Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.309 | 0.309 |
Echinococcus granulosus | acetylcholinesterase | 0.013 | 1 | 1 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0022 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.013 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.013 | 1 | 1 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.309 | 0.309 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.309 | 0.309 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.013 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.309 | 0.309 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.013 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.013 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.013 | 1 | 1 |
Brugia malayi | Choline/ethanolamine kinase family protein | 0.0039 | 0.1564 | 0.1564 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.013 | 1 | 1 |
Loa Loa (eye worm) | choline/ethanolamine kinase | 0.0039 | 0.1564 | 0.1564 |
Echinococcus granulosus | choline:ethanolamine kinase | 0.0039 | 0.1564 | 0.1564 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.013 | 1 | 1 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Plasmodium vivax | choline kinase, putative | 0.0039 | 0.1564 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.309 | 0.309 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.309 | 0.309 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.309 | 0.309 |
Echinococcus granulosus | acetylcholinesterase | 0.013 | 1 | 1 |
Plasmodium falciparum | choline kinase | 0.0039 | 0.1564 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.309 | 0.309 |
Echinococcus multilocularis | choline:ethanolamine kinase | 0.0039 | 0.1564 | 0.1564 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.309 | 0.309 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0022 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0022 | 0 | 0.5 |
Toxoplasma gondii | phosphotransferase enzyme family protein | 0.0039 | 0.1564 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.