Detailed information for compound 69024

Basic information

Technical information
  • TDR Targets ID: 69024
  • Name: 4-acetamido-N-(2,6-dimethylphenyl)-3-methylbe nzamide
  • MW: 296.364 | Formula: C18H20N2O2
  • H donors: 2 H acceptors: 2 LogP: 3.03 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1ccc(cc1C)C(=O)Nc1c(C)cccc1C
  • InChi: 1S/C18H20N2O2/c1-11-6-5-7-12(2)17(11)20-18(22)15-8-9-16(13(3)10-15)19-14(4)21/h5-10H,1-4H3,(H,19,21)(H,20,22)
  • InChiKey: TULDIALSJMUPDC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-acetamido-N-(2,6-dimethylphenyl)-3-methyl-benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis serotonin receptor 0.0149 0.4083 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.008 0.0952 0.5
Schistosoma mansoni adenoreceptor 0.0149 0.4083 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0149 0.4083 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0149 0.4083 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0149 0.4083 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.008 0.0952 0.5
Schistosoma mansoni 6-phosphofructokinase 0.0139 0.3631 0.8556
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0149 0.4083 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0149 0.4083 1
Brugia malayi hypothetical protein 0.0149 0.4083 0.346
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0149 0.4083 0.346
Echinococcus multilocularis rhodopsin orphan GPCR 0.0149 0.4083 1
Onchocerca volvulus 0.0149 0.4083 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0149 0.4083 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0149 0.4083 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.008 0.0952 0.5
Echinococcus granulosus peptide allatostatin:somatostatin 0.0149 0.4083 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.3631 0.2979
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.0082 0.1035 0.0092
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Echinococcus granulosus neuropeptide FF receptor 2 0.0149 0.4083 1
Leishmania major cytochrome p450-like protein 0.008 0.0952 0.0952
Echinococcus granulosus g protein coupled receptor 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0149 0.4083 1
Echinococcus granulosus tm gpcr rhodopsin 0.0149 0.4083 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.008 0.0952 0.5
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Schistosoma mansoni amine GPCR 0.0149 0.4083 1
Schistosoma mansoni hypothetical protein 0.0149 0.4083 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.008 0.0952 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0149 0.4083 1
Brugia malayi GnHR receptor homolog 0.0149 0.4083 0.346
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0149 0.4083 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0149 0.4083 1
Echinococcus multilocularis fmrfamide receptor 0.0149 0.4083 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0149 0.4083 1
Onchocerca volvulus 0.0149 0.4083 1
Echinococcus multilocularis g-protein coupled receptor 0.0149 0.4083 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0149 0.4083 1
Echinococcus granulosus allatostatin A receptor 0.0149 0.4083 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0149 0.4083 1
Echinococcus granulosus g-protein coupled receptor 0.0149 0.4083 1
Schistosoma mansoni neuropeptide receptor 0.0149 0.4083 1
Echinococcus granulosus dro:myosuppressin receptor 0.0149 0.4083 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.008 0.0952 0.5
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0149 0.4083 0.3477
Echinococcus multilocularis serotonin receptor 0.0149 0.4083 1
Brugia malayi ORL1-like opioid receptor 0.0149 0.4083 0.346
Schistosoma mansoni myosin xvIII 0.0149 0.4083 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.008 0.0952 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0149 0.4083 0.3477
Echinococcus granulosus neuropeptide receptor A26 0.0149 0.4083 1
Schistosoma mansoni amine GPCR 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.008 0.0952 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0149 0.4083 0.346
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0149 0.4083 1
Echinococcus granulosus fmrfamide receptor 0.0149 0.4083 1
Brugia malayi hypothetical protein 0.0149 0.4083 0.346
Loa Loa (eye worm) G-protein coupled receptor 0.0149 0.4083 0.3477
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0149 0.4083 0.3477
Schistosoma mansoni alpha-1 adrenergic receptor 0.0149 0.4083 1
Schistosoma mansoni biogenic amine receptor 0.0149 0.4083 1
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0136 0.3524 0.3524
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0149 0.4083 1
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0139 0.3631 0.3631
Echinococcus granulosus 7TM GPCR rhodopsin 0.0149 0.4083 1
Echinococcus multilocularis g protein coupled receptor 0.0149 0.4083 1
Brugia malayi Dopamine receptor protein 1 0.0149 0.4083 0.346
