Detailed information for compound 688892

Basic information

Technical information
  • TDR Targets ID: 688892
  • Name: N-(4-acetylphenyl)-2-[(4-amino-5-cyclohexyl-1 ,2,4-triazol-3-yl)sulfanyl]acetamide
  • MW: 373.473 | Formula: C18H23N5O2S
  • H donors: 2 H acceptors: 4 LogP: 2.81 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)C(=O)C)CSc1nnc(n1N)C1CCCCC1
  • InChi: 1S/C18H23N5O2S/c1-12(24)13-7-9-15(10-8-13)20-16(25)11-26-18-22-21-17(23(18)19)14-5-3-2-4-6-14/h7-10,14H,2-6,11,19H2,1H3,(H,20,25)
  • InChiKey: BMWRNZZDVVMROH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-acetylphenyl)-2-[(4-amino-5-cyclohexyl-1,2,4-triazol-3-yl)thio]acetamide
  • 2-[(4-amino-5-cyclohexyl-1,2,4-triazol-3-yl)sulfanyl]-N-(4-ethanoylphenyl)ethanamide
  • ZINC05257203

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.017 0.2742 0.5279
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0498 0.0954
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0733 0.1044
Schistosoma mansoni alpha-glucosidase 0.0147 0.2341 0.3346
Schistosoma mansoni cpg binding protein 0.0031 0.0396 0.0562
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0077 0.1168 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.2742 0.3918
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0058 0.0058
Echinococcus granulosus survival motor neuron protein 1 0.0265 0.4343 0.6209
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0498 0.0954
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0505 0.2092
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0307 0.0592
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0058 0.0079
Echinococcus multilocularis pyruvate kinase 0.0019 0.0191 0.0269
Mycobacterium ulcerans arylsulfatase AtsD 0.0018 0.0169 0.032
Schistosoma mansoni pyruvate kinase 0.0037 0.0498 0.0708
Chlamydia trachomatis pyruvate kinase 0.0037 0.0498 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0498 0.0954
Brugia malayi CXXC zinc finger family protein 0.003 0.0367 0.0367
Echinococcus granulosus inositol monophosphatase 1 0.0077 0.1168 0.1667
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0058 0.0058
Mycobacterium ulcerans sulfatase 0.0018 0.0169 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0058 0.0079
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0058 0.0079
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0505 0.2092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.0112
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0058 0.0106
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0505 0.0966
Schistosoma mansoni pyruvate kinase 0.0019 0.0191 0.0269
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0105 0.0105
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0058 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0058 0.0112
Schistosoma mansoni coup transcription factor 0.0011 0.0058 0.0079
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0058 0.0058
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0077 0.1168 0.5
Onchocerca volvulus 0.0099 0.153 0.2941
Trypanosoma brucei glucosidase, putative 0.0038 0.0505 0.0966
Leishmania major pyruvate kinase 0.0037 0.0498 0.0954
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0498 0.0954
Leishmania major pyruvate kinase 0.0037 0.0498 0.0954
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.2742 0.3918
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0077 0.1168 0.4857
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Onchocerca volvulus 0.0316 0.5194 1
Brugia malayi hypothetical protein 0.015 0.2401 0.2401
Schistosoma mansoni cpg binding protein 0.0031 0.0396 0.0562
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.078 0.078
Echinococcus multilocularis pyruvate kinase 0.0019 0.0191 0.0269
Schistosoma mansoni inositol monophosphatase 0.0077 0.1168 0.1667
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0733 0.1044
Mycobacterium ulcerans arylsulfatase AtsD 0.0018 0.0169 0.032
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0058 0.0079
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0105 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0733 0.0733
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0316 0.5194 1
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.0058 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0018 0.0169 0.0693
Trichomonas vaginalis conserved hypothetical protein 0.015 0.2401 1
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0498 0.0954
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0505 0.2092
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0498 0.0954
Echinococcus granulosus dnaJ subfamily B 0.0422 0.6991 1
Giardia lamblia Hypothetical protein 0.0018 0.0169 0.3356
Brugia malayi hypothetical protein 0.0265 0.4343 0.4343
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.0112
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0105 0.0422
Onchocerca volvulus 0.003 0.0367 0.0701
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0058 0.0079
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.0112
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0191 0.0362
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0498 0.2065
Giardia lamblia Pyruvate kinase 0.0019 0.0191 0.3792
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0105 0.0422
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0058 0.0079
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0105 0.0422
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0105 0.0869
Loa Loa (eye worm) thymidylate synthase 0.0316 0.5194 1
Echinococcus granulosus lysosomal alpha glucosidase 0.017 0.2742 0.3918
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0505 0.2092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.0112
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0316 0.5194 0.7427
