Detailed information for compound 686781

Basic information

Technical information
  • TDR Targets ID: 686781
  • Name: N'-(4-methyl-2-nitrophenyl)-N-(2-morpholin-4- ylethyl)oxamide
  • MW: 336.343 | Formula: C15H20N4O5
  • H donors: 2 H acceptors: 4 LogP: 1.22 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)[N+](=O)[O-])NC(=O)C(=O)NCCN1CCOCC1
  • InChi: 1S/C15H20N4O5/c1-11-2-3-12(13(10-11)19(22)23)17-15(21)14(20)16-4-5-18-6-8-24-9-7-18/h2-3,10H,4-9H2,1H3,(H,16,20)(H,17,21)
  • InChiKey: JHHOOYCFBFTINN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-(4-methyl-2-nitro-phenyl)-N-(2-morpholinoethyl)oxamide
  • N'-(4-methyl-2-nitrophenyl)-N-(2-morpholinoethyl)oxamide
  • N'-(4-methyl-2-nitro-phenyl)-N-(2-morpholin-4-ylethyl)ethanediamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0245 0.0309
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0053 0.089 0.2803
Schistosoma mansoni transcription factor LCR-F1 0.0084 0.1554 0.1554
Plasmodium vivax thioredoxin reductase, putative 0.0152 0.2982 1
Echinococcus multilocularis tar DNA binding protein 0.0073 0.1329 0.1675
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0245 0.0456
Echinococcus granulosus geminin 0.0387 0.7938 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0245 0.0456
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0053 0.089 0.2803
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.012 0.0223
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0245 0.0309
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0245 0.0245
Onchocerca volvulus 0.0014 0.0076 0.0133
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0142 0.2774 0.3494
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0007 0.0013
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0014 0.0076 0.0141
Toxoplasma gondii thioredoxin reductase 0.0152 0.2982 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0053 0.089 1
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0245 0.0245
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0685 0.2097
Echinococcus granulosus tar DNA binding protein 0.0073 0.1329 0.1675
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0422 0.0787
Brugia malayi hypothetical protein 0.0084 0.1554 0.2895
Schistosoma mansoni sulfide quinone reductase 0.0014 0.0076 0.0076
Echinococcus granulosus lamin 0.003 0.0409 0.0516
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0245 0.0245
Brugia malayi Pre-SET motif family protein 0.0036 0.0537 0.1
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0245 0.0245
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0053 0.089 0.2803
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.012 0.0152
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0245 0.0456
Echinococcus multilocularis thioredoxin glutathione reductase 0.0152 0.2994 0.3772
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0685 0.2097
Leishmania major trypanothione reductase 0.0152 0.2982 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0245 0.0456
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0245 0.0309
Loa Loa (eye worm) hypothetical protein 0.0028 0.0368 0.0686
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0039 0.0596 0.111
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.1168 0.1168
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0053 0.089 0.2803
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0014 0.0076 0.0095
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0385 0.7896 1
Loa Loa (eye worm) hypothetical protein 0.0265 0.5369 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0245 0.0309
Loa Loa (eye worm) MH2 domain-containing protein 0.0141 0.2747 0.5117
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0685 0.0863
Toxoplasma gondii aldehyde dehydrogenase 0.0142 0.2774 0.9284
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0245 0.0309
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0537 0.1587
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0014 0.0076 0.0095
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0326 0.0861
Echinococcus multilocularis musashi 0.003 0.0409 0.0516
Mycobacterium tuberculosis Probable reductase 0.0346 0.7082 0.8958
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0053 0.089 0.2803
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0685 0.1087
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0685 0.0863
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0245 0.0456
Loa Loa (eye worm) hypothetical protein 0.0022 0.0245 0.0456
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.089 0.2803
Schistosoma mansoni cpg binding protein 0.0032 0.0459 0.0459
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0326 0.0861
Brugia malayi hypothetical protein 0.0012 0.0026 0.0049
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0245 0.0456
Echinococcus granulosus survival motor neuron protein 1 0.025 0.506 0.6374
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0014 0.0076 0.0095
Schistosoma mansoni cpg binding protein 0.0032 0.0459 0.0459
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0053 0.089 0.1658
Mycobacterium ulcerans aldehyde dehydrogenase 0.0142 0.2774 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0014 0.0073 0.0136
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0326 0.032
Mycobacterium ulcerans aldehyde dehydrogenase 0.0142 0.2774 1
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0245 0.0456
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0537 0.0537
Brugia malayi RNA binding protein 0.0073 0.1329 0.2476
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0245 0.0431
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0014 0.0076 0.0141
Schistosoma mansoni lamin 0.003 0.0409 0.0409
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0346 0.7082 0.8958
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1329 0.1329
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0092 0.1718 0.3199
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0326 0.3072
