Detailed information for compound 686618

Basic information

Technical information
  • TDR Targets ID: 686618
  • Name: N-(4-fluoro-3-nitrophenyl)-2-[[1-(3-hydroxypr opyl)-2-oxo-6,7-dihydro-5H-cyclopenta[e]pyrim idin-4-yl]sulfanyl]acetamide
  • MW: 422.431 | Formula: C18H19FN4O5S
  • H donors: 2 H acceptors: 5 LogP: 1.58 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCCn1c(=O)nc(c2c1CCC2)SCC(=O)Nc1ccc(c(c1)[N+](=O)[O-])F
  • InChi: 1S/C18H19FN4O5S/c19-13-6-5-11(9-15(13)23(27)28)20-16(25)10-29-17-12-3-1-4-14(12)22(7-2-8-24)18(26)21-17/h5-6,9,24H,1-4,7-8,10H2,(H,20,25)
  • InChiKey: GDAYYYHEESIFOX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-fluoro-3-nitro-phenyl)-2-[[1-(3-hydroxypropyl)-2-oxo-6,7-dihydro-5H-cyclopenta[e]pyrimidin-4-yl]sulfanyl]acetamide
  • N-(4-fluoro-3-nitrophenyl)-2-[[1-(3-hydroxypropyl)-2-oxo-6,7-dihydro-5H-cyclopenta[e]pyrimidin-4-yl]thio]acetamide
  • N-(4-fluoro-3-nitro-phenyl)-2-[[1-(3-hydroxypropyl)-2-keto-6,7-dihydro-5H-cyclopenta[e]pyrimidin-4-yl]thio]acetamide
  • N-(4-fluoro-3-nitro-phenyl)-2-[[1-(3-hydroxypropyl)-2-oxo-6,7-dihydro-5H-cyclopenta[e]pyrimidin-4-yl]sulfanyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0296 0.0205
Loa Loa (eye worm) hypothetical protein 0.0018 0.0121 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0296 0.0236
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0093 0.0093
Brugia malayi PHD-finger family protein 0.003 0.0451 0.0361
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1466 0.1466
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1466 0.1466
Entamoeba histolytica protein kinase, putative 0.0353 0.9679 0.9679
Mycobacterium ulcerans hypothetical protein 0.0163 0.4247 0.5559
Leishmania major cathepsin L-like protease 0.0017 0.0093 0.011
Entamoeba histolytica protein kinase 2, putative 0.0235 0.6301 0.6301
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.326 0.4851
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0844 0.1002
Echinococcus granulosus serine:threonine protein kinase N2 0.0121 0.3057 0.4539
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0655 0.0655
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0093 0.0093
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0296 0.0296
Mycobacterium ulcerans hypothetical protein 0.0037 0.0655 0.0719
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0093 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0093 0.0093
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0655 0.104
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0121 0.3057 0.4539
Mycobacterium ulcerans beta-lactamase 0.0037 0.0655 0.0719
Leishmania major mitochondrial DNA polymerase beta 0.0309 0.8419 1
Toxoplasma gondii hypothetical protein 0.005 0.1026 0.106
Echinococcus granulosus protein kinase c iota type 0.0121 0.3057 0.4539
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0121 0.3057 0.2991
Leishmania major cathepsin L-like protease 0.0017 0.0093 0.011
Loa Loa (eye worm) AGC/PKN protein kinase 0.0121 0.3057 0.2991
Echinococcus granulosus nervana 2 0.0232 0.6226 0.9394
Echinococcus granulosus serine/threonine protein kinase 0.0246 0.6622 1
Echinococcus multilocularis protein kinase c epsilon type 0.0121 0.3057 0.4539
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0121 0.3057 0.2991
Leishmania major cathepsin L-like protease 0.0017 0.0093 0.011
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0296 0.0352
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0093 0.0093
Echinococcus multilocularis thyroid hormone receptor alpha 0.0138 0.3554 0.5301
Loa Loa (eye worm) hypothetical protein 0.0037 0.0655 0.0567
Onchocerca volvulus Alhambra homolog 0.003 0.0451 0.6369
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0451 0.0548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0093 0.0093
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0246 0.6622 0.7866
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0655 0.0903
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.2377 0.3499
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0235 0.6301 0.9508
Schistosoma mansoni inositol monophosphatase 0.0038 0.0682 0.0791
Brugia malayi beta-lactamase 0.0037 0.0655 0.0567
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0121 0.3057 0.2991
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0682 0.0682
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0093 0.0093
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0296 0.0326
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.326 0.4851
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0655 0.0754
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0296 0.0236
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0655 0.0655
Loa Loa (eye worm) hypothetical protein 0.0037 0.0655 0.0567
Brugia malayi protein kinase C II. 0.0121 0.3057 0.2991
Loa Loa (eye worm) glutaminase 2 0.0278 0.7544 0.7521
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0093 0.0093
Trichomonas vaginalis AGC family protein kinase 0.0364 1 1
Leishmania major cathepsin L-like protease 0.0065 0.1466 0.1741
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0296 0.0236
