Detailed information for compound 69300

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 262.349 | Formula: C18H18N2
  • H donors: 0 H acceptors: 1 LogP: 5.46 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C(=C\c1ccccc1)/c1cccn2c1nc(c2C)C
  • InChi: 1S/C18H18N2/c1-13(12-16-8-5-4-6-9-16)17-10-7-11-20-15(3)14(2)19-18(17)20/h4-12H,1-3H3/b13-12+
  • InChiKey: MYGPDJFXLOIBMO-OUKQBFOZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0013 0.0101 0.0636
Schistosoma mansoni neuropeptide receptor 0.0013 0.0101 0.0092
Schistosoma mansoni neuropeptide receptor 0.0013 0.0101 0.0092
Schistosoma mansoni hypothetical protein 0.0015 0.0136 0.0126
Onchocerca volvulus 0.0013 0.0101 0.0553
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Brugia malayi ORL1-like opioid receptor 0.0013 0.0101 0.0636
Brugia malayi RNA, U transporter 1 0.008 0.1104 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0101 0.0092
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0013 0.0101 0.0092
Schistosoma mansoni amine GPCR 0.0013 0.0101 0.0092
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0101 0.0092
Echinococcus multilocularis serotonin receptor 0.0013 0.0101 0.0092
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0136 0.0956
Schistosoma mansoni opsin-like receptor 0.0013 0.0101 0.0092
Echinococcus multilocularis microtubule associated protein 2 0.0676 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0101 0.0092
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0035 0.0026
Brugia malayi Serotonin receptor 0.0013 0.0101 0.0636
Onchocerca volvulus 0.0013 0.0101 0.0553
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0831 0.0823
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0116 0.0775
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0136 0.0126
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0831 0.0823
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Brugia malayi hypothetical protein 0.0013 0.0101 0.0636
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0095 0.0086
Schistosoma mansoni alpha-1 adrenergic receptor 0.0013 0.0101 0.0092
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0013 0.0101 0.0152
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0101 0.0092
Brugia malayi Dopamine receptor protein 1 0.0013 0.0101 0.0636
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0136 0.0126
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0101 0.0092
Brugia malayi hypothetical protein 0.0013 0.0101 0.0636
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0013 0.0101 0.0092
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0299 0.0605
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0012 0.0088 0.0122
Echinococcus granulosus intermediate filament protein 0.0026 0.0299 0.029
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Onchocerca volvulus 0.0013 0.0101 0.0553
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0088 0.0514
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0831 0.0823
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0101 0.0092
Onchocerca volvulus 0.0013 0.0101 0.0553
Brugia malayi hypothetical protein 0.0013 0.0101 0.0636
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0101 0.0092
Schistosoma mansoni neuropeptide receptor 0.0013 0.0101 0.0092
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0701 0.2427
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0101 0.0092
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0136 0.0126
Brugia malayi G-protein coupled receptor 0.0013 0.0101 0.0636
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0101 0.0092
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0101 0.0092
Echinococcus multilocularis neuropeptide receptor A26 0.0013 0.0101 0.0092
Onchocerca volvulus 0.0013 0.0101 0.0553
Echinococcus multilocularis serotonin receptor 0.0013 0.0101 0.0092
Schistosoma mansoni lamin 0.0026 0.0299 0.029
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0101 0.0092
Echinococcus multilocularis sex peptide receptor 0.0013 0.0101 0.0092
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0101 0.0092
Echinococcus multilocularis g-protein coupled receptor 0.0013 0.0101 0.0092
Echinococcus multilocularis dnaJ subfamily B 0.04 0.5888 0.5885
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.018 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Leishmania major importin beta-1 subunit, putative 0.0023 0.0247 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0013 0.0101 0.0636
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0013 0.0101 0.0092
Loa Loa (eye worm) hypothetical protein 0.0049 0.0634 0.137
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0796 0.0788
Schistosoma mansoni hypothetical protein 0.0015 0.0136 0.0126
Echinococcus multilocularis neuropeptide s receptor 0.0013 0.0101 0.0092
Schistosoma mansoni hypothetical protein 0.0013 0.0101 0.0092
