TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 668.886 | Formula: C36H52N4O6S
H donors: 4 H acceptors: 6 LogP: 4.61 Rotable bonds: 18
Rule of 5 violations (Lipinski): 2
SMILES: CC(C[C@@H]([C@@H]([C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1[C@@H]([C@H]1C(=O)N1CCOCC1)Cc1ccccc1)Cc1ncsc1)CC1CCCCC1)O)O)C
InChi: 1S/C36H52N4O6S/c1-23(2)17-30(41)33(42)28(19-25-11-7-4-8-12-25)38-34(43)29(20-26-21-47-22-37-26)39-35(44)31-27(18-24-9-5-3-6-10-24)32(31)36(45)40-13-15-46-16-14-40/h3,5-6,9-10,21-23,25,27-33,41-42H,4,7-8,11-20H2,1-2H3,(H,38,43)(H,39,44)/t27-,28-,29-,30-,31+,32+,33+/m0/s1
InChiKey: DDPPBKSFIPPHAN-OSJIZEKLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	renin	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_126885	All targets in OG5_126885
Theileria parva	pepsinogen, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	Get druggable targets OG5_126885	All targets in OG5_126885
Candida albicans	vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C)	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma japonicum	Cathepsin D precursor, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium falciparum	plasmepsin I	Get druggable targets OG5_126885	All targets in OG5_126885
Theileria parva	cathepsin E, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium vivax	plasmepsin IV, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma mansoni	cathepsin D (A01 family)	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium knowlesi	plasmepsin IV, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Cryptosporidium parvum	membrane bound aspartyl proteinase with a signal peptide plus transmembrane domain	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium falciparum	plasmepsin VI	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma mansoni	cathepsin D (A01 family)	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma japonicum	ko:K01379 cathepsin D [EC3.4.23.5], putative	Get druggable targets OG5_126885	All targets in OG5_126885
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium berghei	plasmepsin IV	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium berghei	plasmepsin VI	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium yoelii	plasmepsin	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium falciparum	plasmepsin II	Get druggable targets OG5_126885	All targets in OG5_126885
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	Get druggable targets OG5_126885	All targets in OG5_126885
Loa Loa (eye worm)	aspartic protease BmAsp-2	Get druggable targets OG5_126885	All targets in OG5_126885
Neospora caninum	Pepsinogen A1, related	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium vivax	aspartyl proteinase, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium falciparum	plasmepsin IV	Get druggable targets OG5_126885	All targets in OG5_126885
Neospora caninum	Renin, related	Get druggable targets OG5_126885	All targets in OG5_126885
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126885	All targets in OG5_126885
Babesia bovis	eukaryotic aspartyl protease family protein	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium knowlesi	aspartyl protease, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Cryptosporidium hominis	aspartyl protease precursor	Get druggable targets OG5_126885	All targets in OG5_126885
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	Get druggable targets OG5_126885	All targets in OG5_126885
Toxoplasma gondii	aspartyl protease ASP1	Get druggable targets OG5_126885	All targets in OG5_126885
Candida albicans	vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C)	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_126885	All targets in OG5_126885

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	plasmepsin X	renin	406 aa	352 aa	26.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0646	1	1
Schistosoma mansoni	cathepsin D (A01 family)	0.0174	0.2533	0.2533
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0646	1	1
Entamoeba histolytica	cysteine protease, putative	0.0333	0.5044	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0119	0.1665	0.1025
Brugia malayi	Papain family cysteine protease containing protein	0.0119	0.1665	0.1665
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0119	0.1665	0.1025
Onchocerca volvulus	Cathepsin L homolog	0.0119	0.1665	0.1665
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0119	0.1665	0.1665
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0333	0.5044	0.4664
Entamoeba histolytica	cysteine protease, putative	0.0333	0.5044	0.4054
Plasmodium falciparum	serine repeat antigen 7	0.0119	0.1665	0.1665
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0623	0.9649	0.9649
Leishmania major	cathepsin L-like protease	0.0646	1	1
Loa Loa (eye worm)	hypothetical protein	0.0432	0.6621	0.6621
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0646	1	1
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3158	0.3158
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0119	0.1665	0.1665
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0646	1	1
