Detailed information for compound 690090

Basic information

Technical information
  • TDR Targets ID: 690090
  • Name: [6-[(4-methyl-1,3-thiazol-2-yl)sulfanylmethyl ]-4-oxopyran-3-yl] 4-nitrobenzoate
  • MW: 404.417 | Formula: C17H12N2O6S2
  • H donors: 0 H acceptors: 5 LogP: 3.36 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)[N+](=O)[O-])Oc1coc(cc1=O)CSc1scc(n1)C
  • InChi: 1S/C17H12N2O6S2/c1-10-8-26-17(18-10)27-9-13-6-14(20)15(7-24-13)25-16(21)11-2-4-12(5-3-11)19(22)23/h2-8H,9H2,1H3
  • InChiKey: VPHVOIIALATIAQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [6-[(4-methylthiazol-2-yl)sulfanylmethyl]-4-oxo-pyran-3-yl] 4-nitrobenzoate
  • 4-nitrobenzoic acid [6-[[(4-methyl-2-thiazolyl)thio]methyl]-4-oxo-3-pyranyl] ester
  • 4-nitrobenzoic acid [4-keto-6-[[(4-methylthiazol-2-yl)thio]methyl]pyran-3-yl] ester
  • [6-[(4-methyl-1,3-thiazol-2-yl)sulfanylmethyl]-4-oxo-pyran-3-yl] 4-nitrobenzoate
  • ZINC04518837

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0032 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0026 0.0066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0225 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0122
Schistosoma mansoni tar DNA-binding protein 0.0191 0.0382 0.0382
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.0268 0.0072
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0002 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0002 0.0002
Brugia malayi Pre-SET motif family protein 0.0059 0.0095 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0032 0.0261
Mycobacterium tuberculosis Conserved protein 0.014 0.0273 0.0271
Schistosoma mansoni smad1 5 8 and 0.004 0.0054 0.0054
Echinococcus multilocularis CREB binding protein 0.0016 0.0003 0.0007
Echinococcus multilocularis tumor protein p63 0.0664 0.1411 0.3624
Onchocerca volvulus 0.0059 0.0095 0.0915
Mycobacterium tuberculosis Probable esterase LipL 0.014 0.0273 0.0271
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0091 0.0233
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0081 0.0081
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.18 0.3885 0.9976
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.002 0.0051
Schistosoma mansoni TGF-beta signal transducer Smad2 0.004 0.0054 0.0054
Echinococcus granulosus FTZ F1 alpha 0.003 0.0032 0.0083
Plasmodium vivax glutathione reductase, putative 0.0046 0.0068 0.0066
Echinococcus multilocularis TGF beta signal transducer SmadC 0.004 0.0054 0.0138
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1804 0.3894 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0065 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0032 0.0032
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0065 0.0065
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0032 0.0083
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.014 0.0273 0.2205
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.461 1 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0069 0.0069
Loa Loa (eye worm) MH1 domain-containing protein 0.004 0.0054 0.0434
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0021 0.0019
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0006 0.0048
Mycobacterium tuberculosis Probable reductase 0.0106 0.0197 0.0195
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0032 0.0032
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0065 0.0065
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0032 0.0083
Mycobacterium tuberculosis Probable lipase LipE 0.014 0.0273 0.0271
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0081 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.004 0.0103
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.0268 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.004 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0032 0.0032
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0065 0.0065
Echinococcus granulosus GPCR family 2 0.0046 0.0068 0.0175
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0008 0.0008
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0002 0.0002
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.0032 0.0261
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0081 0.0081
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.1804 0.3894 1
Loa Loa (eye worm) hypothetical protein 0.014 0.0273 0.2205
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.014 0.0273 0.0271
Trypanosoma cruzi hypothetical protein, conserved 0.014 0.0273 0.0273
Echinococcus granulosus microtubule associated protein 2 0.068 0.1447 0.3715
Echinococcus granulosus CREB binding protein 0.0016 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0013
Brugia malayi TAZ zinc finger family protein 0.0099 0.0183 0.0183
Entamoeba histolytica hypothetical protein 0.007 0.0121 0.0145
Schistosoma mansoni smad 0.004 0.0054 0.0054
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0002 0.0002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.004 0.0103
Echinococcus multilocularis beta LACTamase domain containing family member 0.014 0.0273 0.07
Toxoplasma gondii ABC1 family protein 0.014 0.0273 0.0271
Onchocerca volvulus 0.014 0.0273 0.2729
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0032 0.0083
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.461 1 1
Schistosoma mansoni tar DNA-binding protein 0.0191 0.0382 0.0382
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0068 0.0552
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0197 0.0195
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0081 0.0081
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0583 0.1497
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0081 0.0652
