Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0048 | 0.5286 | 0.8105 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0048 | 0.5286 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.17 | 0.0679 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0025 | 0.17 | 0.117 |
Leishmania major | GTP-binding protein, putative | 0.0021 | 0.1096 | 0.5 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0025 | 0.17 | 0.117 |
Entamoeba histolytica | protein kinase, putative | 0.0025 | 0.17 | 0.0679 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0025 | 0.17 | 0.117 |
Schistosoma mansoni | atypical protein kinase C | 0.0025 | 0.17 | 0.117 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0025 | 0.17 | 0.117 |
Schistosoma mansoni | serine/threonine kinase | 0.0025 | 0.17 | 0.117 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0025 | 0.17 | 0.117 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0054 | 0.6266 | 0.5807 |
Toxoplasma gondii | dynamin-related protein DRPA | 0.0021 | 0.1096 | 0.1215 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2075 | 0.11 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0025 | 0.17 | 0.117 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0054 | 0.6266 | 0.5807 |
Trypanosoma cruzi | Protein kinase B | 0.0054 | 0.6266 | 1 |
Echinococcus multilocularis | dynamin 1 | 0.0027 | 0.2075 | 0.1895 |
Echinococcus multilocularis | nervana 2 | 0.0047 | 0.5204 | 0.7946 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0047 | 0.5204 | 0.7946 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0054 | 0.6266 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.486 | 0.728 |
Trichomonas vaginalis | AGC family protein kinase | 0.0078 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0025 | 0.17 | 0.117 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0025 | 0.17 | 0.117 |
Echinococcus multilocularis | protein kinase c iota type | 0.0025 | 0.17 | 0.117 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0025 | 0.17 | 0.117 |
Echinococcus multilocularis | nervana 2 | 0.0047 | 0.5204 | 0.7946 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0025 | 0.17 | 0.117 |
Trichomonas vaginalis | AGC family protein kinase | 0.0025 | 0.17 | 0.0679 |
Schistosoma mansoni | dynamin | 0.0027 | 0.2075 | 0.1895 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.3508 | 0.4665 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0078 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.486 | 0.4227 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0025 | 0.17 | 0.0679 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0025 | 0.17 | 0.117 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0025 | 0.17 | 0.117 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0025 | 0.17 | 0.117 |
Trichomonas vaginalis | AGC family protein kinase | 0.0025 | 0.17 | 0.0679 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0024 | 0.1618 | 0.0587 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0054 | 0.6266 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0047 | 0.5204 | 0.7946 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0025 | 0.17 | 0.0679 |
Toxoplasma gondii | dynamin-related protein DRPB | 0.0021 | 0.1096 | 0.1215 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0025 | 0.17 | 0.117 |
Brugia malayi | hypothetical protein | 0.0036 | 0.3508 | 0.2709 |
Trichomonas vaginalis | AGC family protein kinase | 0.0078 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0078 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0078 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0078 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0078 | 1 | 1 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0072 | 0.902 | 0.89 |
Echinococcus granulosus | nervana 2 | 0.0047 | 0.5204 | 0.7946 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0048 | 0.5286 | 0.8105 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3508 | 0.2709 |
Echinococcus granulosus | protein kinase c iota type | 0.0025 | 0.17 | 0.117 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.486 | 0.4227 |
Brugia malayi | Protein kinase domain containing protein | 0.0025 | 0.17 | 0.0679 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3508 | 0.2709 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0054 | 0.6266 | 1 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0025 | 0.17 | 0.117 |
Brugia malayi | protein kinase C II. | 0.0025 | 0.17 | 0.0679 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0048 | 0.5286 | 0.8105 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0025 | 0.17 | 0.0679 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.486 | 0.728 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0025 | 0.17 | 0.0679 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3508 | 0.2709 |
Brugia malayi | Protein kinase domain containing protein | 0.0025 | 0.17 | 0.0679 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3508 | 0.2709 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0054 | 0.6266 | 1 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0047 | 0.5204 | 0.7946 |
Trichomonas vaginalis | AGC family protein kinase | 0.0031 | 0.268 | 0.178 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0048 | 0.5286 | 1 |
Brugia malayi | Dynamin | 0.0027 | 0.2075 | 0.11 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.486 | 0.728 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0048 | 0.5286 | 0.8105 |
Echinococcus granulosus | NDR protein kinase | 0.0025 | 0.17 | 0.117 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0072 | 0.902 | 0.89 |
Schistosoma mansoni | dynamin | 0.0027 | 0.2075 | 0.1895 |
Brugia malayi | Hr1 repeat family protein | 0.0025 | 0.17 | 0.0679 |
Entamoeba histolytica | protein kinase, putative | 0.0072 | 0.902 | 0.89 |
Entamoeba histolytica | protein kinase 2, putative | 0.0048 | 0.5286 | 0.4706 |
Toxoplasma gondii | AGC kinase | 0.0072 | 0.902 | 1 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0054 | 0.6266 | 1 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0025 | 0.17 | 0.117 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0025 | 0.17 | 0.117 |
Brugia malayi | Dynamin | 0.0027 | 0.2075 | 0.11 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.486 | 0.728 |
Echinococcus granulosus | nervana 2 | 0.0047 | 0.5204 | 0.7946 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0025 | 0.17 | 0.117 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0025 | 0.17 | 0.0679 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.486 | 0.728 |
Giardia lamblia | Kinase, AGC PKA | 0.0048 | 0.5286 | 1 |
Echinococcus granulosus | protein kinase C gamma type | 0.0025 | 0.17 | 0.117 |
Trichomonas vaginalis | AGC family protein kinase | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0025 | 0.17 | 0.0679 |
Trichomonas vaginalis | AGC family protein kinase | 0.0078 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0025 | 0.17 | 0.117 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.486 | 0.728 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.3508 | 0.4665 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0025 | 0.17 | 0.117 |
Trichomonas vaginalis | AGC family protein kinase | 0.0078 | 1 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0025 | 0.17 | 0.117 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.3508 | 0.4665 |
Trichomonas vaginalis | AGC family protein kinase | 0.0025 | 0.17 | 0.0679 |
Echinococcus granulosus | dynamin 1 | 0.0027 | 0.2075 | 0.1895 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.486 | 0.728 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0078 | 1 | 1 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0025 | 0.17 | 0.117 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.3508 | 0.4665 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0047 | 0.5204 | 0.7946 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.