TDR Targets

Basic information

Technical information

TDR Targets ID: 692834
Name: N-(2-fluorophenyl)-2-[(5-propyl-4-pyrrol-1-yl -1,2,4-triazol-3-yl)sulfanyl]acetamide
MW: 359.421 | Formula: C17H18FN5OS
H donors: 1 H acceptors: 3 LogP: 3.3 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCc1nnc(n1n1cccc1)SCC(=O)Nc1ccccc1F
InChi: 1S/C17H18FN5OS/c1-2-7-15-20-21-17(23(15)22-10-5-6-11-22)25-12-16(24)19-14-9-4-3-8-13(14)18/h3-6,8-11H,2,7,12H2,1H3,(H,19,24)
InChiKey: XSAVFBLGGUZNJK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-fluorophenyl)-2-[[5-propyl-4-(1-pyrrolyl)-1,2,4-triazol-3-yl]thio]acetamide
N-(2-fluorophenyl)-2-[(5-propyl-4-pyrrol-1-yl-1,2,4-triazol-3-yl)thio]acetamide
N-(2-fluorophenyl)-2-[(5-propyl-4-pyrrol-1-yl-1,2,4-triazol-3-yl)sulfanyl]ethanamide
ZINC04518459

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	lamin	0.0027	0.0283	0.0564
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0362	0.5584
Loa Loa (eye worm)	hypothetical protein	0.0236	0.288	1
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0283	0.0975
Entamoeba histolytica	hypothetical protein	0.0071	0.0832	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.012	0.1435	1
Loa Loa (eye worm)	carboxylesterase	0.0236	0.288	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0008	0.0018
Toxoplasma gondii	pyruvate kinase PyKII	0.0017	0.0161	0.2266
Brugia malayi	hypothetical protein	0.0005	0.0015	0.0043
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0059	0.0112
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0248
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0056	0.0647	0.2238
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0128	0.0435
Schistosoma mansoni	pyruvate kinase	0.0033	0.0362	0.0722
Echinococcus multilocularis	para nitrobenzyl esterase	0.004	0.0444	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0008	0.0018
Schistosoma mansoni	hypothetical protein	0.0071	0.0832	0.1657
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0005	0.0015	0.0043
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0074	0.0248
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0362	0.125
Echinococcus granulosus	carboxylesterase 5A	0.0236	0.288	0.5735
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0008	0.0018
Echinococcus granulosus	carbonic anhydrase	0.0056	0.0647	0.1284
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.003	0.0606
Brugia malayi	glutathione reductase	0.0047	0.0535	0.185
Toxoplasma gondii	hypothetical protein	0.0056	0.0647	0.9216
Brugia malayi	nuclear hormone receptor	0.001	0.0074	0.0248
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0152	0.0303
Chlamydia trachomatis	pyruvate kinase	0.0033	0.0362	1
Brugia malayi	conserved hypotetical protein	0.0005	0.0008	0.0018
Mycobacterium tuberculosis	Probable reductase	0.0108	0.1286	0.8958
Brugia malayi	intermediate filament protein	0.0027	0.0283	0.0975
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0037	0.0035
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0074	0.0142
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.004	0.0444	0.0885
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0152	0.2317
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0074	0.0248
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0362	0.8148
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0059	0.0056
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0702	1
Plasmodium falciparum	pyruvate kinase 2	0.0017	0.0161	0.2459
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0037	0.0069
Trypanosoma cruzi	trypanothione reductase, putative	0.0016	0.0152	0.2317
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0056	0.0647	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0008	0.0018
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0152	0.2135
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0074	0.0148
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.011	0.0214
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0152	0.2317
Toxoplasma gondii	pyruvate kinase PyK1	0.0033	0.0362	0.5146
Schistosoma mansoni	cpg binding protein	0.0029	0.0305	0.0608
Loa Loa (eye worm)	pyruvate kinase	0.0007	0.0036	0.0115
Echinococcus multilocularis	lamin	0.0027	0.0283	0.028
Echinococcus multilocularis	Kelch repeat type 1	0.0093	0.1099	0.1096
Entamoeba histolytica	hypothetical protein	0.0071	0.0832	1
Echinococcus multilocularis	choline:ethanolamine kinase	0.0032	0.0345	0.0342
Echinococcus granulosus	pyruvate kinase	0.0033	0.0362	0.0717
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0074	0.0148
Plasmodium falciparum	thioredoxin reductase	0.0016	0.0152	0.2317
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0074	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0104	0.0352
Loa Loa (eye worm)	hypothetical protein	0.004	0.0444	0.1534
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0016	0.0152	0.2135
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0702	0.1398