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0316 0.5194 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0396 0.0562
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0815 0.1563
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.1168 0.2244
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0498 0.0954
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0498 0.0954
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0498 0.0954
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0498 0.0954
Schistosoma mansoni hypothetical protein 0.0422 0.6991 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0505 0.4306
Loa Loa (eye worm) hypothetical protein 0.0014 0.0105 0.0201
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0058 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0058 0.0058
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0505 0.2092
Echinococcus multilocularis muscleblind protein 1 0.0168 0.2694 0.3851
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0058 0.0058
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.002 0.002
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0105 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0316 0.5194 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0105 0.0422
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0498 0.096
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0058 0.0058
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0505 0.0972
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0058 0.0058
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0058 0.0079
Loa Loa (eye worm) inositol-1 0.0077 0.1168 0.2249
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.0018 0.0169 0.0326
Giardia lamblia Hypothetical protein 0.0018 0.0169 0.3356
Schistosoma mansoni pyruvate kinase 0.0037 0.0498 0.0708
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0058 0.0106
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0058 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0058 0.0058
Echinococcus granulosus thymidylate synthase 0.0316 0.5194 0.7427
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0316 0.5194 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0733 0.1044
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0018 0.0169 0.0693
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0105 0.0422
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0058 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0018 0.0169 0.032
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0069 0.1032 0.1981
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0058 0.0079
Giardia lamblia Pyruvate kinase 0.0037 0.0498 1
Echinococcus granulosus pyruvate kinase 0.0037 0.0498 0.0708
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.0112
Echinococcus granulosus muscleblind protein 0.0168 0.2694 0.3851
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0058 0.0079
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0505 0.2092
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0316 0.5194 1
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0498 0.096
Schistosoma mansoni survival motor neuron protein 0.0054 0.078 0.1111
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0058 0.0079
Brugia malayi nuclear receptor NHR-88 0.0011 0.0058 0.0058
Brugia malayi Inositol-1 0.0077 0.1168 0.1168
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0058 0.0079
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0018 0.0169 0.032
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0505 0.0966
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0058 0.0079
Loa Loa (eye worm) hypothetical protein 0.0168 0.2694 0.5188
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0316 0.5194 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0006
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0077 0.1168 0.2244
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0505 0.2092
Loa Loa (eye worm) hypothetical protein 0.0026 0.0307 0.0592
Schistosoma mansoni alpha-glucosidase 0.0147 0.2341 0.3346
Echinococcus multilocularis pyruvate kinase 0.0037 0.0498 0.0708
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0105 0.0422
Brugia malayi thymidylate synthase 0.0316 0.5194 0.5194
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0058 0.0112
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0058 0.0079
Brugia malayi steroid hormone receptor 0.0011 0.0058 0.0058
Echinococcus granulosus pyruvate kinase 0.0019 0.0191 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0058 0.0058
Brugia malayi Inositol monophosphatase family protein 0.0008 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0058 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0018 0.0169 0.0326
Echinococcus granulosus pyruvate kinase 0.0019 0.0191 0.0269
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.1168 0.2244
Plasmodium falciparum pyruvate kinase 0.0037 0.0498 0.0614
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.0112
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0058 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0058 0.0112
Echinococcus multilocularis thymidylate synthase 0.0316 0.5194 0.7427
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0367 0.0707
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0058 0.0106
Onchocerca volvulus 0.0054 0.078 0.1496
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.0112
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0505 0.4306
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Brugia malayi Glycosyl hydrolases family 31 protein 0.017 0.2742 0.2742
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0505 0.0966
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0022 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0058 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.0112
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0498 0.2065
