TDR Targets

Basic information

Technical information

TDR Targets ID: 688534
Name: 1-[4-(4-fluoro-3-methylphenyl)sulfonyl-1-oxa- 4,8-diazaspiro[4.5]decan-8-yl]ethanone
MW: 356.412 | Formula: C16H21FN2O4S
H donors: 0 H acceptors: 3 LogP: 1.13 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)N1CCC2(CC1)OCCN2S(=O)(=O)c1ccc(c(c1)C)F
InChi: 1S/C16H21FN2O4S/c1-12-11-14(3-4-15(12)17)24(21,22)19-9-10-23-16(19)5-7-18(8-6-16)13(2)20/h3-4,11H,5-10H2,1-2H3
InChiKey: VPQDHBUSBRSHCM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[4-(4-fluoro-3-methyl-phenyl)sulfonyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl]ethanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	T-complex protein 1 subunit beta, putative	0.0023	0.0358	0.1757
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0594	0.4029
Entamoeba histolytica	hypothetical protein	0.0035	0.0715	0.727
Echinococcus multilocularis	chaperonin containing TCP1, subunit 2 (beta)	0.0023	0.0358	0.0358
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0103	0.2838	0.2838
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0836	0.0918
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0836	0.0516
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.0836	0.0918
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0594	0.4029
Onchocerca volvulus	Huntingtin homolog	0.0237	0.7061	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0715	0.0715
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0411	0.2264
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0037	0.0776	0.8811
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0023	0.0338	0.0334
Schistosoma mansoni	ran	0.0023	0.0338	0.0338
Schistosoma mansoni	ap endonuclease	0.0039	0.0857	0.0857
Loa Loa (eye worm)	hypothetical protein	0.0254	0.7594	0.751
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0018	0.0175	0.5
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0836	0.0836
Plasmodium vivax	glutathione reductase, putative	0.0051	0.1216	1
Leishmania major	GTP-binding protein, putative	0.0023	0.0338	0.1565
Entamoeba histolytica	T-complex protein 1 beta subunit, putative	0.0023	0.0358	0.0385
Plasmodium vivax	thioredoxin reductase, putative	0.0051	0.1216	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0116	0.3259	0.4282
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0033	0.0655	0.0667
Trichomonas vaginalis	ran, putative	0.0023	0.0338	0.2389
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0116	0.3259	0.4282
Brugia malayi	T-complex protein 1, beta subunit	0.0023	0.0358	0.0425
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0023	0.0335	0.0335
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.0857	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0021	0.0272	0.1424
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0594	0.0266
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.0836	0.0918
Brugia malayi	hypothetical protein	0.0237	0.7061	0.9075
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0116	0.3259	0.8652
Loa Loa (eye worm)	thioredoxin reductase	0.0051	0.1216	0.0909
Brugia malayi	beta-lactamase family protein	0.0039	0.0836	0.1043
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0836	0.0918
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0272	0.1424
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0028	0.0509	0.0509
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0464	0.2782
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0836	0.9692
Entamoeba histolytica	hypothetical protein	0.0035	0.0715	0.727
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0039	0.0857	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0028	0.0498	0.0606
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0331	1	1
Brugia malayi	beta-lactamase	0.0039	0.0836	0.1043
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0411	0.2264
Schistosoma mansoni	cpg binding protein	0.0097	0.2653	0.2653
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0464	0.2782
Plasmodium falciparum	importin beta, putative	0.0031	0.0594	0.4029
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0464	0.2782
Schistosoma mansoni	importin beta-1	0.0031	0.0594	0.0594
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0194	0.5704	0.5704
Loa Loa (eye worm)	glutathione reductase	0.0051	0.1216	0.0909
Toxoplasma gondii	exonuclease III APE	0.0039	0.0857	0.1399
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0836	0.0836
Brugia malayi	Thioredoxin reductase	0.0051	0.1216	0.1533
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0039	0.0857	0.0857
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0103	0.2838	0.2838
Brugia malayi	Inositol-1	0.0037	0.0776	0.0965
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0836	0.9692
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.0857	0.6551
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0039	0.0857	0.0857
Onchocerca volvulus		0.0091	0.2489	0.2656
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0836	0.0602
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0103	0.2838	0.2838
Loa Loa (eye worm)	hypothetical protein	0.0237	0.7061	0.6958
Echinococcus multilocularis	importin subunit beta 1	0.0031	0.0594	0.0594
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0023	0.0338	0.1565
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0129	0.3664	0.4845
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0103	0.2838	0.2838
Brugia malayi	follicle stimulating hormone receptor	0.026	0.7778	1
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0023	0.0338	0.04
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0272	0.1424
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0836	0.0918
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0023	0.0338	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0836	0.0516