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0101 0.0092
Brugia malayi G protein-coupled receptor 0.0013 0.0101 0.0636
Echinococcus granulosus tar DNA binding protein 0.0062 0.0831 0.0823
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Brugia malayi G protein-coupled receptor F59B2.13 0.0013 0.0101 0.0636
Schistosoma mansoni biogenic amine receptor 0.0013 0.0101 0.0092
Entamoeba histolytica hypothetical protein 0.0023 0.0247 1
Echinococcus granulosus lamin 0.0026 0.0299 0.029
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0247 0.0945
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0013 0.0101 0.0636
Toxoplasma gondii exonuclease III APE 0.0018 0.018 0.0364
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.018 0.5783
Schistosoma mansoni hypothetical protein 0.0015 0.0136 0.0126
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0101 0.0092
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Echinococcus multilocularis neuropeptide FF receptor 2 0.0013 0.0101 0.0092
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0013 0.0101 0.0092
Onchocerca volvulus Neuropeptide F receptor homolog 0.0013 0.0101 0.0553
Onchocerca volvulus 0.0013 0.0101 0.0553
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0299 0.2485
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0831 0.0823
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0181 0.2612 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0831 0.1822
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0013 0.0101 0.0092
Schistosoma mansoni hypothetical protein 0.0301 0.4408 0.4403
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0101 0.0092
Brugia malayi intermediate filament protein 0.0026 0.0299 0.2485
Onchocerca volvulus 0.0013 0.0101 0.0553
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Brugia malayi CXXC zinc finger family protein 0.0028 0.0325 0.2724
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0101 0.0092
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0101 0.0092
Plasmodium falciparum enoyl-acyl carrier reductase 0.0181 0.2612 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0013 0.0101 0.0553
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0035 0.0026
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Brugia malayi putative neuropeptide receptor NPR1 0.0013 0.0101 0.0636
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.018 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0634 0.561
Echinococcus multilocularis G protein coupled receptor 139 0.0013 0.0101 0.0092
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.0101 0.0152
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0101 0.0092
Loa Loa (eye worm) hypothetical protein 0.0033 0.0403 0.0843
Echinococcus granulosus fmrfamide receptor 0.0013 0.0101 0.0092
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0013 0.0101 0.0092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0101 0.0092
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0013 0.0101 0.0092
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.018 0.0171
Schistosoma mansoni ap endonuclease 0.0018 0.018 0.0171
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0012 0.0088 0.0079
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0247 0.0945
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0101 0.0092
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0101 0.0092
Schistosoma mansoni lamin 0.0026 0.0299 0.029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0101 0.0092
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0095 0.0086
Brugia malayi putative neuropeptide receptor 0.0013 0.0101 0.0636
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0012 0.0088 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0101 0.0092
Brugia malayi hypothetical protein 0.0013 0.0101 0.0636
Echinococcus granulosus allatostatin A receptor 0.0013 0.0101 0.0092
Onchocerca volvulus 0.0028 0.0325 1
Schistosoma mansoni adenoreceptor 0.0013 0.0101 0.0092
Echinococcus granulosus peptide allatostatin:somatostatin 0.0013 0.0101 0.0092
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Loa Loa (eye worm) retinol dehydrogenase 12 0.0012 0.0088 0.0122
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0831 0.0823
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0101 0.0092
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.018 0.0364
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0013 0.0101 0.0092
Echinococcus granulosus tachykinin peptides receptor 99D 0.0013 0.0101 0.0092
Echinococcus multilocularis cpg binding protein 0.003 0.0349 0.034
Onchocerca volvulus 0.0026 0.0299 0.8918
Schistosoma mansoni amine GPCR 0.0013 0.0101 0.0092
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.018 0.0332
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Schistosoma mansoni hypothetical protein 0.04 0.5888 0.5885
