Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0039 | 0.2824 | 0.2824 |
Echinococcus granulosus | dna polymerase kappa | 0.0022 | 0.1298 | 0.1984 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0323 | 0.0495 |
Echinococcus granulosus | dna polymerase eta | 0.0022 | 0.1298 | 0.1984 |
Echinococcus multilocularis | chromobox protein 1 | 0.0079 | 0.6539 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0022 | 0.1298 | 0.3547 |
Brugia malayi | Valyl-tRNA synthetase | 0.0013 | 0.0459 | 0.0459 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0031 | 0.2154 | 0.2789 |
Echinococcus granulosus | chromobox protein 1 | 0.0079 | 0.6539 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3344 | 0.3344 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0022 | 0.1298 | 0.1298 |
Trichomonas vaginalis | chromobox protein, putative | 0.0079 | 0.6539 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0323 | 0.0495 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.1298 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1298 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.2824 | 1 |
Brugia malayi | hypothetical protein | 0.0013 | 0.0459 | 0.0459 |
Echinococcus multilocularis | dna polymerase kappa | 0.0022 | 0.1298 | 0.1984 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0323 | 0.0323 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.3912 | 0.5983 |
Echinococcus granulosus | chromobox protein 1 | 0.0079 | 0.6539 | 1 |
Brugia malayi | Type III restriction enzyme, res subunit family protein | 0.0013 | 0.0459 | 0.0459 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0459 | 0.0459 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.3912 | 0.5983 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0323 | 0.0495 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1298 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0323 | 0.0495 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0323 | 0.0323 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.3344 | 0.4746 |
Onchocerca volvulus | 0.0035 | 0.2464 | 0.6427 | |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.3344 | 0.9071 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.3912 | 0.3912 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.0323 | 0.0323 |
Onchocerca volvulus | 0.0013 | 0.0459 | 0.0406 | |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0022 | 0.1298 | 0.1984 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.1298 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0022 | 0.1298 | 0.1984 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0022 | 0.1298 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0022 | 0.1298 | 0.1298 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.1298 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0323 | 0.0323 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0323 | 0.0495 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0323 | 0.0323 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0022 | 0.1298 | 1 |
Echinococcus granulosus | chromodomain helicase DNA binding protein 1 | 0.0013 | 0.0459 | 0.0702 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0022 | 0.1298 | 0.138 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.1246 | 0.1246 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0323 | 0.0495 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0323 | 0.0495 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.0323 | 0.0323 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0031 | 0.2154 | 0.2789 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0323 | 0.0323 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.3912 | 0.5983 |
Brugia malayi | Heterochromatin protein 1 | 0.0079 | 0.6539 | 0.6539 |
Trichomonas vaginalis | chromobox protein, putative | 0.0079 | 0.6539 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0079 | 0.6539 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0079 | 0.6539 | 0.6539 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0323 | 0.0323 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.1246 | 0.1905 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0022 | 0.1298 | 0.1298 |
Brugia malayi | Associated with TFs and helicases family protein | 0.0013 | 0.0459 | 0.0459 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.3912 | 0.3912 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0459 | 0.0459 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.0323 | 0.0323 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0013 | 0.0459 | 0.0702 |
Echinococcus granulosus | chromodomain helicase DNA binding protein 4 | 0.0013 | 0.0459 | 0.0702 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.0323 | 0.0495 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.1246 | 0.9179 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0022 | 0.1298 | 0.1984 |
Echinococcus multilocularis | dna polymerase eta | 0.0022 | 0.1298 | 0.1984 |
Schistosoma mansoni | chromobox protein | 0.0079 | 0.6539 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0323 | 0.0495 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0323 | 0.0495 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1298 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.1246 | 0.1295 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0022 | 0.1298 | 0.138 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0323 | 0.0495 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.0323 | 0.0495 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.2464 | 0.2464 |
Echinococcus multilocularis | chromodomain helicase DNA binding protein 4 | 0.0013 | 0.0459 | 0.0702 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.3912 | 0.5983 |
Echinococcus multilocularis | Chromo domain | 0.0013 | 0.0459 | 0.0702 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0323 | 0.0323 |
Trichomonas vaginalis | chromobox protein, putative | 0.0048 | 0.3653 | 0.5254 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.0323 | 0.0495 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0459 | 0.0459 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0022 | 0.1298 | 0.1984 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0323 | 0.0495 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0323 | 0.0495 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.1298 | 1 |
Loa Loa (eye worm) | CHromoDomain protein family member | 0.0013 | 0.0459 | 0.0459 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.0323 | 0.0495 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0323 | 0.0495 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0323 | 0.0323 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1298 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.2824 | 0.4319 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0323 | 0.0323 |
