005
Treponema pallidum hypothetical protein 0.0022 0.0005 0.5
Trypanosoma cruzi UDP-galactopyranose mutase 0.007 0.0072 0.1144
Loa Loa (eye worm) Carm1-pending protein 0.0053 0.0049 0.0049
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0095 0.0108 0.1999
Echinococcus granulosus discoidin domain containing receptor 2 0.0041 0.0031 0.0031
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0022 0.0005 0.0006
Schistosoma mansoni chromatin regulatory protein sir2 0.0067 0.0068 0.0068
Brugia malayi CUB domain containing protein 0.0024 0.0007 0.0007
Entamoeba histolytica DNA repair endonuclease, putative 0.0038 0.0027 0.044
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0161 0.0203 0.4455
Onchocerca volvulus 0.019 0.0244 0.4791
Trichomonas vaginalis conserved hypothetical protein 0.1407 0.1987 0.3249
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0031 0.005
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0053 0.0049 0.0922
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0024 0.0007 0.0007
Echinococcus multilocularis cubilin 0.0024 0.0007 0.0009
Plasmodium vivax hypothetical protein, conserved 0.007 0.0072 0.1326
Schistosoma mansoni site-1 peptidase (S08 family) 0.0311 0.0417 0.0417
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0031 0.005
Loa Loa (eye worm) CUB domain-containing protein 0.0024 0.0007 0.0007
Schistosoma mansoni growth factor receptor-bound protein 0.0138 0.017 0.017
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0053 0.0049 0.0764
Brugia malayi protein kinase C II. 0.0098 0.0113 0.0113
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0039 0.0028 0.0028
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0022 0.0005 0.0055
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0067 0.0068 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.1407 0.1987 0.3249
Schistosoma mansoni protein arginine n-methyltransferase 0.0053 0.0049 0.0049
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Trypanosoma cruzi Protein kinase B 0.0022 0.0005 0.0047
Loa Loa (eye worm) hypothetical protein 0.0032 0.0018 0.0018
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0035 0.0022 0.0369
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0311 0.0417 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0067 0.0068 0.0068
Leishmania major arginine N-methyltransferase, type I 0.0053 0.0049 0.0066
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0022 0.0022
Brugia malayi Nematode astacin protease protein 30 0.0024 0.0007 0.0007
Plasmodium falciparum plasmepsin IV 0.0035 0.0022 0.0388
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0067 0.0068 0.0111
Toxoplasma gondii subtilisin SUB6 0.0311 0.0417 0.862
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0022 0.0005 0.0055
Loa Loa (eye worm) hypothetical protein 0.0096 0.011 0.011
Loa Loa (eye worm) microfilarial chitinase 0.0063 0.0062 0.0062
Treponema pallidum 76K protein 0.0022 0.0005 0.5
Toxoplasma gondii subtilisin SUB9 0.0311 0.0417 0.862
Plasmodium falciparum plasmepsin I 0.0035 0.0022 0.0388
Schistosoma mansoni amine oxidase 0.007 0.0072 0.0072
Plasmodium vivax subtilisin-like protease 2, putative 0.0311 0.0417 0.7819
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0024 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0096 0.011 0.011
Chlamydia trachomatis protoporphyrinogen oxidase 0.007 0.0072 0.5
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0035 0.0022 0.0022
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0311 0.0417 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0022 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.007 0.0072 0.0072
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0311 0.0417 0.0417
Echinococcus granulosus protein kinase c epsilon type 0.0098 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0041 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0032 0.0018 0.0018
Plasmodium vivax subtilisin-like protease 1 0.0311 0.0417 0.7819
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0679 0.0944 0.0944
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0095 0.0108 0.1999
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0311 0.0417 0.0523
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0007
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0095 0.0108 0.0177
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0024 0.0007 0.0007
Echinococcus granulosus Protein kinase C brain isozyme 0.0027 0.0011 0.0011
Brugia malayi hypothetical protein 0.0022 0.0005 0.0005
Echinococcus multilocularis discoidin domain containing receptor 2 0.0041 0.0031 0.0038
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0005 0.0055
Echinococcus granulosus DNA excision repair protein ERCC 1 0.0054 0.0049 0.0049
Brugia malayi Will die slowly protein 0.0136 0.0167 0.0167
Brugia malayi amine oxidase, flavin-containing family protein 0.0099 0.0114 0.0114
Plasmodium vivax LCCL domain-containing protein 0.0041 0.0031 0.0543