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.461 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0032 0.0261
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0081 0.0207
Loa Loa (eye worm) hypothetical protein 0.003 0.0032 0.0261
Schistosoma mansoni Smad4 0.0018 0.0006 0.0006
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0121 0.031
Brugia malayi RNA recognition motif domain containing protein 0.0191 0.0382 0.0382
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0081 0.0207
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0897 0.1919 0.1917
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.461 1 1
Echinococcus granulosus CREB binding protein 0.0016 0.0003 0.0007
Schistosoma mansoni hypothetical protein 0.007 0.0121 0.0121
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.18 0.3885 0.3885
Schistosoma mansoni hypothetical protein 0.0046 0.0068 0.0068
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0002 0.0002
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0006 0.0048
Brugia malayi RNA binding protein 0.0191 0.0382 0.0382
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0095 0.0095
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0095 0.0245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0026 0.0066
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0032 0.0083
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0095 0.0245
Brugia malayi beta-lactamase family protein 0.014 0.0273 0.0273
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.461 1 1
Brugia malayi mothers against decapentaplegic homolog 3 0.0018 0.0006 0.0006
Mycobacterium leprae Probable lipase LipE 0.014 0.0273 0.0077
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0002 0.0002
Loa Loa (eye worm) CBP-B 0.0069 0.0117 0.0947
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.004 0.0103
Plasmodium vivax SET domain protein, putative 0.0059 0.0095 0.0093
Schistosoma mansoni Smad4 0.0018 0.0006 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0095 0.0095
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0081 0.0081
Brugia malayi nuclear hormone receptor 0.003 0.0032 0.0032
Schistosoma mansoni thyroid hormone receptor 0.003 0.0032 0.0032
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0785 0.1675 0.4302
Trichomonas vaginalis D-aminoacylase, putative 0.014 0.0273 0.07
Trichomonas vaginalis esterase, putative 0.014 0.0273 0.07
Trypanosoma cruzi hypothetical protein, conserved 0.014 0.0273 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0045 0.0115
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.0287 0.0287
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0225 0.0457 0.0457
Loa Loa (eye worm) MH2 domain-containing protein 0.004 0.0054 0.0434
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.0287 0.2318
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.0287 0.0287
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0032 0.027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0045 0.0115
Brugia malayi nuclear receptor NHR-88 0.003 0.0032 0.0032
Loa Loa (eye worm) transcription factor SMAD2 0.0584 0.1237 1
Echinococcus granulosus tumor protein p63 0.0664 0.1411 0.3624
Loa Loa (eye worm) hypothetical protein 0.014 0.0273 0.2205
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.014 0.0273 0.0271
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0068 0.0066
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0065 0.0065
Brugia malayi nuclear receptor RXR 0.0016 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0013
Brugia malayi MH2 domain containing protein 0.004 0.0054 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.004 0.0103
Schistosoma mansoni smad 0.0018 0.0006 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0583 0.1497
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0032 0.0032
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0032 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.014 0.0273 0.2205
Brugia malayi MH1 domain containing protein 0.0022 0.0015 0.0015
Echinococcus multilocularis microtubule associated protein 2 0.068 0.1447 0.3715
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0068 0.0549
Schistosoma mansoni dihydroorotate dehydrogenase 0.461 1 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0068 0.0175
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0032 0.0032
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0021 0.0019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.014 0.0273 0.0273
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0002 0.0002
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0002 0.0005
Onchocerca volvulus 0.014 0.0273 0.2729
Brugia malayi MH1 domain containing protein 0.004 0.0054 0.0054
Brugia malayi hypothetical protein 0.0025 0.0021 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0583 0.1497
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0225 0.0457 0.1175
Brugia malayi MH1 domain containing protein 0.004 0.0054 0.0054
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.014 0.0273 0.0273
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0002 0.0002
Brugia malayi MAP kinase sur-1 0.0052 0.0081 0.0081
Echinococcus granulosus mothers against decapentaplegic 5 0.004 0.0054 0.0138
Schistosoma mansoni CREB-binding protein 2 0.0099 0.0183 0.0183
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0032 0.0261
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.014 0.0273 0.0271
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.014 0.0273 0.0273
Schistosoma mansoni coup transcription factor 0.003 0.0032 0.0032
Trichomonas vaginalis D-aminoacylase, putative 0.014 0.0273 0.07
Loa Loa (eye worm) MH2 domain-containing protein 0.0584 0.1237 1
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0068 0.0066