Schistosoma mansoni	acetylcholinesterase	0.004	0.0444	0.0885
Brugia malayi	nuclear receptor NHR-88	0.0005	0.0008	0.0018
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0008	0.0016
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0074	0.0248
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0074	0.0248
Brugia malayi	Carboxylesterase family protein	0.004	0.0444	0.1534
Schistosoma mansoni	transcription factor LCR-F1	0.0071	0.0832	0.1657
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0058	0.0191
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.003	0.0606
Treponema pallidum	NADH oxidase	0.0016	0.0152	1
Trypanosoma brucei	carbonic anhydrase-like protein	0.0056	0.0647	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0074	0.0248
Leishmania major	carbonic anhydrase-like protein	0.0056	0.0647	0.9216
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0074	0.0148
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0074	0.0071
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0016	0.0152	0.2135
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.0535	0.8264
Brugia malayi	pyruvate kinase	0.0007	0.0036	0.0115
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0074	0.0248
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0248
Plasmodium falciparum	glutathione reductase	0.0016	0.0152	0.2317
Brugia malayi	ecdysone receptor	0.0005	0.0008	0.0018
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0037	0.0069
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0074	0.0142
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0362	0.8148
Schistosoma mansoni	BC026374 protein (S09 family)	0.004	0.0444	0.0885
Echinococcus multilocularis	lamin dm0	0.0027	0.0283	0.028
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0043
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0152	0.2317
Loa Loa (eye worm)	hypothetical protein	0.004	0.0444	0.1534
Onchocerca volvulus		0.0005	0.0008	0.0117
Loa Loa (eye worm)	hypothetical protein	0.004	0.0444	0.1534
Echinococcus granulosus	carbonic anhydrase II	0.0056	0.0647	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0277	0.0953
Brugia malayi	nuclear receptor NHR-67	0.0005	0.0008	0.0018
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0074	0.0142
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0108	0.1286	0.8958
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0008	0.0018
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0152	0.0297
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.003	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0043
Trichomonas vaginalis	glutathione reductase, putative	0.0016	0.0152	0.3381
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0074	0.1617
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.0098	0.0331
Trypanosoma brucei	pyruvate kinase 1, putative	0.0033	0.0362	0.5584
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0005	0.0015	0.003
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0152	0.2317
Brugia malayi	ecdysteroid receptor	0.001	0.0074	0.0248
Entamoeba histolytica	pyruvate kinase, putative	0.0023	0.0237	0.2829
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.004	0.0444	0.0885
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0074	0.0248
Schistosoma mansoni	neuroligin 3 (S09 family)	0.004	0.0444	0.0885
Mycobacterium tuberculosis	Probable dehydrogenase	0.0108	0.1286	0.8958
Schistosoma mansoni	glutamate synthase	0.0004	0.0003	0.0006
Onchocerca volvulus		0.004	0.0444	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0008	0.0018
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0283	0.0975
Echinococcus granulosus	acetylcholinesterase	0.0236	0.288	0.5735
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0074	0.1617
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0056	0.0647	0.1289
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0071	0.0832	0.1652
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0074	0.0248
Echinococcus granulosus	nuclear receptor nhr 48	0.0005	0.0008	0.001
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0074	0.0248
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.003	0.0606
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0005	0.0008	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.003	0.0606
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0005	0.0008	0.0005
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0005	0.0008	0.0018
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0056	0.0647	0.2238
Schistosoma mansoni	pyruvate kinase	0.0017	0.0161	0.0321
Echinococcus granulosus	dnaJ subfamily B	0.0409	0.5019	1
Onchocerca volvulus		0.0027	0.0283	0.6353
Plasmodium falciparum	thioredoxin reductase	0.0047	0.0535	0.8264
Onchocerca volvulus		0.0027	0.0283	0.6353
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.004	0.0444	0.0441
Echinococcus granulosus	cpg binding protein	0.003	0.0325	0.0643
Schistosoma mansoni	hypothetical protein	0.0056	0.0647	0.1289
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.003	0.0606
