Detailed information for compound 686170

Basic information

Technical information
  • TDR Targets ID: 686170
  • Name: N-(3-cyanothiophen-2-yl)-2-[(4-fluorophenyl)s ulfonylamino]benzamide
  • MW: 401.435 | Formula: C18H12FN3O3S2
  • H donors: 2 H acceptors: 4 LogP: 4.22 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccsc1NC(=O)c1ccccc1NS(=O)(=O)c1ccc(cc1)F
  • InChi: 1S/C18H12FN3O3S2/c19-13-5-7-14(8-6-13)27(24,25)22-16-4-2-1-3-15(16)17(23)21-18-12(11-20)9-10-26-18/h1-10,22H,(H,21,23)
  • InChiKey: LUSYSPFHPJQMNK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-cyano-2-thienyl)-2-[(4-fluorophenyl)sulfonylamino]benzamide
  • ZINC04270366

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0191 0.0144
Schistosoma mansoni hypothetical protein 0.0073 0.0191 0.0285
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0888 0.3276 0.3266
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0073 0.0191 0.0144
Echinococcus multilocularis serine:threonine protein kinase N2 0.0888 0.3276 0.4882
Entamoeba histolytica protein kinase, putative 0.2664 1 1
Trichomonas vaginalis centaurin alpha, putative 0.0073 0.0191 0.0144
Trypanosoma cruzi hypothetical protein 0.0073 0.0191 0.0263
Loa Loa (eye worm) PH domain-containing protein 0.0073 0.0191 0.0176
Echinococcus multilocularis serine:threonine protein kinase 38 0.0888 0.3276 0.4882
Leishmania major serine/threonine-protein kinase a, putative 0.0092 0.0264 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0048 0.0072
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0073 0.0191 0.0144
Brugia malayi Cadps2 protein 0.0073 0.0191 0.0184
Echinococcus multilocularis serine:threonine protein kinase N2 0.0888 0.3276 0.4882
Onchocerca volvulus 0.0073 0.0191 0.0457
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0073 0.0191 0.0457
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0102 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0191 0.0144
Trypanosoma cruzi PH domain containing protein, putative 0.0073 0.0191 0.0263
Entamoeba histolytica protein kinase, putative 0.0092 0.0264 0.0217
Schistosoma mansoni serine/threonine protein kinase 0.0888 0.3276 0.4882
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0092 0.0264 0.0371
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0073 0.0191 0.0274
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.1722 0.6435 0.9588
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0191 0.0144
Brugia malayi probable spectrin beta chain 0.0073 0.0191 0.0184
Entamoeba histolytica hypothetical protein 0.0073 0.0191 0.0144
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0073 0.0191 0.0144
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0092 0.0264 0.0371
Brugia malayi jmjC domain containing protein 0.0194 0.0648 0.0641
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0073 0.0191 0.0285
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0176
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0139 0.5
Loa Loa (eye worm) cytohesin 3 0.0073 0.0191 0.0176
Echinococcus granulosus pdz domain containing protein 0.0073 0.0191 0.0285
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0092 0.0264 0.0371
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0073 0.0191 0.0144
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0051 0.0075
Entamoeba histolytica PH domain containing protein kinase, putative 0.0092 0.0264 0.0217
Brugia malayi jmjC domain containing protein 0.0074 0.0193 0.0186
Brugia malayi p70 ribosomal S6 kinase beta 0.2591 0.9723 0.9723
Schistosoma mansoni alpha-glucosidase 0.0137 0.0433 0.0645
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0102 0.0094
Onchocerca volvulus 0.0073 0.0191 0.0457
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0073 0.0191 0.0263
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0092 0.0264 0.0249
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0073 0.0191 0.0144
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0888 0.3276 0.4882
Leishmania major folate/biopterin transporter, putative 0.0092 0.0264 1
Trichomonas vaginalis AGC family protein kinase 0.0888 0.3276 0.3243
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0048 0.0041
