Detailed information for compound 692854

Basic information

Technical information
  • TDR Targets ID: 692854
  • Name: N-(2-methoxyphenyl)-2-[[5-[(4-methoxyphenyl)m ethyl]-4-pyrrol-1-yl-1,2,4-triazol-3-yl]sulfa nyl]acetamide
  • MW: 449.525 | Formula: C23H23N5O3S
  • H donors: 1 H acceptors: 3 LogP: 3.91 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)Cc1nnc(n1n1cccc1)SCC(=O)Nc1ccccc1OC
  • InChi: 1S/C23H23N5O3S/c1-30-18-11-9-17(10-12-18)15-21-25-26-23(28(21)27-13-5-6-14-27)32-16-22(29)24-19-7-3-4-8-20(19)31-2/h3-14H,15-16H2,1-2H3,(H,24,29)
  • InChiKey: AFNAWZGVIRFDNA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-methoxyphenyl)-2-[[5-[(4-methoxyphenyl)methyl]-4-(1-pyrrolyl)-1,2,4-triazol-3-yl]thio]acetamide
  • 2-[[5-(4-methoxybenzyl)-4-pyrrol-1-yl-1,2,4-triazol-3-yl]thio]-N-(2-methoxyphenyl)acetamide
  • N-(2-methoxyphenyl)-2-[[5-[(4-methoxyphenyl)methyl]-4-pyrrol-1-yl-1,2,4-triazol-3-yl]sulfanyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0032 0.0287 0.0618
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0154 0.0331
Mycobacterium ulcerans hypothetical protein 0.0035 0.0323 0.3424
Schistosoma mansoni hypothetical protein 0.0032 0.0287 0.0795
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0323 0.3424
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0767 0.165
Loa Loa (eye worm) transcription factor SMAD2 0.0257 0.3186 0.6854
Onchocerca volvulus 0.0035 0.0323 0.2304
Brugia malayi MH2 domain containing protein 0.0017 0.0099 0.0214
Onchocerca volvulus Huntingtin homolog 0.0119 0.1404 1
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0054 0.0117
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0866 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0041 0.0145
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0323 0.1144
Mycobacterium tuberculosis Conserved protein 0.0035 0.0323 0.1044
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0211 0.0453
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2746 1
Brugia malayi Muscleblind-like protein 0.0147 0.1771 0.3811
Loa Loa (eye worm) hypothetical protein 0.0035 0.0323 0.0696
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0866 0.3063
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0323 0.3424
Toxoplasma gondii exonuclease III APE 0.0021 0.0147 0.128
Echinococcus multilocularis lamin dm0 0.0026 0.0211 0.0211
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.1097 0.3904
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.048 0.048
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0323 0.1044
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.1097 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.1404 0.302
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0564 0.1212
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0323 0.8957
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0974 0.345
Schistosoma mansoni tar DNA-binding protein 0.0209 0.2567 0.7107
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0323 0.1044
Loa Loa (eye worm) hypothetical protein 0.0026 0.0204 0.044
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0099 0.0099
Schistosoma mansoni smad1 5 8 and 0.0017 0.0099 0.0275
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0147 0.0147
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0154 0.0417
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0147 0.0315
Leishmania major DNA polymerase eta, putative 0.0022 0.0154 0.3576
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0154 0.3576
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0524 0.1785
Brugia malayi glutathione reductase 0.0037 0.0356 0.0767
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0323 0.1044
Trypanosoma brucei trypanothione reductase 0.0037 0.0356 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0154 0.3576
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0154 0.0426
Onchocerca volvulus 0.0047 0.0476 0.3392
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.118 0.2539
Brugia malayi beta-lactamase family protein 0.0035 0.0323 0.0696
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0154 0.3992
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0287 0.0618
Loa Loa (eye worm) hypothetical protein 0.0053 0.0564 0.1212
Loa Loa (eye worm) hypothetical protein 0.0035 0.0323 0.0696
Schistosoma mansoni tar DNA-binding protein 0.0209 0.2567 0.7107
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.048 0.3417
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0147 0.3349
Entamoeba histolytica hypothetical protein 0.0035 0.0323 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0323 0.0895
Plasmodium falciparum thioredoxin reductase 0.0037 0.0356 0.3823
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0287 0.0618
Onchocerca volvulus 0.0035 0.0323 0.2304
Brugia malayi hypothetical protein 0.0119 0.1404 0.302
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0974 0.8607
Schistosoma mansoni hypothetical protein 0.0167 0.2023 0.5601
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0866 0.0866
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0323 0.1044
