Detailed information for compound 68785

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 486.64 | Formula: C29H42O6
  • H donors: 1 H acceptors: 3 LogP: 3.92 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=CC12CC3C(C2(C(=O)O)C(=C3)C(C)C)(C[C@H]2[C@H]1CC[C@H]2C)CO[C@H]1C[C@@H]2OC[C@@H]([C@@H]2[C@H](O1)C)C
  • InChi: 1S/C29H42O6/c1-15(2)22-8-19-10-27(13-30)21-7-6-16(3)20(21)11-28(19,29(22,27)26(31)32)14-34-24-9-23-25(18(5)35-24)17(4)12-33-23/h8,13,15-21,23-25H,6-7,9-12,14H2,1-5H3,(H,31,32)/t16-,17+,18-,19?,20-,21-,23+,24-,25-,27?,28?,29?/m1/s1
  • InChiKey: UMSYQURYUZUJHN-ULNUMJQQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0019 0.0021
Toxoplasma gondii histone lysine-specific demethylase 0.0101 0.0086 0.1957
Giardia lamblia Sirtuin type 2 0.0101 0.0086 0.0185
Brugia malayi Nuclear hormone receptor-like 1 0.0151 0.0144 0.0144
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0151 0.0144 0.0142
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0031 0.0007 0.0007
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0101 0.0086 0.0132
Brugia malayi aspartic protease BmAsp-1, identical 0.0036 0.0012 0.0012
Mycobacterium tuberculosis Conserved hypothetical protein 0.0101 0.0086 0.1426
Brugia malayi Nuclear hormone receptor E75 0.0135 0.0125 0.0125
Toxoplasma gondii aspartyl protease 0.0036 0.0012 0.015
Onchocerca volvulus 0.0051 0.003 0.0396
Echinococcus granulosus Tolloid protein 1 0.0044 0.0022 0.002
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0043 0.002 0.0018
Loa Loa (eye worm) DPY-31 protein 0.0031 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.0041
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0006 0.0006
Brugia malayi Protein kinase domain containing protein 0.0042 0.002 0.002
Toxoplasma gondii kringle domain-containing protein 0.0051 0.003 0.0578
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0287 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0151 0.0144 0.0144
Onchocerca volvulus 0.0039 0.0016 0.0151
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0287 0.0297 0.037
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0101 0.0086 0.0132
Brugia malayi CUB domain containing protein 0.0031 0.0007 0.0007
Schistosoma mansoni chromatin regulatory protein sir2 0.0101 0.0086 0.0085
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0036 0.0012 0.0012
Giardia lamblia Hypothetical protein 0.0686 0.0751 0.2009
Plasmodium vivax hypothetical protein, conserved 0.0101 0.0086 0.1891
Onchocerca volvulus 0.0039 0.0016 0.0151
Trichomonas vaginalis hypothetical protein 0.0053 0.0031 0.0041
Onchocerca volvulus 0.0039 0.0016 0.0151
Mycobacterium leprae Possible secreted protease 0.0389 0.0414 1
Schistosoma mansoni site-1 peptidase (S08 family) 0.0389 0.0414 0.0412
Toxoplasma gondii subtilisin SUB6 0.0389 0.0414 1
Toxoplasma gondii subtilisin SUB8 0.0389 0.0414 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0101 0.0086 0.0085
Schistosoma mansoni hypothetical protein 0.1761 0.1973 0.1972
Entamoeba histolytica SWIRM domain protein 0.0042 0.0019 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1973 0.3225
Loa Loa (eye worm) hypothetical protein 0.0135 0.0125 0.0125
Plasmodium vivax LCCL domain-containing protein 0.0053 0.0031 0.0594
Loa Loa (eye worm) hypothetical protein 0.0037 0.0014 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0287 0.0297 0.0297
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.0041
Toxoplasma gondii histone deacetylase SIR2-like 0.0101 0.0086 0.1969
Onchocerca volvulus 0.0036 0.0012 0.0093
Plasmodium falciparum plasmepsin VI 0.0036 0.0012 0.0144
Echinococcus multilocularis ecdysone induced protein 78C 0.0287 0.0297 0.037
Schistosoma mansoni coup transcription factor 0.0287 0.0297 0.0296
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0101 0.0086 0.1078
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0287 0.0297 0.0297
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.5397 0.6105 0.6105
Trypanosoma brucei SIR2-like protein 4, putative 0.0101 0.0086 0.1078
Brugia malayi Probable ATP-dependent helicase DHX35 0.0034 0.001 0.001
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0051 0.0029 0.0028
Schistosoma mansoni nuclear hormone receptor 0.0135 0.0125 0.0123
Loa Loa (eye worm) hypothetical protein 0.0151 0.0144 0.0144
Trichomonas vaginalis WD repeat domain, putative 0.0207 0.0206 0.0328
Plasmodium falciparum plasmepsin VII 0.0036 0.0012 0.0144
Echinococcus multilocularis epidermal growth factor receptor 0.0737 0.0809 0.101
Echinococcus multilocularis protoporphyrinogen oxidase 0.0101 0.0086 0.0105
Echinococcus granulosus furin 0.8823 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0014 0.0014
Onchocerca volvulus 0.0537 0.0582 1
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.0041
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0101 0.0086 0.0085
Loa Loa (eye worm) hypothetical protein 0.0042 0.0019 0.0019
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0389 0.0414 1
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.0414 0.0668
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0135 0.0125 0.0125
Mycobacterium ulcerans NAD-dependent deacetylase 0.0101 0.0086 0.0016
Echinococcus granulosus c4b binding protein beta chain 0.0039 0.0016 0.0014
Brugia malayi amine oxidase, flavin-containing family protein 0.0143 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0135 0.0125 0.0125
Schistosoma mansoni hypothetical protein 0.0031 0.0007 0.0005
Leishmania major arginine N-methyltransferase-like protein 0.0158 0.0151 0.1942
Echinococcus multilocularis discoidin domain containing receptor 2 0.0053 0.0031 0.0037
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2151 0.2416 0.3951
Toxoplasma gondii subtilisin SUB10 0.0389 0.0414 1
Echinococcus granulosus protein will die slowly 0.0207 0.0206 0.0205
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.13 0.1449 0.1449
Schistosoma mansoni furin-1 (S08 family) 0.3816 0.4308 0.4307
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.0041
Leishmania major arginine N-methyltransferase, type I 0.0089 0.0072 0.089