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.0101 0.0152
Brugia malayi larval opioid receptor 0.0013 0.0101 0.0636
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0101 0.0092
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.018 0.3849
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Schistosoma mansoni ap endonuclease 0.0018 0.018 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0101 0.0092
Onchocerca volvulus 0.0013 0.0101 0.0553
Echinococcus multilocularis musashi 0.0026 0.0299 0.029
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.4408 1
Schistosoma mansoni intermediate filament proteins 0.0026 0.0299 0.029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0088 0.0122
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0101 0.0092
Brugia malayi RNA binding protein 0.0062 0.0831 0.7453
Echinococcus granulosus 7tm_1 domain containing protein 0.0013 0.0101 0.0092
Echinococcus granulosus G protein coupled receptor 139 0.0013 0.0101 0.0092
Echinococcus multilocularis orexin receptor type 2 0.0013 0.0101 0.0092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0101 0.0092
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0101 0.0092
Schistosoma mansoni hypothetical protein 0.0015 0.0136 0.0126
Plasmodium vivax importin-beta 2, putative 0.0028 0.0327 0.0945
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.0101 0.0152
Brugia malayi Importin beta-1 subunit 0.0028 0.0327 0.274
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0013 0.0101 0.0092
Schistosoma mansoni histamine h1 receptor 0.0013 0.0101 0.0092
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.018 0.5
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0181 0.2612 1
Onchocerca volvulus 0.0013 0.0101 0.0553
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Echinococcus granulosus g protein coupled receptor 0.0013 0.0101 0.0092
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Schistosoma mansoni hypothetical protein 0.0013 0.0101 0.0092
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0101 0.0092
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.018 0.0364
Brugia malayi Serotonin receptor 0.0013 0.0101 0.0636
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0012 0.0088 0.0079
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0101 0.0092
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0013 0.0101 0.0152
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0831 0.0823
Echinococcus multilocularis snurportin 1 0.0301 0.4408 0.4403
Loa Loa (eye worm) oxidoreductase 0.0012 0.0088 0.0122
Schistosoma mansoni hypothetical protein 0.0013 0.0101 0.0092
Schistosoma mansoni cpg binding protein 0.0028 0.0325 0.0316
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0327 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0101 0.0092
Brugia malayi hypothetical protein 0.0013 0.0101 0.0636
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0101 0.0092
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0013 0.0101 0.0152
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0136 0.0126
Loa Loa (eye worm) hypothetical protein 0.0012 0.0088 0.0122
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0327 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0013 0.0101 0.0092
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0116 0.0186
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0101 0.0092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0101 0.0092
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0101 0.0092
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0634 0.561
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Brugia malayi Dopamine receptor protein 2 0.0013 0.0101 0.0636
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0013 0.0101 0.0092
Echinococcus granulosus somatostatin receptor 0.0013 0.0101 0.0092
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Schistosoma mansoni hypothetical protein 0.0033 0.0403 0.0395
Onchocerca volvulus 0.0013 0.0101 0.0553
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0013 0.0101 0.0092
Echinococcus granulosus neuropeptide receptor 0.0013 0.0101 0.0092
Onchocerca volvulus 0.0013 0.0101 0.0553
Echinococcus multilocularis GPCR, family 2 0.0015 0.0136 0.0126
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Echinococcus granulosus neuropeptide FF receptor 2 0.0013 0.0101 0.0092
Schistosoma mansoni hypothetical protein 0.0013 0.0101 0.0092
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0101 0.0092
Echinococcus granulosus neuropeptide receptor 0.0013 0.0101 0.0092
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Echinococcus granulosus lamin dm0 0.0026 0.0299 0.029
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0101 0.0092
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0013 0.0101 0.0092
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.018 0.0689
Echinococcus multilocularis somatostatin receptor 0.0013 0.0101 0.0092
