TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 310.39 | Formula: C19H22N2O2
H donors: 2 H acceptors: 2 LogP: 3.39 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)Nc1c(C)cc(cc1C)C(=O)Nc1c(C)cccc1C
InChi: 1S/C19H22N2O2/c1-11-7-6-8-12(2)17(11)21-19(23)16-9-13(3)18(14(4)10-16)20-15(5)22/h6-10H,1-5H3,(H,20,22)(H,21,23)
InChiKey: GYNOAXJQOMEJDD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	orexin receptor type 2	0.0149	0.4083	1
Schistosoma mansoni	neuropeptide receptor	0.0149	0.4083	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0149	0.4083	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0149	0.4083	0.346
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.008	0.0952	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0149	0.4083	1
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0139	0.3631	0.3631
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0149	0.4083	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Schistosoma mansoni	opsin-like receptor	0.0149	0.4083	1
Brugia malayi	neuropeptide F receptor	0.0149	0.4083	0.346
Echinococcus granulosus	hypothetical protein	0.0149	0.4083	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0149	0.4083	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0149	0.4083	1
Brugia malayi	hypothetical protein	0.0149	0.4083	0.346
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0149	0.4083	0.3477
Echinococcus granulosus	tm gpcr rhodopsin	0.0149	0.4083	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0149	0.4083	1
Brugia malayi	Dopamine receptor	0.0149	0.4083	0.346
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0149	0.4083	1
Brugia malayi	G-protein coupled receptor	0.0149	0.4083	0.346
Trypanosoma cruzi	cytochrome P450, putative	0.0278	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0149	0.4083	1
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.008	0.0952	0.0952
Brugia malayi	Cytochrome P450 family protein	0.0278	1	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Brugia malayi	Dopamine receptor protein 2	0.0149	0.4083	0.346
Onchocerca volvulus		0.0149	0.4083	1
Schistosoma mansoni	biogenic amine receptor	0.0149	0.4083	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Echinococcus granulosus	G protein coupled receptor 139	0.0149	0.4083	1
Echinococcus granulosus	neuropeptides capa receptor	0.0149	0.4083	1
Onchocerca volvulus		0.0149	0.4083	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Echinococcus multilocularis	6 phosphofructo 2 kinase:fructose 2	0.0139	0.3631	0.8556
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0149	0.4083	1
Brugia malayi	G protein-coupled receptor	0.0149	0.4083	0.346
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0149	0.4083	1
Onchocerca volvulus		0.0149	0.4083	1
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.008	0.0952	0.5
Trypanosoma brucei	cytochrome P450, putative	0.0278	1	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Echinococcus multilocularis	dro:myosuppressin receptor	0.0149	0.4083	1
Brugia malayi	hypothetical protein	0.0149	0.4083	0.346
Mycobacterium ulcerans	hypothetical protein	0.0082	0.1035	0.0092
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0149	0.4083	1
Echinococcus granulosus	sex peptide receptor	0.0149	0.4083	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0149	0.4083	0.3477
Echinococcus granulosus	rhodopsin orphan GPCR	0.0149	0.4083	1
Loa Loa (eye worm)	TYRA-2 protein	0.0149	0.4083	0.3477
Loa Loa (eye worm)	cytochrome P450	0.008	0.0952	0.0026
Echinococcus granulosus	neuropeptide Y receptor	0.0149	0.4083	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Echinococcus granulosus	serotonin receptor	0.0149	0.4083	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0149	0.4083	0.346
Echinococcus multilocularis	neuropeptide Y receptor	0.0149	0.4083	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0149	0.4083	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.008	0.0952	0.0026
Loa Loa (eye worm)	neuropeptide F receptor	0.0149	0.4083	0.3477
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.008	0.0952	0.5
Onchocerca volvulus		0.0149	0.4083	1
Brugia malayi	Melatonin receptor type 1A	0.0149	0.4083	0.346
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0149	0.4083	1
Echinococcus multilocularis	sex peptide receptor	0.0149	0.4083	1
Onchocerca volvulus		0.0149	0.4083	1
Brugia malayi	hypothetical protein	0.0149	0.4083	0.346
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Echinococcus multilocularis	g protein coupled receptor	0.0149	0.4083	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0149	0.4083	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0278	1	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Trypanosoma cruzi	cytochrome P450, putative	0.0278	1	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0149	0.4083	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0149	0.4083	1
