Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0104 | 0.2763 | 1 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0095 | 0.2448 | 1 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0095 | 0.2448 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0212 | 0.6807 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0298 | 1 | 0.5 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0095 | 0.2448 | 0.5 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0095 | 0.2448 | 1 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0095 | 0.2448 | 0.3951 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0042 | 0.017 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 1 |
Onchocerca volvulus | 0.0242 | 0.7898 | 1 | |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0095 | 0.2448 | 0.3556 |
Trichomonas vaginalis | set domain proteins, putative | 0.0242 | 0.7898 | 0.7095 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0032 | 0.0081 | 0.0142 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0095 | 0.2448 | 0.3556 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0095 | 0.2448 | 0.5 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0146 | 0.4327 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 1 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0104 | 0.2763 | 1 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0095 | 0.2448 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0146 | 0.4327 | 0.5 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0104 | 0.2763 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0298 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0212 | 0.6807 | 1 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0062 | 0.122 | 0.4331 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0095 | 0.2448 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 1 |
Onchocerca volvulus | 0.0088 | 0.219 | 0.2734 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 1 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0146 | 0.4327 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0298 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.