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.0031 0.0007 0.0007
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1761 0.1973 0.3225
Loa Loa (eye worm) hypothetical protein 0.0537 0.0582 0.0582
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0135 0.0125 0.0123
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0686 0.0751 1
Schistosoma mansoni hypothetical protein 0.0031 0.0007 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0287 0.0297 0.0297
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0247 0.0252 0.3298
Loa Loa (eye worm) hypothetical protein 0.0287 0.0297 0.0297
Schistosoma mansoni protein kinase 0.0248 0.0253 0.0251
Chlamydia trachomatis protoporphyrinogen oxidase 0.0101 0.0086 0.5
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0089 0.0072 0.0109
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0287 0.0297 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.0041
Plasmodium vivax subtilisin-like protease 2, putative 0.0389 0.0414 0.9603
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0006 0.0006
Schistosoma mansoni SWI/SNF complex-related 0.0042 0.0019 0.0017
Echinococcus granulosus growth factor receptor bound protein 2 0.0268 0.0276 0.0274
Brugia malayi conserved hypotetical protein 0.0135 0.0125 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1973 0.3225
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0287 0.0297 0.0297
Onchocerca volvulus Protein ultraspiracle homolog 0.0287 0.0297 0.5044
Onchocerca volvulus 0.0053 0.0031 0.0425
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0151 0.0144 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1973 0.3225
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0101 0.0086 0.0132
Plasmodium vivax subtilisin-like protease 1 0.0389 0.0414 0.9603
Loa Loa (eye worm) hypothetical protein 0.0135 0.0125 0.0125
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0089 0.0072 0.0592
Onchocerca volvulus 0.0036 0.0012 0.0093
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0389 0.0414 1
Toxoplasma gondii subtilisin SUB9 0.0389 0.0414 1
Brugia malayi proprotein convertase 2 0.5577 0.631 0.631
Giardia lamblia High cysteine membrane protein Group 2 0.3246 0.3661 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0496 0.0535 0.0667
Brugia malayi p70 ribosomal S6 kinase beta 0.004 0.0017 0.0017
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0287 0.0297 0.0296
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0217 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0151 0.0144 0.0144
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Brugia malayi hypothetical protein 0.0039 0.0016 0.0016
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2151 0.2416 0.3951
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0053 0.0031 0.003
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0389 0.0414 0.0414
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0101 0.0086 0.0185
Brugia malayi CUB domain containing protein 0.0031 0.0007 0.0007
Schistosoma mansoni thyroid hormone receptor 0.0287 0.0297 0.0296
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0101 0.0086 0.0132
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0135 0.0125 0.0154
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0101 0.0086 0.1879
Loa Loa (eye worm) endoprotease bli-4 0.8823 1 1
Trichomonas vaginalis AGC family protein kinase 0.0042 0.002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0053 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0496 0.0535 0.0535
Schistosoma mansoni chromatin regulatory protein sir2 0.0101 0.0086 0.0085
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0036 0.0012 0.001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0287 0.0297 0.0297
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1267 0.1411 0.141
Loa Loa (eye worm) hypothetical protein 0.0101 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0043 0.002 0.002
Brugia malayi pregnancy-associated plasma protein-A 0.0039 0.0016 0.0016
Echinococcus multilocularis neuroendocrine convertase 2 0.5577 0.631 0.789
Schistosoma mansoni RAR-like nuclear receptor 0.0287 0.0297 0.0296
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0158 0.0151 0.0149
Loa Loa (eye worm) hypothetical protein 0.0044 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0031 0.0007 0.0007
Plasmodium falciparum plasmepsin IX 0.0036 0.0012 0.0144
Loa Loa (eye worm) hypothetical protein 0.0036 0.0012 0.0012
Giardia lamblia Furin precursor putative serine protease 0.1761 0.1973 0.5366
Echinococcus multilocularis nuclear receptor nhr 48 0.0135 0.0125 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.0041
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0089 0.0072 0.0088
Toxoplasma gondii subtilisin SUB2 0.0389 0.0414 1
Brugia malayi Suppressor of lurcher protein 1 precursor 0.0031 0.0007 0.0007
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0287 0.0297 0.0296
Entamoeba histolytica SWIRM domain protein 0.0042 0.0019 0.0174
Loa Loa (eye worm) hypothetical protein 0.0031 0.0007 0.0007
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0158 0.0151 0.3547
Schistosoma mansoni protein kinase 0.0248 0.0253 0.0251
Echinococcus granulosus discoidin domain receptor 0.0053 0.0031 0.003
Brugia malayi ecdysteroid receptor 0.0287 0.0297 0.0297
Schistosoma mansoni hypothetical protein 0.0031 0.0007 0.0005
Echinococcus multilocularis Tolloid protein 1 0.0044 0.0022 0.0025
Schistosoma mansoni hypothetical protein 0.0031 0.0007 0.0005
Plasmodium falciparum LCCL domain-containing protein 0.0053 0.0031 0.0594
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0036 0.0012 0.0011
Trypanosoma cruzi subtilisin peptidase 0.0389 0.0414 0.5326
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5397 0.6105 1
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.0041
Onchocerca volvulus 0.0039 0.0016 0.0151
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0101 0.0086 0.0106
Loa Loa (eye worm) hypothetical protein 0.0099 0.0084 0.0084
Leishmania major UDP-galactopyranose mutase 0.0101 0.0086 0.1071
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0003 0.0002