Schistosoma mansoni opsin-like receptor 0.0149 0.4083 1
Brugia malayi putative neuropeptide receptor 0.0149 0.4083 0.346
Onchocerca volvulus 0.0149 0.4083 1
Brugia malayi neuropeptide F receptor 0.0149 0.4083 0.346
Onchocerca volvulus 0.0149 0.4083 1
Loa Loa (eye worm) G-protein coupled receptor 0.0149 0.4083 0.3477
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.0136 0.3524 0.3524
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.0136 0.3524 0.3524
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0149 0.4083 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0149 0.4083 1
Leishmania major cytochrome p450-like protein 0.008 0.0952 0.0952
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0149 0.4083 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0149 0.4083 0.3477
Brugia malayi Serotonin receptor 0.0149 0.4083 0.346
Echinococcus granulosus neuropeptides capa receptor 0.0149 0.4083 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.008 0.0952 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0149 0.4083 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0149 0.4083 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.008 0.0952 0.0952
Leishmania major lanosterol 14-alpha-demethylase, putative 0.008 0.0952 0.0952
Leishmania major cytochrome p450-like protein 0.0278 1 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0139 0.3631 0.3631
Echinococcus multilocularis neuropeptide receptor 0.0149 0.4083 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0149 0.4083 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.008 0.0952 0.5
Schistosoma mansoni biogenic amine receptor 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Echinococcus granulosus rhodopsin orphan GPCR 0.0149 0.4083 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0149 0.4083 1
Giardia lamblia Hypothetical protein 0.0082 0.1035 0.5
Onchocerca volvulus 0.0149 0.4083 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0149 0.4083 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Mycobacterium leprae putative cytochrome p450 0.008 0.0952 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Schistosoma mansoni hypothetical protein 0.0149 0.4083 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0149 0.4083 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0149 0.4083 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Brugia malayi G-protein coupled receptor 0.0149 0.4083 0.346
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0149 0.4083 1
Echinococcus multilocularis neuropeptide Y receptor 0.0149 0.4083 1
Mycobacterium leprae Conserved hypothetical protein 0.008 0.0952 0.5
Onchocerca volvulus 0.0149 0.4083 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0149 0.4083 1
Echinococcus multilocularis neuropeptides capa receptor 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Schistosoma mansoni histamine h1 receptor 0.0149 0.4083 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0278 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0149 0.4083 1
Echinococcus granulosus neuropeptide receptor 0.0149 0.4083 1
Echinococcus granulosus g protein coupled receptor 0.0149 0.4083 1
Onchocerca volvulus 0.0149 0.4083 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0278 1 1
Brugia malayi hypothetical protein 0.0149 0.4083 0.346
Brugia malayi AKH receptor 0.0149 0.4083 0.346
Onchocerca volvulus 0.0149 0.4083 1
Echinococcus granulosus neuropeptide Y receptor 0.0149 0.4083 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Schistosoma mansoni hypothetical protein 0.0149 0.4083 1
Schistosoma mansoni amine GPCR 0.0149 0.4083 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.008 0.0952 0.0952
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.008 0.0952 0.0952
Echinococcus multilocularis rhodopsin orphan GPCR 0.0149 0.4083 1
Schistosoma mansoni neuropeptide F-like receptor 0.0149 0.4083 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0149 0.4083 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0149 0.4083 1
Brugia malayi follicle stimulating hormone receptor 0.0149 0.4083 0.346
Onchocerca volvulus Neuropeptide F receptor homolog 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Brugia malayi Tachykinin-like peptides receptor 99D 0.0149 0.4083 0.346
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0149 0.4083 1
Schistosoma mansoni neuropeptide F-like receptor 0.0149 0.4083 1
Brugia malayi hypothetical protein 0.0149 0.4083 0.346
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0149 0.4083 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.008 0.0952 0.5
Onchocerca volvulus 0.0149 0.4083 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0149 0.4083 1
Echinococcus multilocularis fmrfamide receptor 0.0149 0.4083 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0149 0.4083 1