Onchocerca volvulus		0.0149	0.4083	1
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.008	0.0952	0.5
Schistosoma mansoni	neuropeptide receptor	0.0149	0.4083	1
Echinococcus multilocularis	neuropeptide receptor	0.0149	0.4083	1
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.008	0.0952	0.5
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0139	0.3631	0.3631
Brugia malayi	larval opioid receptor	0.0149	0.4083	0.346
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.008	0.0952	0.5
Brugia malayi	hypothetical protein	0.0149	0.4083	0.346
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Onchocerca volvulus		0.0149	0.4083	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0149	0.4083	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.008	0.0952	0.5
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Echinococcus granulosus	6 phosphofructo 2 kinase:fructose 2	0.0139	0.3631	0.8556
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.008	0.0952	0.5
Schistosoma mansoni	neuropeptide receptor	0.0149	0.4083	1
Echinococcus multilocularis	somatostatin receptor	0.0149	0.4083	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0149	0.4083	1
Echinococcus granulosus	g protein coupled receptor	0.0149	0.4083	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0149	0.4083	0.346
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Brugia malayi	sulfakinin receptor protein	0.0149	0.4083	0.346
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0149	0.4083	1
Onchocerca volvulus		0.0149	0.4083	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0149	0.4083	0.346
Brugia malayi	RE15519p	0.0149	0.4083	0.346
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.008	0.0952	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0149	0.4083	1
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.008	0.0952	0.5
Brugia malayi	hypothetical protein	0.0149	0.4083	0.346
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0149	0.4083	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0149	0.4083	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0149	0.4083	0.346
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0149	0.4083	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0149	0.4083	1
Echinococcus multilocularis	fmrfamide receptor	0.0149	0.4083	1
Onchocerca volvulus		0.0149	0.4083	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0149	0.4083	1
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.008	0.0952	0.5
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0149	0.4083	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Echinococcus granulosus	somatostatin receptor	0.0149	0.4083	1
Loa Loa (eye worm)	CYP4Cod1	0.0278	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0149	0.4083	1
Loa Loa (eye worm)	hypothetical protein	0.0136	0.3524	0.2861
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0149	0.4083	1
Loa Loa (eye worm)	hypothetical protein	0.0198	0.6345	0.5971
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Echinococcus multilocularis	neuropeptide s receptor	0.0149	0.4083	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0149	0.4083	1
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0082	0.1035	0.5
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0149	0.4083	1
Schistosoma mansoni	amine GPCR	0.0149	0.4083	1
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.0136	0.3524	0.3524
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Echinococcus multilocularis	allatostatin A receptor	0.0149	0.4083	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0149	0.4083	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0149	0.4083	1
Schistosoma mansoni	amine GPCR	0.0149	0.4083	1
Echinococcus granulosus	orexin receptor type 2	0.0149	0.4083	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Echinococcus multilocularis	neuropeptide receptor A26	0.0149	0.4083	1
Giardia lamblia	Hypothetical protein	0.0082	0.1035	0.5
Brugia malayi	hypothetical protein	0.0149	0.4083	0.346
Brugia malayi	hypothetical protein	0.0149	0.4083	0.346
Echinococcus granulosus	neuropeptide s receptor	0.0149	0.4083	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0149	0.4083	0.3477
Schistosoma mansoni	opsin-like receptor	0.0149	0.4083	1
Schistosoma mansoni	hypothetical protein	0.0149	0.4083	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Echinococcus granulosus	neuropeptide receptor	0.0149	0.4083	1
Brugia malayi	Serotonin receptor	0.0149	0.4083	0.346
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0149	0.4083	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0149	0.4083	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0149	0.4083	0.346
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0149	0.4083	1
