Detailed information for compound 690026

Basic information

Technical information
  • TDR Targets ID: 690026
  • Name: methyl 2-[(1,1-dioxo-4H-benzo[e][1,2,4]thiadi azin-3-yl)sulfanyl]acetate
  • MW: 286.327 | Formula: C10H10N2O4S2
  • H donors: 1 H acceptors: 3 LogP: 1.25 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)CSC1=NS(=O)(=O)c2c(N1)cccc2
  • InChi: 1S/C10H10N2O4S2/c1-16-9(13)6-17-10-11-7-4-2-3-5-8(7)18(14,15)12-10/h2-5H,6H2,1H3,(H,11,12)
  • InChiKey: PSSQJKXJDWUUKS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(1,1-dioxo-4H-benzo[e][1,2,4]thiadiazin-3-yl)thio]acetic acid methyl ester
  • 2-[(1,1-diketo-4H-benzo[e][1,2,4]thiadiazin-3-yl)thio]acetic acid methyl ester
  • methyl 2-[(1,1-dioxo-4H-benzo[e][1,2,4]thiadiazin-3-yl)sulfanyl]ethanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni survival motor neuron protein 0.0107 0.0822 0.1061
Loa Loa (eye worm) hypothetical protein 0.0029 0.0062 0.0051
Brugia malayi beta-lactamase 0.0072 0.048 0.0568
Brugia malayi Pre-SET motif family protein 0.0123 0.0974 0.1179
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.048 0.051
Echinococcus multilocularis pyruvate kinase 0.0287 0.258 0.258
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.008 0.008
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.008 0.0103
Loa Loa (eye worm) hypothetical protein 0.0072 0.048 0.0568
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0062 0.0062
Schistosoma mansoni alpha glucosidase 0.0079 0.0553 0.0714
Schistosoma mansoni pyruvate kinase 0.0147 0.1216 0.157
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0723 0.0869
Onchocerca volvulus 0.0031 0.008 0.0065
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.008 0.008
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.008 0.0103
Loa Loa (eye worm) hypothetical protein 0.0031 0.008 0.0074
Giardia lamblia Pyruvate kinase 0.0287 0.258 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.008 0.008
Schistosoma mansoni hypothetical protein 0.0227 0.1993 0.2572
Loa Loa (eye worm) pyruvate kinase-PB 0.02 0.1732 0.2116
Leishmania major hypothetical protein, conserved 0.0072 0.048 0.1835
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.008 0.0074
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0123 0.0974 0.0974
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.008 0.008
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.048 0.1085
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.003 0.0067 0.0229
Loa Loa (eye worm) hypothetical protein 0.0031 0.008 0.0074
Echinococcus multilocularis lysosomal alpha glucosidase 0.0358 0.3268 0.3268
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.28 0.3434
Loa Loa (eye worm) hypothetical protein 0.0072 0.048 0.0568
Echinococcus granulosus pyruvate kinase 0.0147 0.1216 0.1216
Schistosoma mansoni coup transcription factor 0.0031 0.008 0.0103
Echinococcus multilocularis pyruvate kinase 0.0147 0.1216 0.1216
Brugia malayi MH1 domain containing protein 0.0025 0.0027 0.0009
Loa Loa (eye worm) hypothetical protein 0.0051 0.0272 0.0311
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.008 0.0074
Loa Loa (eye worm) beta-lactamase 0.0072 0.048 0.0568
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.008 0.008
Brugia malayi RNA, U transporter 1 0.0083 0.0583 0.0696
Brugia malayi Glycosyl hydrolases family 31 protein 0.0358 0.3268 0.4013
Leishmania major alpha glucosidase II subunit, putative 0.0079 0.0553 0.2118
Loa Loa (eye worm) hypothetical protein 0.0031 0.008 0.0074
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0079 0.0553 0.0658
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0079 0.0553 0.2745
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0459 0.4259 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.008 0.0074
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0427 0.0503
Schistosoma mansoni inositol monophosphatase 0.008 0.0556 0.0717
Brugia malayi pyruvate kinase 0.0061 0.0369 0.0431
Leishmania major hypothetical protein, conserved 0.0051 0.0272 0.1026
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.008 0.0103
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0091 0.0671 0.242
Brugia malayi steroid hormone receptor 0.0031 0.008 0.0074
Loa Loa (eye worm) hypothetical protein 0.0066 0.0427 0.0503
Entamoeba histolytica hypothetical protein 0.0227 0.1993 1
Schistosoma mansoni thyroid hormone receptor 0.0031 0.008 0.0103
