Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.005 | 0.0444 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.2778 | 0.6989 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0128 | 0.2778 | 0.4663 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.2778 | 0.6989 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0054 | 0.0578 | 0.1453 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0128 | 0.2778 | 0.4663 |
Loa Loa (eye worm) | RNA binding protein | 0.0128 | 0.2778 | 0.4663 |
Echinococcus multilocularis | tumor protein p63 | 0.0372 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.2778 | 0.6989 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0578 | 0.0969 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.0444 | 0.5 |
Brugia malayi | hypothetical protein | 0.005 | 0.0444 | 0.0746 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.2778 | 0.6989 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.005 | 0.0444 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.0389 | 0.0979 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.0444 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0128 | 0.2778 | 0.0198 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.005 | 0.0444 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0128 | 0.2778 | 0.4663 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.048 | 0.0806 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.048 | 0.0806 |
Brugia malayi | RNA binding protein | 0.0128 | 0.2778 | 0.4663 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0236 | 0.5959 | 0.4514 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.005 | 0.0444 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.2778 | 0.6989 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.0444 | 0.5 |
Echinococcus multilocularis | geminin | 0.0169 | 0.3976 | 0.1823 |
Echinococcus granulosus | geminin | 0.0169 | 0.3976 | 0.1823 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.3976 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.3976 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.5959 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0444 | 0.0746 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0389 | 0.0653 |
Brugia malayi | hypothetical protein | 0.0236 | 0.5959 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0128 | 0.2778 | 0.4663 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.048 | 0.0806 |
Echinococcus multilocularis | tar DNA binding protein | 0.0128 | 0.2778 | 0.0198 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.2633 | 0.6622 |
Schistosoma mansoni | thyroid hormone receptor | 0.0133 | 0.2927 | 0.7363 |
Onchocerca volvulus | 0.0054 | 0.0578 | 1 | |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0236 | 0.5959 | 0.4514 |
Schistosoma mansoni | thyroid hormone receptor | 0.0133 | 0.2927 | 0.7363 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0389 | 0.0979 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.048 | 0.0806 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0133 | 0.2927 | 0.04 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.0444 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.