Loa Loa (eye worm) hypothetical protein 0.0018 0.0121 0.0029
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.3776 0.3776
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0844 0.1002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0093 0.0093
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0451 0.0361
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0655 0.0903
Trichomonas vaginalis AGC family protein kinase 0.0121 0.3057 0.3057
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0655 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0451 0.0548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0093 0.0093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0093 0.0093
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0235 0.6301 1
Loa Loa (eye worm) glutaminase 0.0278 0.7544 0.7521
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0296 0.0296
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0682 0.0682
Leishmania major cathepsin L-like protease 0.0017 0.0093 0.011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1466 0.1466
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0655 0.0778
Mycobacterium tuberculosis Conserved protein 0.0037 0.0655 0.0903
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0093 0.0093
Echinococcus granulosus protein kinase C gamma type 0.0121 0.3057 0.4539
Schistosoma mansoni serine/threonine-protein kinase 0.0246 0.6622 0.8763
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0682 0.0705
Trichomonas vaginalis AGC family protein kinase 0.0121 0.3057 0.3057
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0121 0.3057 0.4539
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0093 0.0093
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0451 0.0466
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.1068 0.1268
Loa Loa (eye worm) hypothetical protein 0.0037 0.0655 0.0567
Brugia malayi Protein kinase domain containing protein 0.0121 0.3057 0.2991
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.3057 0.3978
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0121 0.3057 0.4539
Loa Loa (eye worm) hypothetical protein 0.0018 0.0121 0.0029
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0655 0.0655
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0093 0.0093
Plasmodium vivax hypothetical protein, conserved 0.003 0.0451 0.0716
Entamoeba histolytica cysteine protease, putative 0.0017 0.0093 0.0093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0093 0.0093
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.1466 0.1741
Echinococcus multilocularis nervana 2 0.0232 0.6226 0.9394
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0682 0.5
Toxoplasma gondii AGC kinase 0.0353 0.9679 1
Leishmania major hypothetical protein, conserved 0.0037 0.0655 0.0778
Trichomonas vaginalis AGC family protein kinase 0.0364 1 1
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0682 0.0903
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.3057 0.3978
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.3057 0.3978
Entamoeba histolytica PH domain containing protein kinase, putative 0.0246 0.6622 0.6622
Loa Loa (eye worm) hypothetical protein 0.0037 0.0655 0.0567
Mycobacterium ulcerans glutaminase 0.0278 0.7544 1
Echinococcus granulosus NDR protein kinase 0.0121 0.3057 0.4539
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0655 0.0778
Schistosoma mansoni thyroid hormone receptor 0.0138 0.3554 0.4645
Loa Loa (eye worm) hypothetical protein 0.003 0.0451 0.0361
Brugia malayi Hr1 repeat family protein 0.0121 0.3057 0.2991
Onchocerca volvulus 0.0037 0.0655 1
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0093 0.0093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0093 0.0093
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0232 0.6226 0.9394
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0093 0.011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0296 0.0205
Plasmodium vivax vivapain-2 0.0017 0.0093 0.0147
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0655 0.0903
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.3057 0.3978
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0655 0.0719
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.3776 0.4485
Leishmania major cathepsin L-like protease 0.0017 0.0093 0.011
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0296 0.0236
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0093 0.0093
Mycobacterium ulcerans hypothetical protein 0.0024 0.0296 0.0236
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0309 0.8419 0.8419
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0235 0.6301 0.9508
Trichomonas vaginalis AGC family protein kinase 0.0364 1 1
Schistosoma mansoni atypical protein kinase C 0.0121 0.3057 0.3978
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0296 0.0236
Echinococcus multilocularis rac serine:threonine kinase 0.0246 0.6622 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0569 0.0765
Schistosoma mansoni serine/threonine kinase 0.0121 0.3057 0.3978
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0121 0.3057 0.4539