Echinococcus granulosus	cathepsin L	0.0333	0.5044	0.4664
Schistosoma mansoni	carbonic anhydrase-related	0.0209	0.3095	0.3095
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0623	0.9649	0.9649
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0646	1	1
Leishmania major	carbonic anhydrase-like protein	0.0412	0.6304	0.5565
Schistosoma mansoni	serine/threonine protein kinase	0.0623	0.9649	0.9649
Schistosoma mansoni	cathepsin s	0.0213	0.3158	0.3158
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0119	0.1665	0.1665
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0646	1	1
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0059	0.0713	0.0713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0432	0.6621	0.6362
Plasmodium falciparum	plasmepsin VI	0.0059	0.0713	0.0713
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0119	0.1665	0.1665
Brugia malayi	Cathepsin L-like precursor	0.0646	1	1
Loa Loa (eye worm)	cysteine protease	0.0646	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0646	1	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0713	0.0713
Onchocerca volvulus		0.0646	1	1
Trypanosoma cruzi	cysteine protease, putative	0.0333	0.5044	0.4054
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0119	0.1665	0.5
Plasmodium falciparum	serine repeat antigen 3	0.0119	0.1665	0.1665
Giardia lamblia	Cathepsin B precursor	0.0119	0.1665	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1665	0.1025
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1665	0.1665
Loa Loa (eye worm)	fibroinase	0.0646	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0646	1	1
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0119	0.1665	0.1665
Trypanosoma cruzi	cruzipain precursor, putative	0.0213	0.3158	0.1791
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0646	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0213	0.3158	0.1791
Brugia malayi	Cathepsin L-like precursor	0.0432	0.6621	0.6621
Brugia malayi	fibroinase precursor	0.0119	0.1665	0.1665
Brugia malayi	Protein kinase domain containing protein	0.0623	0.9649	0.9649
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0646	1	1
Entamoeba histolytica	cysteine protease, putative	0.0333	0.5044	0.4054
Giardia lamblia	Cathepsin B precursor	0.0119	0.1665	0.5
Echinococcus multilocularis	carbonic anhydrase	0.0209	0.3095	0.2565
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0119	0.1665	0.1665
Entamoeba histolytica	cysteine protease, putative	0.0333	0.5044	0.4054
Giardia lamblia	Cathepsin L precursor	0.0119	0.1665	0.5
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0209	0.3095	0.3095
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0119	0.1665	0.1665
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0119	0.1665	0.1665
Entamoeba histolytica	cysteine proteinase, putative	0.0432	0.6621	0.5946
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0412	0.6304	0.6304
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0333	0.5044	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0646	1	1
Giardia lamblia	Cathepsin B precursor	0.0119	0.1665	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0119	0.1665	0.1665
Entamoeba histolytica	cysteine proteinase, putative	0.0333	0.5044	0.4054
Plasmodium falciparum	plasmepsin IV	0.0059	0.0713	0.0713
Plasmodium falciparum	serine repeat antigen 5	0.0119	0.1665	0.1665
Brugia malayi	cathepsin L precursor	0.0119	0.1665	0.1665
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0646	1	1
Plasmodium falciparum	serine repeat antigen 2	0.0119	0.1665	0.1665
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0119	0.1665	0.1665
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0119	0.1665	0.1665
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0119	0.1665	0.1025
Onchocerca volvulus		0.0646	1	1
Schistosoma mansoni	hypothetical protein	0.0209	0.3095	0.3095
Trypanosoma cruzi	cysteine peptidase, putative	0.0646	1	1
Brugia malayi	cathepsin L-like precursor	0.0432	0.6621	0.6621
Plasmodium vivax	vivapain-3	0.0333	0.5044	0.5044
Loa Loa (eye worm)	carbonic anhydrase 3	0.0412	0.6304	0.6304
Schistosoma mansoni	carbonic anhydrase-related	0.0209	0.3095	0.3095
Echinococcus granulosus	carbonic anhydrase	0.0209	0.3095	0.2565
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0412	0.6304	0.6304
Brugia malayi	Papain family cysteine protease containing protein	0.0333	0.5044	0.5044
Giardia lamblia	Cysteine protease	0.0119	0.1665	0.5
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0333	0.5044	0.5044
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0646	1	1
Echinococcus granulosus	cathepsin l1	0.0432	0.6621	0.6362
Trypanosoma cruzi	cysteine peptidase, putative	0.0333	0.5044	0.4054
Echinococcus multilocularis	cathepsin L cysteine protease	0.0646	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0646	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0119	0.1665	0.1665
Plasmodium vivax	unspecified product	0.0119	0.1665	0.1665
Entamoeba histolytica	cysteine proteinase, putative	0.0646	1	1
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3158	0.3158