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0023	0.0335	0.0335
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0037	0.0776	0.1232
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0272	0.1424
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0776	0.5772
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0776	0.8811
Trypanosoma brucei	trypanothione reductase	0.0051	0.1216	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0023	0.0335	0.0335
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0836	0.0516
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0051	0.1216	0.1446
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.0836	0.0918
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0272	0.1424
Toxoplasma gondii	t-complex protein beta subunit	0.0023	0.0358	0.0375
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0776	0.5772
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0039	0.0857	0.6551
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0028	0.0509	0.0509
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0039	0.0857	0.6551
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0464	0.0594
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0103	0.2838	0.2588
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0039	0.0857	1
Schistosoma mansoni	ran	0.0023	0.0338	0.0338
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0836	0.9692
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0464	0.2782
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0272	0.1424
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.0836	0.0918
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0411	0.3456
Mycobacterium tuberculosis	Probable reductase	0.0116	0.3259	0.4282
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0013	0.0033	0.0033
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0039	0.0857	1
Echinococcus multilocularis	snurportin 1	0.0331	1	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0338	0.1565
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0836	0.0602
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0272	0.1424
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0129	0.3664	1
Trichomonas vaginalis	helicase, putative	0.0021	0.0272	0.1424
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0272	0.1424
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0103	0.2838	0.2838
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0411	0.3456
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0272	0.1424
Schistosoma mansoni	hypothetical protein	0.0052	0.1248	0.1248
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.0836	0.0918
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.0776	0.8437
Mycobacterium ulcerans	lipase LipD	0.0039	0.0836	0.9692
Loa Loa (eye worm)	inositol-1	0.0037	0.0776	0.0454
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0018	0.0175	0.0189
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0039	0.0857	0.0947
Trichomonas vaginalis	chaperonin, putative	0.0023	0.0358	0.2682
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0272	0.1424
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.0836	0.0918
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0836	0.9692
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0272	0.1424
Echinococcus granulosus	cpg binding protein	0.0097	0.2653	0.2653
Leishmania major	hypothetical protein, conserved	0.0027	0.0464	0.2782
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0103	0.2838	0.2838
Toxoplasma gondii	ABC1 family protein	0.0039	0.0836	0.1355
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0715	0.0715
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0023	0.0338	0.1565
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0129	0.3664	0.4845
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0272	0.1424
Plasmodium falciparum	T-complex protein 1 subunit beta	0.0023	0.0358	0.1757
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0173	0.5054	1
Echinococcus granulosus	importin subunit beta 1	0.0031	0.0594	0.0594
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0836	0.9692
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0836	0.0516
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0836	0.9692
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.0776	0.0776
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.1248	0.1575
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0272	0.1424
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0023	0.0335	0.0335
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0037	0.0776	0.8811
Entamoeba histolytica	hypothetical protein	0.0025	0.0411	0.1402
Onchocerca volvulus	Huntingtin homolog	0.0237	0.7061	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0836	0.6349
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0464	0.2782
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.0776	0.0776
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0023	0.0358	0.0358
Schistosoma mansoni	hypothetical protein	0.0331	1	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0051	0.1216	1
Brugia malayi	T-complex protein 1, beta subunit	0.0023	0.0358	0.0425
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0776	0.5772
Schistosoma mansoni	survival motor neuron protein	0.0052	0.1248	0.1248
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0039	0.0857	1
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0023	0.0338	0.0338
Toxoplasma gondii	HEAT repeat-containing protein	0.0031	0.0594	0.086
Toxoplasma gondii	thioredoxin reductase	0.0051	0.1216	0.2135
Brugia malayi	hypothetical protein	0.0254	0.7594	0.9763
Mycobacterium tuberculosis	Probable oxidoreductase	0.0129	0.3664	0.4845
Plasmodium falciparum	thioredoxin reductase	0.0051	0.1216	1
