Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.3625 | 0.3625 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.002 | 0.3625 | 0.3625 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.002 | 0.3625 | 0.3625 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.002 | 0.3625 | 0.3625 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.3625 | 0.3625 |
Brugia malayi | nuclear receptor NHR-88 | 0.002 | 0.3625 | 0.3625 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.002 | 0.3625 | 0.3625 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 1 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.002 | 0.3625 | 0.3625 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.3625 | 0.3625 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.002 | 0.3625 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.3625 | 0.3625 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.002 | 0.3625 | 0.3625 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0036 | 1 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.002 | 0.3625 | 0.3625 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.002 | 0.3625 | 0.3625 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0036 | 1 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.002 | 0.3625 | 0.3625 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.002 | 0.3625 | 0.3625 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.002 | 0.3625 | 0.3625 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.002 | 0.3625 | 0.3625 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.3625 | 0.3625 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0036 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.002 | 0.3625 | 0.3625 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.3625 | 0.3625 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.002 | 0.3625 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.002 | 0.3625 | 0.3625 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0036 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 1 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0036 | 1 | 1 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0036 | 1 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0036 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.002 | 0.3625 | 0.3625 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.002 | 0.3625 | 0.3625 |
Loa Loa (eye worm) | steroid hormone receptor | 0.002 | 0.3625 | 0.3625 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.002 | 0.3625 | 0.3625 |
Onchocerca volvulus | Bile acid receptor homolog | 0.002 | 0.3625 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.3625 | 0.3625 |
Echinococcus granulosus | FTZ F1 alpha | 0.002 | 0.3625 | 0.3625 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.002 | 0.3625 | 0.3625 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.002 | 0.3625 | 0.3625 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.002 | 0.3625 | 0.3625 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0036 | 1 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.3625 | 0.3625 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 1 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.002 | 0.3625 | 0.3625 |
Brugia malayi | ecdysteroid receptor | 0.002 | 0.3625 | 0.3625 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.002 | 0.3625 | 0.3625 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.3625 | 0.3625 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.002 | 0.3625 | 0.3625 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.3625 | 0.3625 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.002 | 0.3625 | 0.3625 |
Echinococcus multilocularis | FTZ F1 alpha | 0.002 | 0.3625 | 0.3625 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.3625 | 0.3625 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.002 | 0.3625 | 0.3625 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.3625 | 0.3625 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.002 | 0.3625 | 0.3625 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.002 | 0.3625 | 0.3625 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.002 | 0.3625 | 0.3625 |
Schistosoma mansoni | nuclear hormone receptor | 0.002 | 0.3625 | 0.3625 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.3625 | 0.3625 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.3625 | 0.3625 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0036 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.3625 | 0.3625 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.002 | 0.3625 | 0.3625 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0036 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.002 | 0.3625 | 0.3625 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.3625 | 0.3625 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.3625 | 0.3625 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.3625 | 0.3625 |
Onchocerca volvulus | 0.002 | 0.3625 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.3625 | 0.3625 |
Schistosoma mansoni | coup transcription factor | 0.002 | 0.3625 | 0.3625 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0036 | 1 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.3625 | 0.3625 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.3625 | 0.3625 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 1 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.3625 | 0.3625 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.002 | 0.3625 | 0.3625 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0036 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.002 | 0.3625 | 0.3625 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.3625 | 0.3625 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.002 | 0.3625 | 0.3625 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.002 | 0.3625 | 0.3625 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.3625 | 0.3625 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0036 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.002 | 0.3625 | 0.3625 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.002 | 0.3625 | 0.3625 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 150 uM | Tested for inhibitory activity against Topoisomerase II isolated from HeLa cells by using SDS-K+ precipitation method | ChEMBL. | No reference |
EC50 (binding) | = 150 uM | Tested for inhibitory activity against Topoisomerase II isolated from HeLa cells by using SDS-K+ precipitation method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.