Schistosoma mansoni growth factor receptor-bound protein 0.0268 0.0276 0.0274
Schistosoma mansoni cathepsin D (A01 family) 0.0036 0.0012 0.0011
Schistosoma mansoni btb and poz domain-containing protein 0.0053 0.0031 0.003
Schistosoma mansoni septate junction protein 0.0067 0.0048 0.0046
Echinococcus granulosus cubilin 0.0031 0.0007 0.0005
Brugia malayi celfurPC protein 0.7062 0.7998 0.7998
Schistosoma mansoni hypothetical protein 0.0099 0.0084 0.0082
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.042 0.0449 0.5951
Brugia malayi Will die slowly protein 0.0207 0.0206 0.0206
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0135 0.0125 0.0154
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0053 0.0031 0.0041
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Echinococcus multilocularis tissue type plasminogen activator 0.0051 0.003 0.0035
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0287 0.0297 0.0296
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0101 0.0086 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.0041
Loa Loa (eye worm) sirtuin 4 0.0101 0.0086 0.0086
Brugia malayi Pepsin A precursor 0.0036 0.0012 0.0012
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0101 0.0086 0.1078
Brugia malayi Protein kinase domain containing protein 0.0051 0.003 0.003
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0287 0.0297 0.0296
Toxoplasma gondii bicoid-interacting protein BIN3 0.0089 0.0072 0.1626
Trichomonas vaginalis AGC family protein kinase 0.0042 0.002 0.0022
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0389 0.0414 0.0515
Loa Loa (eye worm) transcriptional regulator 0.0686 0.0751 0.0751
Echinococcus multilocularis chromatin regulatory protein sir2 0.0686 0.0751 0.0937
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Loa Loa (eye worm) hypothetical protein 0.0135 0.0125 0.0125
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0287 0.0297 0.0296
Loa Loa (eye worm) transcriptional regulator 0.0101 0.0086 0.0086
Plasmodium vivax plasmepsin V, putative 0.0404 0.0431 1
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1973 0.3225
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0003 0.0002
Echinococcus granulosus Protein kinase C brain isozyme 0.0028 0.0003 0.0002
Leishmania major subtilisin-like serine peptidase 0.0389 0.0414 0.5474
Toxoplasma gondii subtilisin SUB5 0.0389 0.0414 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.001 0.001
Echinococcus granulosus MAM 0.0099 0.0084 0.0082
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0287 0.0297 0.037
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0217 0.0218 0.0218
Schistosoma mansoni site-1 peptidase (S08 family) 0.0389 0.0414 0.0412
Echinococcus granulosus thyroid hormone receptor alpha 0.0135 0.0125 0.0123
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0101 0.0086 0.0132
Loa Loa (eye worm) hypothetical protein 0.0496 0.0535 0.0535
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0158 0.0151 0.3406
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0135 0.0125 0.0123
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5397 0.6105 1
Echinococcus granulosus Furin 1 0.2151 0.2416 0.2415
Plasmodium falciparum plasmepsin V 0.0404 0.0431 1
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0496 0.0535 0.0533
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0135 0.0125 0.0123
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0006 0.0004
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0389 0.0414 0.0412
Schistosoma mansoni nuclear hormone receptor 0.0135 0.0125 0.0123
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0135 0.0125 0.0154
Brugia malayi hypothetical protein 0.0031 0.0007 0.0007
Toxoplasma gondii aspartyl protease ASP3 0.0036 0.0012 0.015
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Loa Loa (eye worm) TK/ROR protein kinase 0.0051 0.003 0.003
Plasmodium vivax aspartyl proteinase, putative 0.0036 0.0012 0.0144
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0158 0.0151 0.0186
Onchocerca volvulus 0.0039 0.0016 0.0151
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0389 0.0414 1
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.042 0.0449 0.5818
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0287 0.0297 0.0297
Loa Loa (eye worm) CUB domain-containing protein 0.0031 0.0007 0.0007
Toxoplasma gondii aspartyl protease ASP5 0.0368 0.039 0.9412
Entamoeba histolytica protein kinase, putative 0.0042 0.002 0.018
Brugia malayi nuclear hormone receptor 0.0287 0.0297 0.0297
Brugia malayi CUB domain containing protein 0.0031 0.0007 0.0007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0287 0.0297 0.0297
Onchocerca volvulus 0.0135 0.0125 0.2054
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0268 0.0276 0.0276
Plasmodium falciparum plasmepsin I 0.0036 0.0012 0.0144
Schistosoma mansoni growth factor receptor-bound protein 0.0268 0.0276 0.0274
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0006 0.0006
Brugia malayi SWIRM domain containing protein 0.0537 0.0582 0.0582
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2151 0.2416 0.3951
Loa Loa (eye worm) hypothetical protein 0.0151 0.0144 0.0144
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0012 0.0011
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0151 0.0144 0.0142
Leishmania major hypothetical protein, conserved 0.0051 0.003 0.0317
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Brugia malayi aspartic protease BmAsp-2, identical 0.0036 0.0012 0.0012
Echinococcus granulosus C type lectin domian containing protein 0.0039 0.0016 0.0014
Schistosoma mansoni amine oxidase 0.0101 0.0086 0.0084
Echinococcus granulosus discoidin domain containing receptor 2 0.0053 0.0031 0.003
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0012 0.0011
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0031 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0287 0.0297 0.0297
Plasmodium falciparum LCCL domain-containing protein 0.0053 0.0031 0.0594
Echinococcus granulosus discoidin domain containing receptor 2 0.0053 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0051 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.3427 0.3866 0.3866