Loa Loa (eye worm) hypothetical protein 0.0043 0.0076 0.0061
Trichomonas vaginalis centaurin gamma, putative 0.0073 0.0191 0.0144
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0073 0.0191 0.0144
Echinococcus multilocularis rac serine:threonine kinase 0.1795 0.6711 1
Echinococcus granulosus caspase 2 0.0061 0.0145 0.0216
Brugia malayi Bromodomain containing protein 0.0038 0.006 0.0052
Trichomonas vaginalis AGC family protein kinase 0.2664 1 1
Trypanosoma cruzi hypothetical protein 0.0073 0.0191 0.0263
Echinococcus granulosus histone lysine methyltransferase setb 0.0107 0.0319 0.0475
Trichomonas vaginalis set domain proteins, putative 0.0712 0.261 0.2574
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0073 0.0191 0.0285
Toxoplasma gondii protein kinase domain-containing protein 0.0092 0.0264 0.0256
Schistosoma mansoni alpha glucosidase 0.0035 0.0048 0.0072
Echinococcus multilocularis pdz domain containing protein 0.0073 0.0191 0.0285
Schistosoma mansoni caspase-7 (C14 family) 0.0061 0.0145 0.0216
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0176
Entamoeba histolytica PH domain containing protein 0.0073 0.0191 0.0144
Trichomonas vaginalis AGC family protein kinase 0.0961 0.3553 0.3521
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0092 0.0264 0.0217
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0176
Echinococcus multilocularis nervana 2 0.1703 0.6362 0.948
Schistosoma mansoni zinc finger protein 0.0073 0.0191 0.0285
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0191 0.0144
Brugia malayi PH domain containing protein 0.0073 0.0191 0.0184
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.0516 0.0509
Schistosoma mansoni hypothetical protein 0.0034 0.0043 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0191 0.0144
Onchocerca volvulus 0.0092 0.0263 0.0739
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0073 0.0191 0.0285
Echinococcus multilocularis oxysterol binding protein 3 0.0073 0.0191 0.0285
Brugia malayi hypothetical protein 0.0042 0.0076 0.0068
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0089 0.0133
Loa Loa (eye worm) hypothetical protein 0.0059 0.0139 0.0123
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0254 0.0379
Schistosoma mansoni goodpasture antigen-binding protein 0.0073 0.0191 0.0285
Loa Loa (eye worm) AGC/NDR protein kinase 0.0888 0.3276 0.3266
Echinococcus multilocularis jumonji domain containing protein 0.0082 0.0227 0.0338
Echinococcus granulosus protein kinase c iota type 0.0888 0.3276 0.4882
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0 0.0001
Echinococcus granulosus oxysterol binding protein 1 0.0073 0.0191 0.0285
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0092 0.0264 0.0249
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0139 0.0207
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0073 0.0191 0.0285
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0264 0.0217
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0073 0.0191 0.0144
Trypanosoma cruzi rac serine-threonine kinase, putative 0.1722 0.6435 0.9587
Schistosoma mansoni syntrophin 0.0073 0.0191 0.0285
Brugia malayi Cytohesin 3 0.0073 0.0191 0.0184
Loa Loa (eye worm) hypothetical protein 0.0049 0.0102 0.0086
Echinococcus granulosus serine:threonine protein kinase N2 0.0888 0.3276 0.4882
Schistosoma mansoni myotubularin-related protein 0.0073 0.0191 0.0285
Entamoeba histolytica PH domain containing protein 0.0073 0.0191 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0191 0.0144
Schistosoma mansoni centaurin alpha 0.0073 0.0191 0.0285
Echinococcus granulosus cytohesin 1 0.0073 0.0191 0.0285
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0176
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0194 0.0648 0.0966
Schistosoma mansoni hypothetical protein 0.0073 0.0191 0.0285
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0073 0.0191 0.0285
Onchocerca volvulus Protein melted homolog 0.0073 0.0191 0.0457
Trypanosoma brucei rac serine-threonine kinase, putative 0.2664 1 1
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0073 0.0191 0.0285
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0869 0.3204 0.3171
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0073 0.0191 0.0285