Schistosoma mansoni Smad4 0.0025 0.0027 0.0035
Mycobacterium ulcerans lipase LipD 0.0072 0.048 0.0595
Trichomonas vaginalis pyruvate kinase, putative 0.0287 0.258 0.2778
Echinococcus multilocularis microtubule associated protein 2 0.0771 0.73 0.73
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.048 0.1085
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.048 0.0568
Loa Loa (eye worm) hypothetical protein 0.0153 0.1275 0.155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.008 0.0074
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.008 0.0103
Schistosoma mansoni hypothetical protein 0.0172 0.1452 0.1873
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0067 0.0064
Echinococcus multilocularis pyruvate kinase 0.0287 0.258 0.258
Entamoeba histolytica acetyltransferase, GNAT family 0.0084 0.0597 0.2965
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.008 0.0074
Trichomonas vaginalis esterase, putative 0.0072 0.048 0.051
Trypanosoma brucei pyruvate kinase 1, putative 0.0287 0.258 1
Brugia malayi Smad1 0.0025 0.0027 0.0009
Loa Loa (eye worm) acetyltransferase 0.0311 0.2813 0.3451
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0173 0.0189
Brugia malayi RNA recognition motif domain containing protein 0.0785 0.7438 0.9166
Echinococcus multilocularis inositol monophosphatase 1 0.008 0.0556 0.0556
Schistosoma mansoni hypothetical protein 0.004 0.0173 0.0223
Schistosoma mansoni pyruvate kinase 0.0287 0.258 0.3329
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0272 0.0836
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0123 0.0974 0.3623
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0723 0.0933
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0855 0.8113 1
Echinococcus multilocularis tar DNA binding protein 0.0785 0.7438 0.7438
Mycobacterium leprae Probable lipase LipE 0.0072 0.048 0.1797
Loa Loa (eye worm) inositol-1 0.008 0.0556 0.0662
Schistosoma mansoni tar DNA-binding protein 0.0785 0.7438 0.9599
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0311 0.2813 0.363
Plasmodium vivax hypothetical protein, conserved 0.0072 0.048 0.1661
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.008 0.0065
Loa Loa (eye worm) hypothetical protein 0.0031 0.008 0.0074
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.002 0.0047
Brugia malayi beta-lactamase family protein 0.0072 0.048 0.0568
Brugia malayi nuclear hormone receptor 0.0031 0.008 0.0074
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0553 0.0589
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.008 0.008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0723 0.0723
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0173 0.0441
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0553 0.2118
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.021 0.1827 0.2233
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.008 0.008
Loa Loa (eye worm) glutaminase 0.0817 0.7749 0.955
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0087 0.0626 0.0749
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0091 0.0671 0.242
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.008 0.008
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.048 0.1085
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.008 0.0074
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.002 0.006
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0272 0.0836
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0272 0.1026
Brugia malayi glutaminase DH11.1 0.0817 0.7749 0.955
Echinococcus granulosus snurportin 1 0.031 0.28 0.28
Loa Loa (eye worm) hypothetical protein 0.02 0.1732 0.2116
Loa Loa (eye worm) pyruvate kinase 0.0287 0.258 0.3163
Loa Loa (eye worm) hypothetical protein 0.0072 0.048 0.0568
Leishmania major pyruvate kinase 0.0287 0.258 1
Brugia malayi acetyltransferase, GNAT family protein 0.0311 0.2813 0.3451
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0067 0.0064
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.003 0.0067 0.0229
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0071 0.0474 0.1072
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.048 0.1835
Echinococcus multilocularis smad 0.0025 0.0027 0.0027
Brugia malayi Pyruvate kinase, M2 isozyme 0.0287 0.258 0.3163
Plasmodium vivax pyruvate kinase, putative 0.0287 0.258 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0556 0.1962