Brugia malayi CUB domain containing protein 0.0031 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0135 0.0125 0.0125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0287 0.0297 0.0297
Echinococcus multilocularis discoidin domain containing receptor 2 0.0053 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0287 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0031 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.0414 0.0668
Loa Loa (eye worm) hypothetical protein 0.0039 0.0016 0.0016
Brugia malayi protein kinase C II. 0.0101 0.0087 0.0087
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0089 0.0072 0.1626
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Loa Loa (eye worm) hypothetical protein 0.0101 0.0086 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0287 0.0297 0.0297
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0287 0.0297 0.037
Loa Loa (eye worm) WD40 repeat protein 0.0207 0.0206 0.0206
Toxoplasma gondii SWIRM domain-containing protein 0.0042 0.0019 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1973 0.3225
Brugia malayi Furin-like cysteine rich region family protein 0.0737 0.0809 0.0809
Echinococcus multilocularis 0.0101 0.0086 0.0105
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0036 0.0012 0.015
Brugia malayi Cam kinase protein 1 0.0031 0.0006 0.0006
Echinococcus multilocularis adam 0.0056 0.0035 0.0042
Loa Loa (eye worm) TK/ALK protein kinase 0.0099 0.0084 0.0084
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0042 0.0019 0.0022
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1761 0.1973 0.3225
Onchocerca volvulus 0.0099 0.0084 0.1332
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0012 0.0011
Onchocerca volvulus 0.0053 0.0031 0.0425
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0031 0.0007 0.0005
Brugia malayi NAD-dependent deacetylase SIRT1 0.0101 0.0086 0.0086
Brugia malayi hypothetical protein 0.0036 0.0012 0.0012
Schistosoma mansoni chromatin regulatory protein sir2 0.0686 0.0751 0.0749
Loa Loa (eye worm) transcriptional regulator 0.0101 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0135 0.0125 0.0125
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Brugia malayi hypothetical protein 0.0039 0.0016 0.0016
Brugia malayi hypothetical protein 0.0101 0.0086 0.0086
Plasmodium vivax aspartyl protease, putative 0.0036 0.0012 0.0144
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0006 0.0006
Toxoplasma gondii subtilisin SUB11 0.0389 0.0414 1
Echinococcus multilocularis 0.7062 0.7998 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0019 0.0021
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0089 0.0072 0.0592
Loa Loa (eye worm) hypothetical protein 0.8823 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0287 0.0297 0.0297
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.0041
Loa Loa (eye worm) hypothetical protein 0.0101 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0039 0.0016 0.0016
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0135 0.0125 0.0125
Echinococcus multilocularis MAM 0.0099 0.0084 0.0102
Schistosoma mansoni discoidin domain receptor 0.0053 0.0031 0.003
Echinococcus granulosus nuclear receptor nhr 48 0.0135 0.0125 0.0123
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.004 0.0017 0.0017
Giardia lamblia Transcriptional regulator, Sir2 family 0.0101 0.0086 0.0185
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0686 0.0751 0.1221
Entamoeba histolytica hypothetical protein, conserved 0.0101 0.0086 0.1078
Toxoplasma gondii F5/8 type C domain-containing protein 0.0053 0.0031 0.0618
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0389 0.0414 1
Brugia malayi nuclear receptor NHR-67 0.0135 0.0125 0.0125
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0686 0.0751 1
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0089 0.0072 0.089
Plasmodium vivax subtilisin-like serine protease, putative 0.0389 0.0414 0.9603
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2151 0.2416 0.2415
Brugia malayi hypothetical protein 0.0151 0.0144 0.0144
Entamoeba histolytica protein kinase, putative 0.004 0.0017 0.015
Loa Loa (eye worm) aspartyl protease 6 0.0036 0.0012 0.0012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2151 0.2416 0.3951
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0287 0.0297 0.0296
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0287 0.0297 0.0296
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0135 0.0125 0.2054
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0158 0.0151 0.0237
Brugia malayi Nuclear hormone receptor-like 1 0.0151 0.0144 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1973 0.3225
Echinococcus granulosus epidermal growth factor receptor 0.0737 0.0809 0.0807
Schistosoma mansoni chromatin regulatory protein sir2 0.0686 0.0751 0.0749
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0037 0.0014 0.0014
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0151 0.0144 0.0142
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.8823 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0287 0.0297 0.0297
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1973 0.3225
Loa Loa (eye worm) hypothetical protein 0.0054 0.0032 0.0032
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0053 0.0031 0.0037
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0043 0.002 0.0018
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0089 0.0072 0.089
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0042 0.0019 0.0017
Brugia malayi transcriptional regulator, Sir2 family protein 0.0101 0.0086 0.0086
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Plasmodium falciparum cysteine repeat modular protein 1 0.0051 0.003 0.0555
Schistosoma mansoni c4b-binding protein beta chain 0.0039 0.0016 0.0014
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0101 0.0086 0.0084
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0389 0.0414 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0287 0.0297 0.0296
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0101 0.0086 0.0132