Echinococcus multilocularis	cpg binding protein	0.0097	0.2653	0.2653
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0023	0.0358	0.0358
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0836	0.0836
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0411	0.3456
Echinococcus multilocularis	survival motor neuron protein 1	0.0254	0.7594	0.7594
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0836	0.9692
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0836	0.0516
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0836	0.1043
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0116	0.3259	0.4282
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.0857	0.6551
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0018	0.0175	0.0175
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0776	0.8811
Loa Loa (eye worm)	hypothetical protein	0.0237	0.7061	0.6958
Leishmania major	T-complex protein 1, beta subunit, putative	0.0023	0.0358	0.1757
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0715	0.0715
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0051	0.1216	0.1216
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0021	0.0272	0.1424
Echinococcus granulosus	chaperonin containing TCP1 subunit 2 beta	0.0023	0.0358	0.0358
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0715	0.0715
Brugia malayi	beta-lactamase family protein	0.0039	0.0836	0.1043
Brugia malayi	RNA, U transporter 1	0.0088	0.2387	0.3043
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0023	0.0338	0.2389
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0023	0.0338	0.1565
Plasmodium vivax	importin-beta 2, putative	0.0031	0.0594	0.4029
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0272	0.1424
Mycobacterium tuberculosis	Probable dehydrogenase	0.0116	0.3259	0.4282
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0116	0.3259	0.4282
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0464	0.2782
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0023	0.0335	0.0335
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0776	0.5772
Echinococcus granulosus	survival motor neuron protein 1	0.0254	0.7594	0.7594
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0836	0.6349
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0103	0.2838	0.2838
Brugia malayi	exodeoxyribonuclease III family protein	0.0039	0.0857	0.107
Entamoeba histolytica	hypothetical protein	0.0035	0.0715	0.727
Brugia malayi	hypothetical protein	0.0035	0.0715	0.0887
Trypanosoma cruzi	T-complex protein 1, beta subunit, putative	0.0023	0.0358	0.1757
Onchocerca volvulus		0.0052	0.1248	0.0662
Brugia malayi	CXXC zinc finger family protein	0.0091	0.2489	0.3176
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.026	0.7778	0.77
Trichomonas vaginalis	chaperonin-60kD, ch60, putative	0.0023	0.0358	0.2682
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0247	0.7377	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0836	0.0516
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0272	0.1424
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0039	0.0857	0.0538
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.0857	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.0836	0.0918
Schistosoma mansoni	ap endonuclease	0.0039	0.0857	0.0857
Schistosoma mansoni	cpg binding protein	0.0091	0.2489	0.2489
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0023	0.0358	0.0358
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0018	0.0175	0.0175
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0039	0.0857	0.6551
Echinococcus granulosus	thioredoxin glutathione reductase	0.0051	0.1216	0.1216
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0272	0.1424
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0091	0.2489	0.2227
Entamoeba histolytica	hypothetical protein	0.0035	0.0715	0.727
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0039	0.0857	0.6551
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0836	0.0516
Brugia malayi	glutathione reductase	0.0051	0.1216	0.1533
Trypanosoma brucei	T-complex protein 1, beta subunit, putative	0.0023	0.0358	0.1757
Brugia malayi	hypothetical protein	0.0027	0.0464	0.0563
Leishmania major	trypanothione reductase	0.0051	0.1216	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0836	0.9692
Schistosoma mansoni	cpg binding protein	0.0097	0.2653	0.2653
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0776	0.0776
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0018	0.0175	0.0175
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0039	0.0857	1
Leishmania major	hypothetical protein, conserved	0.0039	0.0836	0.6349
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0338	0.1565
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0103	0.2838	0.3626
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0836	0.6349
Brugia malayi	Importin beta-1 subunit	0.0031	0.0594	0.0731
Brugia malayi	hypothetical protein	0.0017	0.0166	0.0178
Plasmodium falciparum	glutathione reductase	0.0051	0.1216	1
Loa Loa (eye worm)	histone methyltransferase	0.0028	0.0509	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0836	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0464	0.0131
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0836	0.9692
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0836	0.0836
Giardia lamblia	TCP-1 chaperonin subunit beta	0.0023	0.0358	0.2682
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0776	0.0776
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.0776	0.8811
Loa Loa (eye worm)	T-complex protein 1	0.0023	0.0358	0.0021
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0836	0.6349
Trichomonas vaginalis	esterase, putative	0.0039	0.0836	0.9692

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 688534