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.0974 0.1257
Mycobacterium leprae Probable pyruvate kinase PykA 0.0287 0.258 1
Brugia malayi nuclear receptor NHR-88 0.0031 0.008 0.0074
Echinococcus granulosus pyruvate kinase 0.0147 0.1216 0.1216
Echinococcus multilocularis GPCR, family 2 0.0066 0.0427 0.0427
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0173 0.0441
Schistosoma mansoni transcription factor LCR-F1 0.0227 0.1993 0.2572
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.0974 0.1257
Mycobacterium ulcerans beta-lactamase 0.0072 0.048 0.0595
Schistosoma mansoni hypothetical protein 0.0172 0.1452 0.1873
Echinococcus granulosus importin subunit beta 1 0.0029 0.0062 0.0062
Onchocerca volvulus 0.0107 0.0822 0.0868
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.008 0.0074
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.048 0.051
Echinococcus multilocularis geminin 0.0172 0.1452 0.1452
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.048 0.1661
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0785 0.7438 0.9166
Trichomonas vaginalis maltase-glucoamylase, putative 0.003 0.0067 0.0064
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.008 0.0074
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.008 0.0103
Trypanosoma cruzi pyruvate kinase 2, putative 0.0287 0.258 1
Schistosoma mansoni hypothetical protein 0.031 0.28 0.3613
Loa Loa (eye worm) Smad1 0.0025 0.0027 0.0009
Brugia malayi Importin beta-1 subunit 0.0029 0.0062 0.0051
Onchocerca volvulus Pyruvate kinase homolog 0.0287 0.258 0.2769
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0553 0.0589
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0723 0.0933
Mycobacterium tuberculosis Conserved protein 0.0072 0.048 0.1085
Trichomonas vaginalis set domain proteins, putative 0.0973 0.9264 1
Mycobacterium ulcerans pyruvate kinase 0.0287 0.258 0.3312
Loa Loa (eye worm) hypothetical protein 0.0072 0.048 0.0568
Brugia malayi hypothetical protein 0.0227 0.1993 0.2438
Mycobacterium leprae conserved hypothetical protein 0.0072 0.048 0.1797
Brugia malayi Glycosyl hydrolases family 31 protein 0.003 0.0067 0.0058
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0067 0.0064
Echinococcus granulosus smad 0.0025 0.0027 0.0027
Echinococcus granulosus lysosomal alpha glucosidase 0.0358 0.3268 0.3268
Trichomonas vaginalis pyruvate kinase, putative 0.0287 0.258 0.2778
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.008 0.0074
Loa Loa (eye worm) hypothetical protein 0.0031 0.008 0.0074
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.008 0.0065
Schistosoma mansoni tar DNA-binding protein 0.0785 0.7438 0.9599
Brugia malayi latrophilin 2 splice variant baaae 0.0144 0.1179 0.1432
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.008 0.0074
Schistosoma mansoni cellular tumor antigen P53 0.0153 0.1275 0.1645
Schistosoma mansoni tar DNA-binding protein 0.0785 0.7438 0.9599
Mycobacterium tuberculosis Conserved protein 0.0072 0.048 0.1085
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0107 0.0822 0.0991
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.002 0.006
Echinococcus granulosus histone acetyltransferase KAT2B 0.0091 0.0671 0.0671
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0272 0.0836
Schistosoma mansoni hypothetical protein 0.0066 0.0427 0.0551
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.008 0.0074
Loa Loa (eye worm) hypothetical protein 0.0072 0.048 0.0568
Schistosoma mansoni smad1 5 8 and 0.0025 0.0027 0.0035
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.048 0.051
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.008 0.0074
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.008 0.008
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.002 0.0047
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.008 0.0103
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.048 0.1835
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0027 0.0027
Brugia malayi TAR-binding protein 0.0785 0.7438 0.9166
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0118 0.093 0.093
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.008 0.008
Trypanosoma brucei glycosyl hydrolase-like protein 0.003 0.0067 0.0021
Leishmania major pyruvate kinase 0.0287 0.258 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0027 0.0035
Plasmodium falciparum pyruvate kinase 0.0287 0.258 1