Echinococcus granulosus protein kinase C gamma type 0.0888 0.3276 0.4882
Schistosoma mansoni serine/threonine protein kinase 0.0888 0.3276 0.4882
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0516 0.077
Echinococcus multilocularis GRB2 associated binding protein 3 0.0073 0.0191 0.0285
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.0516 0.0502
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0139 0.0207
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0139 0.0207
Entamoeba histolytica hypothetical protein 0.0073 0.0191 0.0144
Trypanosoma cruzi hypothetical protein 0.0073 0.0191 0.0263
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0048 0.0049
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0254 0.0246
Trichomonas vaginalis AGC family protein kinase 0.2664 1 1
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0264 0.0217
Trypanosoma brucei glucosidase, putative 0.0035 0.0048 0.0033
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0888 0.3276 0.4882
Echinococcus granulosus jumonji domain containing protein 0.0082 0.0227 0.0338
Echinococcus granulosus Pleckstrin y 0.0073 0.0191 0.0285
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0254 0.0379
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0048 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0191 0.0144
Brugia malayi Bromodomain containing protein 0.0075 0.0198 0.0191
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0073 0.0191 0.0144
Trypanosoma cruzi NIMA-related kinase, putative 0.0092 0.0264 0.0371
Echinococcus granulosus lysine specific demethylase 5A 0.0074 0.0193 0.0288
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0073 0.0191 0.0274
Echinococcus multilocularis oxysterol binding protein 9 0.0073 0.0191 0.0285
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0888 0.3276 0.3266
Brugia malayi Hr1 repeat family protein 0.0888 0.3276 0.3271
Brugia malayi Protein kinase domain containing protein 0.0888 0.3276 0.3271
Echinococcus multilocularis calcium dependent secretion activator 1 0.0073 0.0191 0.0285
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0264 0.0217
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0264 0.0217
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0264 0.0217
Plasmodium falciparum oxysterol-binding protein, putative 0.0073 0.0191 0.0274
Echinococcus granulosus serine threonine protein kinase nrc 0.1722 0.6435 0.9588
Brugia malayi Variant SH3 domain containing protein 0.0073 0.0191 0.0184
Onchocerca volvulus 0.0073 0.0191 0.0457
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0092 0.0264 0.0256
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0073 0.0191 0.0176
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0073 0.0191 0.0285
Echinococcus granulosus nervana 2 0.1703 0.6362 0.948
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0264 0.0217
Echinococcus multilocularis nervana 2 0.1703 0.6362 0.948
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0176
Brugia malayi Plekhf2 protein 0.0073 0.0191 0.0184
Echinococcus granulosus Protein kinase C brain isozyme 0.0888 0.3276 0.4882
Trypanosoma cruzi hypothetical protein 0.0073 0.0191 0.0263
Brugia malayi PHD-finger family protein 0.0059 0.0139 0.0131
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0092 0.0264 0.0371
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0092 0.0264 0.0371
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0191 0.0144
Trypanosoma cruzi PH domain containing protein, putative 0.0073 0.0191 0.0263
Schistosoma mansoni jumonji domain containing protein 0.0154 0.0498 0.0742
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0264 0.0217
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0516 0.077
Brugia malayi Cell death protein 3 precursor 0.0061 0.0145 0.0137
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0073 0.0191 0.0285
Schistosoma mansoni hypothetical protein 0.0059 0.0139 0.0207
Echinococcus multilocularis caspase 2 0.0061 0.0145 0.0216
Echinococcus multilocularis DCC interacting protein 13 beta 0.0073 0.0191 0.0285
Schistosoma mansoni goodpasture antigen-binding protein 0.0073 0.0191 0.0285
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0073 0.0191 0.0144
