Detailed information for compound 693013

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 408.331 | Formula: C18H15F3N4O4
  • H donors: 1 H acceptors: 4 LogP: 1.83 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccnc2c1c(=O)n(CC(=O)Nc1ccccc1C(F)(F)F)c(=O)n2C
  • InChi: 1S/C18H15F3N4O4/c1-24-15-14(12(29-2)7-8-22-15)16(27)25(17(24)28)9-13(26)23-11-6-4-3-5-10(11)18(19,20)21/h3-8H,9H2,1-2H3,(H,23,26)
  • InChiKey: LRRMCOBTFPJFEM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0046 0.0095
Plasmodium falciparum thioredoxin reductase 0.0048 0.0518 1
Mycobacterium ulcerans hypothetical protein 0.0074 0.0851 0.9656
Echinococcus multilocularis inositol monophosphatase 0.0008 0.0021 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0495 0.0574
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0092 0.0941
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0077 0.0881 1
Schistosoma mansoni smad 0.0008 0.0023 0.0018
Schistosoma mansoni hypothetical protein 0.0008 0.0021 0.0016
Loa Loa (eye worm) Smad1 0.0008 0.0023 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0505 0.5678
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0095
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0128 0.1351
Schistosoma mansoni smad1 5 8 and 0.0008 0.0023 0.0018
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0505 0.0845
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0172 0.1858
Echinococcus multilocularis smad 0.0008 0.0023 0.0015
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0851 0.1436
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0128 0.1351
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1419 0.3726
Echinococcus granulosus cytochrome P450 2K1 0.0007 0.001 0.0003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0317 0.0811
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0046 0.0045
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0172 0.0428
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.052 0.1348
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.1285 0.2176
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0012 0.0068 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0046 0.0095
Entamoeba histolytica hypothetical protein 0.0036 0.0368 0.3085
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0172 1
Schistosoma mansoni pap-inositol-14-phosphatase 0.0008 0.0021 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0046 0.0095
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0505 0.4305
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0092 0.0941
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0851 0.966
Schistosoma mansoni myo inositol monophosphatase 0.0008 0.0021 0.0016
Mycobacterium ulcerans beta-lactamase 0.0074 0.0851 0.9656
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0851 0.1436
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0172 0.1858
Mycobacterium tuberculosis Probable reductase 0.0109 0.1285 0.2176
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0046 0.03
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0881 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0172 0.1052
Mycobacterium tuberculosis Conserved protein 0.0074 0.0851 0.1436
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0357 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0476 0.5868 1
Schistosoma mansoni cpg binding protein 0.003 0.0291 0.0334
Onchocerca volvulus 0.0014 0.0092 0.0853
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0046 0.0095
Loa Loa (eye worm) hypothetical protein 0.0074 0.0851 0.2224
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0046 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0046 0.0095
Plasmodium falciparum thioredoxin reductase 0.0017 0.0128 0.0837
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0046 0.0095
Leishmania major myo-inositol-1 phosphatase, putative 0.0008 0.0021 0.0128
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0092 0.0941
Loa Loa (eye worm) hypothetical protein 0.0098 0.1144 0.2998
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0092 0.014
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0092 0.0941
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0046 0.0039
Loa Loa (eye worm) hypothetical protein 0.0069 0.0777 0.2027
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.1437 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0046 0.0045
Schistosoma mansoni ap endonuclease 0.002 0.0172 0.0194
Loa Loa (eye worm) hypothetical protein 0.0235 0.286 0.7534
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0128 0.1449
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0092 0.0941
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0092 0.0217
Onchocerca volvulus 0.0047 0.0505 0.5824
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0014 0.0092 0.0575
Toxoplasma gondii exonuclease III APE 0.002 0.0172 0.1858
Loa Loa (eye worm) hypothetical protein 0.0074 0.0851 0.2224
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1173 0.3075
Loa Loa (eye worm) hypothetical protein 0.0035 0.0357 0.0917
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0023 0.0033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0333 0.0552
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.1144 0.2998
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0092 0.014
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0046 0.0039
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0505 0.5678
Brugia malayi MH1 domain containing protein 0.0008 0.0023 0.0033
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0851 0.966
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0092 0.0941
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0172 0.1858
Schistosoma mansoni patched 1 0.0042 0.0446 0.0516
Mycobacterium tuberculosis Conserved protein 0.0074 0.0851 0.1436
Loa Loa (eye worm) hypothetical protein 0.031 0.3793 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0046 0.0095
Echinococcus multilocularis inositol monophosphatase 1 0.0077 0.0881 0.0874
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0357 0.0592
Schistosoma mansoni thyroid hormone receptor 0.001 0.0046 0.0045
Loa Loa (eye worm) RNA binding protein 0.0253 0.3089 0.8138
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0046 0.0045
Mycobacterium leprae POSSIBLE MONOPHOSPHATASE CYSQ 0.0008 0.0021 0.0078
Echinococcus multilocularis muscleblind protein 1 0.031 0.3793 0.3788