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1718 0.2432 0.3977
Brugia malayi Pepsin A precursor 0.0035 0.0022 0.0022
Onchocerca volvulus 0.0039 0.0028 0.0466
Trichomonas vaginalis AGC family protein kinase 0.0041 0.0032 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0041 0.0032 0.0052
Echinococcus granulosus voltage dependent calcium channel subunit 0.0022 0.0005 0.0005
Onchocerca volvulus 0.0096 0.011 0.2099
Toxoplasma gondii aspartyl protease ASP3 0.0035 0.0022 0.0369
Brugia malayi Sushi domain 0.0039 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0311 0.0417 0.0683
Echinococcus multilocularis growth factor receptor bound protein 2 0.0138 0.017 0.0212
Brugia malayi Helix-hairpin-helix motif family protein 0.0031 0.0016 0.0016
Loa Loa (eye worm) AGC/AKT protein kinase 0.0041 0.0032 0.0032
Entamoeba histolytica hypothetical protein 0.0022 0.0005 0.0075
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.002 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0031 0.005
Mycobacterium ulcerans oxidoreductase 0.007 0.0072 0.0286
Echinococcus multilocularis chromatin regulatory protein sir2 0.0451 0.0618 0.0774
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Toxoplasma gondii AGC kinase 0.0039 0.0029 0.0502
Brugia malayi hypothetical protein 0.0148 0.0184 0.0184
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1718 0.2432 0.3977
Echinococcus multilocularis dna repair endonuclease xpf 0.0038 0.0027 0.0034
Loa Loa (eye worm) TK/ROR protein kinase 0.0051 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0099 0.0114 0.0114
Toxoplasma gondii rhoptry neck protein RON9 0.0039 0.0028 0.0487
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0095 0.0108 0.0108
Toxoplasma gondii bicoid-interacting protein BIN3 0.0053 0.0049 0.0922
Echinococcus granulosus lysine specific histone demethylase 1A 0.007 0.0072 0.0072
Mycobacterium ulcerans dehydrogenase 0.007 0.0072 0.0286
Echinococcus granulosus neuropilin nrp and tolloid tll 0.0024 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Entamoeba histolytica SWIRM domain protein 0.0029 0.0014 0.0226
Brugia malayi Sex muscle abnormal protein 5 0.0138 0.017 0.017
Brugia malayi hypothetical protein 0.0035 0.0022 0.0022
Echinococcus granulosus Tolloid protein 1 0.0024 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0031 0.005
Brugia malayi Endochitinase 0.0073 0.0077 0.0077
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0022 0.0022
Brugia malayi ERCC4 domain containing protein 0.0038 0.0027 0.0027
Schistosoma mansoni c4b-binding protein beta chain 0.0039 0.0028 0.0028
Echinococcus multilocularis membrane bound transcription factor site 1 0.0311 0.0417 0.0523
Brugia malayi hypothetical protein 0.0039 0.0028 0.0028
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0035 0.0022 0.0036
Mycobacterium ulcerans epoxide hydrolase EphA 0.0161 0.0203 0.3964
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0451 0.0618 1
Plasmodium falciparum plasmepsin VI 0.0035 0.0022 0.0388
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0007
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0003 0.0005
Brugia malayi von Willebrand factor type A domain containing protein 0.0022 0.0005 0.0005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0024 0.0007 0.0007
Plasmodium falciparum LCCL domain-containing protein 0.0041 0.0031 0.0543
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0098 0.0113 0.0113
Echinococcus granulosus chromatin regulatory protein sir2 0.0451 0.0618 0.0618
Echinococcus multilocularis epidermal growth factor receptor 0.0659 0.0916 0.1147
Echinococcus multilocularis serine threonine protein kinase 0.0021 0.0002 0.0002
Plasmodium vivax aspartyl proteinase, putative 0.0035 0.0022 0.0388
Plasmodium vivax NAD-dependent deacetylase, putative 0.0067 0.0068 0.1241
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0005 0.0005
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0311 0.0417 1
Toxoplasma gondii subtilisin SUB8 0.0311 0.0417 0.862
Echinococcus multilocularis neuroendocrine convertase 2 0.4433 0.6318 0.7912
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0053 0.0049 0.0061
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0029 0.0014 0.0017
Loa Loa (eye worm) helix-hairpin-helix domain-containing protein family protein 0.0054 0.0049 0.0049
Loa Loa (eye worm) DEAH box polypeptide 35 0.0032 0.0019 0.0019
Loa Loa (eye worm) chitinase I 0.0073 0.0077 0.0077
Brugia malayi SWIRM domain containing protein 0.0029 0.0014 0.0014
Toxoplasma gondii subtilisin SUB7 0.0311 0.0417 0.862
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0031 0.0031
Onchocerca volvulus Putative cubilin 0.0034 0.0021 0.0321
Giardia lamblia Transcriptional regulator, Sir2 family 0.0067 0.0068 0.0181
Schistosoma mansoni growth factor receptor-bound protein 0.0138 0.017 0.017
Brugia malayi astacin protease protein 30 0.0024 0.0007 0.0007
