Detailed information for compound 692888

Basic information

Technical information
  • TDR Targets ID: 692888
  • Name: N-(3,4-dimethylphenyl)-2-[(5-propyl-4-pyrrol- 1-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide
  • MW: 369.484 | Formula: C19H23N5OS
  • H donors: 1 H acceptors: 3 LogP: 3.93 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1nnc(n1n1cccc1)SCC(=O)Nc1ccc(c(c1)C)C
  • InChi: 1S/C19H23N5OS/c1-4-7-17-21-22-19(24(17)23-10-5-6-11-23)26-13-18(25)20-16-9-8-14(2)15(3)12-16/h5-6,8-12H,4,7,13H2,1-3H3,(H,20,25)
  • InChiKey: MYSPQQPRBHMJAX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3,4-dimethylphenyl)-2-[[5-propyl-4-(1-pyrrolyl)-1,2,4-triazol-3-yl]thio]acetamide
  • N-(3,4-dimethylphenyl)-2-[(5-propyl-4-pyrrol-1-yl-1,2,4-triazol-3-yl)thio]acetamide
  • N-(3,4-dimethylphenyl)-2-[(5-propyl-4-pyrrol-1-yl-1,2,4-triazol-3-yl)sulfanyl]ethanamide
  • ZINC04518544

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0712 0.9036 1
Mycobacterium leprae Probable lipase LipE 0.0035 0.034 0.0946
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.034 0.0455
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0147 0.015
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.034 0.0946
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0147 0.015
Trichomonas vaginalis esterase, putative 0.0035 0.034 0.0455
Mycobacterium tuberculosis Conserved protein 0.0035 0.034 0.0946
Schistosoma mansoni intermediate filament proteins 0.0053 0.0575 0.2283
Brugia malayi beta-lactamase family protein 0.0035 0.034 0.0363
Onchocerca volvulus 0.0053 0.0575 0.1919
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.034 0.0946
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0012 0.0012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 0.7464 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 0.7464 1
Onchocerca volvulus Huntingtin homolog 0.0238 0.2945 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0589 0.7464 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0147 0.0584
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0147 0.0163
Schistosoma mansoni hypothetical protein 0.0017 0.0109 0.0433
Loa Loa (eye worm) hypothetical protein 0.002 0.0147 0.015
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0147 0.015
Mycobacterium ulcerans hypothetical protein 0.0035 0.034 0.0946
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0221 0.0221
Echinococcus granulosus FTZ F1 alpha 0.002 0.0147 0.0163
Echinococcus granulosus GPCR family 2 0.0017 0.0109 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0147 0.015
Brugia malayi isocitrate dehydrogenase 0.0016 0.0101 0.0099
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0147 0.0147
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0012 0.0012
Brugia malayi hypothetical protein 0.0238 0.2945 0.3251
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.034 0.0455
Onchocerca volvulus 0.0035 0.034 0.1118
Brugia malayi hypothetical protein 0.0712 0.9036 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.034 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.034 0.0455
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0026 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0147 0.015
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0147 0.015
Onchocerca volvulus 0.0053 0.0575 0.1919
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0288 0.359 1
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0575 0.0624
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0147 0.0163
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0147 0.0584
Loa Loa (eye worm) hypothetical protein 0.0017 0.0109 0.0108
Schistosoma mansoni nuclear receptor 0.0009 0.0012 0.0046
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0109 0.0109
Giardia lamblia Fructose-bisphosphate aldolase 0.0589 0.7464 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0147 0.0147
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0147 0.0584
Mycobacterium leprae conserved hypothetical protein 0.0035 0.034 0.0946
Mycobacterium tuberculosis Conserved protein 0.0035 0.034 0.0946
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0012 0.0012
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0145 0.1756 0.1933
Mycobacterium ulcerans lipase LipD 0.0035 0.034 0.0946
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0101 0.0101
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0101 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0147 0.015
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0147 0.015
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.034 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0147 0.015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 0.7464 1
Brugia malayi nuclear receptor RXR 0.0011 0.0026 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0147 0.015
Schistosoma mansoni tar DNA-binding protein 0.0204 0.2517 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0147 0.015
Loa Loa (eye worm) hypothetical protein 0.0035 0.034 0.0363
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0026 0.0104
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0147 0.015
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0012 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0147 0.015
Loa Loa (eye worm) beta-lactamase 0.0035 0.034 0.0363
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0109 0.0121
Schistosoma mansoni hypothetical protein 0.0017 0.0109 0.0433
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0109 0.0121
Schistosoma mansoni hypothetical protein 0.0017 0.0109 0.0433
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.034 0.0946
Onchocerca volvulus 0.0145 0.1756 0.5946
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0147 0.015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0016
Schistosoma mansoni nuclear hormone receptor 0.002 0.0147 0.0584
