TDR Targets

Basic information

Technical information

TDR Targets ID: 686483
Name: K261-1399
MW: 400.491 | Formula: C21H24N2O4S
H donors: 0 H acceptors: 4 LogP: 4.01 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccc(cc1)N1C(=O)N(CC(=O)C(C)(C)C)c2c(S1(=O)=O)cccc2
InChi: 1S/C21H24N2O4S/c1-5-15-10-12-16(13-11-15)23-20(25)22(14-19(24)21(2,3)4)17-8-6-7-9-18(17)28(23,26)27/h6-13H,5,14H2,1-4H3
InChiKey: RWAFGCITHKSHOK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

NCGC00138317-01
ZINC05043427

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	MH2 domain containing protein	0.0117	0.279	0.3802
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0034	0.0455	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0535	0.0736
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0535	0.0419
Echinococcus multilocularis	peregrin	0.0034	0.0455	0.0339
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0535	0.0886
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0071	0.1509	0.1405
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0928	0.1276
Loa Loa (eye worm)	heterochromatin protein 1	0.008	0.1765	0.2426
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0165	0.0273
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0115	0.2746	0.7171
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.011	0.26	0.2509
Giardia lamblia	PHD finger protein 15	0.0034	0.0455	0.1274
Giardia lamblia	Kinase, PLK	0.0097	0.2224	0.8014
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0165	0.012
Trichomonas vaginalis	chromobox protein, putative	0.008	0.1765	0.2298
Trichomonas vaginalis	glutaminase, putative	0.0277	0.7276	1
Plasmodium vivax	hypothetical protein, conserved	0.0034	0.0455	0.8507
Mycobacterium ulcerans	lipase LipD	0.0036	0.0535	0.0736
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0034	0.0455	0.0339
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0225	0.5821	0.799
Brugia malayi	beta-lactamase family protein	0.0036	0.0535	0.0686
Schistosoma mansoni	hypothetical protein	0.0137	0.3363	0.3281
Loa Loa (eye worm)	hypothetical protein	0.0225	0.5821	0.8001
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0535	0.0886
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0165	0.012
Schistosoma mansoni	hypothetical protein	0.0071	0.1509	0.1405
Trypanosoma brucei	polo-like protein kinase	0.0097	0.2224	0.5747
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0455	0.1274
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0152	0.3781	0.5171
Brugia malayi	Bromodomain containing protein	0.0034	0.0455	0.0575
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0152	0.3781	1
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0535	0.0886
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0165	0.0174
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0097	0.2224	0.3057
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0535	0.0579
Echinococcus multilocularis	geminin	0.0374	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0775	0.0915
Schistosoma mansoni	serine/threonine protein kinase	0.0097	0.2224	0.2129
Onchocerca volvulus		0.0036	0.0535	0.1799
Trichomonas vaginalis	esterase, putative	0.0036	0.0535	0.0579
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0.0121	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0535	0.0736
Schistosoma mansoni	hypothetical protein	0.0071	0.1509	0.1405
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0071	0.1509	0.1405
Brugia malayi	jmjC domain containing protein	0.011	0.26	0.3539
Schistosoma mansoni	hypothetical protein	0.0154	0.3825	0.375
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0535	0.1132
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0535	0.0579
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0535	0.0886
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0535	0.0419
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0115	0.2746	0.7171
Loa Loa (eye worm)	PHD-finger family protein	0.0034	0.0455	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0775	0.1066
Brugia malayi	chromobox protein homolog 3	0.0045	0.0775	0.1018
Trichomonas vaginalis	chromobox protein, putative	0.0048	0.0871	0.1049
Brugia malayi	beta-lactamase family protein	0.0036	0.0535	0.0686
Trypanosoma brucei	RNA helicase, putative	0.0137	0.3363	0.8857
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0097	0.2224	0.5747
Echinococcus multilocularis	transcription factor Dp 1	0.0088	0.1983	0.1885
Echinococcus granulosus	transcription factor Dp 1	0.0088	0.1983	0.1885
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0775	0.0915
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0097	0.2224	0.2129
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0165	0.0273
Schistosoma mansoni	jumonji domain containing protein	0.0088	0.1965	0.1867
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0928	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0165	0.0227
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0165	0.0227
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0407	0.04
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0115	0.2746	0.7171
Loa Loa (eye worm)	glutaminase 2	0.0277	0.7276	1
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0152	0.3781	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0225	0.5821	0.8001
Echinococcus granulosus	mitogen activated protein kinase 3	0.0115	0.2746	0.2657
Echinococcus multilocularis	jumonji domain containing protein	0.0047	0.0825	0.0712
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0535	0.0886
