Detailed information for compound 689789

Basic information

Technical information
  • TDR Targets ID: 689789
  • Name: 2-[(1,1-dioxo-4H-benzo[e][1,2,4]thiadiazin-3- yl)sulfanyl]-N-(3-methoxyphenyl)acetamide
  • MW: 377.438 | Formula: C16H15N3O4S2
  • H donors: 2 H acceptors: 3 LogP: 2.2 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)NC(=O)CSC1=NS(=O)(=O)c2c(N1)cccc2
  • InChi: 1S/C16H15N3O4S2/c1-23-12-6-4-5-11(9-12)17-15(20)10-24-16-18-13-7-2-3-8-14(13)25(21,22)19-16/h2-9H,10H2,1H3,(H,17,20)(H,18,19)
  • InChiKey: BWSIXRXYENNWNG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(1,1-dioxo-4H-benzo[e][1,2,4]thiadiazin-3-yl)thio]-N-(3-methoxyphenyl)acetamide
  • 2-[(1,1-diketo-4H-benzo[e][1,2,4]thiadiazin-3-yl)thio]-N-(3-methoxyphenyl)acetamide
  • 2-[(1,1-dioxo-4H-benzo[e][1,2,4]thiadiazin-3-yl)sulfanyl]-N-(3-methoxyphenyl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.005 1 1
Toxoplasma gondii exonuclease III APE 0.0019 0.1232 0.5
Schistosoma mansoni lamin 0.0027 0.3537 0.6116
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 1 1
Echinococcus granulosus lamin 0.0027 0.3537 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.1232 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0375 0.0375
Onchocerca volvulus 0.0027 0.3537 0.5
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.1232 0.5
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.1232 0.5
Loa Loa (eye worm) intermediate filament protein 0.0027 0.3537 0.3537
Schistosoma mansoni ap endonuclease 0.0019 0.1232 0.1657
Echinococcus multilocularis lamin 0.0027 0.3537 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.1232 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0375 0.0375
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.1232 0.1232
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.3537 0.3537
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.1232 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.5545 0.5545
Schistosoma mansoni lamin 0.0027 0.3537 0.6116
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.1232 0.271
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.1232 0.5
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.1232 0.271
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.1232 0.5
Schistosoma mansoni intermediate filament proteins 0.0027 0.3537 0.6116
Schistosoma mansoni ap endonuclease 0.0019 0.1232 0.1657
Echinococcus multilocularis musashi 0.0027 0.3537 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.1232 0.5
Echinococcus granulosus intermediate filament protein 0.0027 0.3537 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0375 0.0375
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.1232 0.5
Echinococcus multilocularis lamin dm0 0.0027 0.3537 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.3537 0.3537
Loa Loa (eye worm) hypothetical protein 0.0034 0.5545 0.5545
Loa Loa (eye worm) hypothetical protein 0.0016 0.0375 0.0375
Onchocerca volvulus 0.0027 0.3537 0.5
Schistosoma mansoni hypothetical protein 0.0034 0.5545 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.1232 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.3537 0.3537
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.1232 0.5
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.1232 0.1232
Echinococcus granulosus lamin dm0 0.0027 0.3537 1
Brugia malayi intermediate filament protein 0.0027 0.3537 0.3537
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.1232 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.3397 0.3397
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.1232 0.5
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.1232 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.