Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0956 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.138 | 0.1909 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0852 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0242 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0852 | 0.0178 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0852 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0852 | 0.4539 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.1877 | 0.2596 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1984 | 0.2744 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0043 | 0.1186 | 0.0525 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.138 | 0.1909 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0852 | 0.0167 |
Echinococcus granulosus | lamin dm0 | 0.0081 | 0.285 | 0.3942 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0852 | 0.1313 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.1984 | 0.1383 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.1984 | 0.2744 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0852 | 0.0167 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.1877 | 0.2596 |
Brugia malayi | RNA binding protein | 0.0061 | 0.1984 | 0.1383 |
Loa Loa (eye worm) | intermediate filament protein | 0.0081 | 0.285 | 0.2656 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0852 | 0.0167 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0852 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0081 | 0.285 | 0.3942 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.3497 | 0.4837 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0956 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0852 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0032 | 0.0697 | 0.0964 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0852 | 0.0604 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0852 | 0.0604 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.1877 | 0.2596 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0852 | 0.0178 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.1984 | 0.1383 |
Echinococcus multilocularis | lamin dm0 | 0.0081 | 0.285 | 0.3942 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0852 | 0.0604 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.0697 | 0.0445 |
Echinococcus multilocularis | lamin | 0.0081 | 0.285 | 0.3942 |
Onchocerca volvulus | 0.0036 | 0.0852 | 0.072 | |
Plasmodium vivax | pyruvate kinase, putative | 0.0032 | 0.0697 | 0.8181 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.3497 | 0.4837 |
Echinococcus multilocularis | musashi | 0.0081 | 0.285 | 0.3942 |
Schistosoma mansoni | pyruvate kinase | 0.0032 | 0.0697 | 0.0964 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.015 | 0.5949 | 0.5839 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0852 | 0.0178 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0852 | 0.0604 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.1877 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0852 | 0.0178 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0852 | 0.0167 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0956 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0852 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0852 | 0.1313 |
Schistosoma mansoni | lamin | 0.0081 | 0.285 | 0.3942 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0956 | 0.1323 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0852 | 0.1313 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1984 | 0.2744 |
Chlamydia trachomatis | pyruvate kinase | 0.0032 | 0.0697 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.1877 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.138 | 0.1909 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.3497 | 0.4837 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.138 | 0.1147 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.3497 | 0.3321 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.138 | 0.1909 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0852 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0039 | 0.0995 | 0.1377 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0242 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.1984 | 0.2744 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0852 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0697 | 0.0445 |
Brugia malayi | intermediate filament protein | 0.0081 | 0.285 | 0.2314 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.0697 | 0.0964 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0852 | 0.1178 |
Echinococcus granulosus | pyruvate kinase | 0.0032 | 0.0697 | 0.0964 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0852 | 0.1313 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0852 | 0.0604 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0852 | 0.1178 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0956 | 0.1323 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.093 | 0.0684 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0852 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0852 | 0.1313 |
Echinococcus multilocularis | geminin | 0.0179 | 0.7229 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1984 | 0.2744 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0852 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1984 | 0.2744 |
Onchocerca volvulus | 0.0081 | 0.285 | 1 | |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.1877 | 0.2596 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.1984 | 0.1767 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.138 | 0.1909 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0852 | 0.0604 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0032 | 0.0697 | 0.3713 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.3497 | 0.4837 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.3834 | 0.3667 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0852 | 0.1313 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0852 | 0.0178 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0103 | 0.3834 | 0.3372 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.5949 | 0.5839 |
Schistosoma mansoni | lamin | 0.0081 | 0.285 | 0.3942 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0956 | 0.0279 |
Giardia lamblia | Pyruvate kinase | 0.0032 | 0.0697 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0228 | 0.9402 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0956 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.1877 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.285 | 0.2656 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0081 | 0.285 | 0.2656 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0852 | 0.0178 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0043 | 0.1186 | 0.0947 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.3497 | 0.4837 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.1877 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.1984 | 0.1767 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0048 | 0.138 | 0.1147 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0048 | 0.138 | 0.0734 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0956 | 0.1323 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.0697 | 0.0964 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0048 | 0.138 | 0.0734 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.2784 | 0.2589 |
Echinococcus granulosus | lamin | 0.0081 | 0.285 | 0.3942 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0852 | 0.0604 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.138 | 0.1909 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.093 | 0.0684 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1984 | 0.2744 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.0697 | 0.0445 |
Echinococcus multilocularis | pyruvate kinase | 0.0025 | 0.0395 | 0.0547 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.3834 | 0.5304 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.1984 | 0.1767 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0852 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.138 | 0.1909 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0852 | 0.1178 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0852 | 0.0178 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.3497 | 0.301 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0852 | 1 |
Onchocerca volvulus | 0.0036 | 0.0852 | 0.072 | |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.7229 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.7229 | 1 |
Echinococcus granulosus | geminin | 0.0179 | 0.7229 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.015 | 0.5949 | 0.5646 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0956 | 0.1323 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0995 | 0.0751 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0852 | 0.0178 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.138 | 0.1909 |
Echinococcus multilocularis | GPCR, family 2 | 0.0048 | 0.138 | 0.1909 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.015 | 0.5949 | 0.5646 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.0697 | 0.0445 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.1877 | 0.1355 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.3497 | 0.4837 |
Plasmodium falciparum | pyruvate kinase | 0.0032 | 0.0697 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0852 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0852 | 0.1178 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.1877 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0852 | 0.0604 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.3497 | 0.4837 |
Onchocerca volvulus | 0.0081 | 0.285 | 1 | |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0852 | 0.0178 |
Echinococcus granulosus | GPCR family 2 | 0.0048 | 0.138 | 0.1909 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0081 | 0.285 | 0.2314 |
Onchocerca volvulus | 0.0036 | 0.0852 | 0.072 | |
Schistosoma mansoni | intermediate filament proteins | 0.0081 | 0.285 | 0.3942 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0039 | 0.0995 | 0.1377 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0852 | 0.0178 |
Echinococcus granulosus | pyruvate kinase | 0.0032 | 0.0697 | 0.0964 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.