TDR Targets

Basic information

Technical information

TDR Targets ID: 689957
Name: ethyl 1-(4-methylphenyl)-4-[2-[(4-methylpheny l)amino]-2-oxoethoxy]-6-oxopyridazine-3-carbo xylate
MW: 421.446 | Formula: C23H23N3O5
H donors: 1 H acceptors: 3 LogP: 3.48 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1nn(c2ccc(cc2)C)c(=O)cc1OCC(=O)Nc1ccc(cc1)C
InChi: 1S/C23H23N3O5/c1-4-30-23(29)22-19(31-14-20(27)24-17-9-5-15(2)6-10-17)13-21(28)26(25-22)18-11-7-16(3)8-12-18/h5-13H,4,14H2,1-3H3,(H,24,27)
InChiKey: LJRNTCCTTWIGQW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 1-(4-methylphenyl)-4-[2-[(4-methylphenyl)amino]-2-oxo-ethoxy]-6-oxo-pyridazine-3-carboxylate
1-(4-methylphenyl)-4-[2-[(4-methylphenyl)amino]-2-oxoethoxy]-6-oxo-3-pyridazinecarboxylic acid ethyl ester
6-keto-4-[2-keto-2-[(4-methylphenyl)amino]ethoxy]-1-(4-methylphenyl)pyridazine-3-carboxylic acid ethyl ester
ZINC04853586