Schistosoma mansoni oxysterol-binding protein 1 0.0073 0.0191 0.0285
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.2591 0.9723 0.9723
Trichomonas vaginalis AGC family protein kinase 0.0888 0.3276 0.3243
Trichomonas vaginalis protein transport protein sec7, putative 0.0073 0.0191 0.0144
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0176
Loa Loa (eye worm) AGC/AKT protein kinase 0.2664 1 1
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0888 0.3276 0.4882
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0073 0.0191 0.0285
Entamoeba histolytica PH domain containing protein kinase, putative 0.0092 0.0264 0.0217
Loa Loa (eye worm) hypothetical protein 0.0038 0.006 0.0044
Entamoeba histolytica PH domain containing protein 0.0073 0.0191 0.0144
Trypanosoma cruzi rac serine-threonine kinase, putative 0.1795 0.6711 1
Loa Loa (eye worm) syntrophin-1 0.0073 0.0191 0.0176
Plasmodium falciparum calcium-dependent protein kinase 7 0.0092 0.0264 0.0387
Loa Loa (eye worm) hypothetical protein 0.0034 0.0043 0.0027
Entamoeba histolytica hypothetical protein, conserved 0.0073 0.0191 0.0144
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.1722 0.6435 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0139 0.0127
Entamoeba histolytica protein kinase, putative 0.2664 1 1
Trypanosoma cruzi NIMA-related kinase, putative 0.0092 0.0264 0.0371
Echinococcus multilocularis beta 1 syntrophin 0.0073 0.0191 0.0285
Trichomonas vaginalis AGC family protein kinase 0.0888 0.3276 0.3243
Entamoeba histolytica hypothetical protein 0.0073 0.0191 0.0144
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0073 0.0191 0.0144
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0176
Trypanosoma cruzi hypothetical protein 0.0073 0.0191 0.0263
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0264 0.0217
Trichomonas vaginalis AGC family protein kinase 0.2664 1 1
Trichomonas vaginalis centaurin beta, putative 0.0073 0.0191 0.0144
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0176
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0176
Schistosoma mansoni growth factor receptor-bound protein 0.0073 0.0191 0.0285
Schistosoma mansoni serine/threonine-protein kinase 0.1795 0.6711 1
Schistosoma mansoni vav2 0.0073 0.0191 0.0285
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0264 0.0217
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0139 0.0123
Schistosoma mansoni oxysterol-binding protein 1 0.0073 0.0191 0.0285
Entamoeba histolytica hypothetical protein 0.0092 0.0264 0.0217
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0073 0.0191 0.0144
Toxoplasma gondii hypothetical protein 0.0073 0.0191 0.0181
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0139 0.496
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0176
Entamoeba histolytica protein kinase, putative 0.0092 0.0264 0.0217
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0048 0.0034
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0191 0.0144
Echinococcus multilocularis cytohesin 1 0.0073 0.0191 0.0285
Trypanosoma brucei PH domain containing protein, putative 0.0073 0.0191 0.0176
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0264 0.0217
Giardia lamblia Kinase, AGC PKA 0.1722 0.6435 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0089 0.0133
Loa Loa (eye worm) hypothetical protein 0.0061 0.0145 0.0129
Entamoeba histolytica p21-activated kinase 0.0092 0.0264 0.0217
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0048 0.132
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0264 0.0217
Trypanosoma cruzi Protein kinase B 0.1795 0.6711 1
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0191 0.0144
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0073 0.0191 0.0144
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0139 0.0131
Echinococcus granulosus myotubularin protein 13 0.0073 0.0191 0.0285
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0089 0.0133
Toxoplasma gondii phosphatidylinositol transfer protein 0.0073 0.0191 0.0181
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0264 0.0217
Entamoeba histolytica ARF GTPase activating protein, putative 0.0073 0.0191 0.0144