Onchocerca volvulus 0.0149 0.4083 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0149 0.4083 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.008 0.0952 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0149 0.4083 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0149 0.4083 0.346
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.008 0.0952 0.5
Brugia malayi RE15519p 0.0149 0.4083 0.346
Brugia malayi G protein-coupled receptor F59B2.13 0.0149 0.4083 0.346
Echinococcus multilocularis G protein coupled receptor 139 0.0149 0.4083 1
Echinococcus granulosus g protein coupled receptor 0.0149 0.4083 1
Echinococcus multilocularis somatostatin receptor 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.008 0.0952 0.5
Schistosoma mansoni neuropeptide receptor 0.0149 0.4083 1
Brugia malayi sulfakinin receptor protein 0.0149 0.4083 0.346
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Onchocerca volvulus 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Brugia malayi hypothetical protein 0.0149 0.4083 0.346
Brugia malayi larval opioid receptor 0.0149 0.4083 0.346
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.008 0.0952 0.5
Echinococcus granulosus 6 phosphofructo 2 kinase:fructose 2 0.0139 0.3631 0.8556
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.008 0.0952 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Schistosoma mansoni opsin-like receptor 0.0149 0.4083 1
Schistosoma mansoni hypothetical protein 0.0149 0.4083 1
Echinococcus granulosus neuropeptide s receptor 0.0149 0.4083 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0149 0.4083 0.3477
Brugia malayi hypothetical protein 0.0149 0.4083 0.346
Echinococcus granulosus alpha 1A adrenergic receptor 0.0149 0.4083 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0149 0.4083 0.346
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0149 0.4083 1
Brugia malayi Serotonin receptor 0.0149 0.4083 0.346
Echinococcus granulosus neuropeptide receptor 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Echinococcus granulosus orexin receptor type 2 0.0149 0.4083 1
Schistosoma mansoni amine GPCR 0.0149 0.4083 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0149 0.4083 1
Brugia malayi hypothetical protein 0.0149 0.4083 0.346
Giardia lamblia Hypothetical protein 0.0082 0.1035 0.5
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Echinococcus multilocularis neuropeptide receptor A26 0.0149 0.4083 1
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.0136 0.3524 0.3524
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Schistosoma mansoni amine GPCR 0.0149 0.4083 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0149 0.4083 1
Echinococcus multilocularis allatostatin A receptor 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.3524 0.2861
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0149 0.4083 1
Loa Loa (eye worm) CYP4Cod1 0.0278 1 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Echinococcus granulosus somatostatin receptor 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Echinococcus multilocularis neuropeptide s receptor 0.0149 0.4083 1
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0082 0.1035 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0198 0.6345 0.5971
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0149 0.4083 1
Echinococcus granulosus neuropeptides capa receptor 0.0149 0.4083 1
Echinococcus granulosus G protein coupled receptor 139 0.0149 0.4083 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0149 0.4083 1
Brugia malayi G protein-coupled receptor 0.0149 0.4083 0.346
Onchocerca volvulus 0.0149 0.4083 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.008 0.0952 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0149 0.4083 1
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.0139 0.3631 0.8556
Onchocerca volvulus 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Brugia malayi Cytochrome P450 family protein 0.0278 1 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.008 0.0952 0.0952
Echinococcus granulosus rhodopsin orphan GPCR 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Schistosoma mansoni biogenic amine receptor 0.0149 0.4083 1
Brugia malayi Dopamine receptor protein 2 0.0149 0.4083 0.346
Onchocerca volvulus 0.0149 0.4083 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0149 0.4083 0.3477
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0149 0.4083 1
Echinococcus granulosus tm gpcr rhodopsin 0.0149 0.4083 1
Brugia malayi hypothetical protein 0.0149 0.4083 0.346
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Brugia malayi neuropeptide F receptor 0.0149 0.4083 0.346
Echinococcus granulosus hypothetical protein 0.0149 0.4083 1
Schistosoma mansoni opsin-like receptor 0.0149 0.4083 1
Trypanosoma cruzi cytochrome P450, putative 0.0278 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0149 0.4083 1
Brugia malayi G-protein coupled receptor 0.0149 0.4083 0.346
Echinococcus granulosus tm gpcr rhodopsin 0.0149 0.4083 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0149 0.4083 1