Brugia malayi CXXC zinc finger family protein 0.003 0.0422 0.0787
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0245 0.0456
Onchocerca volvulus 0.003 0.0409 0.0721
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0246 0.4966 0.9248
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.0141
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0245 0.0309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0245 0.0456
Loa Loa (eye worm) intermediate filament protein 0.003 0.0409 0.0762
Plasmodium falciparum thioredoxin reductase 0.0152 0.2982 1
Plasmodium falciparum thioredoxin reductase 0.0053 0.089 0.2803
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.012 0.0152
Loa Loa (eye worm) hypothetical protein 0.003 0.0409 0.0762
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0053 0.089 0.2803
Brugia malayi steroid hormone receptor 0.0022 0.0245 0.0456
Schistosoma mansoni hypothetical protein 0.0084 0.1554 0.1554
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.012 0.0152
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1329 0.1329
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0685 0.0685
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.012 0.0152
Loa Loa (eye worm) hypothetical protein 0.0265 0.5369 1
Leishmania major hypothetical protein, conserved 0.0028 0.0368 0.1007
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0053 0.089 0.2803
Giardia lamblia NADH oxidase lateral transfer candidate 0.0053 0.089 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0685 0.0685
Loa Loa (eye worm) thioredoxin reductase 0.0152 0.2982 0.5553
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0014 0.0076 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0245 0.0456
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0326 0.032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0245 0.0309
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0685 0.7479
Loa Loa (eye worm) hypothetical protein 0.0022 0.0245 0.0456
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.012 0.0152
Onchocerca volvulus 0.003 0.0409 0.0721
Schistosoma mansoni disulfide oxidoreductase 0.0014 0.0076 0.0076
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0053 0.089 0.2803
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.012 0.0152
Loa Loa (eye worm) hypothetical protein 0.0043 0.0685 0.1276
Onchocerca volvulus Huntingtin homolog 0.0265 0.5369 0.9453
Onchocerca volvulus 0.0022 0.0245 0.0431
Schistosoma mansoni glutamate synthase 0.0014 0.0076 0.0076
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0053 0.089 0.302
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0326 0.0928
Schistosoma mansoni hypothetical protein 0.0387 0.7938 0.7938
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0245 0.0309
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0014 0.0076 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0245 0.0456
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0368 0.1007
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1329 0.1329
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0537 0.0537
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0346 0.7082 0.8958
Brugia malayi Pre-SET motif family protein 0.0246 0.4966 0.9248
Loa Loa (eye worm) hypothetical protein 0.025 0.506 0.9423
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0537 0.0676
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0245 0.0431
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0368 0.1007
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0685 0.0863
Mycobacterium tuberculosis Probable oxidoreductase 0.0385 0.7896 1
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1329 0.1329
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0245 0.0456
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0326 0.0928
Schistosoma mansoni aldehyde dehydrogenase 0.0142 0.2774 0.2774
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0346 0.7082 0.8958
Loa Loa (eye worm) hypothetical protein 0.0014 0.0073 0.0136
Loa Loa (eye worm) programmed cell death 8 0.0014 0.0076 0.0141
Schistosoma mansoni intermediate filament proteins 0.003 0.0409 0.0409
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0245 0.0456
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0053 0.089 0.2803
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0053 0.089 0.302
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0053 0.089 0.2803
Schistosoma mansoni glutamate synthase 0.0014 0.0076 0.0076
Schistosoma mansoni coup transcription factor 0.0022 0.0245 0.0245
Plasmodium vivax SET domain protein, putative 0.0036 0.0537 0.1587
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0685 0.0863
Brugia malayi glutamate synthase 0.0014 0.0076 0.0141
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.1329 0.2476
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0026 0.0049
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0245 0.0245
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0053 0.089 0.1122
Loa Loa (eye worm) glutathione reductase 0.0152 0.2982 0.5553
Brugia malayi Thioredoxin reductase 0.0152 0.2982 0.5553
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0245 0.0309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0245 0.0456
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0053 0.089 0.1122
Plasmodium falciparum glutathione reductase 0.0152 0.2982 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.012 0.0151
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0084 0.0106
Treponema pallidum NADH oxidase 0.0053 0.089 1
Schistosoma mansoni hypothetical protein 0.0051 0.0858 0.0858
Schistosoma mansoni survival motor neuron protein 0.0051 0.0858 0.0858
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0245 0.0245
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1329 0.1329
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0245 0.0245
Onchocerca volvulus 0.0092 0.1718 0.3024
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.1329 0.2476