Schistosoma mansoni zinc finger protein 0.0135 0.0125 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.0414 0.0668
Echinococcus multilocularis thyroid hormone receptor alpha 0.0287 0.0297 0.037
Schistosoma mansoni hypothetical protein 0.0031 0.0007 0.0005
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0079 0.0061 0.0059
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0101 0.0086 0.144
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0089 0.0072 0.0088
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0089 0.0072 0.0592
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0087 0.0085
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0089 0.0072 0.0072
Brugia malayi hypothetical protein 0.0135 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0039 0.0016 0.0016
Echinococcus multilocularis discoidin domain containing receptor 2 0.0053 0.0031 0.0037
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0389 0.0414 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0031 0.0031
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0005 0.0004
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.5397 0.6105 0.7633
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0101 0.0086 0.1879
Schistosoma mansoni nuclear receptor 0.0135 0.0125 0.0123
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0686 0.0751 1
Loa Loa (eye worm) subtilase 0.0389 0.0414 0.0414
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0287 0.0297 0.0296
Loa Loa (eye worm) reprolysin 0.0043 0.002 0.002
Brugia malayi Calcium binding EGF domain containing protein 0.0046 0.0024 0.0024
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0101 0.0086 0.1078
Loa Loa (eye worm) hypothetical protein 0.0036 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0135 0.0125 0.0125
Echinococcus granulosus neuroendocrine convertase 2 0.5577 0.631 0.631
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0044 0.0022 0.002
Loa Loa (eye worm) nuclear hormone receptor 0.0135 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0151 0.0144 0.0144
Brugia malayi nuclear receptor NHR-88 0.0287 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0039 0.0016 0.0016
Brugia malayi Sushi domain 0.0039 0.0016 0.0016
Brugia malayi astacin protease protein 30 0.0031 0.0007 0.0007
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0051 0.003 0.0555
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0686 0.0751 1
Echinococcus multilocularis discoidin domain receptor 0.0053 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0143 0.0134 0.0134
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0039 0.0016 0.0016
Loa Loa (eye worm) DEAH box polypeptide 35 0.0034 0.001 0.001
Echinococcus granulosus neuropilin nrp and tolloid tll 0.0031 0.0007 0.0005
Echinococcus granulosus ecdysone induced protein 78C 0.0287 0.0297 0.0296
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0287 0.0297 0.037
Brugia malayi Protein kinase domain containing protein 0.0099 0.0084 0.0084
Echinococcus granulosus tissue type plasminogen activator 0.0051 0.003 0.0028
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Loa Loa (eye worm) hypothetical protein 0.0031 0.0007 0.0007
Brugia malayi Nematode astacin protease protein 30 0.0031 0.0007 0.0007
Echinococcus granulosus discoidin domain containing receptor 2 0.0053 0.0031 0.003
Brugia malayi Lectin C-type domain containing protein 0.0031 0.0007 0.0007
Trichomonas vaginalis AGC family protein kinase 0.0042 0.002 0.0022
Echinococcus multilocularis cubilin 0.0031 0.0007 0.0007
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0287 0.0297 0.0296
Brugia malayi transcriptional regulator, Sir2 family protein 0.0686 0.0751 0.0751
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0101 0.0086 0.0132
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0686 0.0751 0.0749
Schistosoma mansoni chromatin regulatory protein sir2 0.0686 0.0751 0.0749
Echinococcus granulosus cubilin 0.0031 0.0007 0.0005
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0287 0.0297 0.5044
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Echinococcus multilocularis CUB 0.0031 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0039 0.0016 0.0016
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0006 0.0006
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0389 0.0414 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0135 0.0125 0.0123
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0053 0.0031 0.0041
Trypanosoma brucei subtilisin peptidase 0.0389 0.0414 0.5474
Onchocerca volvulus 0.0037 0.0014 0.012
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0686 0.0751 0.0937
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Echinococcus granulosus serine:threonine protein kinase N2 0.0074 0.0056 0.0054
Entamoeba histolytica hypothetical protein 0.0247 0.0252 0.3298
Entamoeba histolytica protein kinase, putative 0.0032 0.0008 0.002
Toxoplasma gondii rhoptry neck protein RON1 0.0039 0.0016 0.0233
Echinococcus multilocularis FTZ F1 alpha 0.0287 0.0297 0.037
Loa Loa (eye worm) nuclear receptor NHR-67 0.0135 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0247 0.0252 0.0252
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0248 0.0253 0.0251
Brugia malayi Reprolysin 0.0025 0.0000036068 0.0000036068
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Echinococcus granulosus adam 0.0056 0.0035 0.0034
Echinococcus multilocularis Furin 1 0.2151 0.2416 0.3019
Loa Loa (eye worm) hypothetical protein 0.0287 0.0297 0.0297
Echinococcus granulosus lysine specific histone demethylase 1A 0.0101 0.0086 0.0084
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0287 0.0297 0.0296
Loa Loa (eye worm) hypothetical protein 0.0099 0.0084 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.0041
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0044 0.0022 0.0022
Echinococcus granulosus FTZ F1 alpha 0.0287 0.0297 0.0296
Brugia malayi Nematode astacin protease protein 30 0.0031 0.0007 0.0007
Schistosoma mansoni chromatin regulatory protein sir2 0.0101 0.0086 0.0085
Brugia malayi hypothetical protein 0.0039 0.0016 0.0016