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0629 0.0821
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0121 0.0192
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0682 0.0682
Loa Loa (eye worm) hypothetical protein 0.0018 0.0121 0.0029
Trypanosoma brucei rac serine-threonine kinase, putative 0.0364 1 1
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0682 0.0903
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0296 0.0352
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0093 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0093 0.0093
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0296 0.0296
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0782 0.1056
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0121 0.3057 0.4539
Echinococcus multilocularis nervana 2 0.0232 0.6226 0.9394
Toxoplasma gondii cathepsin CPL 0.0017 0.0093 0.0096
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0629 0.072
Echinococcus granulosus serine threonine protein kinase nrc 0.0235 0.6301 0.9508
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1466 0.1466
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1466 0.1466
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0655 0.0719
Toxoplasma gondii ABC1 family protein 0.0037 0.0655 0.0677
Loa Loa (eye worm) AGC/AKT protein kinase 0.0364 1 1
Trichomonas vaginalis esterase, putative 0.0037 0.0655 0.0655
Echinococcus granulosus Glutaredoxin protein 5 0.0232 0.6226 0.9394
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0093 0.0093
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0296 0.0205
Loa Loa (eye worm) hypothetical protein 0.0024 0.0296 0.0205
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.3057 0.3978
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0296 0.0352
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0682 0.081
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0093 0.0093
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0655 0.0861
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0655 0.0903
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0024 0.0296 0.0205
Trypanosoma cruzi Protein kinase B 0.0246 0.6622 0.7866
Brugia malayi Protein kinase domain containing protein 0.0121 0.3057 0.2991
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0682 0.0682
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0296 0.0236
Trichomonas vaginalis AGC family protein kinase 0.0132 0.3378 0.3378
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0655 0.0903
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0682 0.081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0093 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1466 0.1466
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.2377 0.3499
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0655 0.0754
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1466 0.1466
Mycobacterium tuberculosis Conserved protein 0.0037 0.0655 0.0903
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.1466 0.1741
Brugia malayi jmjC domain containing protein 0.0036 0.0629 0.0541
Brugia malayi beta-lactamase family protein 0.0037 0.0655 0.0567
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0121 0.3057 0.2991
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.8419 1
Trichomonas vaginalis AGC family protein kinase 0.0364 1 1
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0121 0.0192
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0451 0.0466
Brugia malayi Bromodomain containing protein 0.003 0.0451 0.0361
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0629 0.0541
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0569 0.7609
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0655 0.0903
Brugia malayi Inositol-1 0.0038 0.0682 0.0595
Schistosoma mansoni glutaminase 0.0278 0.7544 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0655 0.0903
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0353 0.9679 0.9676
Trichomonas vaginalis glutaminase, putative 0.0278 0.7544 0.7544
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0037 0.0655 0.0567
Entamoeba histolytica protein kinase, putative 0.0364 1 1
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0118 0.2982 0.2982
Loa Loa (eye worm) hypothetical protein 0.0121 0.3057 0.2991
Echinococcus multilocularis serine:threonine protein kinase N2 0.0121 0.3057 0.4539
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0629 0.0821
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0682 0.081
Echinococcus granulosus peregrin 0.003 0.0451 0.0548
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0629 0.072
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0844 0.0844
Loa Loa (eye worm) beta-lactamase 0.0037 0.0655 0.0567
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0121 0.3057 0.4539
Echinococcus multilocularis serine:threonine protein kinase 38 0.0121 0.3057 0.4539
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0655 0.0861
Entamoeba histolytica protein kinase, putative 0.0364 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1466 0.1466