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0702	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0005	0.0008	0.0018
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.003	0.0606
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.012	0.1435	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0152	1
Echinococcus multilocularis	carbonic anhydrase	0.0056	0.0647	0.0644
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0059	0.0195
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0074	0.0071
Plasmodium falciparum	glutathione reductase	0.0047	0.0535	0.8264
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0005	0.0008	0.0005
Echinococcus granulosus	pyruvate kinase	0.0017	0.0161	0.0316
Onchocerca volvulus		0.004	0.0444	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.0535	0.0532
Echinococcus granulosus	pyruvate kinase	0.0017	0.0161	0.0316
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0074	0.0142
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.004	0.0444	1
Brugia malayi	nuclear hormone receptor	0.0005	0.0008	0.0018
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0152	0.2317
Loa Loa (eye worm)	hypothetical protein	0.004	0.0444	0.1534
Brugia malayi	pyruvate kinase, muscle isozyme	0.0007	0.0036	0.0115
Echinococcus multilocularis	carbonic anhydrase	0.0056	0.0647	0.0644
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0074	0.0148
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0005	0.0008	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0043
Echinococcus multilocularis	carbonic anhydrase	0.0056	0.0647	0.0644
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0074	0.0248
Echinococcus multilocularis	neuroligin	0.004	0.0444	0.0441
Brugia malayi	orphan nuclear receptor NR2E1	0.0005	0.0008	0.0018
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0033	0.0362	0.2511
Brugia malayi	Nuclear hormone receptor E75	0.0005	0.0008	0.0018
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0056	0.0647	0.2238
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0702	0.4879
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.003	0.0606
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.003	0.0606
Schistosoma mansoni	carbonic anhydrase-related	0.0056	0.0647	0.1289
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0702	1
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0016	0.0152	0.2135
Schistosoma mansoni	carbonic anhydrase-related	0.0056	0.0647	0.1289
Loa Loa (eye worm)	glutathione reductase	0.0047	0.0535	0.185
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0005	0.0015	0.0012
Trichomonas vaginalis	mercuric reductase, putative	0.0016	0.0152	0.3381
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0016	0.0152	0.2135
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0074	0.0071
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.011	0.0107
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0005	0.0015	0.0024
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0702	1
Echinococcus multilocularis	carboxylesterase 5A	0.0236	0.288	0.2878
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0074	0.0148
Echinococcus granulosus	pyruvate kinase	0.0033	0.0362	0.0717
Trypanosoma brucei	pyruvate kinase 1	0.0033	0.0362	0.5584
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0236	0.288	0.5738
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0248
Toxoplasma gondii	thioredoxin reductase	0.0047	0.0535	0.7617
Schistosoma mansoni	disulfide oxidoreductase	0.0004	0.0003	0.0006
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0074	0.0148
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0283	0.0975
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0074	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0008	0.0018
Schistosoma mansoni	nuclear receptor	0.0005	0.0008	0.0016
Brugia malayi	nuclear receptor NHR-88	0.001	0.0074	0.0248
Plasmodium falciparum	choline kinase	0.0032	0.0345	0.5306
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0074	0.0248
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0305	0.105
Brugia malayi	hypothetical protein	0.004	0.0444	0.1534
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0016	0.0152	0.2803
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0005	0.0008	0.001
Echinococcus multilocularis	pyruvate kinase	0.0017	0.0161	0.0158
Loa Loa (eye worm)	hypothetical protein	0.004	0.0444	0.1534
Schistosoma mansoni	hypothetical protein	0.0093	0.1099	0.2189
Onchocerca volvulus		0.004	0.0444	1
Brugia malayi	hypothetical protein	0.0071	0.0832	0.2881
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0074	0.0248
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0074	0.0071
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0248
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0056	0.0647	0.2238
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0056	0.0647	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0104	0.0352
