TDR Targets

Basic information

Technical information

TDR Targets ID: 687037
Name: 3-fluoro-N-[4-(6-morpholin-4-ylpyridazin-3-yl )phenyl]benzamide
MW: 378.4 | Formula: C21H19FN4O2
H donors: 1 H acceptors: 3 LogP: 2.52 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Fc1cccc(c1)C(=O)Nc1ccc(cc1)c1ccc(nn1)N1CCOCC1
InChi: 1S/C21H19FN4O2/c22-17-3-1-2-16(14-17)21(27)23-18-6-4-15(5-7-18)19-8-9-20(25-24-19)26-10-12-28-13-11-26/h1-9,14H,10-13H2,(H,23,27)
InChiKey: UPZRDKMNCKUQAR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-fluoro-N-[4-(6-morpholinopyridazin-3-yl)phenyl]benzamide
3-fluoro-N-[4-(6-morpholino-3-pyridazinyl)phenyl]benzamide
ZINC05259348

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	lamin	0.0027	0.0893	0.0893
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0227	0.015
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.1237	1
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0034	0.118	0.2544
Trypanosoma brucei	pyruvate kinase 1, putative	0.0034	0.118	0.9444
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0012	0.0227	0.0227
Echinococcus granulosus	cpg binding protein	0.0031	0.1045	0.1045
Echinococcus granulosus	ferritin	0.0008	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1237	0.1167
Echinococcus multilocularis	pyruvate kinase	0.0017	0.045	0.045
Echinococcus granulosus	pyruvate kinase	0.0017	0.045	0.045
Plasmodium vivax	pyruvate kinase 2, putative	0.0017	0.045	0.2203
Mycobacterium leprae	Probable lipase LipE	0.0035	0.1237	1
Trypanosoma brucei	pyruvate kinase 1	0.0034	0.118	0.9444
Mycobacterium ulcerans	hypothetical protein	0.0035	0.1237	1
Onchocerca volvulus		0.0027	0.0893	0.6594
Schistosoma mansoni	apoferritin-2	0.0008	0.0044	0.0044
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0012	0.0227	0.0227
Echinococcus granulosus	lamin dm0	0.0027	0.0893	0.0893
Brugia malayi	Peptidase family M1 containing protein	0.0012	0.0227	0.0353
Echinococcus multilocularis	pyruvate kinase	0.0027	0.0864	0.0864
Echinococcus multilocularis	lamin	0.0027	0.0893	0.0893
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1237	0.1167
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0012	0.0227	0.1537
Echinococcus multilocularis	pyruvate kinase	0.0017	0.045	0.045
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.1237	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0227	0.0227
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.1298	0.1298
Echinococcus multilocularis	ferritin	0.0008	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0893	0.082
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0232	1	1
Onchocerca volvulus		0.0027	0.0893	0.6594
Schistosoma mansoni	hypothetical protein	0.0036	0.1298	0.1298
Loa Loa (eye worm)	beta-lactamase	0.0035	0.1237	0.1167
Schistosoma mansoni	ferritin	0.0008	0.0044	0.0044
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0972	0.2064
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.1237	0.1244
Brugia malayi	intermediate filament protein	0.0027	0.0893	0.1883
Plasmodium falciparum	pyruvate kinase 2	0.0017	0.045	0.2333
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0329	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0027	0.087	0.0798
Entamoeba histolytica	hypothetical protein	0.0036	0.1298	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0227	0.0227
Treponema pallidum	bacterioferrin (TpF1)	0.0008	0.0044	0.5
Schistosoma mansoni	ferritin	0.0008	0.0044	0.0044
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0329	0.0587
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0034	0.118	0.9444
Echinococcus granulosus	geminin	0.0164	0.701	0.701
Loa Loa (eye worm)	pyruvate kinase	0.0034	0.118	0.111
Mycobacterium tuberculosis	Conserved protein	0.0035	0.1237	0.1244
Onchocerca volvulus		0.0035	0.1237	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1237	0.1167
Brugia malayi	hypothetical protein	0.0012	0.0227	0.0353
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.1237	0.1167
Schistosoma mansoni	ferritin light chain	0.0008	0.0044	0.0044
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0034	0.118	0.1185
Echinococcus granulosus	expressed protein	0.0008	0.0044	0.0044
Schistosoma mansoni	cpg binding protein	0.0029	0.0972	0.0972
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0012	0.0227	0.0227
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.2128	1
