Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0095 | 0.2448 | 0.3951 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0146 | 0.4327 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0042 | 0.017 |
Onchocerca volvulus | 0.0242 | 0.7898 | 1 | |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0298 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 1 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0104 | 0.2763 | 1 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0095 | 0.2448 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0242 | 0.7898 | 0.7095 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0062 | 0.122 | 0.4331 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0146 | 0.4327 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 1 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0104 | 0.2763 | 1 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0095 | 0.2448 | 0.3556 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0095 | 0.2448 | 0.5 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0095 | 0.2448 | 0.3556 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0095 | 0.2448 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0212 | 0.6807 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0146 | 0.4327 | 0.5 |
Onchocerca volvulus | 0.0088 | 0.219 | 0.2734 | |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0095 | 0.2448 | 0.5 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0095 | 0.2448 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0298 | 1 | 1 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0095 | 0.2448 | 0.5 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0095 | 0.2448 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 1 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0104 | 0.2763 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0298 | 1 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0212 | 0.6807 | 1 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0032 | 0.0081 | 0.0142 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.