Entamoeba histolytica PH domain containing protein kinase, putative 0.0076 0.0058 0.0701
Schistosoma mansoni discoidin domain receptor 0.0053 0.0031 0.003
Toxoplasma gondii F5/8 type C domain-containing protein 0.0053 0.0031 0.0618
Brugia malayi Sex muscle abnormal protein 5 0.0268 0.0276 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0287 0.0297 0.0297
Schistosoma mansoni steroid hormone receptor ad4bp 0.0287 0.0297 0.0296
Onchocerca volvulus 0.0039 0.0016 0.0151
Brugia malayi hypothetical protein 0.0036 0.0012 0.0012
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0135 0.0125 0.0123
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0089 0.0072 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.0041
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2151 0.2416 0.3951
Echinococcus multilocularis protein kinase c epsilon type 0.0101 0.0087 0.0106
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0101 0.0087 0.0087
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0101 0.0086 0.1891
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0287 0.0297 0.0297
Toxoplasma gondii PA14 domain-containing protein 0.0053 0.0031 0.0618
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0287 0.0297 0.0297
Schistosoma mansoni protein arginine n-methyltransferase 0.0089 0.0072 0.0071
Onchocerca volvulus Putative cubilin 0.0046 0.0024 0.0291
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0012 0.0011
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0101 0.0086 0.1891
Loa Loa (eye worm) hypothetical protein 0.0031 0.0007 0.0007
Plasmodium vivax NAD-dependent deacetylase, putative 0.0101 0.0086 0.1891
Schistosoma mansoni cathepsin D (A01 family) 0.0036 0.0012 0.0011
Plasmodium falciparum subtilisin-like protease 1 0.0389 0.0414 0.9603
Toxoplasma gondii subtilisin SUB7 0.0389 0.0414 1
Onchocerca volvulus 0.0207 0.0206 0.3466
Schistosoma mansoni dock 0.0053 0.0031 0.003
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0248 0.0253 0.0314
Schistosoma mansoni hypothetical protein 0.0207 0.0206 0.0205
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0012 0.0011
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0053 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0006
Brugia malayi hypothetical protein 0.0039 0.0016 0.0016
Schistosoma mansoni retinoic acid receptor RXR 0.0287 0.0297 0.0296
Loa Loa (eye worm) TK/EGFR protein kinase 0.0737 0.0809 0.0809
Echinococcus multilocularis C type lectin domian containing protein 0.0039 0.0016 0.0017
Onchocerca volvulus 0.0287 0.0297 0.5044
Schistosoma mansoni thyroid hormone receptor 0.0287 0.0297 0.0296
Toxoplasma gondii subtilisin SUB4 0.0389 0.0414 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0051 0.0029 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0287 0.0297 0.0297
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0389 0.0414 0.0412
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0101 0.0086 0.1957
Plasmodium vivax aspartyl protease, putative 0.0036 0.0012 0.0144
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0005 0.0003
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0101 0.0086 0.1879
Loa Loa (eye worm) hypothetical protein 0.0287 0.0297 0.0297
Onchocerca volvulus 0.0039 0.0016 0.0151
Entamoeba histolytica protein kinase, putative 0.0042 0.002 0.018
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1973 0.3225
Loa Loa (eye worm) hypothetical protein 0.0046 0.0024 0.0024
Toxoplasma gondii subtilisin SUB1 0.0389 0.0414 1
Plasmodium falciparum plasmepsin X 0.0036 0.0012 0.0144
Loa Loa (eye worm) hypothetical protein 0.0135 0.0125 0.0125
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0089 0.0072 0.0592
Echinococcus granulosus protein arginine N methyltransferase 8 0.0158 0.0151 0.0149
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0036 0.0012 0.015
Loa Loa (eye worm) hypothetical protein 0.0389 0.0414 0.0414
Loa Loa (eye worm) DR-78 0.0135 0.0125 0.0125
Toxoplasma gondii F5/8 type C domain-containing protein 0.0053 0.0031 0.0618
Onchocerca volvulus 0.0039 0.0016 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.0041
Plasmodium vivax LCCL domain-containing protein 0.0053 0.0031 0.0594
Loa Loa (eye worm) hypothetical protein 0.0135 0.0125 0.0125
Plasmodium vivax aspartyl proteinase, putative 0.0036 0.0012 0.0144
Plasmodium vivax plasmepsin IV, putative 0.0036 0.0012 0.0144
Echinococcus granulosus Nuclear hormone receptor HR96 0.0135 0.0125 0.0123
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0287 0.0297 0.0296
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0389 0.0414 0.0412
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0151 0.0144 0.0144
Schistosoma mansoni nuclear receptor 0.0135 0.0125 0.0123
Plasmodium falciparum protoporphyrinogen oxidase 0.0101 0.0086 0.1879
Brugia malayi Nuclear hormone receptor-like 1 0.0287 0.0297 0.0297
Schistosoma mansoni protein kinase 0.0248 0.0253 0.0251
Brugia malayi hypothetical protein 0.0039 0.0016 0.0016
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0135 0.0125 0.0154
Plasmodium falciparum plasmepsin IV 0.0036 0.0012 0.0144
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0101 0.0086 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1973 0.3225
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0031 0.0007 0.0007
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0056 0.0035 0.0034
Loa Loa (eye worm) hypothetical protein 0.0287 0.0297 0.0297
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0287 0.0297 0.0297
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0287 0.0297 0.037
Toxoplasma gondii AGC kinase 0.004 0.0017 0.0273
Onchocerca volvulus 0.0039 0.0016 0.0151
Loa Loa (eye worm) hypothetical protein 0.0135 0.0125 0.0125
Brugia malayi nuclear hormone receptor 0.0135 0.0125 0.0125
Trypanosoma brucei rac serine-threonine kinase, putative 0.0042 0.002 0.018
Onchocerca volvulus Bile acid receptor homolog 0.0287 0.0297 0.5044
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0158 0.0151 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.0414 0.0668
Schistosoma mansoni chromatin regulatory protein sir2 0.0101 0.0086 0.0085
