Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | chaperonin containing TCP1 subunit 2 beta | 0.0028 | 0.8089 | 0.8021 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0031 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 1 | 1 |
Trypanosoma cruzi | T-complex protein 1, beta subunit, putative | 0.0028 | 0.8089 | 1 |
Onchocerca volvulus | 0.0031 | 1 | 0.5 | |
Leishmania major | T-complex protein 1, beta subunit, putative | 0.0028 | 0.8089 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.9658 | 0.9658 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.1333 | 0.1333 |
Echinococcus multilocularis | musashi | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0342 | 0.0342 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0028 | 0.8089 | 0.6617 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | T-complex protein 1 | 0.0028 | 0.8089 | 0.8089 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0.4351 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0022 | 0.4351 | 0.4151 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 1 | 1 |
Onchocerca volvulus | 0.0031 | 1 | 0.5 | |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.4351 | 0.3482 |
Schistosoma mansoni | lamin | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0031 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.4351 | 0.5 |
Trypanosoma brucei | T-complex protein 1, beta subunit, putative | 0.0028 | 0.8089 | 1 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0028 | 0.8089 | 0.6617 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 1 | 1 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0028 | 0.8089 | 0.7795 |
Plasmodium falciparum | T-complex protein 1 subunit beta | 0.0028 | 0.8089 | 1 |
Entamoeba histolytica | T-complex protein 1 beta subunit, putative | 0.0028 | 0.8089 | 1 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0028 | 0.8089 | 0.6617 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0022 | 0.4351 | 0.4151 |
Trichomonas vaginalis | chaperonin, putative | 0.0028 | 0.8089 | 1 |
Trichomonas vaginalis | chaperonin-60kD, ch60, putative | 0.0028 | 0.8089 | 1 |
Toxoplasma gondii | t-complex protein beta subunit | 0.0028 | 0.8089 | 1 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0028 | 0.8089 | 0.7795 |
Giardia lamblia | TCP-1 chaperonin subunit beta | 0.0028 | 0.8089 | 1 |
Echinococcus granulosus | lamin | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 1 | 1 |
Echinococcus multilocularis | chaperonin containing TCP1, subunit 2 (beta) | 0.0028 | 0.8089 | 0.8021 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.4351 | 0.5 |
Plasmodium vivax | T-complex protein 1 subunit beta, putative | 0.0028 | 0.8089 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.4351 | 0.4351 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0.4351 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.