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0046 0.0039
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0128 0.1351
Echinococcus granulosus expressed conserved protein 0.0092 0.107 0.1251
Mycobacterium ulcerans inositol-monophosphatase ImpA 0.0008 0.0021 0.0128
Mycobacterium ulcerans monophosphatase CysQ 0.0008 0.0021 0.0128
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.1144 1
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0518 0.1344
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0505 0.1308
Plasmodium falciparum glutathione reductase 0.0017 0.0128 0.0837
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0092 0.0941
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0357 0.349
Loa Loa (eye worm) hypothetical protein 0.0074 0.0851 0.2224
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0495 0.0488
Schistosoma mansoni tar DNA-binding protein 0.0253 0.3089 0.3629
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0008 0.0021 0.0241
Echinococcus multilocularis protein dispatched 1 0.0048 0.052 0.0513
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0046 0.0095
Plasmodium falciparum glutathione reductase 0.0048 0.0518 1
Mycobacterium leprae Probable monophosphatase 0.0008 0.0021 0.0078
Brugia malayi CXXC zinc finger family protein 0.0028 0.0271 0.0691
Onchocerca volvulus 0.001 0.0046 0.03
Loa Loa (eye worm) hypothetical protein 0.0074 0.0851 0.2224
Schistosoma mansoni nuclear hormone receptor 0.001 0.0046 0.0045
Schistosoma mansoni thyroid hormone receptor 0.001 0.0046 0.0045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0128 0.1351
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0046 0.0095
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0505 0.1308
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0357 0.6214
Brugia malayi MH2 domain containing protein 0.0008 0.0023 0.0033
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0046 0.0039
Echinococcus granulosus smad 0.0008 0.0023 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0095
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0128 0.1351
Loa Loa (eye worm) TAR-binding protein 0.0253 0.3089 0.8138
Schistosoma mansoni hypothetical protein 0.0041 0.0427 0.0494
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0851 0.1436
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0851 0.9656
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0023 0.0018
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.1437 0.2436
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0518 0.5616
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0095
Brugia malayi MH1 domain containing protein 0.0008 0.0023 0.0033
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0128 0.1449
Onchocerca volvulus 0.0014 0.0092 0.0853
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0271 0.0691
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0357 0.3983
Toxoplasma gondii hypothetical protein 0.0008 0.0021 0.0128
Trypanosoma brucei trypanothione reductase 0.0048 0.0518 0.5835
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0128 0.047
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0023 0.0018
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0172 0.1951
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0851 0.966
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0092 0.0941
Loa Loa (eye worm) hypothetical protein 0.0042 0.0446 0.1152
Trypanosoma brucei inositol polyphosphate 1-phosphatase, putative 0.0008 0.0021 0.0128
Plasmodium vivax glutathione reductase, putative 0.0048 0.0518 0.5616
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0128 0.1351
Brugia malayi TAR-binding protein 0.0253 0.3089 0.8138
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0092 0.0941
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0172 0.0276
Schistosoma mansoni cpg binding protein 0.0028 0.0271 0.031
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0092 0.0084
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0368 0.0424
Loa Loa (eye worm) hypothetical protein 0.0074 0.0851 0.2224
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0172 1
Echinococcus multilocularis microtubule associated protein 2 0.0686 0.8498 0.8497
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0046 0.0095
Brugia malayi steroid hormone receptor 0.001 0.0046 0.0095
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.0008 0.0021 0.0128
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0495 0.0488
Schistosoma mansoni Smad4 0.0008 0.0023 0.0018
Brugia malayi MH2 domain containing protein 0.0008 0.0023 0.0033
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0172 0.1951
Echinococcus granulosus FTZ F1 alpha 0.001 0.0046 0.0045
Brugia malayi hypothetical protein 0.0235 0.286 0.7534
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0446 0.0516
Onchocerca volvulus 0.0014 0.0092 0.0853
Echinococcus multilocularis 0.0007 0.001 0.0002
Echinococcus granulosus GPCR family 2 0.0032 0.0317 0.0364
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0128 0.1351
Brugia malayi MH2 domain containing protein 0.012 0.1419 0.3726
Echinococcus granulosus Smad4 0.0008 0.0023 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0495 0.0574
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0851 0.1436
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0029 0.005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0046 0.0095
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0505 0.3468
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0128 0.0311
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0851 0.9656
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0172 0.0164
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0029 0.0025
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0128 0.047
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0073 0.0166
Brugia malayi Inositol-1 0.0077 0.0881 0.2303
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0046 0.0039
Schistosoma mansoni inositol monophosphatase 0.0077 0.0881 0.1029
Schistosoma mansoni hypothetical protein 0.0007 0.001 0.0003
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0518 0.0511
Trichomonas vaginalis esterase, putative 0.0074 0.0851 0.966
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0092 0.0941
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0128 0.7067
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0092 0.0217
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1419 0.3726