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1466 0.1466
Schistosoma mansoni hypothetical protein 0.0128 0.326 0.4251
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.1352 0.1271
Trichomonas vaginalis AGC family protein kinase 0.0364 1 1
Brugia malayi p70 ribosomal S6 kinase beta 0.0353 0.9679 0.9676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0093 0.0093
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0121 0.3057 0.4539
Brugia malayi jmjC domain containing protein 0.0097 0.2377 0.2306
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0093 0.011
Schistosoma mansoni thyroid hormone receptor 0.0138 0.3554 0.4645
Echinococcus multilocularis serine:threonine protein kinase N2 0.0121 0.3057 0.4539
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1466 0.1466
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.6318 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0232 0.6226 0.9394
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.3057 0.3978
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.1466 0.1741
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.3776 0.4485
Brugia malayi glutaminase DH11.1 0.0278 0.7544 0.7521
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0093 0.0147
Mycobacterium tuberculosis Conserved protein 0.0037 0.0655 0.0903
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0782 0.1056
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0093 0.0093
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0296 0.0326
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0093 0.0093
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0121 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0655 0.0655
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0296 0.0236
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0655 0.0567
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0682 0.0682
Trichomonas vaginalis AGC family protein kinase 0.0364 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.3057 0.3978
Mycobacterium ulcerans lipase LipD 0.0037 0.0655 0.0719
Plasmodium vivax vivapain-2 0.0017 0.0093 0.0147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1466 0.1466
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0235 0.6301 0.7484
Loa Loa (eye worm) inositol-1 0.0038 0.0682 0.0595
Loa Loa (eye worm) AGC/NDR protein kinase 0.0121 0.3057 0.2991
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.1115 0.1324
Giardia lamblia Kinase, AGC PKA 0.0235 0.6301 1
Schistosoma mansoni inositol monophosphatase 0.0038 0.0682 0.0791
Trichomonas vaginalis AGC family protein kinase 0.0364 1 1
Mycobacterium leprae Probable lipase LipE 0.0037 0.0655 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0655 0.0655
Echinococcus granulosus Protein kinase C brain isozyme 0.0121 0.3057 0.4539
Onchocerca volvulus 0.0037 0.0655 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0093 0.0093
Echinococcus granulosus nervana 2 0.0232 0.6226 0.9394
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0844 0.1002
Echinococcus granulosus protein kinase c epsilon type 0.0121 0.3057 0.4539
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.8419 1
Echinococcus multilocularis protein kinase c iota type 0.0121 0.3057 0.4539
Leishmania major cathepsin L-like protease 0.0065 0.1466 0.1741
Loa Loa (eye worm) hypothetical protein 0.0037 0.0655 0.0567
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0682 0.0756
Loa Loa (eye worm) hypothetical protein 0.0018 0.0121 0.0029
Brugia malayi beta-lactamase family protein 0.0037 0.0655 0.0567
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.4247 0.6674
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0235 0.6301 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.1305 0.155
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.1466 0.1741
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0655 0.0567
Trichomonas vaginalis AGC family protein kinase 0.0121 0.3057 0.3057
Schistosoma mansoni serine/threonine-protein kinase 0.0246 0.6622 0.8763
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0296 0.0205
Entamoeba histolytica PH domain containing protein kinase, putative 0.0246 0.6622 0.6622
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0121 0.0045
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0451 0.0481
Schistosoma mansoni hypothetical protein 0.003 0.0451 0.0481
Entamoeba histolytica protein kinase, putative 0.0121 0.3057 0.3057
Loa Loa (eye worm) hypothetical protein 0.0051 0.1056 0.0972
Schistosoma mansoni jumonji domain containing protein 0.0077 0.1807 0.2301
Leishmania major cathepsin L-like protease 0.0065 0.1466 0.1741
Echinococcus multilocularis serine threonine protein kinase 0.0121 0.3057 0.4539
Plasmodium falciparum phd finger protein, putative 0.003 0.0451 0.0716
Echinococcus multilocularis peregrin 0.003 0.0451 0.0548
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0655 0.0655
Onchocerca volvulus 0.0037 0.0655 1
Onchocerca volvulus 0.0024 0.0296 0.3616
Echinococcus multilocularis Glutaredoxin protein 5 0.0232 0.6226 0.9394

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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