Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2803 | 0.2803 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.2803 | 0.2803 |
Trichomonas vaginalis | ferritin, putative | 0.0009 | 0 | 0.5 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.0119 | 0.5482 | 0.3749 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2803 | 0.2803 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2803 | 0.2803 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.2803 | 0.2803 |
Brugia malayi | Raf kinase | 0.0203 | 0.9636 | 1 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.021 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0009 | 0 | 0.5 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0009 | 0 | 0.5 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2803 | 0.2803 |
Loa Loa (eye worm) | raf kinase | 0.0209 | 0.9949 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2803 | 0.2803 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0009 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.021 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.