Brugia malayi hypothetical protein 0.0035 0.0323 0.0695
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0154 0.3576
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.2316 0.2316
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0154 0.3576
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0154 0.3576
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0041 0.0113
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0099 0.0352
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0323 1
Toxoplasma gondii ABC1 family protein 0.0035 0.0323 0.3424
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0866 1
Loa Loa (eye worm) glutathione reductase 0.0037 0.0356 0.0767
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0356 0.1165
Schistosoma mansoni hypothetical protein 0.0035 0.0323 0.0894
Onchocerca volvulus 0.0035 0.0323 0.2304
Echinococcus multilocularis GPCR, family 2 0.0032 0.0287 0.0287
Plasmodium falciparum glutathione reductase 0.0037 0.0356 0.3823
Brugia malayi TAR-binding protein 0.0209 0.2567 0.5523
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0211 0.0453
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0866 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0287 0.1016
Echinococcus granulosus dna polymerase kappa 0.0022 0.0154 0.0544
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0154 0.3576
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0154 0.1367
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.2827 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0065
Echinococcus granulosus intermediate filament protein 0.0026 0.0211 0.0745
Mycobacterium ulcerans beta-lactamase 0.0035 0.0323 0.3424
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0356 1
Mycobacterium leprae Probable lipase LipE 0.0035 0.0323 0.1223
Loa Loa (eye worm) MH2 domain-containing protein 0.0257 0.3186 0.6854
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0147 0.0315
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.1097 0.3904
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0067 0.082
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0524 0.1785
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0154 0.3576
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0154 0.1367
Giardia lamblia DINP protein human, muc B family 0.0022 0.0154 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0147 0.128
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0078
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0323 0.1143
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0154 0.3576
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0099 0.0275
Onchocerca volvulus 0.0026 0.0211 0.15
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0323 0.1223
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.048 0.1697
Echinococcus multilocularis muscleblind protein 0.0147 0.1771 0.1771
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0323 0.8957
Schistosoma mansoni hypothetical protein 0.0047 0.0476 0.1318
Schistosoma mansoni hypothetical protein 0.029 0.3612 1
Brugia malayi Thioredoxin reductase 0.0037 0.0356 0.0767
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.048 0.1032
Loa Loa (eye worm) hypothetical protein 0.0026 0.0211 0.0453
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0323 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0323 0.0696
Brugia malayi Probable ClpP-like protease 0.0077 0.0866 0.1863
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0524 0.3498
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0147 0.3349
Schistosoma mansoni tar DNA-binding protein 0.0209 0.2567 0.7107
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.2827 0.2827
Plasmodium vivax glutathione reductase, putative 0.0037 0.0356 0.3823
Trypanosoma brucei unspecified product 0.0015 0.0067 0.082
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0866 0.7374
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0216 0.2116
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0154 0.0544
Echinococcus granulosus lamin dm0 0.0026 0.0211 0.0745
Loa Loa (eye worm) beta-lactamase 0.0035 0.0323 0.0696
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.2316 0.8194
Brugia malayi RNA recognition motif domain containing protein 0.0209 0.2567 0.5523
Brugia malayi intermediate filament protein 0.0026 0.0211 0.0453
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0323 0.8957
Echinococcus multilocularis tar DNA binding protein 0.0209 0.2567 0.2567
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0147 0.3349
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0363 0.1283
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.048 0.1328
Loa Loa (eye worm) STAT protein 0.037 0.4648 1
Schistosoma mansoni survival motor neuron protein 0.0047 0.0476 0.1318
Mycobacterium tuberculosis Conserved protein 0.0035 0.0323 0.1044
Toxoplasma gondii hypothetical protein 0.0026 0.0216 0.2116
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0216 0.2116
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0154 0.3576
Entamoeba histolytica hypothetical protein 0.0035 0.0323 1
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0323 0.1044