Loa Loa (eye worm) hypothetical protein 0.0287 0.0297 0.0297
Brugia malayi Subtilase family protein 0.0389 0.0414 0.0414
Leishmania major sir2-family protein-like protein 0.0101 0.0086 0.1078
Plasmodium falciparum plasmepsin VIII, putative 0.0036 0.0012 0.0144
Toxoplasma gondii subtilisin SUB12 0.0389 0.0414 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0006 0.0004
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0101 0.0086 0.0085
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0028 0.0003 0.0002
Schistosoma mansoni nuclear receptor nhr-48 0.0135 0.0125 0.0123
Plasmodium vivax apical sushi protein, putative 0.0039 0.0016 0.0224
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0287 0.0297 0.0296
Brugia malayi hypothetical protein 0.0039 0.0016 0.0016
Echinococcus multilocularis serine:threonine protein kinase N2 0.0094 0.0078 0.0095
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0043 0.002 0.0023
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0389 0.0414 1
Brugia malayi nuclear receptor RXR 0.0151 0.0144 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1973 0.3225
Echinococcus granulosus CUB 0.0031 0.0007 0.0005
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0101 0.0086 0.0786
Toxoplasma gondii aspartyl protease ASP1 0.0036 0.0012 0.015
Brugia malayi nuclear hormone receptor family member odr-7 0.0135 0.0125 0.0125
Trypanosoma cruzi UDP-galactopyranose mutase 0.0101 0.0086 0.0779
Echinococcus granulosus protein kinase c epsilon type 0.0101 0.0087 0.0085
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0031 0.0007 0.0005
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0036 0.0012 0.0012
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0012 0.0011
Mycobacterium ulcerans Sir2-like regulatory protein 0.0101 0.0086 0.0016
Loa Loa (eye worm) hypothetical protein 0.0031 0.0007 0.0007
Plasmodium vivax aspartyl protease, putative 0.0036 0.0012 0.0144
Brugia malayi transcriptional regulator, Sir2 family protein 0.0101 0.0086 0.0086
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Loa Loa (eye worm) CUB domain-containing protein 0.0031 0.0007 0.0007
Mycobacterium tuberculosis Possible oxidoreductase 0.0101 0.0086 0.1426
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0101 0.0086 0.0786
Onchocerca volvulus 0.0135 0.0125 0.2054
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.0041
Loa Loa (eye worm) hypothetical protein 0.0135 0.0125 0.0125
Echinococcus multilocularis growth factor receptor bound protein 2 0.0268 0.0276 0.0343
Loa Loa (eye worm) hypothetical protein 0.0136 0.0126 0.0126
Brugia malayi hypothetical protein 0.0247 0.0252 0.0252
Loa Loa (eye worm) AGC/AKT protein kinase 0.0042 0.002 0.002
Brugia malayi tailless protein 0.0135 0.0125 0.0125
Echinococcus granulosus methyltransferase protein 5 0.0089 0.0072 0.0071
Schistosoma mansoni tyrosine kinase 0.0737 0.0809 0.0807
Loa Loa (eye worm) hypothetical protein 0.0036 0.0012 0.0012
Echinococcus granulosus lysine specific histone demethylase 1A 0.0496 0.0535 0.0533
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0031 0.0007 0.0007
Echinococcus multilocularis protein arginine methyltransferase 0.0158 0.0151 0.0186
Brugia malayi GCC2 and GCC3 family protein 0.0054 0.0032 0.0032
Plasmodium falciparum plasmepsin II 0.0036 0.0012 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.0414 0.0668
Toxoplasma gondii histone deacetylase SIR2 0.0101 0.0086 0.1969
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1973 0.3225
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0686 0.0751 0.1221
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Brugia malayi SWIRM domain containing protein 0.0042 0.0019 0.0019
Trichomonas vaginalis hypothetical protein 0.1761 0.1973 0.3225
Loa Loa (eye worm) steroid hormone receptor 0.0287 0.0297 0.0297
Plasmodium falciparum subtilisin-like protease 2 0.0389 0.0414 0.9603
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0158 0.0151 0.0237
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0101 0.0086 0.1426
Brugia malayi Steroid receptor seven-up type 2 0.0287 0.0297 0.0297
Brugia malayi hypothetical protein 0.0135 0.0125 0.0125
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0247 0.0252 0.3298
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0287 0.0297 0.0297
Brugia malayi hypothetical protein 0.0099 0.0084 0.0084
Brugia malayi Protein arginine N-methyltransferase 0.0089 0.0072 0.0072
Brugia malayi photoreceptor-specific nuclear receptor 0.0287 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0039 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0099 0.0084 0.0082
Brugia malayi nuclear receptor RXR 0.0135 0.0125 0.0125
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0089 0.0072 0.0109
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0247 0.0252 0.3079
Plasmodium vivax hypothetical protein, conserved 0.0101 0.0086 0.1879
Brugia malayi hypothetical protein 0.0056 0.0035 0.0035
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0053 0.0031 0.0041
Plasmodium vivax hypothetical protein, conserved 0.0101 0.0086 0.1879
Loa Loa (eye worm) hypothetical protein 0.0031 0.0007 0.0007
Trichomonas vaginalis AGC family protein kinase 0.0042 0.002 0.0022
Brugia malayi ecdysone receptor 0.0135 0.0125 0.0125
Echinococcus multilocularis cubilin 0.0031 0.0007 0.0007
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0158 0.0151 0.3406
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0247 0.0252 0.3079
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2151 0.2416 0.3951
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0686 0.0751 1
Loa Loa (eye worm) Carm1-pending protein 0.0089 0.0072 0.0072
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Trichomonas vaginalis AGC family protein kinase 0.0042 0.002 0.0022
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0089 0.0072 0.0109
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0012 0.0011
Brugia malayi CUB domain containing protein 0.0031 0.0007 0.0007
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.042 0.0449 0.5818
Onchocerca volvulus 0.0218 0.0219 0.3691
Brugia malayi Protein kinase domain containing protein 0.0053 0.0031 0.0031
