Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.3422 | 0.2924 |
Brugia malayi | RNA binding protein | 0.0061 | 0.3581 | 0.3585 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.3422 | 0.2924 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.2613 | 0.2053 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.1117 | 0.0514 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.3581 | 0.3585 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.2169 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3581 | 0.3094 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.3422 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.3581 | 0.3585 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.2613 | 0.2053 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.3581 | 0.3585 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0042 | 0.2389 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.3422 | 0.2924 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.2613 | 0.2053 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.2613 | 0.2053 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.1117 | 0.0514 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0042 | 0.2389 | 0.62 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.3422 | 0.2924 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.3422 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.3581 | 0.3094 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.2613 | 0.2053 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.3422 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0039 | 0.2169 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.3422 | 0.5 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0144 | 0.8728 | 0.8632 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0015 | 0.0704 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.3581 | 0.3585 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.2613 | 0.2053 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0042 | 0.2389 | 0.1813 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0144 | 0.8728 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.0144 | 0.8728 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.014 | 0.8476 | 0.8361 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.2613 | 0.2379 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0144 | 0.8728 | 0.8632 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0015 | 0.0704 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3581 | 0.3094 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 1 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0015 | 0.0704 | 0.5 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0042 | 0.2389 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.2613 | 0.2379 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.3581 | 0.3585 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.3581 | 0.3094 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.3422 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3581 | 0.3094 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3581 | 0.3094 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.3422 | 1 |
Echinococcus multilocularis | geminin | 0.0164 | 1 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0039 | 0.2169 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3581 | 0.3094 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0042 | 0.2389 | 0.62 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0042 | 0.2389 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.2613 | 0.2053 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0015 | 0.0704 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.