Echinococcus granulosus	PHD finger protein rhinoceros	0.0034	0.0455	0.0339
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0115	0.2746	0.7171
Loa Loa (eye worm)	hypothetical protein	0.0097	0.224	0.3078
Brugia malayi	hypothetical protein	0.0097	0.224	0.3041
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0328	0.0451
Trichomonas vaginalis	CAMK family protein kinase	0.0097	0.2224	0.294
Brugia malayi	jmjC domain containing protein	0.0041	0.0654	0.0849
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0041	0.0654	0.0539
Echinococcus granulosus	lysine specific demethylase 5A	0.0041	0.0654	0.0539
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0.0121	0.02
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0535	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0928	0.0817
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0535	0.0686
Onchocerca volvulus	Alhambra homolog	0.0034	0.0455	0.1411
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0165	0.0227
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0928	0.0817
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0115	0.2746	0.2657
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0535	0.0579
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0928	0.1229
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0152	0.3781	0.3705
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0535	0.0736
Echinococcus multilocularis	GPCR, family 2	0.0071	0.1509	0.1405
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0165	0.0227
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0535	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0165	0.012
Trichomonas vaginalis	CAMK family protein kinase	0.0097	0.2224	0.294
Brugia malayi	Heterochromatin protein 1	0.008	0.1765	0.2386
Trichomonas vaginalis	CMGC family protein kinase	0.0115	0.2746	0.3669
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0.0121	0.0166
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0165	0.0227
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0152	0.3781	0.3705
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0121	0.2654
Echinococcus granulosus	peregrin	0.0034	0.0455	0.0339
Schistosoma mansoni	hypothetical protein	0.0374	1	1
Trichomonas vaginalis	chromobox protein, putative	0.0048	0.0871	0.1049
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0928	0.0817
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0928	0.0817
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0	0.5
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0535	0.0736
Loa Loa (eye worm)	jmjC domain-containing protein	0.0041	0.0654	0.0898
Schistosoma mansoni	kinase	0.005	0.0905	0.0794
Loa Loa (eye worm)	jmjC domain-containing protein	0.0069	0.1459	0.2005
Echinococcus multilocularis	mitogen activated protein kinase	0.0115	0.2746	0.2657
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0165	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0503	0.0691
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0121	0.0113
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0328	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0455	0.0626
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0152	0.3781	0.3705
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.279	0.3835
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0535	0.0886
Echinococcus multilocularis	lysine specific demethylase 5A	0.0041	0.0654	0.0539
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0535	0.0419
Giardia lamblia	Kinase, CMGC MAPK	0.0115	0.2746	1
Trichomonas vaginalis	CAMK family protein kinase	0.0048	0.087	0.1047
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0165	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1129	0.1551
Trypanosoma cruzi	polo-like protein kinase, putative	0.0097	0.2224	0.5747
Schistosoma mansoni	chromobox protein	0.008	0.1765	0.1665
Loa Loa (eye worm)	hypothetical protein	0.0154	0.3825	0.5258
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0328	0.7197
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0535	0.0886
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0121	0.0166
Onchocerca volvulus		0.0036	0.0535	0.1799
Schistosoma mansoni	hypothetical protein	0.0071	0.1509	0.1405
Brugia malayi	latrophilin 2 splice variant baaae	0.0154	0.3825	0.5232
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0535	0.0579
Onchocerca volvulus		0.0035	0.0503	0.1641
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0.0121	0.5
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0535	0.0736
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0407	0.04
Trichomonas vaginalis	CMGC family protein kinase	0.0115	0.2746	0.3669
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0535	0.0736
Trichomonas vaginalis	CAMK family protein kinase	0.0097	0.2224	0.294
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0535	0.0886
Echinococcus multilocularis	chromobox protein 1	0.008	0.1765	0.1665
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0115	0.2746	0.7171
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0328	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0535	0.0736
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0328	0.7197
Schistosoma mansoni	hypothetical protein	0.0374	1	1
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0165	0.0174
Brugia malayi	serine/threonine-protein kinase plk-2	0.0097	0.2224	0.302
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0152	0.3781	1
Brugia malayi	glutaminase DH11.1	0.0277	0.7276	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.011	0.26	0.2509
