Detailed information for compound 687549

Basic information

Technical information
  • TDR Targets ID: 687549
  • Name: ethyl 4-[[2-[[5-[(4-chlorophenyl)methyl]-4-py rrol-1-yl-1,2,4-triazol-3-yl]sulfanyl]acetyl] amino]benzoate
  • MW: 495.981 | Formula: C24H22ClN5O3S
  • H donors: 1 H acceptors: 4 LogP: 4.81 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc(cc1)NC(=O)CSc1nnc(n1n1cccc1)Cc1ccc(cc1)Cl
  • InChi: 1S/C24H22ClN5O3S/c1-2-33-23(32)18-7-11-20(12-8-18)26-22(31)16-34-24-28-27-21(30(24)29-13-3-4-14-29)15-17-5-9-19(25)10-6-17/h3-14H,2,15-16H2,1H3,(H,26,31)
  • InChiKey: PANFJLVFRCHJTQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[[2-[[5-[(4-chlorophenyl)methyl]-4-(1-pyrrolyl)-1,2,4-triazol-3-yl]thio]-1-oxoethyl]amino]benzoic acid ethyl ester
  • 4-[[2-[[5-(4-chlorobenzyl)-4-pyrrol-1-yl-1,2,4-triazol-3-yl]thio]acetyl]amino]benzoic acid ethyl ester
  • ethyl 4-[2-[[5-[(4-chlorophenyl)methyl]-4-pyrrol-1-yl-1,2,4-triazol-3-yl]sulfanyl]ethanoylamino]benzoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0371 0.4843 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0064 0.0064
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0025 0.0125 0.0368
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0271 0.0798
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0064 0.0064
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0064 0.0064
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0044 0.0044
Schistosoma mansoni rab6-interacting 0.0021 0.0064 0.0064
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0208 0.0208
Mycobacterium tuberculosis Conserved protein 0.0036 0.0271 0.0472
Trichomonas vaginalis esterase, putative 0.0036 0.0271 0.0472
Schistosoma mansoni lipoxygenase 0.0086 0.0962 0.0962
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0271 0.0472
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.1062 0.2121
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0025 0.0125 0.0127
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0101 0.0101
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0168
Leishmania major trypanothione reductase 0.0037 0.0287 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0125 0.0168
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0689 0.2033
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0044 0.0044
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0064 0.0064
Trichomonas vaginalis glutaminase, putative 0.0264 0.3389 0.697
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.1568 0.4626
Echinococcus multilocularis muscleblind protein 1 0.0146 0.1775 0.1775
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0025 0.0125 0.0168
Toxoplasma gondii thioredoxin reductase 0.0037 0.0287 0.0391
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0371 0.4843 1
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0023 0.0101 0.711
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0471 0.1391
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0271 0.0271
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.039 0.039
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0168
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0371 0.4843 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0224 0.0224
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.039 0.039
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0025 0.0125 0.0168
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0146 0.1775 0.5238
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0125 0.0168
Trichomonas vaginalis set domain proteins, putative 0.0257 0.3289 0.6762
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0271 0.0472
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0168
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0025 0.0125 0.0127
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0689 0.0689
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0933 0.1853
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0101 0.0101
Trypanosoma brucei pteridine reductase 1 0.0025 0.0125 0.3329
Loa Loa (eye worm) hypothetical protein 0.0036 0.0271 0.0798
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0287 1
Brugia malayi Muscleblind-like protein 0.0146 0.1775 0.5238
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0044 0.0129
Onchocerca volvulus 0.0032 0.0224 0.0495
Brugia malayi glutathione reductase 0.0037 0.0287 0.0846
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0471 0.1391
Schistosoma mansoni polycystin 1-related 0.0021 0.0064 0.0064
Onchocerca volvulus 0.0036 0.0271 0.064
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0025 0.0125 0.0168
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0125 0.0168
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0271 0.0472
Echinococcus granulosus tar DNA binding protein 0.0066 0.0689 0.0689
Schistosoma mansoni loxhd1 0.0021 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0036 0.0271 0.0798
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0933 0.1714
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0224 0.0259
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0025 0.0125 1
Echinococcus granulosus dna polymerase eta 0.0019 0.0044 0.0044
Echinococcus granulosus geminin 0.0339 0.4417 0.4417
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0277 0.0818
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0101 0.0101
Schistosoma mansoni rab6-interacting 0.0021 0.0064 0.0064
Echinococcus multilocularis dna polymerase eta 0.0019 0.0044 0.0044
Echinococcus multilocularis microtubule associated protein 2 0.0748 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0271 0.0798
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0023 0.0101 0.2367
Brugia malayi RNA binding protein 0.0066 0.0689 0.2033
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0124 0.1471 0.1471
Onchocerca volvulus 0.0025 0.0125 0.0187
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0293 0.0293
Plasmodium falciparum T-complex protein 1 subunit beta 0.0023 0.0101 0.0078
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0025 0.0125 0.0049
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0253 0.0747