Schistosoma mansoni hypothetical protein 0.0054 0.078 0.1111
Loa Loa (eye worm) hypothetical protein 0.0037 0.0498 0.096
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0022 0.0026
Mycobacterium ulcerans arylsulfatase, AslA 0.0018 0.0169 0.032
Echinococcus granulosus pyruvate kinase 0.0037 0.0498 0.0708
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0058 0.0079
Trichomonas vaginalis inositol monophosphatase, putative 0.0077 0.1168 0.4857
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0058 0.0058
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0058 0.0079
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0077 0.1168 0.4857
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0733 0.1411
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0316 0.5194 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Mycobacterium tuberculosis Probable sulfatase 0.0018 0.0169 0.032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0733 0.1044
Loa Loa (eye worm) hypothetical protein 0.0254 0.4157 0.8003
Loa Loa (eye worm) hypothetical protein 0.0168 0.2694 0.5188
Mycobacterium tuberculosis Possible hydrolase 0.0018 0.0169 0.032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0733 0.1044
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0105 0.0195
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0928 0.1323
Brugia malayi nuclear hormone receptor 0.0011 0.0058 0.0058
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0058 0.0079
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0505 0.0718
Echinococcus multilocularis pyruvate kinase 0.0019 0.0191 0.0269
Loa Loa (eye worm) hypothetical protein 0.0265 0.4343 0.8361
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0498 0.0954
Brugia malayi Sulfatase family protein 0.0018 0.0169 0.0169
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0018 0.0169 0.032
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0058 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0058 0.0058
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0058 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.1168 0.2244
Brugia malayi hypothetical protein 0.0018 0.0169 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.1168 0.2244
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0498 0.096
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0105 0.0422
Brugia malayi Muscleblind-like protein 0.0168 0.2694 0.2694
Brugia malayi Inositol monophosphatase family protein 0.0008 0.0003 0.0003
Mycobacterium tuberculosis Hypothetical protein 0.015 0.2401 0.462
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0022 0.0026
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0058 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Brugia malayi ecdysteroid receptor 0.0011 0.0058 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0505 0.0966
Mycobacterium ulcerans arylsulfatase AtsB 0.0018 0.0169 0.032
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0105 0.0195
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0105 0.0422
Echinococcus granulosus cpg binding protein 0.0031 0.0396 0.0562
Echinococcus granulosus pyruvate kinase 0.0019 0.0191 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0058 0.0058
Echinococcus multilocularis survival motor neuron protein 1 0.0265 0.4343 0.6209
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0058 0.0079
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0058 0.0079
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0498 0.0498
Echinococcus multilocularis dnaJ subfamily B 0.0422 0.6991 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0058 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0058 0.0058
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0307 0.261
Echinococcus multilocularis inositol monophosphatase 1 0.0077 0.1168 0.1667
Mycobacterium ulcerans hydrolase 0.0018 0.0169 0.032
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0505 0.2092
Echinococcus multilocularis pyruvate kinase 0.003 0.0365 0.0518
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0069 0.1032 0.1981
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.015 0.2401 0.462
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0058 0.0079
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0058 0.0079
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0058 0.0079
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0058 0.0079
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0077 0.1168 0.2244
Mycobacterium ulcerans thymidylate synthase 0.0316 0.5194 1
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0498 0.0614
Echinococcus multilocularis pyruvate kinase 0.0037 0.0498 0.0708
Onchocerca volvulus 0.0011 0.0058 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0733 0.1044
Schistosoma mansoni alpha glucosidase 0.0038 0.0505 0.0718
Echinococcus multilocularis muscleblind protein 0.0168 0.2694 0.3851
Schistosoma mansoni inositol monophosphatase 0.0077 0.1168 0.1667
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0733 0.1044
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0058 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0058 0.0112
Schistosoma mansoni cpg binding protein 0.003 0.0367 0.0521
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0316 0.5194 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0169 0.0693
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0505 0.0718
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0105 0.0195
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0006
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0505 0.0505
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0058 0.0112
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0505 0.2092

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

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