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0038	0.0158	0.033
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0126	0.1283	1
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0105	0.1008	0.5381
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0398	0.4769	0.4894
Brugia malayi	beta-lactamase	0.0072	0.0594	0.1548
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.0594	0.1197
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0079	0.0681	0.1436
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0302	0.3532	0.9257
Mycobacterium ulcerans	lipase LipD	0.0072	0.0594	0.0963
Echinococcus multilocularis	transfer RNA-Lys	0.0046	0.0252	0.0246
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0296	0.0298
Onchocerca volvulus		0.01	0.0944	0.6905
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0143	0.1497	0.3674
Loa Loa (eye worm)	hypothetical protein	0.011	0.1083	0.5782
Echinococcus granulosus	polycomb protein SCMH1	0.0097	0.0911	0.093
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0105	0.1008	0.2333
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0105	0.1008	0.2333
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0034	0.0179
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.011	0.1083	0.1107
Echinococcus granulosus	aryl hydrocarbon receptor	0.0133	0.1371	0.1402
Echinococcus granulosus	expressed protein	0.0365	0.4341	0.4454
Onchocerca volvulus	Alhambra homolog	0.0029	0.0034	0.0202
Echinococcus multilocularis	tumor protein p63	0.0727	0.8978	0.8977
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0133	0.1371	0.1365
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0105	0.1008	0.2333
Brugia malayi	MAP kinase sur-1	0.0105	0.1008	0.2639
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0172	0.1873	1
Brugia malayi	Bromodomain containing protein	0.0029	0.0034	0.0072
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0079	0.0681	0.0693
Schistosoma mansoni	alpha-glucosidase	0.0148	0.1566	0.1603
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0594	0.3171
Trichomonas vaginalis	CMGC family protein kinase	0.0105	0.1008	0.7557
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0176	0.017
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0126	0.1283	0.1277
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0126	0.1283	0.1312
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0353	0.0913
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.0594	0.1197
Echinococcus granulosus	SAM and MBT domain containing protein	0.0097	0.0911	0.093
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0105	0.1008	0.2333
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0072	0.0594	0.0963
Toxoplasma gondii	ABC1 family protein	0.0072	0.0594	0.1487
Trichomonas vaginalis	CMGC family protein kinase	0.0105	0.1008	0.7557
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0034	0.0028
Onchocerca volvulus		0.0097	0.0911	0.6665
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0079	0.0681	0.1436
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0353	0.1883
Echinococcus multilocularis	lysine specific demethylase 5A	0.0034	0.011	0.0104
Schistosoma mansoni	sex comb on midleg homolog	0.0097	0.0911	0.093
Brugia malayi	aryl hydrocarbon receptor AHR-1	0.0116	0.1159	0.3037
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0105	0.1008	0.2333
Brugia malayi	PAS domain containing protein	0.0062	0.0457	0.1187
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0594	0.3877
Trichomonas vaginalis	ap endonuclease, putative	0.0079	0.0681	0.4652
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	0.0323	0.3802	1
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0097	0.0911	0.093
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0296	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0594	0.3171
Loa Loa (eye worm)	hypothetical protein	0.0132	0.1364	0.7281
Schistosoma mansoni	myelin transcription factor 1 myt1	0.011	0.1083	0.1107
Onchocerca volvulus		0.0072	0.0594	0.4329
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0294	0.1571
Mycobacterium ulcerans	esterase/lipase LipP	0.0072	0.0594	0.0963
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0038	0.0158	0.0399
Schistosoma mansoni	serine/threonine protein kinase	0.0105	0.1008	0.1029
Trichomonas vaginalis	CMGC family protein kinase	0.0105	0.1008	0.7557
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	0.0323	0.3802	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.011	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0594	0.3171
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0323	0.3802	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0462	0.558	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0126	0.1283	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0126	0.1283	1
Schistosoma mansoni	hypothetical protein	0.0037	0.0136	0.0134
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0105	0.1008	0.1002
Onchocerca volvulus		0.0072	0.0594	0.4329
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.0594	0.3877
Echinococcus granulosus	microtubule associated protein 2	0.0786	0.9738	1
Brugia malayi	PHD-finger family protein	0.0029	0.0034	0.0072
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0126	0.1283	0.3087
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0136	0.0342
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	0.0323	0.3802	1
Schistosoma mansoni	alpha glucosidase	0.0038	0.0158	0.0156
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0072	0.0594	0.3171
Mycobacterium ulcerans	hypothetical protein	0.0072	0.0594	0.0963
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0323	0.3802	1
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0079	0.0681	0.4652
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0105	0.1008	0.2333
Echinococcus multilocularis	polycomb protein SCMH1	0.0097	0.0911	0.0905
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0296	0.0764
Schistosoma mansoni	cellular tumor antigen P53	0.0106	0.1031	0.1053
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0398	0.4769	0.4766
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0159	0.1703	0.2225
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0126	0.1283	1
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.011	0.1083	0.1078
Brugia malayi	jmjC domain containing protein	0.0034	0.011	0.0274
Plasmodium falciparum	dihydroorotate dehydrogenase	0.0323	0.3802	1
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	0.0323	0.3802	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0072	0.0594	0.0604
Echinococcus granulosus	lysine specific demethylase 5A	0.0034	0.011	0.0107
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0079	0.0681	0.6646
Onchocerca volvulus		0.0132	0.1364	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0136	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0594	0.3171
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0034	0.0028
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0126	0.1283	0.1312
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0006	0.0033
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0212	0.0148
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0079	0.0681	0.0675
Schistosoma mansoni	single-minded	0.0062	0.0457	0.0463
Trypanosoma brucei	hypothetical protein, conserved	0.0072	0.0594	0.1197
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0093	0.0864	0.0881
Loa Loa (eye worm)	jmjC domain-containing protein	0.0034	0.011	0.0589
Echinococcus granulosus	histone acetyltransferase MYST2	0.011	0.1083	0.1107
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1166	0.6224