Brugia malayi hypothetical protein 0.0016 0.0002 0.0002
Brugia malayi Pre-SET motif family protein 0.041 0.086 0.086
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0197 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0065 0.0167
Leishmania major hypothetical protein, conserved 0.0025 0.0021 0.0021
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0032 0.0083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0225 0.0457 0.1175
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0095 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0045 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.002 0.0051
Entamoeba histolytica hypothetical protein 0.007 0.0121 0.0145
Schistosoma mansoni Smad4 0.004 0.0054 0.0054
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0197 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.002 0.0051
Echinococcus multilocularis tar DNA binding protein 0.0191 0.0382 0.0981
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0095 0.0095
Trichomonas vaginalis D-aminoacylase, putative 0.014 0.0273 0.07
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0002 0.0005
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0045 0.0115
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0013 0.0013
Echinococcus granulosus CREB binding protein 0.0061 0.01 0.0258
Toxoplasma gondii thioredoxin reductase 0.0046 0.0068 0.0066
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1804 0.3894 1
Onchocerca volvulus 0.014 0.0273 0.2729
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0081 0.0207
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0223 0.0221
Schistosoma mansoni hypothetical protein 0.01 0.0186 0.0186
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0021 0.0019
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0065 0.0065
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0021 0.0019
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.0583 1
Echinococcus granulosus CREB binding protein 0.0099 0.0183 0.047
Entamoeba histolytica hypothetical protein 0.007 0.0121 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.004 0.0103
Onchocerca volvulus 0.003 0.0032 0.027
Brugia malayi glutathione reductase 0.0046 0.0068 0.0068
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.1804 0.3894 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0002 0.0004
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.461 1 1
Brugia malayi MH1 domain containing protein 0.0022 0.0015 0.0015
Echinococcus multilocularis Smad4 0.004 0.0054 0.0138
Brugia malayi hypothetical protein 0.023 0.0468 0.0468
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0081 0.0207
Schistosoma mansoni tar DNA-binding protein 0.0191 0.0382 0.0382
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.461 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0225 0.0457 0.1175
Loa Loa (eye worm) nuclear factor I 0.0022 0.0015 0.0122
Brugia malayi hypothetical protein 0.0016 0.0002 0.0002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0068 0.0175
Echinococcus multilocularis mothers against decapentaplegic 6 0.0018 0.0006 0.0015
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0121 0.031
Loa Loa (eye worm) hypothetical protein 0.0147 0.0287 0.2318
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0032 0.0032
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0065 0.0167
Echinococcus multilocularis mothers against decapentaplegic 5 0.004 0.0054 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.014 0.0273 0.2205
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0583 0.1497
Trypanosoma brucei trypanothione reductase 0.0046 0.0068 0.0068
Plasmodium falciparum thioredoxin reductase 0.0046 0.0068 0.0066
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0583 0.1497
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0032 0.0261
Echinococcus granulosus smad 0.004 0.0054 0.0138
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.18 0.3885 0.9976
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0032 0.0083
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0032 0.027
Echinococcus multilocularis CREB binding protein 0.0068 0.0115 0.0296
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0068 0.0175
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0225 0.0457 0.0457
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0223 0.0221
Loa Loa (eye worm) hypothetical protein 0.0025 0.0021 0.017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0065 0.0065
Echinococcus multilocularis CREB binding protein 0.0016 0.0003 0.0007
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.0268 0.0266
Trypanosoma brucei protein kinase, putative 0.0052 0.0081 0.0081
Mycobacterium ulcerans esterase/lipase LipP 0.014 0.0273 0.0271
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.0186 0.0186
Brugia malayi steroid hormone receptor 0.003 0.0032 0.0032
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0032 0.0083
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0021 0.0021
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0068 0.0068
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0032 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0033 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0032 0.0261
Mycobacterium ulcerans hypothetical protein 0.014 0.0273 0.0271
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0068 0.0175
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.004 0.0038
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0032 0.0032
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0032 0.0032
Schistosoma mansoni tar DNA-binding protein 0.0191 0.0382 0.0382
Brugia malayi beta-lactamase family protein 0.014 0.0273 0.0273
