Detailed information for compound 690938

Basic information

Technical information
  • TDR Targets ID: 690938
  • Name: N-[5-(1,1-dioxo-1,2-thiazolidin-2-yl)-2-methy lphenyl]-2-methylbenzamide
  • MW: 344.428 | Formula: C18H20N2O3S
  • H donors: 1 H acceptors: 3 LogP: 2.77 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1NC(=O)c1ccccc1C)N1CCCS1(=O)=O
  • InChi: 1S/C18H20N2O3S/c1-13-6-3-4-7-16(13)18(21)19-17-12-15(9-8-14(17)2)20-10-5-11-24(20,22)23/h3-4,6-9,12H,5,10-11H2,1-2H3,(H,19,21)
  • InChiKey: LWGSAPIMRWDJAB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[5-(1,1-dioxo-1,2-thiazolidin-2-yl)-2-methyl-phenyl]-2-methyl-benzamide
  • N-[5-(1,1-diketo-1,2-thiazolidin-2-yl)-2-methyl-phenyl]-2-methyl-benzamide
  • ZINC05339258

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0705 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.5637 0.5637
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.3815 0.3815
Loa Loa (eye worm) hypothetical protein 0.002 0.0705 0.0705
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.5637 0.5637
Schistosoma mansoni tar DNA-binding protein 0.0068 1 1
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0705 0.5
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0705 0.5
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.0705 0.0705
Brugia malayi TAR-binding protein 0.0068 1 1
Schistosoma mansoni hypothetical protein 0.0036 0.3848 0.3848
Loa Loa (eye worm) hypothetical protein 0.0036 0.3848 0.3848
Entamoeba histolytica hypothetical protein 0.0036 0.3815 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.5637 0.5637
Entamoeba histolytica hypothetical protein 0.0036 0.3815 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.7163 0.7163
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0705 0.5
Schistosoma mansoni tar DNA-binding protein 0.0068 1 1
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0705 0.0705
Schistosoma mansoni DNA ligase IV 0.002 0.0705 0.0705
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.0705 0.5
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0705 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.5637 0.5637
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.5637 0.5637
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0705 0.5
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0705 0.5
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.0705 0.0705
Brugia malayi hypothetical protein 0.002 0.0705 0.0705
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0705 0.5
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0705 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.7163 0.7163
Echinococcus granulosus tar DNA binding protein 0.0068 1 1
Schistosoma mansoni tar DNA-binding protein 0.0068 1 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0705 0.5
Loa Loa (eye worm) TAR-binding protein 0.0068 1 1
Schistosoma mansoni tar DNA-binding protein 0.0068 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.3815 0.3815
Loa Loa (eye worm) hypothetical protein 0.0053 0.7163 0.7163
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0705 0.0705
Entamoeba histolytica hypothetical protein 0.0036 0.3815 1
Brugia malayi DKFZp564C0469 protein 0.002 0.0705 0.0705
Loa Loa (eye worm) hypothetical protein 0.002 0.0705 0.0705
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.002 0.0705 0.5
Echinococcus multilocularis nibrin 0.002 0.0705 0.0705
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.002 0.0705 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.7163 0.7163
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.5637 0.5637
Loa Loa (eye worm) hypothetical protein 0.002 0.0705 0.0705
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.3815 0.3815
Schistosoma mansoni topbp1 0.002 0.0705 0.0705
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0705 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0705 0.0705
Chlamydia trachomatis DNA ligase 0.002 0.0705 0.5
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.0705 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0705 0.0705
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.5637 0.5637
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.0705 0.5
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0705 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0705 0.0705
Brugia malayi RNA recognition motif domain containing protein 0.0068 1 1
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0705 0.5
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.002 0.0705 0.5
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.0705 0.5
Onchocerca volvulus 0.002 0.0705 0.5
Brugia malayi hypothetical protein 0.0036 0.3815 0.3815
Echinococcus multilocularis tar DNA binding protein 0.0068 1 1
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0705 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.3848 0.3848
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.5637 0.5637
Schistosoma mansoni topbp1 0.002 0.0705 0.0705
Giardia lamblia Replication factor C, subunit 1 0.002 0.0705 0.5
Entamoeba histolytica hypothetical protein 0.0036 0.3815 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0705 0.5
Echinococcus granulosus replication factor c subunit 1 0.002 0.0705 0.0705
Schistosoma mansoni hypothetical protein 0.0036 0.3815 0.3815
Schistosoma mansoni tar DNA-binding protein 0.0068 1 1
Echinococcus granulosus nibrin 0.002 0.0705 0.0705
Treponema pallidum DNA ligase (lig) 0.002 0.0705 0.5
Brugia malayi topoisomerase 0.002 0.0705 0.0705
Brugia malayi hypothetical protein 0.002 0.0705 0.0705
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.5637 0.5637
Loa Loa (eye worm) RNA binding protein 0.0068 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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