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0409 0.0762
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.012 0.0151
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0496 0.0624
Echinococcus granulosus lamin dm0 0.003 0.0409 0.0516
Schistosoma mansoni lamin 0.003 0.0409 0.0409
Echinococcus multilocularis lamin dm0 0.003 0.0409 0.0516
Entamoeba histolytica hypothetical protein 0.0084 0.1554 1
Echinococcus granulosus intermediate filament protein 0.003 0.0409 0.0516
Echinococcus multilocularis geminin 0.0387 0.7938 1
Brugia malayi intermediate filament protein 0.003 0.0409 0.0762
Onchocerca volvulus 0.0051 0.0858 0.151
Echinococcus multilocularis glutamate synthase 0.0014 0.0076 0.0095
Toxoplasma gondii NADPH-glutathione reductase 0.0053 0.089 0.2803
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0245 0.0456
Loa Loa (eye worm) hypothetical protein 0.0022 0.0245 0.0456
Loa Loa (eye worm) RNA binding protein 0.0073 0.1329 0.2476
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0053 0.089 0.2803
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0007 0.0009
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0026 0.0033
Loa Loa (eye worm) hypothetical protein 0.0022 0.0245 0.0456
Entamoeba histolytica hypothetical protein 0.0084 0.1554 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0142 0.2774 0.3494
Schistosoma mansoni aldehyde dehydrogenase 0.0142 0.2774 0.2774
Mycobacterium tuberculosis Probable dehydrogenase 0.0346 0.7082 0.8958
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0245 0.0309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0245 0.0456
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0326 0.0861
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0014 0.0076 0.0095
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0049
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0385 0.7896 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0053 0.089 0.2803
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0014 0.0076 0.0095
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0537 0.0537
Onchocerca volvulus 0.0036 0.0537 0.0945
Loa Loa (eye worm) hypothetical protein 0.0029 0.0398 0.0741
Loa Loa (eye worm) hypothetical protein 0.0022 0.0245 0.0456
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0685 0.0863
Schistosoma mansoni cpg binding protein 0.003 0.0422 0.0422
Brugia malayi isocitrate dehydrogenase 0.0016 0.012 0.0223
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.012 0.0152
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0685 0.4121
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0245 0.0456
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0053 0.089 0.2803
Schistosoma mansoni hypothetical protein 0.0014 0.0076 0.0076
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0053 0.089 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0053 0.089 0.2803
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0326 0.0861
Loa Loa (eye worm) hypothetical protein 0.0022 0.0245 0.0456
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0045 0.0056
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0053 0.089 0.2803
Plasmodium falciparum glutathione reductase 0.0053 0.089 0.2803
Loa Loa (eye worm) hypothetical protein 0.0022 0.0245 0.0456
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0053 0.089 0.2803
Brugia malayi hypothetical protein 0.0018 0.016 0.0299
Brugia malayi TAR-binding protein 0.0073 0.1329 0.2476
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0142 0.2774 0.9284
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0409 0.0762
Echinococcus multilocularis L aminoadipate semialdehyde 0.0092 0.1718 0.2164
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0004 0.0008
Entamoeba histolytica hypothetical protein 0.0026 0.0326 0.1693
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0053 0.089 0.2803
Schistosoma mansoni hypothetical protein 0.0387 0.7938 0.7938
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0245 0.0456
Echinococcus granulosus L aminoadipate semialdehyde 0.0092 0.1718 0.2164
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0084 0.1554 0.1958
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0142 0.2774 0.345
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0685 0.0863
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0326 0.0861
Onchocerca volvulus 0.003 0.0422 0.0744
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.012 0.0152
Loa Loa (eye worm) TAR-binding protein 0.0073 0.1329 0.2476
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0049
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0245 0.0309
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0007 0.0009
Trichomonas vaginalis set domain proteins, putative 0.028 0.568 1
Brugia malayi ecdysteroid receptor 0.0022 0.0245 0.0456
Brugia malayi nuclear receptor RXR 0.0012 0.0026 0.0049
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.506 0.6374
Echinococcus granulosus glutamate synthase 0.0014 0.0076 0.0095
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0326 0.3072
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0118 0.0219
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0014 0.0076 0.0095
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0245 0.0309
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0245 0.0456
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0245 0.0245
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0537 0.0676
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0685 0.1087
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0346 0.7082 0.8958
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0368 0.1007
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.012 0.0151
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0053 0.089 0.302
Onchocerca volvulus Huntingtin homolog 0.0265 0.5369 0.9453
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0053 0.089 0.089
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.012 0.0151
