Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.4885 | 0.4885 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0126 | 0.4885 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0126 | 0.4885 | 0.4885 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0021 | 0 | 0.5 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 | |
Brugia malayi | Choline/ethanolamine kinase family protein | 0.0038 | 0.0764 | 0.0764 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.4885 | 0.4885 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0236 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.232 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0126 | 0.4885 | 1 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1129 | 0.231 |
Brugia malayi | Carboxylesterase family protein | 0.0126 | 0.4885 | 0.4885 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1129 | 0.231 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0071 | 0.232 | 0.4748 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1129 | 0.1129 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1129 | 0.231 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.232 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0126 | 0.4885 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0021 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0126 | 0.4885 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1129 | 0.231 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1129 | 0.231 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1129 | 0.231 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.232 | 0.4748 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.232 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0126 | 0.4885 | 0.4885 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0071 | 0.232 | 0.4748 |
Toxoplasma gondii | phosphotransferase enzyme family protein | 0.0038 | 0.0764 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1129 | 0.231 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0126 | 0.4885 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1129 | 0.1129 |
Echinococcus granulosus | choline:ethanolamine kinase | 0.0038 | 0.0764 | 0.1564 |
Brugia malayi | hypothetical protein | 0.0071 | 0.232 | 0.232 |
Plasmodium falciparum | choline kinase | 0.0038 | 0.0764 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0126 | 0.4885 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0126 | 0.4885 | 0.4885 |
Loa Loa (eye worm) | choline/ethanolamine kinase | 0.0038 | 0.0764 | 0.0764 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0236 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0126 | 0.4885 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.232 | 0.5 |
Plasmodium vivax | choline kinase, putative | 0.0038 | 0.0764 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0071 | 0.232 | 0.4748 |
Echinococcus multilocularis | choline:ethanolamine kinase | 0.0038 | 0.0764 | 0.1564 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0021 | 0 | 0.5 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.