Onchocerca volvulus		0.0035	0.1237	1
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0008	0.0044	0.5
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0012	0.0227	0.1537
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0012	0.0227	0.0227
Schistosoma mansoni	apoferritin-2	0.0008	0.0044	0.0044
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.1237	1
Echinococcus multilocularis	musashi	0.0027	0.0893	0.0893
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0034	0.118	0.9444
Leishmania major	pyruvate kinase	0.0034	0.118	0.9444
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0012	0.0227	0.015
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.1237	0.1244
Entamoeba histolytica	pyruvate kinase, putative	0.0023	0.0726	0.4657
Trichomonas vaginalis	pyruvate kinase, putative	0.0034	0.118	0.9529
Mycobacterium ulcerans	lipase LipD	0.0035	0.1237	1
Echinococcus multilocularis	pyruvate kinase	0.0034	0.118	0.118
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.1237	0.1237
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0726	0.0652
Echinococcus multilocularis	lamin dm0	0.0027	0.0893	0.0893
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0242	0.0165
Toxoplasma gondii	pyruvate kinase PyKII	0.0017	0.045	0.117
Toxoplasma gondii	ABC1 family protein	0.0035	0.1237	0.531
Schistosoma mansoni	ferritin	0.0008	0.0044	0.0044
Trichomonas vaginalis	esterase, putative	0.0035	0.1237	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0893	0.082
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.1298	0.1298
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0227	0.0227
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.1237	0.1237
Schistosoma mansoni	hypothetical protein	0.0164	0.701	0.701
Entamoeba histolytica	hypothetical protein	0.0036	0.1298	1
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0893	0.082
Trichomonas vaginalis	pyruvate kinase, putative	0.0034	0.118	0.9529
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.1237	0.1244
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0972	0.09
Plasmodium vivax	pyruvate kinase, putative	0.0034	0.118	0.9444
Loa Loa (eye worm)	TATA binding protein associated factor	0.0012	0.0227	0.015
Brugia malayi	TATA binding protein associated factor	0.0012	0.0227	0.0353
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.1237	1
Mycobacterium ulcerans	aminopeptidase N PepN	0.0012	0.0227	0.1537
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0227	0.015
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0232	1	1
Echinococcus granulosus	pyruvate kinase	0.0017	0.045	0.045
Loa Loa (eye worm)	pyruvate kinase	0.0034	0.118	0.111
Echinococcus multilocularis	expressed protein	0.0008	0.0044	0.0044
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.1237	1
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0012	0.0227	0.0227
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0012	0.0227	0.0227
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0012	0.0227	0.0227
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0012	0.0227	0.0227
Entamoeba histolytica	hypothetical protein	0.0036	0.1298	1
Mycobacterium tuberculosis	Conserved protein	0.0035	0.1237	0.1244
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0223	0.963	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.2421	0.2421
Schistosoma mansoni	pyruvate kinase	0.0034	0.118	0.118
Onchocerca volvulus	Pyruvate kinase homolog	0.0034	0.118	0.9444
Mycobacterium ulcerans	pyruvate kinase	0.0034	0.118	0.9529
Leishmania major	pyruvate kinase	0.0034	0.118	0.9444
Brugia malayi	beta-lactamase	0.0035	0.1237	0.2673
Mycobacterium ulcerans	beta-lactamase	0.0035	0.1237	1
Plasmodium falciparum	pyruvate kinase	0.0034	0.118	1
Brugia malayi	beta-lactamase family protein	0.0035	0.1237	0.2673
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.1237	0.1244
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0079	0.0079
Schistosoma mansoni	ferritin light chain	0.0008	0.0044	0.0044
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0265	0.0265
Echinococcus multilocularis	geminin	0.0164	0.701	0.701
Toxoplasma gondii	pyruvate kinase PyK1	0.0034	0.118	0.5015
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1237	0.1167
Echinococcus granulosus	intermediate filament protein	0.0027	0.0893	0.0893
