Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.01 | 0.1063 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0288 | 0.391 | 0.713 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0057 | 0.0146 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.01 | 0.1063 | 0.261 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0327 | 0.4497 | 0.3871 |
Echinococcus granulosus | tumor protein p63 | 0.0396 | 0.5535 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0364 | 0.5056 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0327 | 0.4497 | 0.3843 |
Mycobacterium ulcerans | hypothetical protein | 0.0364 | 0.5056 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.01 | 0.1063 | 0.2703 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0429 | 0.1096 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.01 | 0.1063 | 0.0045 |
Plasmodium vivax | glutathione reductase, putative | 0.0288 | 0.391 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.01 | 0.1063 | 0.0045 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0008 | 0.0021 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0057 | 0.0125 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0058 | 0.0429 | 0.1077 |
Toxoplasma gondii | thioredoxin reductase | 0.0288 | 0.391 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0057 | 0.0125 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0288 | 0.391 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0288 | 0.391 | 0.7059 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0057 | 0.0125 |
Treponema pallidum | NADH oxidase | 0.01 | 0.1063 | 0.5 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.01 | 0.1063 | 0.261 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0288 | 0.391 | 0.3217 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.01 | 0.1063 | 0.0045 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0691 | 1 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0038 | 0.0055 |
Leishmania major | trypanothione reductase | 0.0288 | 0.391 | 0.3186 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0118 | 0.1343 | 0.0358 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0057 | 0.0125 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.01 | 0.1063 | 0.5 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.01 | 0.1063 | 0.0045 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0057 | 0.0088 |
Echinococcus multilocularis | tumor protein p63 | 0.0396 | 0.5535 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.01 | 0.1063 | 0.0045 |
Onchocerca volvulus | 0.0058 | 0.0429 | 0.1186 | |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.01 | 0.1063 | 0.0045 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0691 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.01 | 0.1063 | 0.5 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.01 | 0.1063 | 0.1908 |
Trichomonas vaginalis | set domain proteins, putative | 0.0265 | 0.3553 | 1 |
Brugia malayi | glutathione reductase | 0.0288 | 0.391 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0008 | 0.0021 |
Loa Loa (eye worm) | glutathione reductase | 0.0288 | 0.391 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0288 | 0.391 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0057 | 0.0088 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.01 | 0.1063 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.01 | 0.1063 | 0.0045 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0073 | 0.0662 | 0.1675 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.01 | 0.1063 | 0.0045 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0691 | 1 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0232 | 0.3067 | 0.7845 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0327 | 0.4497 | 0.3871 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0057 | 0.0088 |
Trypanosoma brucei | trypanothione reductase | 0.0288 | 0.391 | 0.3217 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0057 | 0.0125 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.01 | 0.1063 | 0.0045 |
Plasmodium falciparum | glutathione reductase | 0.0288 | 0.391 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.01 | 0.1063 | 0.1908 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.01 | 0.1063 | 0.5 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.01 | 0.1063 | 0.0045 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.01 | 0.1063 | 0.2703 |
Brugia malayi | Pre-SET motif family protein | 0.0232 | 0.3067 | 0.7841 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.01 | 0.1063 | 0.261 |
Onchocerca volvulus | 0.0265 | 0.3553 | 1 | |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0073 | 0.0662 | 0.1675 |
Onchocerca volvulus | 0.0033 | 0.0057 | 0.0137 | |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0288 | 0.391 | 0.7059 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.01 | 0.1063 | 0.261 |
Brugia malayi | Thioredoxin reductase | 0.0288 | 0.391 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0111 | 0.1238 | 0.3065 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.01 | 0.1063 | 0.0045 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.01 | 0.1063 | 0.0045 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0008 | 0.0021 |
Plasmodium falciparum | thioredoxin reductase | 0.0288 | 0.391 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.01 | 0.1063 | 0.0045 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.