Echinococcus granulosus NDR protein kinase 0.0888 0.3276 0.4882
Toxoplasma gondii AtPH1 family protein 0.0073 0.0191 0.0181
Echinococcus granulosus oxysterol binding protein 9 0.0073 0.0191 0.0285
Echinococcus granulosus protein kinase c epsilon type 0.0888 0.3276 0.4882
Loa Loa (eye worm) oxysterol binding protein 0.0073 0.0191 0.0176
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0139 0.0207
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0264 0.0217
Plasmodium vivax SET domain protein, putative 0.009 0.0254 0.0372
Brugia malayi PH domain containing protein 0.0073 0.0191 0.0184
Onchocerca volvulus Alhambra homolog 0.0059 0.0139 0.0249
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0139 0.0207
Entamoeba histolytica PH domain containing protein kinase, putative 0.0092 0.0264 0.0217
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.1703 0.6362 0.948
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0089 0.0081
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0242 0.036
Onchocerca volvulus 0.0073 0.0191 0.0457
Echinococcus multilocularis Oxysterol binding protein 11 0.0073 0.0191 0.0285
Schistosoma mansoni dynamin 0.0073 0.0191 0.0285
Echinococcus multilocularis apoptotic protease activating factor 1 0.0042 0.0076 0.0113
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0051 0.0075
Echinococcus multilocularis Pleckstrin y 0.0073 0.0191 0.0285
Echinococcus multilocularis Ras associated and pleckstrin y 0.0073 0.0191 0.0285
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.1722 0.6435 0.9588
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0073 0.0191 0.0274
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0139 0.0192
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.0193 0.0288
Schistosoma mansoni serine/threonine protein kinase 0.0888 0.3276 0.4882
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0073 0.0191 0.0184
Echinococcus multilocularis Glutaredoxin protein 5 0.1703 0.6362 0.948
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0089 0.0133
Brugia malayi Variant SH3 domain containing protein 0.0073 0.0191 0.0184
Schistosoma mansoni hypothetical protein 0.0073 0.0191 0.0285
Brugia malayi Pleckstrin Homology Domain 0.0073 0.0191 0.0184
Loa Loa (eye worm) hypothetical protein 0.0101 0.0299 0.0284
Echinococcus granulosus apoptotic protease activating factor 1 0.0042 0.0076 0.0113
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0139 0.5
Echinococcus granulosus serine/threonine protein kinase 0.1795 0.6711 1
Toxoplasma gondii hypothetical protein 0.0073 0.0191 0.0181
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0264 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0191 0.0144
Entamoeba histolytica protein kinase, putative 0.2591 0.9723 0.9722
Entamoeba histolytica protein kinase, putative 0.0092 0.0264 0.0217
Echinococcus granulosus oxysterol binding protein 3 0.0073 0.0191 0.0285
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0073 0.0191 0.0144
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0092 0.0264 0.0387
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0073 0.0191 0.0144
Echinococcus multilocularis Rho GTPase activating protein 24 0.0073 0.0191 0.0285
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0073 0.0191 0.0176
Loa Loa (eye worm) uncoordinated protein 104 0.0073 0.0191 0.0176
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0073 0.0191 0.0263
Plasmodium vivax PH domain containing protein 0.0073 0.0191 0.0274
Onchocerca volvulus 0.0073 0.0191 0.0457
Leishmania major hypothetical protein, conserved 0.0073 0.0191 0.7081
Echinococcus granulosus beta 1 syntrophin 0.0073 0.0191 0.0285
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0073 0.0191 0.0144
Entamoeba histolytica protein kinase 2, putative 0.1722 0.6435 0.6417
Brugia malayi PHD-finger family protein 0.0025 0.0009 0.0001
Brugia malayi PH domain containing protein 0.0073 0.0191 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0191 0.0144
Entamoeba histolytica PH domain containing protein kinase, putative 0.1795 0.6711 0.6695
Echinococcus granulosus GRB2 associated binding protein 3 0.0073 0.0191 0.0285
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0176