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0069 0.0781 0.1316
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.1437 0.2436
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0851 0.966
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0317 0.0364
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0046 0.0045
Schistosoma mansoni cpg binding protein 0.003 0.0291 0.0334
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0014 0.0092 0.0575
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.1669 0.1663
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0128 0.012
Toxoplasma gondii thioredoxin reductase 0.0048 0.0518 0.5835
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0777 0.2027
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0128 0.1351
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0585 0.6598
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0077 0.0881 1
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0851 0.9656
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0128 0.0837
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0851 0.0994
Mycobacterium ulcerans hypothetical protein 0.0047 0.0505 0.5678
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0128 0.1351
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0495 0.0574
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0046 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0495 0.0574
Brugia malayi CHE-14 protein 0.0042 0.0446 0.1152
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0077 0.0881 1
Schistosoma mansoni hypothetical protein 0.0008 0.0021 0.0016
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0495 0.1281
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0505 0.3468
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0073 0.0166
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0008 0.0021 0.0014
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0092 0.0217
Trichomonas vaginalis inositol monophosphatase, putative 0.0008 0.0021 0.0241
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0505 0.5678
Schistosoma mansoni survival motor neuron protein 0.0048 0.052 0.0603
Schistosoma mansoni microtubule-associated protein tau 0.0686 0.8498 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0008 0.0021 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0046 0.0095
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0095
Onchocerca volvulus 0.0074 0.0851 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0505 0.5678
Schistosoma mansoni hypothetical protein 0.0041 0.0427 0.0494
Brugia malayi beta-lactamase family protein 0.0074 0.0851 0.2224
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.1669 0.1957
Leishmania major inositol polyphosphate 1-phosphatase, putative 0.0008 0.0021 0.0128
Echinococcus granulosus tar DNA binding protein 0.0253 0.3089 0.3629
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0505 0.5678
Schistosoma mansoni hypothetical protein 0.0032 0.0317 0.0364
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0023 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0253 0.3089 0.3629
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0046 0.0045
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0046 0.0095
Schistosoma mansoni smad1 5 8 and 0.0008 0.0023 0.0018
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0851 0.1436
Echinococcus granulosus muscleblind protein 0.031 0.3793 0.4458
Loa Loa (eye worm) hypothetical protein 0.0032 0.0317 0.0811
Schistosoma mansoni hypothetical protein 0.0041 0.0427 0.0494
Onchocerca volvulus 0.0048 0.052 0.6009
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.1144 0.1138
Brugia malayi hypothetical protein 0.0036 0.0368 0.0946
Schistosoma mansoni tar DNA-binding protein 0.0253 0.3089 0.3629
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0092 0.0941
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0446 0.0516
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0092 0.0941
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0046 0.0095
Trichomonas vaginalis inositol monophosphatase, putative 0.0008 0.0021 0.0241
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0046 0.0095
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0046 0.0045
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0128 0.1351
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0851 0.1436
Onchocerca volvulus 0.0074 0.0851 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0851 0.966
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0092 0.0941
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0505 0.5678
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0028 0.0047
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0505 0.1308
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0172 0.1873
Loa Loa (eye worm) glutathione reductase 0.0048 0.0518 0.1344
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0092 0.0941
Brugia malayi beta-lactamase family protein 0.0074 0.0851 0.2224
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0333 0.0552
Schistosoma mansoni hypothetical protein 0.0069 0.0777 0.0906
Loa Loa (eye worm) hypothetical protein 0.0035 0.0357 0.0917
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0851 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0046 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0046 0.0095
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0128 0.1351
Loa Loa (eye worm) beta-lactamase 0.0074 0.0851 0.2224
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0092 0.014
Mycobacterium ulcerans lipase LipD 0.0074 0.0851 0.9656
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0172 0.0587
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0046 0.0045
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0046 0.0045
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0664 0.0774
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0851 0.9656
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0128 0.1351
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0046 0.0045
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.1144 0.1339
Loa Loa (eye worm) inositol-1 0.0077 0.0881 0.2303
Loa Loa (eye worm) hypothetical protein 0.0047 0.0505 0.1308
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0046 0.0045
Mycobacterium ulcerans monophosphatase 0.0008 0.0021 0.0128
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0172 0.0428