Mycobacterium leprae	putative cytochrome p450	0.008	0.0952	0.5
Schistosoma mansoni	biogenic amine receptor	0.0149	0.4083	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.008	0.0952	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0149	0.4083	1
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0139	0.3631	0.3631
Echinococcus multilocularis	neuropeptide receptor	0.0149	0.4083	1
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.008	0.0952	0.0952
Leishmania major	cytochrome p450-like protein	0.0278	1	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0149	0.4083	1
Onchocerca volvulus		0.0149	0.4083	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0149	0.4083	1
Giardia lamblia	Hypothetical protein	0.0082	0.1035	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0149	0.4083	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0149	0.4083	1
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.008	0.0952	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0149	0.4083	1
Brugia malayi	Serotonin receptor	0.0149	0.4083	0.346
Echinococcus granulosus	neuropeptides capa receptor	0.0149	0.4083	1
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.008	0.0952	0.0952
Echinococcus granulosus	rhodopsin orphan GPCR	0.0149	0.4083	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0149	0.4083	0.3477
Trypanosoma brucei	6-phosphofructo-2-kinase 2	0.0136	0.3524	0.3524
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.0136	0.3524	0.3524
Onchocerca volvulus		0.0149	0.4083	1
Brugia malayi	neuropeptide F receptor	0.0149	0.4083	0.346
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0149	0.4083	0.3477
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0149	0.4083	1
Leishmania major	cytochrome p450-like protein	0.008	0.0952	0.0952
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0149	0.4083	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0149	0.4083	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0149	0.4083	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0149	0.4083	1
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.008	0.0952	0.0952
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.008	0.0952	0.0952
Brugia malayi	follicle stimulating hormone receptor	0.0149	0.4083	0.346
Echinococcus granulosus	biogenic amine 5HT receptor	0.0149	0.4083	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0149	0.4083	1
Brugia malayi	AKH receptor	0.0149	0.4083	0.346
Schistosoma mansoni	amine GPCR	0.0149	0.4083	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Schistosoma mansoni	hypothetical protein	0.0149	0.4083	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0149	0.4083	1
Echinococcus granulosus	neuropeptide Y receptor	0.0149	0.4083	1
Onchocerca volvulus		0.0149	0.4083	1
Schistosoma mansoni	histamine h1 receptor	0.0149	0.4083	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Echinococcus multilocularis	neuropeptides capa receptor	0.0149	0.4083	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0278	1	1
Brugia malayi	hypothetical protein	0.0149	0.4083	0.346
Echinococcus granulosus	g protein coupled receptor	0.0149	0.4083	1
Echinococcus granulosus	neuropeptide receptor	0.0149	0.4083	1
Onchocerca volvulus		0.0149	0.4083	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0149	0.4083	1
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0278	1	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0149	0.4083	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0149	0.4083	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Echinococcus granulosus	rhodopsin orphan GPCR	0.0149	0.4083	1
Schistosoma mansoni	hypothetical protein	0.0149	0.4083	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0149	0.4083	1
Onchocerca volvulus		0.0149	0.4083	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0149	0.4083	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0149	0.4083	1
Mycobacterium leprae	Conserved hypothetical protein	0.008	0.0952	0.5
Brugia malayi	G-protein coupled receptor	0.0149	0.4083	0.346
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0149	0.4083	1
Brugia malayi	GnHR receptor homolog	0.0149	0.4083	0.346
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.008	0.0952	0.5
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0149	0.4083	1
Echinococcus multilocularis	g-protein coupled receptor	0.0149	0.4083	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0149	0.4083	1
Onchocerca volvulus		0.0149	0.4083	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0149	0.4083	1
Echinococcus multilocularis	fmrfamide receptor	0.0149	0.4083	1
Leishmania major	cytochrome p450-like protein	0.008	0.0952	0.0952
Echinococcus granulosus	neuropeptide FF receptor 2	0.0149	0.4083	1
Echinococcus granulosus	g protein coupled receptor	0.0149	0.4083	1
