Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | pyruvate kinase | 0.0066 | 1 | 1 |
Giardia lamblia | Pyruvate kinase | 0.0066 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0066 | 1 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.0066 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0066 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.85 | 0.85 |
Plasmodium falciparum | pyruvate kinase | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.85 | 0.7587 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0066 | 1 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.85 | 0.7587 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.85 | 0.7587 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0066 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0066 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0066 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.85 | 0.85 |
Leishmania major | pyruvate kinase | 0.0066 | 1 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0066 | 1 | 0.5 |
Plasmodium vivax | pyruvate kinase, putative | 0.0066 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.85 | 0.85 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0046 | 0.3783 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0066 | 1 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0052 | 0.5671 | 0.5671 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.85 | 0.85 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0066 | 1 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.0066 | 1 | 0.5 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0066 | 1 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0066 | 1 | 1 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0066 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.85 | 0.85 |
Loa Loa (eye worm) | pyruvate kinase | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0066 | 1 | 1 |
Leishmania major | pyruvate kinase | 0.0066 | 1 | 0.5 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0066 | 1 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0066 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.85 | 0.85 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0066 | 1 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.85 | 0.85 |
Echinococcus multilocularis | pyruvate kinase | 0.0066 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0066 | 1 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.0066 | 1 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.0066 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.