Brugia malayi PH domain containing protein 0.0073 0.0191 0.0184
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0888 0.3276 0.4882
Brugia malayi Syntrophin-1 0.0073 0.0191 0.0184
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0073 0.0191 0.0285
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0048 0.0033
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0264 0.0217
Onchocerca volvulus outspread protein homolog 0.0073 0.0191 0.0457
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0073 0.0191 0.0274
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0888 0.3276 0.4882
Echinococcus granulosus Pleckstrin y 0.0073 0.0191 0.0285
Loa Loa (eye worm) hypothetical protein 0.0888 0.3276 0.3266
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0888 0.3276 0.3266
Trichomonas vaginalis AGC family protein kinase 0.2664 1 1
Onchocerca volvulus 0.0073 0.0191 0.0457
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0194 0.0648 0.0966
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0191 0.0144
Loa Loa (eye worm) hypothetical protein 0.0041 0.0069 0.0053
Entamoeba histolytica hypothetical protein 0.0073 0.0191 0.0144
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0073 0.0191 0.0285
Echinococcus granulosus Rho GTPase activating protein 24 0.0073 0.0191 0.0285
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0124 0.0108
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0089 0.0133
Loa Loa (eye worm) hypothetical protein 0.0071 0.0182 0.0167
Brugia malayi Bromodomain containing protein 0.0062 0.0148 0.014
Schistosoma mansoni hypothetical protein 0.0042 0.0076 0.0113
Schistosoma mansoni serine/threonine kinase 0.0888 0.3276 0.4882
Schistosoma mansoni bromodomain containing protein 0.0063 0.0154 0.0229
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0254 0.0379
Loa Loa (eye worm) AGC/PKN protein kinase 0.0888 0.3276 0.3266
Brugia malayi Protein kinase domain containing protein 0.0888 0.3276 0.3271
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0073 0.0191 0.0285
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0139 0.5
Echinococcus multilocularis lysine specific demethylase 5A 0.0072 0.0186 0.0277
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0264 0.0217
Loa Loa (eye worm) Plekhf2 protein 0.0073 0.0191 0.0176
Echinococcus granulosus peregrin 0.0062 0.0148 0.022
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0264 0.0217
Brugia malayi Pre-SET motif family protein 0.0625 0.2282 0.2277
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0073 0.0191 0.0184
Echinococcus multilocularis peregrin 0.0062 0.0148 0.022
Trichomonas vaginalis hypothetical protein 0.0073 0.0191 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0191 0.0144
Loa Loa (eye worm) hypothetical protein 0.0107 0.0319 0.0304
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0073 0.0191 0.0285
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0264 0.0217
Schistosoma mansoni rho gtpase activating protein 0.0073 0.0191 0.0285
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0107 0.0319 0.0475
Trichomonas vaginalis centaurin/arf, putative 0.0073 0.0191 0.0144
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0092 0.0264 0.0217
Toxoplasma gondii Oxysterol-binding protein 0.0073 0.0191 0.0181
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.0193 0.0178
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0073 0.0191 0.0285
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0073 0.0191 0.0285
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0139 0.0207
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0092 0.0264 1
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0073 0.0191 0.0144
Trichomonas vaginalis protein transport protein sec7, putative 0.0073 0.0191 0.0144
Leishmania major protein kinase, putative 0.0092 0.0264 1
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0092 0.0264 1
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0073 0.0191 0.0263
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.0516 0.077
Trichomonas vaginalis AGC family protein kinase 0.2664 1 1
Trypanosoma cruzi hypothetical protein 0.0073 0.0191 0.0263
Schistosoma mansoni zinc finger protein 0.0073 0.0191 0.0285