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0317 0.031
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0046 0.03
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0851 0.2224
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0851 0.5897
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0077 0.0881 1
Schistosoma mansoni hypothetical protein 0.0032 0.0317 0.0364
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1173 0.3075
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0092 0.014
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0092 0.1045
Echinococcus multilocularis muscleblind protein 0.031 0.3793 0.3788
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1173 0.3075
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0046 0.0045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0128 0.1351
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0128 0.3172
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0368 0.036
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0092 0.0941
Brugia malayi Smad1 0.0008 0.0023 0.0033
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0023 0.0018
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0851 0.2224
Loa Loa (eye worm) hypothetical protein 0.031 0.3793 1
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0092 0.0099
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0505 0.4305
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0505 0.5678
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0092 0.0941
Brugia malayi glutathione reductase 0.0048 0.0518 0.1344
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0128 0.1351
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0446 0.1152
Onchocerca volvulus 0.0014 0.0092 0.0853
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0495 0.1281
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0046 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0095
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0128 0.0141
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0092 0.0631
Schistosoma mansoni hypothetical protein 0.0032 0.0317 0.0364
Brugia malayi ecdysteroid receptor 0.001 0.0046 0.0095
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.286 0.2854
Brugia malayi Inositol monophosphatase family protein 0.0008 0.0021 0.003
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0092 0.0941
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0046 0.03
Loa Loa (eye worm) hypothetical protein 0.0035 0.0357 0.0917
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0092 0.014
Brugia malayi nuclear receptor NHR-88 0.001 0.0046 0.0095
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0172 0.0194
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0128 0.0201
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0505 0.5678
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0092 0.0099
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0317 0.031
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0046 0.0039
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0368 0.0424
Schistosoma mansoni tar DNA-binding protein 0.0253 0.3089 0.3629
Brugia malayi Thioredoxin reductase 0.0048 0.0518 0.1344
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0046 0.0045
Schistosoma mansoni smad1 5 8 and 0.0008 0.0023 0.0018
Brugia malayi RNA recognition motif domain containing protein 0.0253 0.3089 0.8138
Loa Loa (eye worm) hypothetical protein 0.0008 0.0021 0.003
Leishmania major hypothetical protein, conserved 0.0074 0.0851 0.9656
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0128 0.1351
Toxoplasma gondii ABC1 family protein 0.0074 0.0851 0.9656
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0046 0.0045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0128 0.1351
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0128 0.0141
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0008 0.0021 0.0016
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.1285 0.2176
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0881 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0092 0.0941
Schistosoma mansoni coup transcription factor 0.001 0.0046 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0095
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0092 0.0941
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative 0.0008 0.0021 0.0128
Mycobacterium tuberculosis Monophosphatase CysQ 0.0008 0.0021 0.0019
Brugia malayi nuclear hormone receptor 0.001 0.0046 0.0095
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0092 0.014
Loa Loa (eye worm) hypothetical protein 0.0035 0.0357 0.0917
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0851 0.0994
Mycobacterium ulcerans monophosphatase CysQ 0.0008 0.0021 0.0128
Echinococcus granulosus microtubule associated protein 2 0.0686 0.8498 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0077 0.0881 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0317 0.0364
Loa Loa (eye worm) hypothetical protein 0.01 0.1173 0.3075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0046 0.0095
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0881 1
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0046 0.0095
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0446 0.0438
Leishmania major trypanothione reductase 0.0048 0.0518 0.5835
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0023 0.0015
Entamoeba histolytica hypothetical protein 0.0036 0.0368 0.3085
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0092 0.0941
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0092 0.0217
Mycobacterium leprae Probable lipase LipE 0.0074 0.0851 0.5897
Onchocerca volvulus 0.0028 0.0271 0.3012
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0253 0.3089 0.8138
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0092 0.1045
Echinococcus multilocularis GPCR, family 2 0.0032 0.0317 0.031
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0092 0.0941
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0505 0.5678
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.1285 0.2176
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0495 0.0574
Echinococcus multilocularis Smad4 0.0008 0.0023 0.0015
Brugia malayi Inositol monophosphatase family protein 0.0008 0.0021 0.003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0128 0.1351
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0092 0.0941