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0013 0.0101 0.0636
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Loa Loa (eye worm) hypothetical protein 0.0026 0.0299 0.0605
Brugia malayi hypothetical protein 0.0013 0.0101 0.0636
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.018 0.0364
Brugia malayi AKH receptor 0.0013 0.0101 0.0636
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0013 0.0101 0.0152
Echinococcus granulosus sex peptide receptor 0.0013 0.0101 0.0092
Brugia malayi RE15519p 0.0013 0.0101 0.0636
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0181 0.2612 1
Brugia malayi follicle stimulating hormone receptor 0.0013 0.0101 0.0636
Onchocerca volvulus 0.0013 0.0101 0.0553
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0403 0.3456
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Brugia malayi hypothetical protein 0.0013 0.0101 0.0636
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0013 0.0101 0.0092
Echinococcus multilocularis lamin dm0 0.0026 0.0299 0.029
Loa Loa (eye worm) hypothetical protein 0.0015 0.0136 0.023
Schistosoma mansoni importin beta-1 0.0028 0.0327 0.0318
Schistosoma mansoni opsin-like receptor 0.0013 0.0101 0.0092
Brugia malayi GnHR receptor homolog 0.0013 0.0101 0.0636
Echinococcus granulosus hypothetical protein 0.0013 0.0101 0.0092
Loa Loa (eye worm) hypothetical protein 0.0012 0.0088 0.0122
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0101 0.0092
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0181 0.2612 1
Echinococcus granulosus dnaJ subfamily B 0.04 0.5888 0.5885
Schistosoma mansoni cpg binding protein 0.003 0.0349 0.034
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0101 0.0092
Trichomonas vaginalis hypothetical protein 0.0181 0.2612 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0101 0.0092
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0013 0.0101 0.0152
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Schistosoma mansoni biogenic amine receptor 0.0013 0.0101 0.0092
Echinococcus granulosus importin subunit beta 1 0.0028 0.0327 0.0318
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0013 0.0101 0.0092
Schistosoma mansoni neuropeptide receptor 0.0013 0.0101 0.0092
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.0101 0.0092
Echinococcus granulosus alpha 1A adrenergic receptor 0.0013 0.0101 0.0092
Schistosoma mansoni myosin xvIII 0.0013 0.0101 0.0092
Brugia malayi TAR-binding protein 0.0062 0.0831 0.7453
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0101 0.0092
Onchocerca volvulus 0.0013 0.0101 0.0553
Onchocerca volvulus 0.0013 0.0101 0.0553
Echinococcus granulosus GPCR family 2 0.0015 0.0136 0.0126
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0101 0.0092
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0101 0.0092
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0101 0.0092
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0831 0.7453
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.018 0.0364
Schistosoma mansoni growth hormone secretagogue receptor 0.0013 0.0101 0.0092
Echinococcus granulosus g-protein coupled receptor 0.0013 0.0101 0.0092
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0101 0.0092
Plasmodium falciparum importin beta, putative 0.0028 0.0327 0.0945
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0101 0.0092
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Brugia malayi Tachykinin-like peptides receptor 99D 0.0013 0.0101 0.0636
Loa Loa (eye worm) TYRA-2 protein 0.0013 0.0101 0.0152
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0247 0.0945
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0013 0.0101 0.0636
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0325 0.0663
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0327 0.0945
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0013 0.0101 0.0092
Loa Loa (eye worm) melatonin receptor type 1A 0.0013 0.0101 0.0152
Echinococcus granulosus dro:myosuppressin receptor 0.0013 0.0101 0.0092
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.018 0.137
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0013 0.0101 0.0092
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Echinococcus granulosus 7TM GPCR rhodopsin 0.0013 0.0101 0.0092
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.018 0.5783
Brugia malayi hypothetical protein 0.0013 0.0101 0.0636
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.018 0.0364
Schistosoma mansoni amine GPCR 0.0013 0.0101 0.0092
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0136 0.0956
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0101 0.0092
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0013 0.0101 0.0092
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0101 0.0092
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.018 0.5783
Echinococcus granulosus snurportin 1 0.0301 0.4408 0.4403