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0089 0.0074
Plasmodium falciparum phd finger protein, putative 0.0059 0.0139 0.0192
Onchocerca volvulus 0.0073 0.0191 0.0457
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0176
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0073 0.0191 0.0285
Trichomonas vaginalis kinesin light chain, putative 0.0073 0.0191 0.0144
Trichomonas vaginalis AGC family protein kinase 0.2664 1 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0888 0.3276 0.4882
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0888 0.3276 0.4882
Schistosoma mansoni serine/threonine protein kinase 0.0888 0.3276 0.4882
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0176
Echinococcus granulosus dynamin 1 0.0073 0.0191 0.0285
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0073 0.0191 0.0274
Schistosoma mansoni alpha-glucosidase 0.0137 0.0433 0.0645
Echinococcus multilocularis protein kinase c iota type 0.0888 0.3276 0.4882
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0176
Echinococcus granulosus DCC interacting protein 13 beta 0.0073 0.0191 0.0285
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0176
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0107 0.0319 0.0475
Echinococcus granulosus Pleckstrin y 0.0073 0.0191 0.0285
Brugia malayi PH domain containing protein 0.0073 0.0191 0.0184
Schistosoma mansoni serine/threonine protein kinase 0.0888 0.3276 0.4882
Brugia malayi protein kinase C II. 0.0888 0.3276 0.3271
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0092 0.0264 0.0249
Brugia malayi Oxysterol-binding protein 0.0073 0.0191 0.0184
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0176
Schistosoma mansoni atypical protein kinase C 0.0888 0.3276 0.4882
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0073 0.0191 0.0144
Entamoeba histolytica PH domain containing protein kinase, putative 0.1795 0.6711 0.6695
Echinococcus multilocularis myotubularin protein 13 0.0073 0.0191 0.0285
Onchocerca volvulus 0.009 0.0254 0.0706
Trichomonas vaginalis alpha chimerin, putative 0.0073 0.0191 0.0144
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0073 0.0191 0.0285
Schistosoma mansoni serine/threonine protein kinase 0.0888 0.3276 0.4882
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0264 0.0217
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0092 0.0264 0.0371
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0048 0.0049
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0139 0.0127
Trichomonas vaginalis centaurin/arf, putative 0.0073 0.0191 0.0144
Schistosoma mansoni serine/threonine-protein kinase 0.1795 0.6711 1
Trichomonas vaginalis AGC family protein kinase 0.2664 1 1
Echinococcus multilocularis protein kinase c epsilon type 0.0888 0.3276 0.4882
Echinococcus multilocularis oxysterol binding protein 1 0.0073 0.0191 0.0285
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0092 0.0264 0.0371
Toxoplasma gondii AGC kinase 0.2591 0.9723 1
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0073 0.0191 0.0144
Onchocerca volvulus Putative zinc finger protein 0.0073 0.0191 0.0457
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.014 0.0209
Brugia malayi MAX-1A 0.0073 0.0191 0.0184
Brugia malayi Oxysterol binding protein 0.0073 0.0191 0.0184
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0073 0.0191 0.0144
Echinococcus multilocularis actin binding protein anillin 0.0073 0.0191 0.0285
Brugia malayi hypothetical protein 0.0073 0.0191 0.0184
Echinococcus granulosus Glutaredoxin protein 5 0.1703 0.6362 0.948
Plasmodium falciparum PH domain-containing protein, putative 0.0073 0.0191 0.0274
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0073 0.0191 0.0176
Echinococcus multilocularis Pleckstrin y 0.0073 0.0191 0.0285
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0073 0.0191 0.0285
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0089 0.0133
Brugia malayi Pre-SET motif family protein 0.009 0.0254 0.0247
Brugia malayi Dynamin 0.0073 0.0191 0.0184
Brugia malayi TBC domain containing protein 0.0073 0.0191 0.0184
Leishmania major protein kinase, putative 0.0092 0.0264 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0073 0.0191 0.0144