Schistosoma mansoni	carbonic anhydrase	0.0056	0.0647	0.1289
Plasmodium falciparum	carbonic anhydrase	0.0056	0.0647	1
Brugia malayi	Carboxylesterase family protein	0.004	0.0444	0.1534
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0074	0.0248
Brugia malayi	Carboxylesterase family protein	0.004	0.0444	0.1534
Brugia malayi	Carboxylesterase family protein	0.004	0.0444	0.1534
Echinococcus multilocularis	kelch ECH associated protein 1	0.0093	0.1095	0.1093
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0074	0.0248
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0074	0.0248
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0305	0.105
Loa Loa (eye worm)	choline/ethanolamine kinase	0.0032	0.0345	0.1188
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0043
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0074	0.0248
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0033	0.0362	0.125
Toxoplasma gondii	phosphotransferase enzyme family protein	0.0032	0.0345	0.489
Brugia malayi	Thioredoxin reductase	0.0047	0.0535	0.185
Brugia malayi	hypothetical protein	0.0005	0.0008	0.0018
Schistosoma mansoni	nuclear receptor nhr-48	0.0005	0.0008	0.0016
Schistosoma mansoni	hypothetical protein	0.0004	0.0003	0.0006
Echinococcus granulosus	neuroligin	0.004	0.0444	0.088
Echinococcus multilocularis	dnaJ subfamily B	0.0409	0.5019	0.5017
Plasmodium vivax	pyruvate kinase, putative	0.0033	0.0362	0.6756
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0074	0.0148
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.003	0.0606
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0362	0.125
Echinococcus granulosus	choline:ethanolamine kinase	0.0032	0.0345	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0647	0.2238
Echinococcus granulosus	thyroid hormone receptor alpha	0.0005	0.0008	0.001
Loa Loa (eye worm)	DR-78	0.0005	0.0008	0.0018
Plasmodium falciparum	pyruvate kinase	0.0033	0.0362	0.5584
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0108	0.1286	0.8958
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0016	0.0152	0.4149
Brugia malayi	Carboxylesterase family protein	0.0236	0.288	1
Brugia malayi	hypothetical protein	0.0005	0.0015	0.0043
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0093	0.1095	0.2178
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0647	0.2238
Echinococcus granulosus	intermediate filament protein	0.0027	0.0283	0.0559
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0362	0.125
Brugia malayi	steroid hormone receptor	0.001	0.0074	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0008	0.0018
Onchocerca volvulus		0.0029	0.0305	0.6845
Echinococcus granulosus	acetylcholinesterase	0.0236	0.288	0.5735
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0074	0.0142
Schistosoma mansoni	lamin	0.0027	0.0283	0.0564
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0702	0.1393
Loa Loa (eye worm)	hypothetical protein	0.004	0.0444	0.1534
Echinococcus granulosus	lamin	0.0027	0.0283	0.0559
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0152	0.0149
Loa Loa (eye worm)	carbonic anhydrase 3	0.0056	0.0647	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0236	0.288	1
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0074	0.0148
Leishmania major	trypanothione reductase	0.0047	0.0535	0.7617
Loa Loa (eye worm)	hypothetical protein	0.004	0.0444	0.1534
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0047	0.0535	0.3716
Brugia malayi	nuclear receptor RXR	0.0005	0.0015	0.0043
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0074	0.0248
Brugia malayi	nuclear receptor RXR	0.0005	0.0008	0.0018
Schistosoma mansoni	glutamate synthase	0.0004	0.0003	0.0006
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0016	0.0152	0.2317
Giardia lamblia	Pyruvate kinase	0.0033	0.0362	1
Brugia malayi	tailless protein	0.0005	0.0008	0.0018
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0362	0.036
Brugia malayi	hypothetical protein	0.0005	0.0008	0.0018
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0093	0.1095	0.2178
Mycobacterium ulcerans	carboxylesterase, LipT	0.004	0.0444	0.6316
Mycobacterium tuberculosis	Carboxylesterase LipT	0.004	0.0444	0.3081
Onchocerca volvulus		0.004	0.0444	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.012	0.1435	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0283	0.0975
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0248
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0005	0.0008	0.0016
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0005	0.0008	0.0018
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0005	0.0008	0.001
Echinococcus multilocularis	pyruvate kinase	0.0017	0.0161	0.0158
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0016	0.0152	0.2803
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0074	0.0148
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0074	0.0071
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0074	0.0148
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.004	0.0444	0.3081