Echinococcus granulosus	aminopeptidase N	0.0012	0.0227	0.0227
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0227	0.0227
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.1237	1
Echinococcus multilocularis	aminopeptidase N	0.0012	0.0227	0.0227
Schistosoma mansoni	lamin	0.0027	0.0893	0.0893
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.1237	1
Loa Loa (eye worm)	aminopeptidase N	0.0012	0.0227	0.015
Echinococcus granulosus	pyruvate kinase	0.0034	0.118	0.118
Mycobacterium ulcerans	aminopeptidase N PepN	0.0012	0.0227	0.1537
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0893	0.1883
Echinococcus multilocularis	cpg binding protein	0.0031	0.1045	0.1045
Echinococcus granulosus	pyruvate kinase	0.0017	0.045	0.045
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0242	0.0165
Schistosoma mansoni	cpg binding protein	0.0031	0.1045	0.1045
Chlamydia trachomatis	pyruvate kinase	0.0034	0.118	0.5
Brugia malayi	hypothetical protein	0.0012	0.0227	0.0353
Schistosoma mansoni	cpg binding protein	0.0031	0.1045	0.1045
Onchocerca volvulus	Pyruvate kinase homolog	0.0034	0.118	0.9444
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.1237	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0227	0.015
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.1237	0.1244
Loa Loa (eye worm)	pyruvate kinase-PB	0.0023	0.0726	0.0652
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.1237	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0265	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0034	0.118	0.111
Schistosoma mansoni	pyruvate kinase	0.0034	0.118	0.118
Onchocerca volvulus		0.0035	0.1237	1
Brugia malayi	beta-lactamase family protein	0.0035	0.1237	0.2673
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0232	1	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0012	0.0227	0.0227
Echinococcus multilocularis	pyruvate kinase	0.0034	0.118	0.118
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.1237	1
Brugia malayi	Peptidase family M1 containing protein	0.0012	0.0227	0.0353
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.1237	0.1244
Schistosoma mansoni	hypothetical protein	0.0164	0.701	0.701
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.1237	1
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0012	0.0227	0.0227
Entamoeba histolytica	hypothetical protein	0.0036	0.1298	1
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0034	0.118	0.2544
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0034	0.118	0.9529
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0227	0.0227
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.1237	0.1237
Mycobacterium tuberculosis	Conserved protein	0.0035	0.1237	0.1244
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0265	0.0265
Schistosoma mansoni	ferritin	0.0008	0.0044	0.0044
Echinococcus granulosus	pyruvate kinase	0.0034	0.118	0.118
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.001	0.0133	0.0137
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.1298	0.1298
Schistosoma mansoni	pyruvate kinase	0.0017	0.045	0.045
Leishmania major	hypothetical protein, conserved	0.0035	0.1237	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0227	0.0227
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.1237	0.1244
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0893	0.0893
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0012	0.0227	0.1537
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.1237	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1237	0.1167
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.1237	0.2673
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1237	0.1167
Giardia lamblia	Pyruvate kinase	0.0034	0.118	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0079	0.0079
Brugia malayi	hypothetical protein	0.0106	0.4424	1
Loa Loa (eye worm)	pyruvate kinase	0.0034	0.118	0.111
Schistosoma mansoni	lamin	0.0027	0.0893	0.0893
Onchocerca volvulus	Pyruvate kinase homolog	0.0034	0.118	0.9444
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.1237	0.1237
Onchocerca volvulus		0.0029	0.0972	0.7375
Echinococcus multilocularis	pyruvate kinase	0.0017	0.045	0.045
Brugia malayi	hypothetical protein	0.0036	0.1298	0.2815
Brugia malayi	Peptidase family M1 containing protein	0.0012	0.0227	0.0353

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 687037