Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.0109 | 0.4973 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.4973 | 0.4973 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0963 | 0.0963 |
Echinococcus multilocularis | carbonic anhydrase | 0.0109 | 0.4973 | 0.4973 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0202 | 1 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.2413 | 0.2413 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0203 | 0.0203 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0202 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0109 | 0.4973 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0143 | 0.0143 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0109 | 0.4973 | 0.4973 |
Echinococcus granulosus | muscleblind protein | 0.0156 | 0.7486 | 0.7486 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0202 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0202 | 1 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0311 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.4973 | 0.4973 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0109 | 0.4973 | 0.4739 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1855 | 0.1477 |
Schistosoma mansoni | carbonic anhydrase | 0.0109 | 0.4973 | 0.4973 |
Brugia malayi | Muscleblind-like protein | 0.0156 | 0.7486 | 0.7369 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.2413 | 0.2413 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1855 | 0.1855 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.1068 | 0.1068 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0109 | 0.4973 | 0.4739 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0202 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0109 | 0.4973 | 0.4973 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0202 | 1 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0203 | 0.0203 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.1068 | 0.1068 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0202 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0963 | 0.0543 |
Echinococcus multilocularis | carbonic anhydrase | 0.0109 | 0.4973 | 0.4973 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0109 | 0.4973 | 0.4739 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.1202 | 0.0793 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.7486 | 0.7486 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0035 | 0.0035 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0963 | 0.0963 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0109 | 0.4973 | 0.4739 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.7486 | 0.7486 |
Schistosoma mansoni | bromodomain containing protein | 0.0066 | 0.2615 | 0.2615 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0143 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1206 | 0.1206 |
Echinococcus multilocularis | carbonic anhydrase | 0.0109 | 0.4973 | 0.4973 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0109 | 0.4973 | 0.4973 |
Echinococcus granulosus | carbonic anhydrase II | 0.0202 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0109 | 0.4973 | 0.4973 |
Echinococcus granulosus | carbonic anhydrase | 0.0109 | 0.4973 | 0.4973 |
Echinococcus granulosus | carbonic anhydrase | 0.0109 | 0.4973 | 0.4973 |
Leishmania major | carbonic anhydrase-like protein | 0.0202 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1448 | 0.1448 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0143 | 0.0143 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1855 | 0.1477 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0156 | 0.7486 | 0.7486 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.134 | 0.134 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.3036 | 0.3036 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0202 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1855 | 0.1855 |
Echinococcus granulosus | carbonic anhydrase | 0.0109 | 0.4973 | 0.4973 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0311 | 0.0311 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0109 | 0.4973 | 0.4739 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.4973 | 0.4973 |
Schistosoma mansoni | hypothetical protein | 0.0109 | 0.4973 | 0.4973 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0202 | 1 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0078 | 0.3278 | 0.2965 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0311 | 0.0311 |
Echinococcus multilocularis | muscleblind protein | 0.0156 | 0.7486 | 0.7486 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 4 mM | Inhibition of Monoamine oxidase-B from Bovine liver | ChEMBL. | 8510099 |
Ki (binding) | = 4 mM | Inhibition of Monoamine oxidase-B from Bovine liver | ChEMBL. | 8510099 |
kinact (binding) | = 4.6 min-1 | Inactivation kinetic constant Monoamine oxidase-B from Bovine liver | ChEMBL. | 8510099 |
kinact (binding) | = 4.6 min-1 | Inactivation kinetic constant Monoamine oxidase-B from Bovine liver | ChEMBL. | 8510099 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.