Echinococcus multilocularis pyruvate kinase 0.0147 0.1216 0.1216
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0427 0.0503
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.008 0.0556 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.008 0.0074
Plasmodium falciparum pyruvate kinase 2 0.0147 0.1216 0.4586
Brugia malayi MH2 domain containing protein 0.0374 0.3424 0.4206
Entamoeba histolytica myo-inositol monophosphatase, putative 0.008 0.0556 0.2759
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.008 0.0074
Onchocerca volvulus 0.0072 0.048 0.0497
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0272 0.0836
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0553 0.0589
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.002 0.006
Schistosoma mansoni microtubule-associated protein tau 0.0771 0.73 0.9421
Schistosoma mansoni hypothetical protein 0.0066 0.0427 0.0551
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0079 0.0553 0.0589
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.048 0.048
Echinococcus granulosus FTZ F1 alpha 0.0031 0.008 0.008
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0427 0.0503
Toxoplasma gondii ABC1 family protein 0.0072 0.048 0.1661
Echinococcus multilocularis tumor protein p63 0.1048 1 1
Echinococcus granulosus pyruvate kinase 0.0147 0.1216 0.1216
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.003 0.0067 0.0064
Schistosoma mansoni smad 0.0025 0.0027 0.0035
Loa Loa (eye worm) TAR-binding protein 0.0785 0.7438 0.9166
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.008 0.008
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.048 0.1085
Onchocerca volvulus 0.0153 0.1275 0.1357
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.008 0.008
Trichomonas vaginalis maltase-glucoamylase, putative 0.0079 0.0553 0.0589
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.008 0.0074
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0123 0.0974 0.1257
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0723 0.0723
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.008 0.0074
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0071 0.0474 0.1775
Mycobacterium tuberculosis Conserved protein 0.0072 0.048 0.1085
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.048 0.0595
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0173 0.0173
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0144 0.1179 0.1432
Plasmodium vivax pyruvate kinase 2, putative 0.0147 0.1216 0.4586
Echinococcus granulosus histone lysine methyltransferase setb 0.0123 0.0974 0.0974
Echinococcus multilocularis survival motor neuron protein 1 0.0525 0.4894 0.4894
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.008 0.0074
Brugia malayi RNA binding protein 0.0785 0.7438 0.9166
Echinococcus multilocularis neutral alpha glucosidase AB 0.0079 0.0553 0.0553
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0091 0.0671 0.0716
Echinococcus granulosus inositol monophosphatase 1 0.008 0.0556 0.0556
Brugia malayi pyruvate kinase, muscle isozyme 0.0061 0.0369 0.0431
Onchocerca volvulus 0.0207 0.1797 0.1922
Echinococcus multilocularis pyruvate kinase 0.0147 0.1216 0.1216
Echinococcus multilocularis pyruvate kinase 0.0227 0.199 0.199
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.008 0.008
Brugia malayi hypothetical protein 0.0036 0.0135 0.0141
Loa Loa (eye worm) RNA binding protein 0.0785 0.7438 0.9166
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.008 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0553 0.2118
Echinococcus granulosus Smad4 0.0025 0.0027 0.0027
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.008 0.0103
Schistosoma mansoni glutaminase 0.0817 0.7749 1
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.048 0.1085
Echinococcus granulosus pyruvate kinase 0.0287 0.258 0.258
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0723 0.0869
Brugia malayi Glycosyl hydrolases family 31 protein 0.0079 0.0553 0.0658
Echinococcus granulosus histone acetyltransferase KAT2B 0.0302 0.2728 0.2728
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.048 0.0595
Loa Loa (eye worm) hypothetical protein 0.0072 0.048 0.0568
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0556 0.213
Echinococcus granulosus tar DNA binding protein 0.0785 0.7438 0.7438
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0027 0.0027
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0556 0.213