Echinococcus granulosus neuropeptide receptor A26 0.0013 0.0101 0.0092
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Echinococcus granulosus serotonin receptor 0.0013 0.0101 0.0092
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Brugia malayi neuropeptide F receptor 0.0013 0.0101 0.0636
Onchocerca volvulus 0.0013 0.0101 0.0553
Brugia malayi neuropeptide F receptor 0.0013 0.0101 0.0636
Onchocerca volvulus 0.0013 0.0101 0.0553
Brugia malayi G-protein coupled receptor 0.0013 0.0101 0.0636
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0101 0.0092
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0101 0.0092
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0088 0.0514
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.018 0.0689
Echinococcus multilocularis lamin 0.0026 0.0299 0.029
Schistosoma mansoni cpg binding protein 0.003 0.0349 0.034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0101 0.0092
Onchocerca volvulus 0.0026 0.0299 0.8918
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0013 0.0101 0.0092
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.0101 0.0092
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0181 0.2612 1
Echinococcus granulosus cpg binding protein 0.003 0.0349 0.034
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0013 0.0101 0.0092
Schistosoma mansoni amine GPCR 0.0013 0.0101 0.0092
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0101 0.0092
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0181 0.2612 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0095 0.0138
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0831 0.1822
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Brugia malayi sulfakinin receptor protein 0.0013 0.0101 0.0636
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0136 0.023
Brugia malayi Melatonin receptor type 1A 0.0013 0.0101 0.0636
Brugia malayi hypothetical protein 0.0013 0.0101 0.0636
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0634 0.137
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0299 0.0605
Echinococcus granulosus orexin receptor type 2 0.0013 0.0101 0.0092
Echinococcus granulosus g protein coupled receptor 0.0013 0.0101 0.0092
Echinococcus multilocularis dro:myosuppressin receptor 0.0013 0.0101 0.0092
Loa Loa (eye worm) RNA binding protein 0.0062 0.0831 0.1822
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0101 0.0092
Schistosoma mansoni dihydropteridine reductase 0.0012 0.0088 0.0079
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Brugia malayi hypothetical protein 0.0013 0.0101 0.0636
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0101 0.0092
Schistosoma mansoni biogenic amine receptor 0.0013 0.0101 0.0092
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.0101 0.0152
Echinococcus granulosus g protein coupled receptor 0.0013 0.0101 0.0092
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0101 0.0092
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0327 0.0318
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0101 0.0092
Loa Loa (eye worm) hypothetical protein 0.0026 0.0292 0.0588
Onchocerca volvulus 0.0013 0.0101 0.0553
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0152
Echinococcus multilocularis allatostatin A receptor 0.0013 0.0101 0.0092
Brugia malayi Dopamine receptor 0.0013 0.0101 0.0636
Schistosoma mansoni opsin-like receptor 0.0013 0.0101 0.0092
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0247 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0013 0.0101 0.0092
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0181 0.2612 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0101 0.0092
Schistosoma mansoni amine GPCR 0.0013 0.0101 0.0092
Echinococcus granulosus neuropeptide s receptor 0.0013 0.0101 0.0092
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0101 0.0092
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.018 0.5783
Schistosoma mansoni microtubule-associated protein tau 0.0676 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0327 0.0667
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0101 0.0092

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 5 mg kg-1 Effective dose inhibiting ethanol-induced lesions was determined 1 h, after oral administration of absolute ethanol in rat ChEMBL. 2754693
Inhibition (functional) = 29 % Inhibition of histamine stimulated gastric acid secretion in adult mongrel dogs at 8 mg/kg compound administered perorally ChEMBL. 2754693
Inhibition (functional) = 44 % Inhibition of histamine stimulated gastric acid secretion in adult mongrel dogs at 2 mg/kg i.v. ChEMBL. 2754693
Inhibition (functional) = 71 % Antisecretory activity of intraperitoneally injected compound (40 mg/kg) in pylorus-ligated rat ChEMBL. 2754693

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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