Brugia malayi hypothetical protein 0.0229 0.2827 0.6082
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0287 0.1016
Schistosoma mansoni hypothetical protein 0.0069 0.0767 0.2123
Loa Loa (eye worm) TAR-binding protein 0.0209 0.2567 0.5523
Leishmania major hypothetical protein, conserved 0.0035 0.0323 0.8957
Loa Loa (eye worm) hypothetical protein 0.0147 0.1771 0.3811
Loa Loa (eye worm) hypothetical protein 0.0069 0.0767 0.165
Schistosoma mansoni hypothetical protein 0.0032 0.0287 0.0795
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0866 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0065
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0866 1
Echinococcus multilocularis dna polymerase eta 0.0022 0.0154 0.0154
Schistosoma mansoni smad1 5 8 and 0.0017 0.0099 0.0275
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0323 0.0894
Brugia malayi mbt repeat family protein 0.0047 0.048 0.1032
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0154 0.0331
Brugia malayi Smad1 0.0017 0.0099 0.0214
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.118 0.2539
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0067 0.082
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0866 1
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0147 0.3739
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0323 0.1044
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0564 0.0564
Schistosoma mansoni hypothetical protein 0.0167 0.2023 0.5601
Schistosoma mansoni smad1 5 8 and 0.0017 0.0099 0.0275
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.048 0.1328
Mycobacterium tuberculosis Conserved protein 0.0035 0.0323 0.1044
Leishmania major DNA polymerase kappa, putative 0.0022 0.0154 0.3576
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0866 1
Onchocerca volvulus 0.0047 0.048 0.3417
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0323 0.0323
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0147 0.9367
Echinococcus granulosus GPCR family 2 0.0032 0.0287 0.1016
Brugia malayi mbt repeat family protein 0.0047 0.048 0.1032
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0147 0.3349
Loa Loa (eye worm) hypothetical protein 0.0022 0.0154 0.0331
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0147 0.0519
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0041 0.0088
Entamoeba histolytica hypothetical protein 0.0035 0.0323 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0974 0.345
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0147 0.128
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0356 0.0767
Schistosoma mansoni tar DNA-binding protein 0.0209 0.2567 0.7107
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0147 0.128
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0154 0.0417
Entamoeba histolytica hypothetical protein 0.0035 0.0323 1
Echinococcus granulosus lamin 0.0026 0.0211 0.0745
Brugia malayi MH2 domain containing protein 0.0257 0.3186 0.6854
Brugia malayi beta-lactamase family protein 0.0035 0.0323 0.0696
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0154 0.3576
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0147 0.039
Loa Loa (eye worm) Smad1 0.0017 0.0099 0.0214
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0154 0.3576
Echinococcus granulosus Smad4 0.0017 0.0099 0.0352
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.118 0.2539
Loa Loa (eye worm) hypothetical protein 0.0047 0.048 0.1032
Loa Loa (eye worm) hypothetical protein 0.0035 0.0323 0.0696
Schistosoma mansoni intermediate filament proteins 0.0026 0.0211 0.0583
Trichomonas vaginalis esterase, putative 0.0035 0.0323 1
Onchocerca volvulus Huntingtin homolog 0.0119 0.1404 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0041 0.0041
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0154 0.3576
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0067 0.082
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0323 0.3424
Schistosoma mansoni ap endonuclease 0.0021 0.0147 0.0406
Mycobacterium tuberculosis Probable reductase 0.0085 0.0974 0.345
Loa Loa (eye worm) MBCTL1 0.0053 0.0564 0.1212
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0323 0.0696
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0099 0.0099
Schistosoma mansoni DNA polymerase eta 0.0022 0.0154 0.0426
Echinococcus granulosus muscleblind protein 0.0147 0.1771 0.6266
Echinococcus granulosus tar DNA binding protein 0.0209 0.2567 0.9081
Trypanosoma brucei unspecified product 0.0022 0.0154 0.3576
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.048 0.1697
Loa Loa (eye worm) hypothetical protein 0.0229 0.2827 0.6082
Schistosoma mansoni lamin 0.0026 0.0211 0.0583
Echinococcus multilocularis geminin 0.0167 0.2023 0.2023
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0476 0.1024
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0866 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0211 0.0453
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0099 0.0214
Loa Loa (eye worm) hypothetical protein 0.0035 0.0323 0.0696
Brugia malayi RNA binding protein 0.0209 0.2567 0.5523
