Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0431 | 0.0431 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0431 | 0.0431 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0431 | 0.0431 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0431 | 0.0431 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0431 | 0.0431 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.2676 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0431 | 0.1612 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0231 | 0.0864 |
Brugia malayi | Smad1 | 0.0008 | 0.0231 | 0.0231 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0431 | 0.1612 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0431 | 0.0431 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0431 | 0.1612 |
Brugia malayi | hypothetical protein | 0.0035 | 0.2676 | 0.2676 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0431 | 0.0431 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.2676 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0431 | 0.1612 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0431 | 0.1612 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0431 | 0.1612 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0431 | 0.1612 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0431 | 0.1612 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0231 | 0.0864 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0431 | 0.0431 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.0231 | 0.0864 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0431 | 0.0431 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0231 | 0.0864 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0231 | 0.0231 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0431 | 0.0431 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0431 | 0.1612 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0431 | 0.1612 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0431 | 0.0431 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0431 | 0.0431 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0431 | 0.0431 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0431 | 0.0431 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0431 | 0.1612 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0431 | 0.1612 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0431 | 0.0431 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0431 | 0.0431 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0431 | 0.1612 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.2676 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0431 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0431 | 0.1612 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0431 | 0.1612 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0431 | 0.0431 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0431 | 0.0431 |
Echinococcus granulosus | smad | 0.0008 | 0.0231 | 0.0864 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0431 | 0.1612 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0231 | 0.0231 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0431 | 0.0431 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0431 | 0.1612 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.2676 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.2676 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0431 | 0.1612 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0431 | 0.0431 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0431 | 0.0431 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0431 | 0.0431 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.0231 | 0.0864 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0431 | 0.1612 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0431 | 0.1612 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0431 | 0.0431 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0231 | 0.0864 |
Onchocerca volvulus | 0.001 | 0.0431 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.2676 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0431 | 0.0431 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.2676 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0231 | 0.0231 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0431 | 0.0431 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0431 | 0.1612 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0431 | 0.0431 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0431 | 0.1612 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0231 | 0.0231 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0231 | 0.0864 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0431 | 0.0431 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0431 | 0.0431 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0431 | 0.0431 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.0231 | 0.0864 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0231 | 0.0231 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0431 | 0.0431 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0431 | 0.0431 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0431 | 0.0431 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0431 | 0.1612 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.2676 | 1 |
Echinococcus multilocularis | smad | 0.0008 | 0.0231 | 0.0864 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0431 | 0.0431 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0231 | 0.0231 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0431 | 0.0431 |
Schistosoma mansoni | smad | 0.0008 | 0.0231 | 0.0864 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0431 | 0.1612 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0431 | 0.1612 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.0231 | 0.0864 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0431 | 0.1612 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0431 | 0.1612 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.0231 | 0.0864 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.0231 | 0.0864 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0431 | 0.1612 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0431 | 0.1612 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0431 | 0.0431 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0431 | 0.1612 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0431 | 0.1612 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0431 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0431 | 0.0431 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0431 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0231 | 0.0231 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.