Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0083 | 0.2625 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0069 | 0.2084 | 0.2763 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0564 | 0.0564 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0069 | 0.2084 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0214 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0055 | 0.1522 | 0.1522 |
Schistosoma mansoni | survival motor neuron protein | 0.0055 | 0.1522 | 0.1932 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0269 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0193 | 0.6981 | 0.6915 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0564 | 0.0517 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0214 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0564 | 0.0357 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0069 | 0.2084 | 0.1911 |
Brugia malayi | hypothetical protein | 0.0083 | 0.2625 | 0.2625 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.0214 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0564 | 0.0357 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0069 | 0.2084 | 0.2763 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0083 | 0.2625 | 0.2463 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.0214 | 0.0214 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.0214 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0083 | 0.2625 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.2084 | 1 |
Onchocerca volvulus | 0.0055 | 0.1522 | 1 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0564 | 0.0564 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0564 | 0.0357 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.2084 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.0214 | 0.0214 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0.0214 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.6981 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0214 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.1522 | 0.1932 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0083 | 0.2625 | 0.2463 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0214 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0564 | 0.0564 |
Echinococcus granulosus | lamin | 0.0031 | 0.0564 | 0.0357 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0069 | 0.2084 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0069 | 0.2084 | 0.1911 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0542 | 0.0542 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0564 | 0.0564 |
Entamoeba histolytica | hypothetical protein | 0.0083 | 0.2625 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0083 | 0.2625 | 0.3562 |
Entamoeba histolytica | hypothetical protein | 0.0083 | 0.2625 | 1 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0564 | 0.0564 |
Schistosoma mansoni | lamin | 0.0031 | 0.0564 | 0.0517 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0564 | 0.0357 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0022 | 0.0214 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0214 | 0.5 |
Schistosoma mansoni | lamin | 0.0031 | 0.0564 | 0.0517 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0564 | 0.0357 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0214 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0069 | 0.2084 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0269 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.2084 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.6981 | 1 |
Echinococcus granulosus | geminin | 0.0193 | 0.6981 | 0.6915 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.2625 | 0.3562 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.