Onchocerca volvulus		0.0106	0.1031	0.755
Brugia malayi	beta-lactamase family protein	0.0072	0.0594	0.1548
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.0618	0.0629
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0072	0.0594	0.1548
Schistosoma mansoni	sex comb on midleg homolog	0.0097	0.0911	0.093
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0296	0.0298
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0296	0.029
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0302	0.3532	0.9257
Echinococcus multilocularis	histone acetyltransferase MYST2	0.011	0.1083	0.1078
Schistosoma mansoni	hypothetical protein	0.0029	0.0034	0.0028
Echinococcus granulosus	mitogen activated protein kinase 3	0.0105	0.1008	0.1029
Echinococcus granulosus	lysosomal alpha glucosidase	0.0172	0.1873	0.1918
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0353	0.1883
Trichomonas vaginalis	ap endonuclease, putative	0.0079	0.0681	0.4652
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0594	0.3171
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0093	0.0864	0.0858
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0097	0.0911	0.6665
Brugia malayi	Zinc finger, C2H2 type family protein	0.0126	0.1283	0.3363
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0296	0.0298
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0079	0.0681	0.3636
Schistosoma mansoni	ap endonuclease	0.0079	0.0681	0.0693
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	0.0323	0.3802	1
Mycobacterium ulcerans	hypothetical protein	0.0159	0.1703	0.4088
Echinococcus granulosus	neutral alpha glucosidase AB	0.0038	0.0158	0.0156
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0079	0.0681	0.5
Echinococcus multilocularis	microtubule associated protein 2	0.0786	0.9738	0.9738
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0079	0.0681	0.1436
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0323	0.3802	1
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.0212	0.0148
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0079	0.0681	0.1209
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0006	0.0033
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0097	0.0911	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0594	0.3171
Schistosoma mansoni	aryl hydrocarbon receptor	0.0178	0.1954	0.2001
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0079	0.0681	0.1718
Schistosoma mansoni	alpha-glucosidase	0.0148	0.1566	0.1603
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0296	0.029
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.011	0.0107
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0594	0.3877
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0911	0.4864
Brugia malayi	jmjC domain containing protein	0.0093	0.0864	0.2259
Trichomonas vaginalis	CMGC family protein kinase	0.0105	0.1008	0.7557
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0172	0.1873	0.1868
Leishmania major	hypothetical protein, conserved	0.0072	0.0594	0.1197
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.0594	0.0604
Onchocerca volvulus		0.0046	0.0259	0.1859
Echinococcus granulosus	single minded 2	0.0046	0.0252	0.0252
Loa Loa (eye worm)	mbt repeat family protein	0.0097	0.0911	0.4864
Trichomonas vaginalis	esterase, putative	0.0072	0.0594	0.3877
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0105	0.1008	0.2333
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0212	0.0148
Leishmania major	mitochondrial DNA polymerase beta	0.0302	0.3532	0.9257
Echinococcus multilocularis	expressed protein	0.0365	0.4341	0.4338
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0006	0.0033
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	0.0323	0.3802	0.6434
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.0594	0.0604
Leishmania major	dihydroorotate dehydrogenase	0.0323	0.3802	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.0212	0.0148
Trypanosoma brucei	protein kinase, putative	0.0105	0.1008	0.2333
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1031	0.5505
Echinococcus multilocularis	peregrin	0.0029	0.0034	0.0027
Schistosoma mansoni	hypothetical protein	0.0606	0.7426	0.7624
Plasmodium vivax	hypothetical protein, conserved	0.0072	0.0594	0.1487
Brugia malayi	bHLH-PAS transcription factor	0.0046	0.0252	0.0647
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0126	0.1283	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0034	0.0179
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0038	0.0158	0.0842
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0126	0.1283	0.1277
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	0.0323	0.3802	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0072	0.0594	0.0588
Toxoplasma gondii	hypothetical protein	0.0049	0.0292	0.0685
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0296	0.0298
Loa Loa (eye worm)	beta-lactamase	0.0072	0.0594	0.3171
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0323	0.3802	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0594	0.3877
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0052	0.0331	0.0474
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0296	0.1582
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0143	0.1497	0.3674
Mycobacterium ulcerans	beta-lactamase	0.0072	0.0594	0.0963
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0353	0.0913
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.011	0.1083	0.2837
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.0594	0.3877
Loa Loa (eye worm)	MBCTL1	0.011	0.1083	0.5782
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.0422	0.2254
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0079	0.0681	0.1436
Schistosoma mansoni	microtubule-associated protein tau	0.0786	0.9738	1
Brugia malayi	mbt repeat family protein	0.0097	0.0911	0.2384
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0105	0.1008	0.2585
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0126	0.1283	1
Giardia lamblia	Kinase, CMGC MAPK	0.0105	0.1008	1
Echinococcus granulosus	peregrin	0.0029	0.0034	0.0028
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0172	0.1873	0.4918
Echinococcus granulosus	tumor protein p63	0.0727	0.8978	0.9219
Schistosoma mansoni	dihydroorotate dehydrogenase	0.0323	0.3802	0.3901
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0176	0.0175
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0172	0.1873	0.1868
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0323	0.3802	1
Schistosoma mansoni	ap endonuclease	0.0079	0.0681	0.0693
Brugia malayi	beta-lactamase family protein	0.0072	0.0594	0.1548
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0143	0.1497	0.3674
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0034	0.0027
Brugia malayi	mbt repeat family protein	0.0097	0.0911	0.2384
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0038	0.0158	0.0152
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0302	0.3532	0.9257
Brugia malayi	exodeoxyribonuclease III family protein	0.0079	0.0681	0.1778
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0079	0.0681	0.1718
Onchocerca volvulus		0.0072	0.0594	0.4329
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0079	0.0681	0.0175
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0126	0.1283	1
Toxoplasma gondii	exonuclease III APE	0.0079	0.0681	0.1718
Echinococcus multilocularis	mitogen activated protein kinase	0.0105	0.1008	0.1002
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1159	0.6188
Echinococcus granulosus	mitogen activated protein kinase	0.0105	0.1008	0.1029

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 689957