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.034 0.0946
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0257 0.0272
Loa Loa (eye worm) hypothetical protein 0.0035 0.034 0.0363
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0147 0.015
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0147 0.0461
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.034 0.0363
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0147 0.0163
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0499 0.0499
Loa Loa (eye worm) hypothetical protein 0.0025 0.0208 0.0218
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0288 0.359 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.034 0.0455
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0238 0.2945 0.3251
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0012 0.0046
Brugia malayi RNA binding protein 0.0204 0.2517 0.2776
Mycobacterium tuberculosis Conserved protein 0.0035 0.034 0.0946
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0581 0.0631
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2758 0.7683
Loa Loa (eye worm) hypothetical protein 0.002 0.0147 0.015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.034 0.1349
Loa Loa (eye worm) hypothetical protein 0.0052 0.0562 0.061
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.034 0.0946
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0204 0.2517 0.2776
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0147 0.0147
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0101 0.0101
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0147 0.0584
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0147 0.0584
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0147 0.0147
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0499 0.0552
Echinococcus granulosus survival motor neuron protein 1 0.0712 0.9036 1
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0147 0.0461
Loa Loa (eye worm) hypothetical protein 0.0053 0.0575 0.0624
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0147 0.0163
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1396 0.1534
Echinococcus granulosus intermediate filament protein 0.0053 0.0575 0.0636
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0147 0.015
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0147 0.015
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0147 0.0584
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0589 0.7464 0.5
Brugia malayi TAR-binding protein 0.0204 0.2517 0.2776
Brugia malayi beta-lactamase 0.0035 0.034 0.0363
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0581 0.0631
Onchocerca volvulus Huntingtin homolog 0.0238 0.2945 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.034 0.0946
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.034 0.1349
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1396 0.1534
Loa Loa (eye worm) hypothetical protein 0.0163 0.1982 0.2183
Loa Loa (eye worm) hypothetical protein 0.0037 0.0362 0.0389
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.034 0.0946
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0012 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0147 0.015
Schistosoma mansoni coup transcription factor 0.002 0.0147 0.0584
Schistosoma mansoni lamin 0.0053 0.0575 0.2283
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0101 0.0401
Loa Loa (eye worm) hypothetical protein 0.0025 0.0208 0.0218
Echinococcus multilocularis survival motor neuron protein 1 0.0712 0.9036 0.9036
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0012 0.0046
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0012 0.0046
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0101 0.5
Plasmodium vivax hypothetical protein, conserved 0.0035 0.034 1
Brugia malayi follicle stimulating hormone receptor 0.0267 0.3325 0.3672
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0147 0.0584
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0147 0.015
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.034 0.0946
Loa Loa (eye worm) hypothetical protein 0.002 0.0147 0.015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0016
Schistosoma mansoni thyroid hormone receptor 0.002 0.0147 0.0584
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0101 0.0112
Loa Loa (eye worm) hypothetical protein 0.0035 0.034 0.0363
Brugia malayi ecdysteroid receptor 0.002 0.0147 0.015
Schistosoma mansoni tar DNA-binding protein 0.0204 0.2517 1
Echinococcus granulosus tar DNA binding protein 0.0204 0.2517 0.2785
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0147 0.0163
Brugia malayi hypothetical protein 0.0163 0.1982 0.2183
Onchocerca volvulus 0.002 0.0147 0.0461
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.034 0.0946
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0147 0.0163
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0101 0.0101
Echinococcus granulosus lamin 0.0053 0.0575 0.0636
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0109 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0147 0.015
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0147 0.015
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0147 0.0461
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0026 0.0016
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0267 0.3325 0.3672
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.034 0.0455
Brugia malayi steroid hormone receptor 0.002 0.0147 0.015
Loa Loa (eye worm) hypothetical protein 0.0035 0.034 0.0363
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0147 0.0163
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0575 0.0624
Brugia malayi hypothetical protein 0.0011 0.0026 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0499 0.1984
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0012 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0499 0.1984
Schistosoma mansoni thyroid hormone receptor 0.002 0.0147 0.0584