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0412	0.6304	0.5565
Onchocerca volvulus		0.0646	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0646	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0333	0.5044	0.4054
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0646	1	1
Leishmania major	cathepsin L-like protease	0.0646	1	1
Onchocerca volvulus		0.0119	0.1665	0.1665
Toxoplasma gondii	aspartyl protease ASP1	0.0059	0.0713	0.0713
Echinococcus multilocularis	cathepsin b	0.0119	0.1665	0.1025
Plasmodium falciparum	carbonic anhydrase	0.0209	0.3095	0.3095
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0646	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0333	0.5044	0.5044
Loa Loa (eye worm)	cathepsin B	0.0119	0.1665	0.1665
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0623	0.9649	0.9622
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1665	0.1025
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0119	0.1665	0.1025
Brugia malayi	Cathepsin L-like precursor	0.0432	0.6621	0.6621
Entamoeba histolytica	cysteine proteinase 2	0.0333	0.5044	0.4054
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0432	0.6621	0.6621
Plasmodium falciparum	plasmepsin I	0.0059	0.0713	0.0713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0646	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0646	1	1
Giardia lamblia	Cathepsin B precursor	0.0119	0.1665	0.5
Echinococcus granulosus	carbonic anhydrase II	0.0412	0.6304	0.602
Loa Loa (eye worm)	ctsf protein	0.0646	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0646	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0646	1	1
Giardia lamblia	Cathepsin L precursor	0.0119	0.1665	0.5
Schistosoma mansoni	cathepsin F (C01 family)	0.0432	0.6621	0.6621
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0412	0.6304	0.6304
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0119	0.1665	0.5
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0119	0.1665	0.1665
Brugia malayi	cathepsin L-like cysteine proteinase	0.0119	0.1665	0.1665
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0119	0.1665	0.1025
Plasmodium vivax	serine-repeat antigen (SERA)	0.0119	0.1665	0.1665
Loa Loa (eye worm)	hypothetical protein	0.0209	0.3095	0.3095
Entamoeba histolytica	cysteine proteinase, putative	0.0333	0.5044	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0646	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0119	0.1665	0.1025
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0412	0.6304	0.6304
Giardia lamblia	Cathepsin L precursor	0.0119	0.1665	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0646	1	1
Echinococcus granulosus	cysteine protease	0.0333	0.5044	0.4664
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0646	1	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0209	0.3095	0.3095
Echinococcus granulosus	carbonic anhydrase	0.0209	0.3095	0.2565
Entamoeba histolytica	cysteine protease, putative	0.0333	0.5044	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1665	0.1665
Plasmodium vivax	vivapain-2	0.0646	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0646	1	1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0119	0.1665	0.1665
Plasmodium vivax	unspecified product	0.0333	0.5044	0.5044
Echinococcus multilocularis	carbonic anhydrase	0.0209	0.3095	0.2565
Entamoeba histolytica	cysteine protease, putative	0.0333	0.5044	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0646	1	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0333	0.5044	0.4054
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0209	0.3095	0.3095
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0646	1	1
Entamoeba histolytica	cysteine protease, putative	0.0333	0.5044	0.4054
Plasmodium falciparum	plasmepsin II	0.0059	0.0713	0.0713
Onchocerca volvulus	Cathepsin F homolog	0.0646	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0119	0.1665	0.5
Giardia lamblia	Cysteine protease	0.0119	0.1665	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0432	0.6621	0.6362
Schistosoma mansoni	cathepsin D (A01 family)	0.0174	0.2533	0.2533
Loa Loa (eye worm)	hypothetical protein	0.0209	0.3095	0.3095
Entamoeba histolytica	cysteine protease, putative	0.0333	0.5044	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0646	1	1
Toxoplasma gondii	cathepsin B	0.0119	0.1665	0.1665
Entamoeba histolytica	cysteine protease, putative	0.0646	1	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0059	0.0713	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3158	0.3158
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1665	0.1025
Echinococcus multilocularis	cysteine protease	0.0646	1	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1665	0.1665
Giardia lamblia	Cathepsin B precursor	0.0119	0.1665	0.5
Onchocerca volvulus		0.0432	0.6621	0.6621
Giardia lamblia	Cathepsin L precursor	0.0119	0.1665	0.5
Brugia malayi	Cathepsin L-like precursor	0.0646	1	1
Plasmodium vivax	vivapain-1	0.0333	0.5044	0.5044
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0119	0.1665	0.1025
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0213	0.3158	0.3158