Echinococcus multilocularis GPCR, family 2 0.0046 0.0068 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0032 0.0032
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0032 0.027
Brugia malayi MH2 domain containing protein 0.0584 0.1237 0.1237
Loa Loa (eye worm) hypothetical protein 0.014 0.0273 0.2205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0032 0.0261
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0002 0.0013
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0032 0.0032
Mycobacterium tuberculosis Probable conserved lipoprotein 0.014 0.0273 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.002 0.0051
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.0583 0.1352
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0068 0.0175
Loa Loa (eye worm) beta-lactamase 0.014 0.0273 0.2205
Echinococcus multilocularis smad 0.004 0.0054 0.0138
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0032 0.0083
Leishmania major trypanothione reductase 0.0046 0.0068 0.0068
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0032 0.0083
Entamoeba histolytica hypothetical protein 0.007 0.0121 0.0145
Onchocerca volvulus 0.0467 0.0984 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0081 0.0081
Schistosoma mansoni microtubule-associated protein tau 0.068 0.1447 0.1447
Loa Loa (eye worm) hypothetical protein 0.003 0.0032 0.0261
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0081 0.0207
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0059 0.0095 0.0771
Echinococcus granulosus TGF beta signal transducer SmadC 0.004 0.0054 0.0138
Echinococcus granulosus Smad4 0.004 0.0054 0.0138
Brugia malayi Smad1 0.004 0.0054 0.0054
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0032 0.0032
Echinococcus multilocularis mothers against decapentaplegic 2 0.0018 0.0006 0.0015
Echinococcus granulosus beta LACTamase domain containing family member 0.014 0.0273 0.07
Giardia lamblia GTOR 0.0045 0.0065 0.1082
Loa Loa (eye worm) hypothetical protein 0.003 0.0032 0.0261
Loa Loa (eye worm) glutathione reductase 0.0046 0.0068 0.0549
Loa Loa (eye worm) hypothetical protein 0.023 0.0468 0.3782
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0099 0.0183 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0032 0.0032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0032 0.0083
Mycobacterium tuberculosis Probable lipase LipD 0.014 0.0273 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0065 0.0167
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0032 0.0083
Brugia malayi ecdysteroid receptor 0.003 0.0032 0.0032
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0081 0.1353
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.18 0.3885 0.9976
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0002 0.0002
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0121 0.0121
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0032 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0065 0.0167
Loa Loa (eye worm) TAR-binding protein 0.0191 0.0382 0.3086
Mycobacterium ulcerans lipase LipD 0.014 0.0273 0.0271
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0002 0.0002
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0032 0.0032
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.0468 0.1202
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0045 0.0045
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.1804 0.3894 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0045 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0095 0.0095
Echinococcus granulosus mothers against decapentaplegic 2 0.0018 0.0006 0.0015
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.041 0.086 0.6955
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.01 0.0186 0.1501
Loa Loa (eye worm) hypothetical protein 0.014 0.0273 0.2205
Schistosoma mansoni smad1 5 8 and 0.004 0.0054 0.0054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0225 0.0457 0.1175
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0032 0.0032
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0032 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.002 0.0051
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0013
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.1804 0.3894 1
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.461 1 1
Brugia malayi hypothetical protein 0.007 0.0121 0.0121
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0081 0.0079
Plasmodium falciparum dihydroorotate dehydrogenase 0.461 1 1
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.0583 1
Schistosoma mansoni survival motor neuron protein 0.0047 0.0069 0.0069
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0197 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0045 0.0115
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0081 0.0081
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0032 0.0032
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0081 0.0207
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0002 0.0002
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0002 0.0002
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0032 0.0261
Schistosoma mansoni hypothetical protein 0.0047 0.0069 0.0069
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0032 0.0083
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0002 0.0002
Mycobacterium leprae conserved hypothetical protein 0.014 0.0273 0.0077
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.461 1 1
Schistosoma mansoni nuclear hormone receptor 0.003 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0097 0.0179 0.1444
Schistosoma mansoni cellular tumor antigen P53 0.0097 0.0179 0.0179
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0032 0.0083