Schistosoma mansoni | chromodomain helicase DNA binding protein | 0.0013 | 0.0459 | 0.0702 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0048 | 0.3653 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0323 | 0.0323 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0323 | 0.0323 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.1246 | 1 |
Onchocerca volvulus | 0.0013 | 0.0459 | 0.0406 | |
Schistosoma mansoni | chromobox protein-related (chromobox 1) (heterochromatin 1) | 0.0013 | 0.0459 | 0.0702 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1298 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1298 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0323 | 0.0323 |
Leishmania major | DNA polymerase kappa, putative | 0.0022 | 0.1298 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.1298 | 1 |
Brugia malayi | Protein cec-1. | 0.0013 | 0.0459 | 0.0459 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0323 | 0.0495 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.1246 | 0.1905 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1298 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0022 | 0.1298 | 1 |
Brugia malayi | M-phase phosphoprotein, mpp8 | 0.0013 | 0.0459 | 0.0459 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0323 | 0.0323 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0022 | 0.1298 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0459 | 0.0702 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1298 | 0.1298 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.3344 | 0.4746 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.3912 | 0.5983 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0323 | 0.0323 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.1246 | 0.5 |
Schistosoma mansoni | chromodomain helicase DNA binding protein | 0.0013 | 0.0459 | 0.0702 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0323 | 0.0323 |
Echinococcus multilocularis | chromodomain helicase DNA binding protein 1 | 0.0013 | 0.0459 | 0.0702 |
Echinococcus granulosus | Chromo domain | 0.0013 | 0.0459 | 0.0702 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0323 | 0.0495 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0022 | 0.1298 | 0.1984 |
Echinococcus granulosus | chromobox protein 2 | 0.0013 | 0.0459 | 0.0702 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.1298 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0022 | 0.1298 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.2824 | 1 |
Echinococcus multilocularis | chromobox protein 2 | 0.0013 | 0.0459 | 0.0702 |
Brugia malayi | chromobox protein homolog 3 | 0.0044 | 0.3344 | 0.3344 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0323 | 0.0323 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.1246 | 0.1246 |
Brugia malayi | CHD4 protein | 0.0013 | 0.0459 | 0.0459 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0323 | 0.0495 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.0323 | 0.0323 |
Trichomonas vaginalis | chromobox protein, putative | 0.0048 | 0.3653 | 0.5254 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0323 | 0.0495 |
Giardia lamblia | DINP protein human, muc B family | 0.0022 | 0.1298 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.2824 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0323 | 0.0495 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.0323 | 0.0323 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0323 | 0.0323 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.2824 | 0.4319 |
Schistosoma mansoni | chromobox protein | 0.0079 | 0.6539 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.0323 | 0.0495 |
Brugia malayi | SET domain containing protein | 0.0013 | 0.0459 | 0.0459 |
Echinococcus granulosus | Chromobox protein 3 | 0.0013 | 0.0459 | 0.0702 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.0323 | 0.0495 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1298 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0323 | 0.0495 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.0323 | 0.0323 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.2824 | 0.4319 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0323 | 0.0495 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0323 | 0.0495 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0323 | 0.0323 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0323 | 0.0323 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.1246 | 0.1295 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.1246 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1298 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0323 | 0.0323 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0022 | 0.1298 | 1 |
Loa Loa (eye worm) | helicase | 0.0013 | 0.0459 | 0.0459 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0323 | 0.0495 |
Schistosoma mansoni | chromobox protein | 0.0013 | 0.0459 | 0.0702 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.1246 | 0.3328 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0459 | 0.0459 |
Echinococcus multilocularis | Chromobox protein 3 | 0.0013 | 0.0459 | 0.0702 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.2824 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0323 | 0.0323 |
Schistosoma mansoni | chromobox protein-related (chromobox 1) (heterochromatin 1) | 0.0013 | 0.0459 | 0.0702 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.1298 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.1298 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1298 | 1 |
Schistosoma mansoni | chromobox protein | 0.0013 | 0.0459 | 0.0702 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.0323 | 0.0323 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.2824 | 0.4319 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.1298 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.3912 | 0.5983 |
Trypanosoma brucei | unspecified product | 0.0022 | 0.1298 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.0323 | 0.0495 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0323 | 0.0323 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.3912 | 0.5983 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.1246 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0459 | 0.0459 |
Onchocerca volvulus | 0.0013 | 0.0459 | 0.0406 | |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0459 | 0.0459 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.1246 | 0.1905 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.1246 | 0.1905 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.1246 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.0323 | 0.0495 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0323 | 0.0495 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0459 | 0.0459 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.