Loa Loa (eye worm) pyruvate kinase 0.0287 0.258 0.3163
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0079 0.0553 0.1951
Echinococcus granulosus survival motor neuron protein 1 0.0525 0.4894 0.4894
Trichomonas vaginalis glutaminase, putative 0.0817 0.7749 0.8362
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0027 0.0009
Loa Loa (eye worm) pigment dispersing factor receptor c 0.021 0.1827 0.2233
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0079 0.0553 0.2745
Chlamydia trachomatis pyruvate kinase 0.0287 0.258 0.5
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.003 0.0067 0.0051
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.008 0.0556 0.1962
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.008 0.008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0123 0.0974 0.0974
Trichomonas vaginalis myo inositol monophosphatase, putative 0.008 0.0556 0.0592
Onchocerca volvulus 0.0973 0.9264 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0553 0.0589
Trichomonas vaginalis inositol monophosphatase, putative 0.008 0.0556 0.0592
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.008 0.0074
Trypanosoma brucei glucosidase, putative 0.0079 0.0553 0.1951
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0553 0.0589
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0027 0.0027
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0173 0.0441
Onchocerca volvulus 0.0123 0.0974 0.1032
Trypanosoma cruzi pyruvate kinase 2, putative 0.0287 0.258 1
Brugia malayi hypothetical protein 0.0051 0.0272 0.0311
Schistosoma mansoni pyruvate kinase 0.0287 0.258 0.3329
Loa Loa (eye worm) hypothetical protein 0.0287 0.258 0.3163
Loa Loa (eye worm) hypothetical protein 0.0031 0.008 0.0074
Loa Loa (eye worm) hypothetical protein 0.0525 0.4894 0.6023
Brugia malayi ecdysteroid receptor 0.0031 0.008 0.0074
Plasmodium vivax SET domain protein, putative 0.0123 0.0974 0.3623
Schistosoma mansoni hypothetical protein 0.0144 0.1179 0.1522
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0358 0.3268 0.4013
Loa Loa (eye worm) hypothetical protein 0.0123 0.0974 0.1179
Loa Loa (eye worm) MH2 domain-containing protein 0.0374 0.3424 0.4206
Toxoplasma gondii pyruvate kinase PyKII 0.0147 0.1216 0.4586
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.048 0.051
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.048 0.0619
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.008 0.0074
Trypanosoma brucei pyruvate kinase 1 0.0287 0.258 1
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0173 0.0189
Loa Loa (eye worm) hypothetical protein 0.0031 0.008 0.0074
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0427 0.0427
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.003 0.0067 0.0297
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.008 0.0074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.0974 0.1257
Echinococcus multilocularis Smad4 0.0025 0.0027 0.0027
Brugia malayi hypothetical protein 0.0525 0.4894 0.6023
Brugia malayi MH2 domain containing protein 0.0025 0.0027 0.0009
Brugia malayi hypothetical protein 0.0036 0.0135 0.0141
Schistosoma mansoni alpha-glucosidase 0.0308 0.2782 0.359
Schistosoma mansoni nuclear hormone receptor 0.0031 0.008 0.0103
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.048 0.0568
Brugia malayi Pre-SET motif family protein 0.0855 0.8113 1
Onchocerca volvulus 0.0072 0.048 0.0497
Schistosoma mansoni importin beta-1 0.0029 0.0062 0.008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.008 0.0074
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0227 0.1993 0.1993
Echinococcus granulosus GPCR family 2 0.0066 0.0427 0.0427
Entamoeba histolytica hypothetical protein 0.0227 0.1993 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.021 0.1827 0.2233
Loa Loa (eye worm) pyruvate kinase 0.0061 0.0369 0.0431
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0067 0.0064
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0311 0.2813 0.2813
Echinococcus granulosus pyruvate kinase 0.0287 0.258 0.258
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0091 0.0671 0.242
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.008 0.008
Entamoeba histolytica hypothetical protein 0.0227 0.1993 1
Echinococcus granulosus geminin 0.0172 0.1452 0.1452
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.048 0.1085
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0427 0.0427
