Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0061 | 0.014 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0262 | 0.3526 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.0382 | 0.5542 | 0.5542 |
Brugia malayi | Pre-SET motif family protein | 0.0211 | 0.267 | 0.2602 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.01 | 0.0797 | 0.1441 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0332 | 0.47 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.024 | 0.3161 | 0.7593 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.01 | 0.0797 | 0.0711 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0143 | 0.1519 | 0.3024 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.01 | 0.0797 | 0.1441 |
Echinococcus multilocularis | integrin beta 2 | 0.0283 | 0.3877 | 0.8195 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0061 | 0.014 | 0.0048 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0382 | 0.5542 | 0.5501 |
Brugia malayi | Choline O-acetyltransferase | 0.0061 | 0.014 | 0.0048 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0101 | 0.0823 | 0.2475 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0262 | 0.3526 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0332 | 0.47 | 1 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0058 | 0.0093 | 0.0093 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0332 | 0.47 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0061 | 0.014 | 0.5 |
Echinococcus multilocularis | expressed conserved protein | 0.0094 | 0.0695 | 0.1218 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.014 | 0.014 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0332 | 0.47 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0262 | 0.3526 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0061 | 0.014 | 0.0048 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0061 | 0.014 | 0.014 |
Echinococcus granulosus | expressed conserved protein | 0.0094 | 0.0695 | 0.1218 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0262 | 0.3526 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0143 | 0.1519 | 0.3024 |
Onchocerca volvulus | 0.024 | 0.3161 | 1 | |
Echinococcus granulosus | integrin beta 2 | 0.0283 | 0.3877 | 0.8195 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0061 | 0.014 | 0.014 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0172 | 0.201 | 0.6189 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0061 | 0.014 | 0.0048 |
Schistosoma mansoni | integrin beta subunit | 0.0225 | 0.29 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0262 | 0.3526 | 0.3466 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.01 | 0.0797 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0061 | 0.014 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0181 | 0.2165 | 0.1027 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0262 | 0.3526 | 0.3526 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0262 | 0.3526 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0061 | 0.014 | 0.5 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0061 | 0.014 | 0.014 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0262 | 0.3526 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0332 | 0.47 | 1 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0061 | 0.014 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0647 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0181 | 0.2165 | 0.1027 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0211 | 0.267 | 0.267 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0797 | 0.0797 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.