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0119	0.1665	0.1665
Schistosoma mansoni	carbonic anhydrase	0.0209	0.3095	0.3095
Echinococcus multilocularis	cathepsin L cysteine protease	0.0646	1	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0119	0.1665	0.1665
Leishmania major	cathepsin L-like protease	0.0646	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0333	0.5044	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0119	0.1665	0.1025
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0059	0.0713	0.0713
Entamoeba histolytica	cysteine protease, putative	0.0333	0.5044	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1665	0.1665
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0119	0.1665	0.1025
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0646	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0119	0.1665	0.1665
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0412	0.6304	0.6304
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0119	0.1665	0.1665
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1665	0.1025
Trypanosoma cruzi	cysteine peptidase, putative	0.0646	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0119	0.1665	0.1665
Giardia lamblia	Cathepsin L-like protease	0.0119	0.1665	0.5
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1665	0.1665
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0333	0.5044	0.4664
Brugia malayi	cathepsin F-like cysteine proteinase	0.0119	0.1665	0.1665
Giardia lamblia	Cathepsin L precursor	0.0119	0.1665	0.5
Entamoeba histolytica	cysteine protease, putative	0.0333	0.5044	0.4054
Echinococcus granulosus	carbonic anhydrase	0.0209	0.3095	0.2565
Brugia malayi	Cathepsin L-like precursor	0.0646	1	1
Plasmodium vivax	plasmepsin IV, putative	0.0059	0.0713	0.0713
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0119	0.1665	0.1665
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0119	0.1665	0.1665
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0646	1	1
Leishmania major	cathepsin L-like protease	0.0646	1	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0333	0.5044	0.5044
Echinococcus multilocularis	cathepsin b	0.0119	0.1665	0.1025
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0209	0.3095	0.3095
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0646	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0646	1	1
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0412	0.6304	0.5565
Plasmodium falciparum	serine repeat antigen 9	0.0119	0.1665	0.1665
Echinococcus multilocularis	carbonic anhydrase II	0.0412	0.6304	0.602
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1665	0.1665
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0119	0.1665	0.1665
Plasmodium falciparum	serine repeat antigen 6	0.0119	0.1665	0.1665
Echinococcus granulosus	cathepsin L	0.0119	0.1665	0.1025
Plasmodium falciparum	serine repeat antigen 8	0.0119	0.1665	0.1665
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0209	0.3095	0.3095
Giardia lamblia	Cathepsin B precursor	0.0119	0.1665	0.5
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1665	0.1665
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1665	0.1025
Echinococcus multilocularis	cysteine protease	0.0646	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0646	1	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0119	0.1665	0.1665
Leishmania major	cathepsin L-like protease	0.0646	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0333	0.5044	0.4054
Trypanosoma cruzi	cysteine proteinase, putative	0.0333	0.5044	0.4054
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0646	1	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0119	0.1665	0.1665
Onchocerca volvulus		0.0646	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0646	1	1
Echinococcus multilocularis	carbonic anhydrase	0.0209	0.3095	0.2565
Leishmania major	cathepsin L-like protease	0.0646	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0333	0.5044	0.4054
Plasmodium vivax	aspartyl proteinase, putative	0.0059	0.0713	0.0713
Toxoplasma gondii	cathepsin CPC1	0.0119	0.1665	0.1665
Schistosoma mansoni	carbonic anhydrase-related	0.0209	0.3095	0.3095
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0119	0.1665	0.5
Echinococcus granulosus	cathepsin b	0.0119	0.1665	0.1025
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0119	0.1665	0.1665
Giardia lamblia	Cathepsin B precursor	0.0119	0.1665	0.5
Echinococcus granulosus	cathepsin l1	0.0646	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0646	1	1
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0623	0.9649	0.9622
Brugia malayi	Cathepsin L-like precursor	0.0646	1	1
Onchocerca volvulus		0.0646	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0646	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0646	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0119	0.1665	0.1025
Loa Loa (eye worm)	hypothetical protein	0.0646	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0213	0.3158	0.3158
Giardia lamblia	Cysteine protease	0.0119	0.1665	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0119	0.1665	0.1665