Trypanosoma cruzi	polo-like protein kinase, putative	0.0097	0.2224	0.5747
Loa Loa (eye worm)	glutaminase	0.0277	0.7276	1
Toxoplasma gondii	ABC1 family protein	0.0036	0.0535	0.1579
Loa Loa (eye worm)	hypothetical protein	0.0097	0.224	0.3078
Brugia malayi	hypothetical protein	0.0029	0.0328	0.0399
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0115	0.2746	0.7171
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0097	0.2224	0.5747
Onchocerca volvulus		0.0036	0.0535	0.1799
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0455	0.1274
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0225	0.5821	0.799
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0041	0.0654	0.0539
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0071	0.1509	0.1405
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0152	0.3781	1
Echinococcus granulosus	chromobox protein 1	0.008	0.1765	0.1665
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0048	0.0871	0.343
Leishmania major	hypothetical protein, conserved	0.0029	0.0328	0.0565
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0328	0.6123
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0928	0.0817
Trichomonas vaginalis	CMGC family protein kinase	0.0115	0.2746	0.3669
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0535	0.1132
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0115	0.2746	0.7171
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0165	0.012
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0165	0.0227
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0152	0.3781	0.5197
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0152	0.3781	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0165	0.012
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0535	0.0886
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0535	0.0736
Schistosoma mansoni	hypothetical protein	0.0034	0.0455	0.0339
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0535	0.0736
Trichomonas vaginalis	CMGC family protein kinase	0.0115	0.2746	0.3669
Brugia malayi	PHD-finger family protein	0.0034	0.0455	0.0575
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0535	0.0736
Leishmania major	hypothetical protein, conserved	0.0036	0.0535	0.1132
Echinococcus granulosus	jumonji domain containing protein	0.0047	0.0825	0.0712
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.279	0.3835
Brugia malayi	Latrophilin receptor protein 2	0.0071	0.1509	0.2031
Mycobacterium ulcerans	glutaminase	0.0277	0.7276	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0165	0.0227
Echinococcus multilocularis	chromobox protein 1	0.008	0.1765	0.1665
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0328	0.0565
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0233	0.6045	1
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0115	0.2746	1
Schistosoma mansoni	glutaminase	0.0277	0.7276	0.7242
Trypanosoma brucei	protein kinase, putative	0.0115	0.2746	0.7171
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0165	0.0227
Trichomonas vaginalis	CAMK family protein kinase	0.0097	0.2224	0.294
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0071	0.1509	0.1405
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0121	0.2258
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0165	0.0227
Brugia malayi	MAP kinase sur-1	0.0115	0.2746	0.374
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0097	0.2224	1
Echinococcus granulosus	GPCR family 2	0.0071	0.1509	0.1405
Trichomonas vaginalis	CAMK family protein kinase	0.0097	0.2224	0.294
Trichomonas vaginalis	chromobox protein, putative	0.008	0.1765	0.2298
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0097	0.2224	0.2129
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0535	0.0579
Plasmodium falciparum	phd finger protein, putative	0.0034	0.0455	1
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0115	0.2746	0.3774
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0071	0.1509	0.2074
Echinococcus granulosus	chromobox protein 1	0.008	0.1765	0.1665
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0535	0.0736
Schistosoma mansoni	serine/threonine protein kinase	0.0115	0.2746	0.2657
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0165	0.012
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0071	0.1509	0.2031
Schistosoma mansoni	eyes absent homolog	0.0097	0.224	0.2145
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0045	0.0775	0.2965
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0535	0.0736
Echinococcus granulosus	mitogen activated protein kinase	0.0115	0.2746	0.2657
Schistosoma mansoni	chromobox protein	0.008	0.1765	0.1665
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0535	1
Trichomonas vaginalis	CAMK family protein kinase	0.0097	0.2224	0.294
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0928	0.0817
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0535	0.0886
Trichomonas vaginalis	CAMK family protein kinase	0.0097	0.2224	0.294
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0165	0.0174
Schistosoma mansoni	hypothetical protein	0.0071	0.1509	0.1405
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0535	0.1132
Brugia malayi	beta-lactamase	0.0036	0.0535	0.0686
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0328	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1509	0.2074
Trichomonas vaginalis	CAMK family protein kinase	0.0048	0.087	0.1047
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0535	0.0419

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1899063
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 686483