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.012 0.0057
Brugia malayi glutathione reductase 0.0152 0.2982 0.5553
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0014 0.0076 0.0141
Entamoeba histolytica hypothetical protein 0.0084 0.1554 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0245 0.0309
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0053 0.089 0.1042
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0118 0.0219
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0014 0.0076 0.0095
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0053 0.089 0.2803
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0157
Entamoeba histolytica hypothetical protein 0.0084 0.1554 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.012 0.0151
Schistosoma mansoni hypothetical protein 0.0012 0.0045 0.0045
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0014 0.0076 0.0095
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0368 0.1007
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0685 0.2097
Trichomonas vaginalis glutathione reductase, putative 0.0053 0.089 0.1454
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0014 0.0076 0.0095
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0245 0.0309
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0026 0.0026
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0326 0.0861
Loa Loa (eye worm) hypothetical protein 0.0092 0.1718 0.3199
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0685 0.1276
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0245 0.0309
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0685 0.2097
Schistosoma mansoni sulfide quinone reductase 0.0014 0.0076 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0245 0.0456
Trypanosoma cruzi trypanothione reductase, putative 0.0152 0.2982 1
Echinococcus multilocularis lamin 0.003 0.0409 0.0516
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0537 0.0676
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0245 0.0309
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0084 0.0106
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0014 0.0076 0.0095
Trichomonas vaginalis mercuric reductase, putative 0.0053 0.089 0.1454
Brugia malayi nuclear hormone receptor 0.0022 0.0245 0.0456
Mycobacterium ulcerans aldehyde dehydrogenase 0.0142 0.2774 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0053 0.089 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0049
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0022 0.0245 0.0456
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0152 0.2982 0.3716
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0053 0.089 0.2803
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.012 0.0151
Schistosoma mansoni glutamate synthase 0.0014 0.0076 0.0076
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0245 0.0245
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0053 0.089 0.2803
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0045 0.0056
Brugia malayi hypothetical protein 0.025 0.506 0.9423
Brugia malayi hypothetical protein 0.0028 0.0368 0.0686
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0026 0.0049
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0245 0.0431
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.1023 0.326
Loa Loa (eye worm) transcription factor SMAD2 0.0141 0.2747 0.5117
Brugia malayi nuclear receptor NHR-88 0.0022 0.0245 0.0456
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0039 0.0596 0.111
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0026 0.0049
Brugia malayi Isocitrate dehydrogenase 0.0016 0.012 0.0223
Echinococcus granulosus cpg binding protein 0.0032 0.0459 0.0578
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0245 0.0309
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0245 0.0309
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0014 0.0076 0.0095
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0245 0.0456
Echinococcus granulosus thioredoxin glutathione reductase 0.0152 0.2994 0.3772
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0368 0.1007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0049
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0368 0.1007
Brugia malayi hypothetical protein 0.0012 0.0026 0.0049
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.012 0.012
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0245 0.0456
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0368 0.1007
Plasmodium vivax glutathione reductase, putative 0.0152 0.2982 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0537 0.1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0346 0.7082 0.8958
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0385 0.7896 1
Brugia malayi hypothetical protein 0.0265 0.5369 1
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0326 0.3072
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0685 0.1087
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0858 0.1598
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0092 0.1718 0.1718
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0245 0.0456
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0245 0.0245
Echinococcus multilocularis cpg binding protein 0.0032 0.0459 0.0578
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0245 0.0245
Onchocerca volvulus 0.028 0.568 1
Trypanosoma brucei trypanothione reductase 0.0152 0.2982 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.012 0.0152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0245 0.0456
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0537 0.0537
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0084 0.1554 0.1958
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0026 0.0033
Brugia malayi MH2 domain containing protein 0.0141 0.2747 0.5117
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0053 0.089 0.2803

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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