Echinococcus multilocularis lysosomal alpha glucosidase 0.0358 0.3268 0.3268
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0427 0.0427
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0723 0.0723
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.003 0.0067 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.008 0.0074
Loa Loa (eye worm) hypothetical protein 0.021 0.1827 0.2233
Loa Loa (eye worm) transcription factor SMAD2 0.0374 0.3424 0.4206
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.048 0.0619
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0556 0.213
Loa Loa (eye worm) hypothetical protein 0.004 0.0173 0.0189
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.002 0.0047
Schistosoma mansoni hypothetical protein 0.0066 0.0427 0.0551
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.008 0.0065
Onchocerca volvulus Pyruvate kinase homolog 0.0287 0.258 0.2769
Brugia malayi Inositol-1 0.008 0.0556 0.0662
Trichomonas vaginalis sucrase-isomaltase, putative 0.0079 0.0553 0.0589
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0723 0.0723
Schistosoma mansoni smad1 5 8 and 0.0025 0.0027 0.0035
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0287 0.258 0.6038
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0027 0.0009
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.048 0.051
Trichomonas vaginalis myo inositol monophosphatase, putative 0.008 0.0556 0.0592
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0227 0.1993 0.1993
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0173 0.0189
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0723 0.0933
Leishmania major glycosyl hydrolase-like protein 0.003 0.0067 0.0229
Brugia malayi beta-lactamase family protein 0.0072 0.048 0.0568
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0067 0.0064
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0079 0.0553 0.0589
Schistosoma mansoni tar DNA-binding protein 0.0785 0.7438 0.9599
Entamoeba histolytica pyruvate kinase, putative 0.02 0.1732 0.8686
Schistosoma mansoni hypothetical protein 0.0107 0.0822 0.1061
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.008 0.0103
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.048 0.1085
Schistosoma mansoni alpha-glucosidase 0.0308 0.2782 0.359
Trichomonas vaginalis bromodomain-containing protein, putative 0.0091 0.0671 0.0716
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.008 0.0556 0.0693
Brugia malayi hypothetical protein 0.0033 0.0097 0.0095
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0272 0.0836
Toxoplasma gondii pyruvate kinase PyK1 0.0287 0.258 1
Schistosoma mansoni tar DNA-binding protein 0.0785 0.7438 0.9599
Loa Loa (eye worm) glutaminase 2 0.0817 0.7749 0.955
Brugia malayi MH2 domain containing protein 0.0025 0.0027 0.0009
Schistosoma mansoni smad1 5 8 and 0.0025 0.0027 0.0035
Loa Loa (eye worm) pyruvate kinase 0.0287 0.258 0.3163
Mycobacterium ulcerans hypothetical protein 0.0072 0.048 0.0595
Echinococcus granulosus neutral alpha glucosidase AB 0.0079 0.0553 0.0553
Onchocerca volvulus Pyruvate kinase homolog 0.0287 0.258 0.2769
Mycobacterium ulcerans glutaminase 0.0817 0.7749 1
Entamoeba histolytica hypothetical protein 0.0227 0.1993 1
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.008 0.0074
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0427 0.0427
Brugia malayi MH1 domain containing protein 0.0025 0.0027 0.0009
Plasmodium falciparum histone acetyltransferase GCN5 0.0084 0.0597 0.2124
Onchocerca volvulus 0.0072 0.048 0.0497
Brugia malayi Pyruvate kinase, muscle isozyme 0.0287 0.258 0.3163
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.008 0.0103
Schistosoma mansoni hypothetical protein 0.0066 0.0427 0.0551
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.008 0.0074
Giardia lamblia Pyruvate kinase 0.0147 0.1216 0.3125
Echinococcus multilocularis snurportin 1 0.031 0.28 0.28
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.048 0.048
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.008 0.008
Schistosoma mansoni inositol monophosphatase 0.008 0.0556 0.0717
Echinococcus granulosus microtubule associated protein 2 0.0771 0.73 0.73
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0272 0.1026
Schistosoma mansoni thyroid hormone receptor 0.0031 0.008 0.0103

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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