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0287 0.0287
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0564 0.0564
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0564 0.1993
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0564 0.1993
Schistosoma mansoni ap endonuclease 0.0021 0.0147 0.0406
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.1097 0.3904
Loa Loa (eye worm) hypothetical protein 0.0077 0.0866 0.1863
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0866 1
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.048 0.1328
Loa Loa (eye worm) hypothetical protein 0.0147 0.1771 0.3811
Brugia malayi MH1 domain containing protein 0.0017 0.0099 0.0214
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0147 0.128
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0154 0.3576
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0154 0.3576
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0154 0.3576
Echinococcus granulosus smad 0.0017 0.0099 0.0352
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0154 0.3992
Toxoplasma gondii thioredoxin reductase 0.0037 0.0356 0.3823
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0356 0.3823
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0154 0.0331
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0974 0.345
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0209 0.2567 0.5523
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0323 0.0696
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0564 0.156
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0323 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0866 0.2397
Echinococcus multilocularis muscleblind protein 1 0.0147 0.1771 0.1771
Schistosoma mansoni smad 0.0017 0.0099 0.0275
Echinococcus multilocularis Smad4 0.0017 0.0099 0.0099
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0154 0.0426
Schistosoma mansoni Smad4 0.0017 0.0099 0.0275
Schistosoma mansoni hypothetical protein 0.0032 0.0287 0.0795
Brugia malayi STAT protein, DNA binding domain containing protein 0.037 0.4648 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0147 0.128
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0154 0.3576
Trypanosoma brucei unspecified product 0.0015 0.0067 0.082
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0154 0.3576
Leishmania major trypanothione reductase 0.0037 0.0356 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0974 0.345
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0054 0.0117
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0154 0.3576
Brugia malayi MH2 domain containing protein 0.0017 0.0099 0.0214
Loa Loa (eye worm) hypothetical protein 0.0035 0.0323 0.0696
Echinococcus multilocularis musashi 0.0026 0.0211 0.0211
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0154 0.0154
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0524 0.0524
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0323 0.0895
Loa Loa (eye worm) hypothetical protein 0.0119 0.1404 0.302
Brugia malayi MH1 domain containing protein 0.0017 0.0099 0.0214
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0099 0.0214
Schistosoma mansoni tar DNA-binding protein 0.0209 0.2567 0.7107
Schistosoma mansoni lamin 0.0026 0.0211 0.0583
Brugia malayi beta-lactamase 0.0035 0.0323 0.0696
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0036 0.0128
Echinococcus multilocularis lamin 0.0026 0.0211 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0154 0.3576
Echinococcus multilocularis smad 0.0017 0.0099 0.0099
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0323 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0154 0.0154
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0974 0.345
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0323 0.0323
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0154 0.3576
Echinococcus granulosus geminin 0.0167 0.2023 0.7157
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0099 0.0352
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0287 0.0618
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0323 0.1044
Loa Loa (eye worm) hypothetical protein 0.0101 0.118 0.2539
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0036 0.0036
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0363 0.0363
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0216 0.2116
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0147 0.3739
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0524 0.1854
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0323 1
Onchocerca volvulus 0.0026 0.0211 0.15
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0866 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0154 0.0404
Schistosoma mansoni hypothetical protein 0.0032 0.0287 0.0795
Mycobacterium ulcerans lipase LipD 0.0035 0.0323 0.3424
Echinococcus granulosus dna polymerase eta 0.0022 0.0154 0.0544
Loa Loa (eye worm) RNA binding protein 0.0209 0.2567 0.5523
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.048 0.048

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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