Loa Loa (eye worm) T-complex protein 1 0.0023 0.0101 0.0299
Brugia malayi beta-lactamase 0.0036 0.0271 0.0798
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0025 0.0125 0.3329
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0025 0.0125 0.0368
Mycobacterium ulcerans glutaminase 0.0264 0.3389 0.697
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0025 0.0125 0.0168
Brugia malayi TAR-binding protein 0.0066 0.0689 0.2033
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0125 0.0168
Brugia malayi T-complex protein 1, beta subunit 0.0023 0.0101 0.0299
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0025 0.0125 0.0125
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0271 0.0472
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.1062 0.2121
Plasmodium vivax SET domain protein, putative 0.0032 0.0224 0.0334
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0168
Loa Loa (eye worm) hypothetical protein 0.0146 0.1775 0.5238
Schistosoma mansoni hypothetical protein 0.0021 0.0064 0.0064
Loa Loa (eye worm) RNA binding protein 0.0066 0.0689 0.2033
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0025 0.0125 0.3329
Schistosoma mansoni hypothetical protein 0.0035 0.0253 0.0253
Loa Loa (eye worm) glutathione reductase 0.0037 0.0287 0.0846
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0129
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0271 0.0472
Loa Loa (eye worm) glutaminase 0.0264 0.3389 1
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0023 0.0101 0.0101
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0025 0.0125 0.0125
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0125 0.0168
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.039 0.039
Loa Loa (eye worm) glutaminase 2 0.0264 0.3389 1
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0168
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0271 0.0309
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0025 0.0125 0.3329
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0044 0.0044
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0293 0.0293
Plasmodium falciparum thioredoxin reductase 0.0037 0.0287 0.0465
Brugia malayi MH2 domain containing protein 0.0131 0.1568 0.4626
Mycobacterium ulcerans lipase LipD 0.0036 0.0271 0.0472
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.005 0.0471 0.1391
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0933 0.1853
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0189
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0023 0.0101 0.012
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0023 0.0101 0.0078
Brugia malayi Doublecortin family protein 0.0021 0.0064 0.0189
Schistosoma mansoni hypothetical protein 0.0339 0.4417 0.4417
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0689 0.2033
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0025 0.0125 0.0125
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0271 0.0472
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0271 0.0472
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.1568 0.4626
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0689 0.0689
Loa Loa (eye worm) beta-lactamase 0.0036 0.0271 0.0798
Plasmodium vivax glutathione reductase, putative 0.0037 0.0287 0.0465
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0125 0.0168
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0025 0.0125 0.0168
Brugia malayi T-complex protein 1, beta subunit 0.0023 0.0101 0.0299
Mycobacterium tuberculosis Possible oxidoreductase 0.0025 0.0125 0.0168
Mycobacterium tuberculosis Probable oxidoreductase 0.0025 0.0125 0.0168
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0287 0.0506
Onchocerca volvulus 0.0036 0.0271 0.064
Brugia malayi Cytochrome P450 family protein 0.0036 0.0277 0.0818
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0271 0.0271
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0125 0.0168
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0064 0.0189
Loa Loa (eye worm) oxidoreductase 0.0025 0.0125 0.0368
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0933 0.1853
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0271 0.0271
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0025 0.0125 0.0168
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0025 0.0125 0.0168
Schistosoma mansoni glutaminase 0.0264 0.3389 0.3389
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0271 0.9339
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0271 0.0798
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0287 0.0465
Loa Loa (eye worm) hypothetical protein 0.0025 0.0125 0.0368
Mycobacterium ulcerans beta-lactamase 0.0036 0.0271 0.0472
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0125 0.0168
Brugia malayi hypothetical protein 0.0021 0.0064 0.0189
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0224 0.0224
Mycobacterium leprae Probable lipase LipE 0.0036 0.0271 0.0309
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.039 0.039
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0168
Echinococcus multilocularis muscleblind protein 0.0146 0.1775 0.1775
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0689 0.2033
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0271 0.0472
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.1062 0.2121
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0064 0.0064
Brugia malayi Pre-SET motif family protein 0.0226 0.2864 0.845
Echinococcus granulosus RUN 0.0021 0.0064 0.0064
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0371 0.4843 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.039 0.1151
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0168
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0168
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0224 0.0224
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0023 0.0101 0.2367
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0168
Schistosoma mansoni lipoxygenase 0.0124 0.1471 0.1471
Brugia malayi beta-lactamase family protein 0.0036 0.0271 0.0798
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0271 0.0271