Mycobacterium ulcerans	fructose-2,6-bisphosphatase GpmB	0.0082	0.1035	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3631	0.2979
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.008	0.0952	0.5
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Schistosoma mansoni	hypothetical protein	0.0149	0.4083	1
Schistosoma mansoni	amine GPCR	0.0149	0.4083	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0149	0.4083	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0149	0.4083	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0149	0.4083	1
Brugia malayi	hypothetical protein	0.0149	0.4083	0.346
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0149	0.4083	1
Onchocerca volvulus		0.0149	0.4083	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0149	0.4083	0.346
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0149	0.4083	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0149	0.4083	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0149	0.4083	1
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.008	0.0952	0.5
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0149	0.4083	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0149	0.4083	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0149	0.4083	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0149	0.4083	1
Schistosoma mansoni	adenoreceptor	0.0149	0.4083	1
Toxoplasma gondii	cytochrome p450 superfamily protein	0.008	0.0952	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0149	0.4083	1
Echinococcus multilocularis	serotonin receptor	0.0149	0.4083	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0149	0.4083	1
Schistosoma mansoni	6-phosphofructokinase	0.0139	0.3631	0.8556
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.008	0.0952	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0149	0.4083	1
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0139	0.3631	0.3631
Echinococcus granulosus	7TM GPCR rhodopsin	0.0149	0.4083	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0149	0.4083	1
Onchocerca volvulus		0.0149	0.4083	1
Brugia malayi	putative neuropeptide receptor	0.0149	0.4083	0.346
Schistosoma mansoni	opsin-like receptor	0.0149	0.4083	1
Brugia malayi	Dopamine receptor protein 1	0.0149	0.4083	0.346
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0149	0.4083	0.3477
Loa Loa (eye worm)	G-protein coupled receptor	0.0149	0.4083	0.3477
Echinococcus granulosus	fmrfamide receptor	0.0149	0.4083	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0149	0.4083	1
Brugia malayi	hypothetical protein	0.0149	0.4083	0.346
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0136	0.3524	0.3524
Schistosoma mansoni	biogenic amine receptor	0.0149	0.4083	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0149	0.4083	1
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.008	0.0952	0.5
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.008	0.0952	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0149	0.4083	0.3477
Echinococcus granulosus	neuropeptide receptor A26	0.0149	0.4083	1
Schistosoma mansoni	amine GPCR	0.0149	0.4083	1
Schistosoma mansoni	myosin xvIII	0.0149	0.4083	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0149	0.4083	0.346
Echinococcus granulosus	dro:myosuppressin receptor	0.0149	0.4083	1
Schistosoma mansoni	neuropeptide receptor	0.0149	0.4083	1
Echinococcus granulosus	g-protein coupled receptor	0.0149	0.4083	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0149	0.4083	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0149	0.4083	1
Echinococcus granulosus	allatostatin A receptor	0.0149	0.4083	1
Brugia malayi	ORL1-like opioid receptor	0.0149	0.4083	0.346
Echinococcus multilocularis	serotonin receptor	0.0149	0.4083	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0149	0.4083	0.3477
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.008	0.0952	0.5
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4083	0.3477

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	0 mg kg-1	Ataxia or neurological deficit was measured as horizontal screen test(HS) in mice at a dose of 160 mg/kg; NA means Not active	ChEMBL.	3656350
ED50 (functional)	= 170 mg kg-1	Antagonistic activity against MES (Maximal Elecroshock)-induced seizures after oral administration to mice	ChEMBL.	3656350
ED50 (functional)	= 170 mg kg-1	Antagonistic activity against MES (Maximal Elecroshock)-induced seizures after oral administration to mice	ChEMBL.	3656350
TPE (functional)	= 2 hr	Time taken for peak anticonvulsant effect(TPE) was measured by oral administration to mice	ChEMBL.	3656350
TPE (functional)	= 2 hr	Time taken for peak anticonvulsant effect(TPE) was measured by oral administration to mice	ChEMBL.	3656350

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL45517

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 69025