Brugia malayi Dopamine receptor 0.0149 0.4083 0.346
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0149 0.4083 0.346
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.008 0.0952 0.5
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Schistosoma mansoni neuropeptide receptor 0.0149 0.4083 1
Echinococcus multilocularis orexin receptor type 2 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0149 0.4083 1
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0139 0.3631 0.3631
Echinococcus multilocularis g protein coupled receptor 0.0149 0.4083 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0149 0.4083 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0149 0.4083 1
Trypanosoma cruzi cytochrome P450, putative 0.0278 1 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0139 0.3631 0.3631
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.008 0.0952 0.5
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.008 0.0952 0.5
Schistosoma mansoni neuropeptide receptor 0.0149 0.4083 1
Echinococcus multilocularis neuropeptide receptor 0.0149 0.4083 1
Onchocerca volvulus 0.0149 0.4083 1
Onchocerca volvulus 0.0149 0.4083 1
Brugia malayi hypothetical protein 0.0149 0.4083 0.346
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Echinococcus multilocularis sex peptide receptor 0.0149 0.4083 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0149 0.4083 1
Onchocerca volvulus 0.0149 0.4083 1
Brugia malayi Melatonin receptor type 1A 0.0149 0.4083 0.346
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Schistosoma mansoni biogenic amine (5HT) receptor 0.0149 0.4083 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0278 1 1
Echinococcus multilocularis g protein coupled receptor 0.0149 0.4083 1
Loa Loa (eye worm) cytochrome P450 family protein 0.008 0.0952 0.0026
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0149 0.4083 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.008 0.0952 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0149 0.4083 0.3477
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0149 0.4083 1
Echinococcus granulosus sex peptide receptor 0.0149 0.4083 1
Mycobacterium ulcerans hypothetical protein 0.0082 0.1035 0.0092
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477
Echinococcus multilocularis dro:myosuppressin receptor 0.0149 0.4083 1
Brugia malayi hypothetical protein 0.0149 0.4083 0.346
Trypanosoma brucei cytochrome P450, putative 0.0278 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0149 0.4083 1
Brugia malayi putative neuropeptide receptor NPR1 0.0149 0.4083 0.346
Loa Loa (eye worm) cytochrome P450 0.008 0.0952 0.0026
Loa Loa (eye worm) TYRA-2 protein 0.0149 0.4083 0.3477
Echinococcus granulosus neuropeptide Y receptor 0.0149 0.4083 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0149 0.4083 0.3477
Echinococcus granulosus rhodopsin orphan GPCR 0.0149 0.4083 1
Echinococcus granulosus serotonin receptor 0.0149 0.4083 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.4083 0.3477

Activities

Activity type Activity value Assay description Source Reference
Concentration (functional) = 79 ng ml-1 Plasma concentration was determined after 30 min of oral administration of the compound in mice ChEMBL. 3656350
Concentration (functional) = 79 ng ml-1 Plasma concentration was determined after 30 min of oral administration of the compound in mice ChEMBL. 3656350
Concentration (functional) = 91 ng ml-1 Plasma concentration was determined after 120 min of oral administration of the compound in mice ChEMBL. 3656350
Concentration (functional) = 91 ng ml-1 Plasma concentration was determined after 120 min of oral administration of the compound in mice ChEMBL. 3656350
Concentration (functional) = 97 ng ml-1 Plasma concentration was determined after 60 min of oral administration of the compound in mice ChEMBL. 3656350
Concentration (functional) = 97 ng ml-1 Plasma concentration was determined after 60 min of oral administration of the compound in mice ChEMBL. 3656350
ED50 (functional) = 4.5 mg kg-1 Antagonistic activity against MES (Maximal Elecroshock)-induced seizures after oral administration to mice ChEMBL. 3656350
ED50 (functional) = 4.5 mg kg-1 Antagonistic activity against MES (Maximal Elecroshock)-induced seizures after oral administration to mice ChEMBL. 3656350
ED50 (functional) = 56 mg kg-1 Ataxia or neurological deficit was measured as horizontal screen test(HS) in mice ChEMBL. 3656350
ED50 (functional) = 56 mg kg-1 Ataxia or neurological deficit was measured as horizontal screen test(HS) in mice ChEMBL. 3656350
TPE (functional) = 1 hr Time taken for peak anticonvulsant effect(TPE) was measured by oral administration to mice ChEMBL. 3656350
TPE (functional) = 1 hr Time taken for peak anticonvulsant effect(TPE) was measured by oral administration to mice ChEMBL. 3656350

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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