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.461 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0583 0.1497
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0002 0.0002
Schistosoma mansoni smad1 5 8 and 0.004 0.0054 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0051 0.013
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0065 0.0525
Brugia malayi Thioredoxin reductase 0.0046 0.0068 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.002 0.0051
Leishmania major hypothetical protein, conserved 0.014 0.0273 0.0273
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0191 0.0382 0.3086
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0068 0.0068
Brugia malayi TAR-binding protein 0.0191 0.0382 0.0382
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0583 0.1497
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0032 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0031 0.0079
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.0583 0.1352
Echinococcus granulosus survival motor neuron protein 1 0.023 0.0468 0.1202
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0002 0.0002
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0095 0.0245
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0002 0.0002
Trichomonas vaginalis penicillin-binding protein, putative 0.014 0.0273 0.07
Loa Loa (eye worm) RNA binding protein 0.0191 0.0382 0.3086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.004 0.0103
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0013
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0045 0.0045
Plasmodium vivax hypothetical protein, conserved 0.014 0.0273 0.0271
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0032 0.0083
Mycobacterium tuberculosis Conserved protein 0.014 0.0273 0.0271
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0065 0.0065
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0002 0.0005
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0223 0.0026
Loa Loa (eye worm) hypothetical protein 0.003 0.0032 0.0261
Mycobacterium ulcerans beta-lactamase 0.014 0.0273 0.0271
Schistosoma mansoni hypothetical protein 0.0046 0.0068 0.0068
Brugia malayi beta-lactamase 0.014 0.0273 0.0273
Schistosoma mansoni hypothetical protein 0.0046 0.0068 0.0068
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0021 0.0021
Mycobacterium tuberculosis Probable hydrolase 0.014 0.0273 0.0271
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0032 0.0261
Loa Loa (eye worm) hypothetical protein 0.003 0.0032 0.0261
Echinococcus granulosus tar DNA binding protein 0.0191 0.0382 0.0981
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0065 0.0065
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.1804 0.3894 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0025 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0583 0.1497
Echinococcus multilocularis CREB binding protein 0.0016 0.0003 0.0007
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0225 0.0457 0.3698
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0021 0.0021
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0047 0.0069 0.0555
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0197 0.0195
Onchocerca volvulus 0.0047 0.0069 0.0649
Trichomonas vaginalis penicillin-binding protein, putative 0.014 0.0273 0.07
Leishmania major dihydroorotate dehydrogenase 0.461 1 1
Schistosoma mansoni hypothetical protein 0.0046 0.0068 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0225 0.0457 0.0457
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0002 0.0005
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0025 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0026 0.0066
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0048
Loa Loa (eye worm) hypothetical protein 0.003 0.0032 0.0261
Brugia malayi hypothetical protein 0.0016 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0032 0.0032
Trichomonas vaginalis set domain proteins, putative 0.0467 0.0984 0.2527
Schistosoma mansoni tar DNA-binding protein 0.0191 0.0382 0.0382
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0032 0.0083
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.461 1 1
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0081 0.0207
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0002 0.0002
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0223 0.0221
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0013
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.18 0.3885 0.9976
Trypanosoma brucei hypothetical protein, conserved 0.014 0.0273 0.0273
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0032 0.0032
Mycobacterium tuberculosis Conserved protein 0.014 0.0273 0.0271
Plasmodium falciparum glutathione reductase 0.0046 0.0068 0.0066
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0032 0.0032
Loa Loa (eye worm) Smad1 0.004 0.0054 0.0434
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0002 0.5
Onchocerca volvulus 0.0097 0.0179 0.1766
Brugia malayi MH2 domain containing protein 0.004 0.0054 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0032 0.0032
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0068 0.0175
Echinococcus granulosus mothers against decapentaplegic 6 0.0018 0.0006 0.0015
Schistosoma mansoni thyroid hormone receptor 0.003 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0046 0.0068 0.0552
Brugia malayi Zinc finger, C2H2 type family protein 0.18 0.3885 0.3885
Brugia malayi MH2 domain containing protein 0.0018 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0032 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.002 0.0051

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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