Echinococcus multilocularis	cpg binding protein	0.003	0.0325	0.0322
Schistosoma mansoni	gliotactin	0.004	0.0444	0.0885
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.001	0.0074	0.0248
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0152	0.2135
Schistosoma mansoni	glutamate synthase	0.0004	0.0003	0.0006
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0074	0.0248
Echinococcus multilocularis	BC026374 protein (S09 family)	0.004	0.0444	0.0441
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.003	0.0606
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0008	0.0016
Echinococcus multilocularis	musashi	0.0027	0.0283	0.028
Schistosoma mansoni	hypothetical protein	0.0409	0.5019	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0152	0.2317
Loa Loa (eye worm)	carboxylesterase	0.004	0.0444	0.1534
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0074	0.0148
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0016	0.0152	0.2135
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0016	0.0152	0.2317
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0074	0.0142
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.012	0.1435	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0128	0.0435
Giardia lamblia	Pyruvate kinase	0.0017	0.0161	0.4403
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0074	0.0071
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0016	0.0152	0.1042
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0108	0.1286	0.8958
Brugia malayi	nuclear hormone receptor family member odr-7	0.0005	0.0008	0.0018
Schistosoma mansoni	cpg binding protein	0.003	0.0325	0.0648
Brugia malayi	Choline/ethanolamine kinase family protein	0.0032	0.0345	0.1188
Schistosoma mansoni	sulfide quinone reductase	0.0004	0.0003	0.0006
Loa Loa (eye worm)	carboxylesterase	0.004	0.0444	0.1534
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0362	0.125
Echinococcus multilocularis	kelch ECH associated protein 1	0.0093	0.1095	0.1093
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0015	0.0043
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0152	0.2317
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.004	0.0444	0.0885
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0074	0.0071
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0362	0.036
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0008	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0008	0.0018
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.004	0.0444	0.3081
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0056	0.0647	0.2238
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0015	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.003	0.0606
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0056	0.0647	0.1289
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0074	0.0071
Mycobacterium ulcerans	pyruvate kinase	0.0033	0.0362	0.5146
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0074	0.0148
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.003	0.0606
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.0098	0.0331
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0108	0.1286	0.8958
Trichomonas vaginalis	helicase, putative	0.0007	0.003	0.0606
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0704	0.1403
Echinococcus granulosus	pyruvate kinase	0.0017	0.0161	0.0316
Echinococcus multilocularis	pyruvate kinase	0.0026	0.0275	0.0273
Onchocerca volvulus		0.004	0.0444	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0702	1
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0016	0.0152	0.2135
Onchocerca volvulus		0.001	0.0074	0.1617
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0152	0.2317
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0248
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0056	0.0647	0.2238
Leishmania major	pyruvate kinase	0.0033	0.0362	0.5146
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0008	0.0018
Loa Loa (eye worm)	pyruvate kinase-PB	0.0023	0.0237	0.0815
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0008	0.0018
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0005	0.0008	0.0117
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0056	0.0647	0.2238
Brugia malayi	Carboxylesterase family protein	0.0236	0.288	1
Schistosoma mansoni	carbonic anhydrase-related	0.0056	0.0647	0.1289
Schistosoma mansoni	cpg binding protein	0.003	0.0325	0.0648
Echinococcus granulosus	carbonic anhydrase	0.0056	0.0647	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0013	0.011	0.0373
Brugia malayi	Nuclear hormone receptor E75	0.0005	0.0008	0.0018
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0005	0.0008	0.0005
Echinococcus multilocularis	acetylcholinesterase	0.0236	0.288	0.2878
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0108	0.1286	0.8958
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0283	0.0564
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0248
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0074	0.0248