Schistosoma mansoni serine/threonine protein kinase 0.0888 0.3276 0.4882
Loa Loa (eye worm) rho-GTPase-activating 0.0073 0.0191 0.0176
Brugia malayi Uncoordinated protein 104 0.0073 0.0191 0.0184
Entamoeba histolytica hypothetical protein 0.0073 0.0191 0.0144
Onchocerca volvulus 0.0712 0.261 1
Echinococcus multilocularis Pleckstrin y 0.0073 0.0191 0.0285
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.1722 0.6435 1
Onchocerca volvulus Cell death protein 3 homolog 0.0061 0.0145 0.0273
Brugia malayi PH domain containing protein 0.0073 0.0191 0.0184
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0176
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0107 0.0319 0.0475
Brugia malayi PH domain containing protein 0.0073 0.0191 0.0184
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0073 0.0191 0.0274
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0264 0.0217
Echinococcus granulosus nervana 2 0.1703 0.6362 0.948
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0191 0.0144
Brugia malayi hypothetical protein 0.0027 0.0016 0.0008
Trypanosoma cruzi PH domain containing protein, putative 0.0073 0.0191 0.0263
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0073 0.0191 0.0184
Entamoeba histolytica protein kinase, putative 0.0092 0.0264 0.0217
Echinococcus multilocularis serine threonine protein kinase 0.0888 0.3276 0.4882
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0191 0.0144
Entamoeba histolytica PH domain containing protein kinase, putative 0.0092 0.0264 0.0217
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0073 0.0191 0.0144
Trypanosoma cruzi hypothetical protein 0.0073 0.0191 0.0263
Echinococcus granulosus calcium dependent secretion activator 1 0.0073 0.0191 0.0285
Schistosoma mansoni hypothetical protein 0.0073 0.0191 0.0285
Echinococcus multilocularis pleckstrin y domain containing family A 0.0073 0.0191 0.0285
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0043 0.0035
Loa Loa (eye worm) hypothetical protein 0.0042 0.0076 0.006
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0092 0.0264 0.0249
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.1703 0.6362 0.948
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.0193 0.0288
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0176
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0073 0.0191 0.0285
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0102 0.0086
Trypanosoma brucei protein kinase, putative 0.0092 0.0264 0.0249
Entamoeba histolytica protein kinase, putative 0.0092 0.0264 0.0217
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.014 0.0209
Echinococcus granulosus pleckstrin y domain containing family A 0.0073 0.0191 0.0285
Loa Loa (eye worm) hypothetical protein 0.0073 0.0191 0.0176
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0888 0.3276 0.3266
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0073 0.0191 0.0457
Brugia malayi PH domain containing protein 0.0073 0.0191 0.0184
Echinococcus granulosus Oxysterol binding protein 11 0.0073 0.0191 0.0285
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0073 0.0191 0.0176
Schistosoma mansoni dynamin 0.0073 0.0191 0.0285
Entamoeba histolytica hypothetical protein 0.0092 0.0264 0.0217
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0092 0.0264 0.0371
Echinococcus multilocularis dynamin 1 0.0073 0.0191 0.0285
Trypanosoma cruzi PH domain containing protein, putative 0.0073 0.0191 0.0263
Brugia malayi Dynamin 0.0073 0.0191 0.0184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0089 0.0133
Brugia malayi PH domain containing protein 0.0073 0.0191 0.0184
Schistosoma mansoni hypothetical protein 0.0073 0.0191 0.0285
Entamoeba histolytica protein kinase, putative 0.0888 0.3276 0.3243
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0625 0.2282 0.227
Leishmania major hypothetical protein, conserved 0.0073 0.0191 0.7081
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0191 0.0274
Loa Loa (eye worm) jmjC domain-containing protein 0.0122 0.0377 0.0362
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0191 0.0144

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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