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0101 0.0086 0.0132
Leishmania major silent information regulator 2, putative 0.0686 0.0751 1
Schistosoma mansoni memapsin-2 (A01 family) 0.0036 0.0012 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0287 0.0297 0.0297
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0158 0.0151 0.0237
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0036 0.0012 0.0013
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0158 0.0151 0.0149
Loa Loa (eye worm) hypothetical protein 0.0031 0.0007 0.0007
Plasmodium falciparum apical sushi protein 0.0039 0.0016 0.0224
Echinococcus granulosus membrane bound transcription factor site 1 0.0389 0.0414 0.0412
Schistosoma mansoni hypothetical protein 0.0089 0.0072 0.0071
Echinococcus granulosus protein arginine N methyltransferase 7 0.0089 0.0072 0.0071
Brugia malayi Angiotensin-converting enzyme family protein 0.13 0.1449 0.1449
Brugia malayi Nuclear hormone receptor E75 0.0135 0.0125 0.0125
Echinococcus multilocularis membrane bound transcription factor site 1 0.0389 0.0414 0.0515
Brugia malayi Kringle domain containing protein 0.0051 0.003 0.003
Echinococcus granulosus protein arginine methyltransferase 0.0158 0.0151 0.0149
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0414 0.0668
Echinococcus granulosus chromatin regulatory protein sir2 0.0686 0.0751 0.0749
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0089 0.0072 0.1626
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0012 0.0011
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0101 0.0086 0.1879
Entamoeba histolytica hypothetical protein 0.0042 0.0019 0.0174
Brugia malayi Carm1-pending protein 0.0089 0.0072 0.0072
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0389 0.0414 0.5326
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0012 0.0011
Brugia malayi hypothetical protein 0.0151 0.0144 0.0144
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0006 0.0004
Schistosoma mansoni hypothetical protein 0.0051 0.003 0.0028
Schistosoma mansoni amine oxidase 0.0101 0.0086 0.0084
Loa Loa (eye worm) hypothetical protein 0.0099 0.0084 0.0084
Brugia malayi orphan nuclear receptor NR2E1 0.0135 0.0125 0.0125
Brugia malayi nuclear hormone receptor family member nhr-6 0.0135 0.0125 0.0125
Onchocerca volvulus 0.0389 0.0414 0.7071
Brugia malayi neuroendocrine convertase 1 precursor 0.5577 0.631 0.631
Echinococcus multilocularis c4b binding protein beta chain 0.0039 0.0016 0.0017
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0031 0.0007 0.0007
Trichomonas vaginalis AGC family protein kinase 0.0042 0.002 0.0022
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0006 0.0004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0287 0.0297 0.0297
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0101 0.0086 0.0106
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0101 0.0086 0.1078
Brugia malayi nuclear receptor NHR-88 0.0135 0.0125 0.0125
Onchocerca volvulus 0.0099 0.0084 0.1332
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.0041
Schistosoma mansoni nuclear hormone receptor 0.0287 0.0297 0.0296
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0389 0.0414 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.0125 0.0125
Echinococcus multilocularis protein will die slowly 0.0207 0.0206 0.0256
Plasmodium falciparum plasmepsin III 0.0036 0.0012 0.0144
Trypanosoma cruzi UDP-galactopyranose mutase 0.0101 0.0086 0.0779
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0135 0.0125 0.2054
Loa Loa (eye worm) hypothetical protein 0.0135 0.0125 0.0125
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1761 0.1973 0.3225
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0135 0.0125 0.0154
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0043 0.002 0.0018
Brugia malayi hypothetical protein 0.0039 0.0016 0.0016
Brugia malayi Kelch motif family protein 0.0031 0.0007 0.0007
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.023 0.0233 0.0232
Brugia malayi Eukaryotic aspartyl protease family protein 0.0036 0.0012 0.0012
Loa Loa (eye worm) proprotein convertase 2 0.2151 0.2416 0.2416
Onchocerca volvulus 0.0039 0.0016 0.0151
Trichomonas vaginalis AGC family protein kinase 0.0042 0.002 0.0022
Schistosoma mansoni hypothetical protein 0.0053 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0287 0.0297 0.0297
Toxoplasma gondii rhoptry neck protein RON9 0.0039 0.0016 0.0233
Plasmodium falciparum subtilisin-like protease 3 0.0389 0.0414 0.9603
Brugia malayi steroid hormone receptor 0.0287 0.0297 0.0297
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0089 0.0072 0.089
Loa Loa (eye worm) hypothetical protein 0.0039 0.0016 0.0016
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0389 0.0414 0.0414

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.001 ug ml-1 Minimal inhibitory effect against the C. albicans (2005E). ChEMBL. 12067540
MIC (functional) < 0.001 ug ml-1 Minimal inhibitory effect against the C. pseudo (2371E). ChEMBL. 12067540
MIC (functional) = 0.001 ug ml-1 Minimal inhibitory effect against the C. albicans (2005E). ChEMBL. 12067540
MIC (functional) = 0.004 ug ml-1 Minimal inhibitory effect against the C. albicans (4711E). ChEMBL. 12067540
MIC (functional) = 0.004 ug ml-1 Minimal inhibitory effect against the C. albicans (4711E). ChEMBL. 12067540
MIC (functional) = 0.03 ug ml-1 Minimal inhibitory effect against the C. tropicalis (2808E). ChEMBL. 12067540
MIC (functional) = 0.5 ug ml-1 Minimal inhibitory effect against the C. neoformans (2867E). ChEMBL. 12067540
MIC (functional) = 0.5 ug ml-1 Minimal inhibitory effect against the C. neoformans (2867E). ChEMBL. 12067540
MIC (functional) = 16 ug ml-1 Minimal inhibitory effect against the C. glabrata (2375E). ChEMBL. 12067540
MIC (functional) > 125 ug ml-1 Minimal inhibitory effect against the C. parapsilosis (2372E). ChEMBL. 12067540
MIC (functional) > 125 ug ml-1 Minimal inhibitory effect against the A. flavus (C1150). ChEMBL. 12067540

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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