Schistosoma mansoni	pyruvate kinase	0.0033	0.0362	0.0722
Leishmania major	pyruvate kinase	0.0033	0.0362	0.5146
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0702	0.0699
Toxoplasma gondii	NADPH-glutathione reductase	0.0016	0.0152	0.2135
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.003	0.0606
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0362	0.8148
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.003	0.0606
Trichomonas vaginalis	spcc417.12 protein, putative	0.004	0.0444	1
Echinococcus multilocularis	acetylcholinesterase	0.0236	0.288	0.2878
Plasmodium vivax	choline kinase, putative	0.0032	0.0345	0.642
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.0535	0.1061
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0237	0.0815
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0033	0.0362	0.125
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0005	0.0008	0.0005
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0074	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0008	0.0018
Schistosoma mansoni	zinc finger protein	0.0005	0.0008	0.0016
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.0535	0.185
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0362	0.5584
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0056	0.0647	0.2238
Echinococcus granulosus	para nitrobenzyl esterase	0.004	0.0444	0.088
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0005	0.0008	0.0117
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0152	1
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0362	0.8148
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0005	0.0008	0.0005
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0074	0.0248
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0033	0.0362	0.2511
Schistosoma mansoni	sulfide quinone reductase	0.0004	0.0003	0.0006
Echinococcus granulosus	carbonic anhydrase	0.0056	0.0647	0.1284
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0074	0.0142
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0037	0.0074
Echinococcus granulosus	BC026374 protein S09 family	0.004	0.0444	0.088
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0152	0.2317
Entamoeba histolytica	hypothetical protein	0.0071	0.0832	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0005	0.0008	0.001
Echinococcus multilocularis	pyruvate kinase	0.0017	0.0161	0.0158
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0071	0.0832	0.0829
Plasmodium vivax	glutathione reductase, putative	0.0047	0.0535	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0074	0.0248
Echinococcus multilocularis	carbonic anhydrase II	0.0056	0.0647	0.0644
Trypanosoma brucei	trypanothione reductase	0.0047	0.0535	0.8264
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0074	0.1617
Schistosoma mansoni	nuclear receptor	0.0005	0.0008	0.0016
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0362	0.8148
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0152	0.2317
Echinococcus multilocularis	nuclear receptor nhr 48	0.0005	0.0008	0.0005
Echinococcus granulosus	lamin dm0	0.0027	0.0283	0.0559
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0056	0.0647	0.2238
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0016	0.0152	0.2317
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0647	0.2238
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.003	0.0606
Entamoeba histolytica	hypothetical protein	0.0071	0.0832	1
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0152	0.0519
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.0535	1
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0005	0.0008	0.0016
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0005	0.0015	0.003
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.0623	0.8881
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0037	0.0035
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0074	0.0248
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0016	0.0152	0.4149
Loa Loa (eye worm)	acetylcholinesterase 1	0.0236	0.288	1
Plasmodium vivax	pyruvate kinase 2, putative	0.0017	0.0161	0.2975
Echinococcus granulosus	kelch ECH associated protein 1	0.0093	0.1095	0.2178
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.004	0.0444	0.088
Onchocerca volvulus		0.0005	0.0008	0.0117
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.003	0.0606
Schistosoma mansoni	coup transcription factor	0.001	0.0074	0.0148
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0074	0.0142
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0702	0.1398
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0074	0.0071
Loa Loa (eye worm)	nuclear hormone receptor	0.0005	0.0008	0.0018
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0016	0.0152	0.2317
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0015	0.0043

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

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Detailed information for compound 692834