Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0341 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 0.3275 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0039 | 0.0568 | 0.1178 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0341 | 0.0707 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.3275 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0092 | 0.3275 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 0.3275 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0052 | 0.1219 | 0.2527 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0052 | 0.1219 | 0.2993 |
Schistosoma mansoni | jumonji domain containing protein | 0.0074 | 0.2325 | 0.482 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0341 | 0.0707 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0341 | 0.2797 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0123 | 0.4824 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0092 | 0.3275 | 0.6789 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0092 | 0.3275 | 0.6789 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0341 | 0.0707 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0341 | 0.0707 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0034 | 0.0305 | 0.0633 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0034 | 0.0305 | 0.0633 |
Plasmodium falciparum | phd finger protein, putative | 0.0028 | 0 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0341 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0092 | 0.3275 | 0.6789 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.1545 | 0.3203 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0305 | 0.0633 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0341 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0052 | 0.1219 | 0.2527 |
Loa Loa (eye worm) | TAR-binding protein | 0.0123 | 0.4824 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.4824 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.4824 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0123 | 0.4824 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.4824 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0341 | 0.0707 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0341 | 0.0707 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0341 | 0.0707 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0092 | 0.3275 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0123 | 0.4824 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0052 | 0.1219 | 0.2993 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0046 | 0.0901 | 0.1907 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.1219 | 0.2993 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0341 | 0.0707 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0341 | 0.0707 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0305 | 0.0633 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0341 | 0.0707 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0052 | 0.1219 | 0.2527 |
Onchocerca volvulus | 0.0035 | 0.0341 | 0.1041 | |
Brugia malayi | jmjC domain containing protein | 0.0034 | 0.0305 | 0.0633 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0341 | 0.5 |
Giardia lamblia | Kinase, PLK | 0.0092 | 0.3275 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0341 | 0.0707 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0052 | 0.1219 | 0.2993 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.3275 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0092 | 0.3275 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.3275 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0341 | 0.0707 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0052 | 0.1219 | 0.2993 |
Brugia malayi | MAP kinase sur-1 | 0.0052 | 0.1219 | 0.2527 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0341 | 0.0707 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1037 | 0.2149 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0092 | 0.3275 | 0.6789 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0052 | 0.1219 | 0.3723 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0093 | 0.3302 | 0.6845 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0039 | 0.0568 | 0.1178 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.3275 | 1 |
Brugia malayi | RNA binding protein | 0.0123 | 0.4824 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.3275 | 1 |
Onchocerca volvulus | 0.0035 | 0.0341 | 0.1041 | |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0052 | 0.1219 | 0.2527 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0341 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.1219 | 0.2993 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.1219 | 0.2527 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.3275 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0052 | 0.1219 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0052 | 0.1219 | 0.2993 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.4824 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0341 | 1 |
Onchocerca volvulus | 0.0035 | 0.0341 | 0.1041 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0123 | 0.4824 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0034 | 0.0305 | 0.0633 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0052 | 0.1219 | 0.2993 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0046 | 0.0901 | 0.1907 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.1219 | 0.2993 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0052 | 0.1219 | 0.2527 |
Trypanosoma brucei | protein kinase, putative | 0.0052 | 0.1219 | 0.2993 |
Loa Loa (eye worm) | RNA binding protein | 0.0123 | 0.4824 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0341 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0093 | 0.3302 | 0.6845 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0092 | 0.3275 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0341 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0341 | 0.0707 |
Brugia malayi | jmjC domain containing protein | 0.0093 | 0.3302 | 0.6845 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0341 | 0.0707 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0052 | 0.1219 | 0.2993 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.1219 | 0.2993 |
Schistosoma mansoni | kinase | 0.0047 | 0.0963 | 0.1995 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.3275 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.4824 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0341 | 0.0707 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0092 | 0.3275 | 0.6789 |
Brugia malayi | TAR-binding protein | 0.0123 | 0.4824 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.