Brugia malayi CUB domain containing protein 0.0024 0.0007 0.0007
Brugia malayi Eukaryotic aspartyl protease family protein 0.0035 0.0022 0.0022
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0067 0.0068 0.0068
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0451 0.0618 0.342
Brugia malayi hypothetical protein 0.0096 0.011 0.011
Echinococcus multilocularis protein kinase c epsilon type 0.0098 0.0113 0.0141
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0024 0.0007 0.0007
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.002 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Toxoplasma gondii rhoptry neck protein RON1 0.0039 0.0028 0.0487
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0031 0.005
Echinococcus granulosus MAM 0.0096 0.011 0.011
Toxoplasma gondii subtilisin SUB1 0.0311 0.0417 0.862
Brugia malayi hypothetical protein 0.0039 0.0028 0.0028
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0053 0.0049 0.0789
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0031 0.005
Brugia malayi hypothetical protein 0.0039 0.0028 0.0028
Onchocerca volvulus 0.0039 0.0028 0.0466
Loa Loa (eye worm) hypothetical protein 0.0311 0.0417 0.0417
Toxoplasma gondii aspartyl protease ASP1 0.0035 0.0022 0.0369
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0007
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0022 0.0022
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0451 0.0618 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4291 0.6114 1
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0053 0.0049 0.0922
Echinococcus granulosus discoidin domain containing receptor 2 0.0041 0.0031 0.0031
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0067 0.0068 0.0068
Brugia malayi Angiotensin-converting enzyme family protein 0.0679 0.0944 0.0944
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1407 0.1987 0.3249
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0067 0.0068 0.1095
Onchocerca volvulus Putative endochitinase 0.0073 0.0077 0.1457
Brugia malayi NAD-dependent deacetylase SIRT1 0.0067 0.0068 0.0068
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0067 0.0068 0.0085
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Trichomonas vaginalis hypothetical protein 0.1407 0.1987 0.3249
Schistosoma mansoni hypothetical protein 0.0096 0.011 0.011
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.7006 1 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0451 0.0618 0.0618
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0311 0.0417 0.0683
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0041 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0032 0.0019 0.0019
Brugia malayi hypothetical protein 0.0039 0.0028 0.0028
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0035 0.0022 0.0369
Schistosoma mansoni SWI/SNF complex-related 0.0029 0.0014 0.0014
Echinococcus granulosus dna repair endonuclease xpf 0.0038 0.0027 0.0027
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0027 0.0011 0.0014
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0053 0.0049 0.008
Echinococcus multilocularis serine:threonine protein kinase N2 0.0091 0.0102 0.0128
Plasmodium falciparum ERCC1 nucleotide excision repair protein, putative 0.0054 0.0049 0.0899
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0031 0.005
Loa Loa (eye worm) DPY-31 protein 0.0024 0.0007 0.0007
Toxoplasma gondii subtilisin SUB2 0.0311 0.0417 0.862

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 65 % Percent inhibition of calcium-induced contraction on K+ depolarized guinea pig aortic strip. ChEMBL. 10346921
Activity (functional) = 77 % Decrease in developed tension of the left atrium of guinea pig expressed as the negative inotropy. ChEMBL. 10346921
Activity (functional) = 92 % Decrease in developed tension of the right atrium of guinea pig expressed as the negative chronotropy. ChEMBL. 10346921
Alpha max (functional) = 0.8 The efficacy in reverting MDR was evaluated on human erythroleukaemia K-562 cell line ChEMBL. 10346921
Dead cells (ADMET) = 0 % Percentage of the dead cells of K-562 cells was determined for the compound ChEMBL. 10346921
Dead cells (ADMET) = 0 % Percentage of the dead cells of K-562 cells was determined for the compound ChEMBL. 10346921
EC30 (functional) = 0.24 uM Potency expressed as EC30 for the negative chronotropic activity. ChEMBL. 10346921
EC50 (functional) = 16 uM Potency expressed as EC50 for the negative inotropic activity. ChEMBL. 10346921
IC50 (functional) = 3.42 uM Potency expressed as IC50 for the vasorelaxant activity. ChEMBL. 10346921
Potency (functional) = 1.3 uM Potency that causes a half maximal increase in nuclear concentration of pirarubicin. ChEMBL. 10346921
Potency (functional) = 1.3 uM Potency that causes a half maximal increase in nuclear concentration of pirarubicin. ChEMBL. 10346921

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 10346921

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.