Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | beta-hydroxyacyl-acyl carrier protein dehydratase (FABZ) | 0.0219 | 0.3528 | 0.5327 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0372 | 0.6624 | 1 |
Trypanosoma cruzi | DNA topoisomerase type IB small subunit, putative | 0.0539 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0372 | 0.6624 | 1 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0092 | 0.0944 | 0.1425 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0372 | 0.6624 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0372 | 0.6624 | 1 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | (3R)-hydroxymyristoyl-ACP dehydratase | 0.0219 | 0.3528 | 0.5327 |
Plasmodium vivax | topoisomerase I, putative | 0.0092 | 0.0944 | 0.1425 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0092 | 0.0944 | 1 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0092 | 0.0944 | 1 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0092 | 0.0944 | 1 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0092 | 0.0944 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0372 | 0.6624 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0372 | 0.6624 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0372 | 0.6624 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0372 | 0.6624 | 1 |
Trypanosoma brucei | DNA topoisomerase type IB small subunit | 0.0539 | 1 | 1 |
Chlamydia trachomatis | 3-hydroxyacyl-ACP dehydratase | 0.0219 | 0.3528 | 0.5327 |
Plasmodium vivax | beta-hydroxyacyl-ACP dehydratase precursor, putative | 0.0219 | 0.3528 | 0.5327 |
Plasmodium falciparum | topoisomerase I | 0.0092 | 0.0944 | 0.1425 |
Plasmodium falciparum | beta-hydroxyacyl-ACP dehydratase | 0.0219 | 0.3528 | 0.5327 |
Trichomonas vaginalis | hypothetical protein | 0.0372 | 0.6624 | 0.5 |
Brugia malayi | DNA topoisomerase I | 0.0092 | 0.0944 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0045 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.