Brugia malayi	cathepsin B-like cysteine proteinase	0.0119	0.1665	0.1665
Echinococcus granulosus	cathepsin b	0.0119	0.1665	0.1025
Plasmodium vivax	unspecified product	0.0213	0.3158	0.3158
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0119	0.1665	0.1665
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0646	1	1
Loa Loa (eye worm)	hypothetical protein	0.0432	0.6621	0.6621
Onchocerca volvulus		0.0646	1	1
Giardia lamblia	Cysteine protease	0.0119	0.1665	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0646	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0119	0.1665	0.1025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0646	1	1
Leishmania major	cathepsin L-like protease	0.0646	1	1
Plasmodium falciparum	serine repeat antigen 4	0.0119	0.1665	0.1665
Schistosoma mansoni	cathepsin B (C01 family)	0.0119	0.1665	0.1665
Giardia lamblia	Hypothetical protein	0.0119	0.1665	0.5
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0119	0.1665	0.1665
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0119	0.1665	0.1665
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0333	0.5044	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0646	1	1
Giardia lamblia	Cathepsin L precursor	0.0119	0.1665	0.5
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0119	0.1665	0.1665
Brugia malayi	Papain family cysteine protease containing protein	0.0333	0.5044	0.5044
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0119	0.1665	0.1665
Brugia malayi	Cathepsin L-like precursor	0.0646	1	1
Giardia lamblia	Cathepsin L-like protease	0.0119	0.1665	0.5
Trypanosoma brucei	carbonic anhydrase-like protein	0.0412	0.6304	0.5565
Trichomonas vaginalis	conserved hypothetical protein	0.0119	0.1665	0.1025
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0333	0.5044	0.5044
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0646	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1665	0.1025
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0646	1	1
Giardia lamblia	Hypothetical protein	0.0119	0.1665	0.5
Loa Loa (eye worm)	hypothetical protein	0.0432	0.6621	0.6621
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0119	0.1665	0.1665
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0209	0.3095	0.3095
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0623	0.9649	0.9649
Brugia malayi	cathepsin F-like cysteine proteinase	0.0213	0.3158	0.3158
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0646	1	1
Plasmodium falciparum	serine repeat antigen 1	0.0119	0.1665	0.1665
Echinococcus granulosus	cathepsin L cysteine protease	0.0333	0.5044	0.4664
Leishmania major	cysteine peptidase A (CPA)	0.0646	1	1
Schistosoma mansoni	cathepsin C	0.0119	0.1665	0.1665
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0119	0.1665	0.1665
Onchocerca volvulus	Cathepsin L homolog	0.0646	1	1
Entamoeba histolytica	cysteine protease, putative	0.0333	0.5044	0.4054
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0646	1	1
Toxoplasma gondii	cathepsin CPL	0.0646	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0646	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0646	1	1
Toxoplasma gondii	cathepsin CPC2	0.0119	0.1665	0.1665
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0432	0.6621	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0333	0.5044	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0119	0.1665	0.1025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0119	0.1665	0.1025
Schistosoma mansoni	cathepsin S (C01 family)	0.0119	0.1665	0.1665
Giardia lamblia	Cathepsin B precursor	0.0119	0.1665	0.5
Loa Loa (eye worm)	hypothetical protein	0.0209	0.3095	0.3095
Onchocerca volvulus		0.0646	1	1
Plasmodium vivax	vivapain-2	0.0646	1	1
Brugia malayi	Cathepsin L-like precursor	0.0213	0.3158	0.3158
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0646	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0646	1	1
Leishmania major	cathepsin L-like protease	0.0646	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0646	1	1
Giardia lamblia	Encystation-specific protease	0.0119	0.1665	0.5
Toxoplasma gondii	hypothetical protein	0.0209	0.3095	0.3095
Entamoeba histolytica	cysteine protease, putative	0.0333	0.5044	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0119	0.1665	0.1665
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0119	0.1665	0.1665
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0119	0.1665	0.1665
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0646	1	1
Echinococcus multilocularis	cathepsin L	0.0333	0.5044	0.4664
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0623	0.9649	0.9649
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0119	0.1665	0.1665
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0646	1	1
Echinococcus multilocularis	cathepsin L	0.0119	0.1665	0.1025

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 120 nM	In vitro inhibition of purified human renin at a pH of 6.0.	ChEMBL.	1588553
IC50 (binding)	= 120 nM	In vitro inhibition of purified human renin at a pH of 6.0.	ChEMBL.	1588553

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 69307