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0124 0.1471 0.1471
Leishmania major pteridine reductase 1 0.0025 0.0125 0.3329
Plasmodium falciparum enoyl-acyl carrier reductase 0.0371 0.4843 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0224 0.0661
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0224 0.0224
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0471 0.1391
Mycobacterium tuberculosis Probable reductase 0.0084 0.0933 0.1853
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0025 0.0125 0.3329
Mycobacterium ulcerans oxidoreductase 0.0025 0.0125 0.0168
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.039 0.039
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0271 0.0472
Trypanosoma brucei trypanothione reductase 0.0037 0.0287 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.1062 0.1986
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0933 0.1853
Mycobacterium tuberculosis Conserved protein 0.0036 0.0271 0.0472
Mycobacterium tuberculosis Conserved protein 0.0036 0.0271 0.0472
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.2904 0.596
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0689 0.0689
Leishmania major oxidoreductase-like protein 0.0025 0.0125 0.3329
Loa Loa (eye worm) hypothetical protein 0.0036 0.0271 0.0798
Brugia malayi hypothetical protein 0.0021 0.0064 0.0189
Schistosoma mansoni DNA polymerase eta 0.0019 0.0044 0.0044
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0064 0.0064
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0271 0.0472
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0125 0.0168
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0271 0.0432
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0025 0.0125 0.3329
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0271 0.0472
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0371 0.4843 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.0271 0.0472
Schistosoma mansoni hypothetical protein 0.0339 0.4417 0.4417
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0371 0.4843 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0044 0.0129
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0287 0.0846
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0689 0.0689
Brugia malayi beta-lactamase family protein 0.0036 0.0271 0.0798
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0689 0.0689
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0271 0.0472
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0224 0.0224
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0025 0.0125 0.0049
Mycobacterium tuberculosis Possible oxidoreductase 0.0025 0.0125 0.0168
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0025 0.0125 0.3329
Echinococcus multilocularis geminin 0.0339 0.4417 0.4417
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0025 0.0125 0.3329
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.2864 0.845
Schistosoma mansoni microtubule-associated protein tau 0.0748 1 1
Brugia malayi Thioredoxin reductase 0.0037 0.0287 0.0846
Loa Loa (eye worm) hypothetical protein 0.0036 0.0271 0.0798
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0044 0.0044
Onchocerca volvulus 0.0257 0.3289 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0125 0.0168
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0025 0.0125 0.0168
Onchocerca volvulus 0.0025 0.0125 0.0187
Loa Loa (eye worm) hypothetical protein 0.0035 0.0253 0.0747
Onchocerca volvulus 0.0036 0.0271 0.064
Trypanosoma brucei oxidoreductase-like protein 0.0025 0.0125 0.3329
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0271 0.0472
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0689 0.0689
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0025 0.0125 0.0168
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0224 0.0224
Giardia lamblia TCP-1 chaperonin subunit beta 0.0023 0.0101 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0271 0.9339
Toxoplasma gondii ABC1 family protein 0.0036 0.0271 0.0357
Leishmania major hypothetical protein, conserved 0.0036 0.0271 0.9339
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0168
Loa Loa (eye worm) hypothetical protein 0.0036 0.0271 0.0798
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0168
Trichomonas vaginalis hypothetical protein 0.0371 0.4843 1
Loa Loa (eye worm) retinol dehydrogenase 12 0.0025 0.0125 0.0368
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0189
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0025 0.0125 0.0168
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.039 0.1151
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0125 0.0168
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0025 0.0125 0.0049
Brugia malayi glutaminase DH11.1 0.0264 0.3389 1
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0371 0.4843 1
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0168
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0271 0.9339
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0125 0.0168
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0025 0.0125 0.0368
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0023 0.0101 0.0101
Plasmodium falciparum glutathione reductase 0.0037 0.0287 0.0465
Leishmania major T-complex protein 1, beta subunit, putative 0.0023 0.0101 0.2367
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0933 0.1853
Echinococcus granulosus dna polymerase kappa 0.0019 0.0044 0.0044
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0224 0.0224
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0044 0.0129
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0125 0.0168
Trichomonas vaginalis chaperonin, putative 0.0023 0.0101 0.012
Brugia malayi Pre-SET motif family protein 0.0032 0.0224 0.0661
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0271 0.0472
Echinococcus granulosus muscleblind protein 0.0146 0.1775 0.1775
Schistosoma mansoni dihydropteridine reductase 0.0025 0.0125 0.0125
Echinococcus multilocularis RUN 0.0021 0.0064 0.0064

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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