Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0175 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.1271 | 0.3604 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.3326 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0123 | 0.3005 | 0.288 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0123 | 0.3005 | 0.288 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.3005 | 0.9 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0175 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0626 | 0.4925 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0175 | 0.1379 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0175 | 0.0195 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0175 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.1271 | 0.3604 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0275 | 0.216 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0175 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0626 | 0.4432 |
Onchocerca volvulus | 0.0036 | 0.0175 | 0.2859 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0175 | 0.0195 |
Echinococcus multilocularis | tumor protein p63 | 0.0337 | 1 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0175 | 0.5 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.1271 | 0.1115 |
Brugia malayi | Heterochromatin protein 1 | 0.0069 | 0.1271 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0626 | 0.4925 |
Onchocerca volvulus | 0.0049 | 0.0613 | 1 | |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0039 | 0.0275 | 0.4478 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0175 | 0.1379 |
Onchocerca volvulus | 0.0036 | 0.0175 | 0.2859 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0175 | 0.1379 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.649 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0175 | 0.1379 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0175 | 0.0541 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0175 | 0.0541 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0175 | 0.1379 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0132 | 0.3326 | 0.3207 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0275 | 0.0906 |
Onchocerca volvulus | 0.0036 | 0.0175 | 0.2859 | |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0175 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0175 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.3326 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.0371 | 0.6052 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.1271 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0371 | 0.1787 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.1271 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.1271 | 0.1115 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.1271 | 0.1115 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0371 | 0.1787 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0175 | 0.0541 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0175 | 0.1379 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0113 | 0.0886 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0069 | 0.1271 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0613 | 0.1557 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0175 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0626 | 0.4432 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0175 | 0.1379 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0175 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0175 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0275 | 0.0906 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0175 | 0.1379 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0613 | 0.4824 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0175 | 0.0541 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0175 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.1271 | 0.1115 |
Brugia malayi | chromobox protein homolog 3 | 0.0039 | 0.0275 | 0.1398 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0175 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0175 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.