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0092 0.0217
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0095
Mycobacterium tuberculosis Conserved protein 0.0074 0.0851 0.1436
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0046 0.0039
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.1163 0.1361
Schistosoma mansoni hypothetical protein 0.0032 0.0317 0.0364
Loa Loa (eye worm) hypothetical protein 0.0074 0.0851 0.2224
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0317 0.0811
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0092 0.0217
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0092 0.014
Loa Loa (eye worm) hypothetical protein 0.0008 0.0021 0.003
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.1285 0.2176
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0069 0.0781 0.5402
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0092 0.0941
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0851 0.0844
Echinococcus granulosus cpg binding protein 0.003 0.0291 0.0334
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0128 0.1351
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0092 0.0941
Schistosoma mansoni inositol monophosphatase 0.0077 0.0881 0.1029
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0092 0.0941
Onchocerca volvulus 0.0074 0.0851 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0128 0.1351
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0092 0.0941
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0092 0.014
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0023 0.0033
Schistosoma mansoni hypothetical protein 0.0041 0.0427 0.0494
Brugia malayi beta-lactamase 0.0074 0.0851 0.2224
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0518 0.5835
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0092 0.0941
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0092 0.014
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0317 0.0811
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0046 0.0095
Loa Loa (eye worm) hypothetical protein 0.0035 0.0357 0.0917
Echinococcus granulosus inositol monophosphatase 1 0.0077 0.0881 0.1029
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0518 0.0602
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0046 0.0095
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0095
Schistosoma mansoni hypothetical protein 0.0048 0.052 0.0603
Brugia malayi Cytochrome P450 family protein 0.0026 0.0251 0.0638
Mycobacterium tuberculosis Probable monophosphatase 0.0008 0.0021 0.0019
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0092 0.0217
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0014 0.0092 0.0575
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0046 0.0095
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0046 0.0045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0333 0.0552
Brugia malayi Muscleblind-like protein 0.031 0.3793 1
Echinococcus multilocularis tar DNA binding protein 0.0253 0.3089 0.3083
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.1285 0.8933
Entamoeba histolytica hypothetical protein 0.0036 0.0368 0.3085
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0505 0.5678
Brugia malayi RNA binding protein 0.0253 0.3089 0.8138
Entamoeba histolytica hypothetical protein 0.0036 0.0368 0.3085
Echinococcus granulosus inositol monophosphatase 0.0008 0.0021 0.0016
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0029 0.0021
Loa Loa (eye worm) hypothetical protein 0.0051 0.0564 0.1464
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0518 0.0868
Schistosoma mansoni ap endonuclease 0.002 0.0172 0.0194
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0077 0.0881 0.7659
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0128 0.1351
Schistosoma mansoni tar DNA-binding protein 0.0253 0.3089 0.3629
Loa Loa (eye worm) hypothetical protein 0.0047 0.0505 0.1308
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0128 0.1351
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0046 0.0095
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.1285 0.2176
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0505 0.4305
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0251 0.0638
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0128 0.0837
Trichomonas vaginalis inositol monophosphatase, putative 0.0077 0.0881 1
Schistosoma mansoni cytochrome P450 0.0007 0.001 0.0003
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0851 0.1436
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0046 0.0045
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0881 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0092 0.014
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0851 0.0994
Echinococcus multilocularis cpg binding protein 0.003 0.0291 0.0284
Loa Loa (eye worm) hypothetical protein 0.0014 0.0092 0.0217
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0092 0.014
Schistosoma mansoni hypothetical protein 0.0036 0.0368 0.0424
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.286 0.3359
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0046 0.0095
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0172 0.1342
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0851 0.9656
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0046 0.0039
Loa Loa (eye worm) oxidoreductase 0.0014 0.0092 0.0217
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0333 0.0552
Echinococcus multilocularis expressed conserved protein 0.0092 0.107 0.1063
Loa Loa (eye worm) hypothetical protein 0.0047 0.0505 0.1308
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0092 0.0217
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0092 0.0941
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.0008 0.0021 0.0128
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0505 0.0845
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0128 0.1351
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0172 0.1858
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0092 0.0941
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0172 0.1858
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.1437 0.2436
Echinococcus multilocularis protein patched 0.0042 0.0446 0.0438
Loa Loa (eye worm) hypothetical protein 0.0014 0.0092 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0446 0.5057

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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