Loa Loa (eye worm) hypothetical protein 0.0026 0.0221 0.0232
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0288 0.359 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0147 0.015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0499 0.0552
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0012 0.0013
Brugia malayi hypothetical protein 0.0011 0.0026 0.0016
Schistosoma mansoni survival motor neuron protein 0.0145 0.1756 0.6977
Brugia malayi intermediate filament protein 0.0053 0.0575 0.0624
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0575 0.0624
Loa Loa (eye worm) hypothetical protein 0.0035 0.034 0.0363
Schistosoma mansoni tar DNA-binding protein 0.0204 0.2517 1
Toxoplasma gondii ABC1 family protein 0.0035 0.034 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0109 0.0108
Brugia malayi beta-lactamase family protein 0.0035 0.034 0.0363
Loa Loa (eye worm) hypothetical protein 0.0054 0.0581 0.0631
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 0.7464 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0 0.5
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0101 0.0281
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0026 0.0016
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0101 0.0101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0147 0.015
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0499 0.054
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0147 0.0147
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0221 0.0244
Schistosoma mansoni lamin 0.0053 0.0575 0.2283
Echinococcus multilocularis tar DNA binding protein 0.0204 0.2517 0.2517
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0147 0.0147
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0026 0.0026
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0012 0.0013
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0026 0.0104
Schistosoma mansoni nuclear receptor 0.0009 0.0012 0.0046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0147 0.015
Schistosoma mansoni zinc finger protein 0.0009 0.0012 0.0046
Echinococcus multilocularis GPCR, family 2 0.0017 0.0109 0.0109
Treponema pallidum fructose-bisphosphate aldolase 0.0589 0.7464 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0147 0.015
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.034 1
Loa Loa (eye worm) TAR-binding protein 0.0204 0.2517 0.2776
Onchocerca volvulus 0.0163 0.1982 0.6716
Onchocerca volvulus 0.0035 0.034 0.1118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0147 0.015
Loa Loa (eye worm) RNA binding protein 0.0204 0.2517 0.2776
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 0.7464 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0016
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0581 0.0631
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0147 0.0147
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0362 0.0389
Brugia malayi nuclear receptor NHR-88 0.002 0.0147 0.015
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0101 0.0099
Mycobacterium ulcerans beta-lactamase 0.0035 0.034 0.0946
Echinococcus granulosus lamin dm0 0.0053 0.0575 0.0636
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0016
Onchocerca volvulus 0.0035 0.034 0.1118
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 0.7464 1
Schistosoma mansoni hypothetical protein 0.0017 0.0109 0.0433
Schistosoma mansoni tar DNA-binding protein 0.0204 0.2517 1
Loa Loa (eye worm) hypothetical protein 0.0238 0.2945 0.3251
Brugia malayi nuclear hormone receptor 0.002 0.0147 0.015
Brugia malayi RNA recognition motif domain containing protein 0.0204 0.2517 0.2776
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0499 0.1984
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0147 0.0584
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0499 0.054
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0147 0.015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 0.7464 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0147 0.0163
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0499 0.0499
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0026 0.0016
Schistosoma mansoni hypothetical protein 0.0145 0.1756 0.6977
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0101 0.0101
Echinococcus multilocularis lamin dm0 0.0053 0.0575 0.0575
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0147 0.0147
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.034 0.0363
Echinococcus multilocularis musashi 0.0053 0.0575 0.0575
Loa Loa (eye worm) hypothetical protein 0.0035 0.034 0.0363
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0147 0.0147
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0147 0.0584
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0012 0.0046
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.034 0.034
Echinococcus multilocularis lamin 0.0053 0.0575 0.0575
Loa Loa (eye worm) hypothetical protein 0.002 0.0147 0.015
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0012 0.0013
Schistosoma mansoni hypothetical protein 0.0037 0.0362 0.144
Schistosoma mansoni tar DNA-binding protein 0.0204 0.2517 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.034 0.0376
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0257 0.0272
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0109 0.0108
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 0.7464 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0012 0.0012
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0109 0.0108
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0147 0.015
Brugia malayi MH2 domain containing protein 0.0117 0.1396 0.1534
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0012 0.0046
Leishmania major hypothetical protein, conserved 0.0035 0.034 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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