TDR Targets

Basic information

Technical information

TDR Targets ID: 693328
Name: 2-[4-(1-benzofuran-2-yl)-2-oxochromen-6-yl]ox yacetamide
MW: 335.31 | Formula: C19H13NO5
H donors: 1 H acceptors: 2 LogP: 2.44 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: NC(=O)COc1ccc2c(c1)c(cc(=O)o2)c1cc2c(o1)cccc2
InChi: 1S/C19H13NO5/c20-18(21)10-23-12-5-6-16-13(8-12)14(9-19(22)25-16)17-7-11-3-1-2-4-15(11)24-17/h1-9H,10H2,(H2,20,21)
InChiKey: CSJUDTICUMFRFG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[4-(benzofuran-2-yl)-2-oxo-chromen-6-yl]oxyacetamide
2-[[4-(2-benzofuranyl)-2-oxo-6-chromenyl]oxy]acetamide
2-[4-(benzofuran-2-yl)-2-keto-chromen-6-yl]oxyacetamide
2-[4-(1-benzofuran-2-yl)-2-oxo-chromen-6-yl]oxyethanamide
ZINC04586249

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	nuclear receptor NHR-88	0.0031	0.019	0.0433
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0031	0.019	0.0433
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0015	0.0053	0.009
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.019	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0193	0.0469
Echinococcus multilocularis	regulator of G protein signaling	0.002	0.0097	0.0169
Loa Loa (eye worm)	runx1	0.0062	0.0441	0.1092
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0053	0.012
Loa Loa (eye worm)	hypothetical protein	0.002	0.0097	0.0229
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.019	0.0338
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.1218	1	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0291	0.0518
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0031	0.019	0.0433
Trichomonas vaginalis	penicillin-binding protein, putative	0.0107	0.0817	0.4167
Schistosoma mansoni	nuclear receptor	0.0015	0.0053	0.0097
Schistosoma mansoni	hypothetical protein	0.0032	0.0193	0.035
Schistosoma mansoni	hypothetical protein	0.005	0.0344	0.0626
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0031	0.019	0.0433
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0031	0.019	0.0345
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0015	0.0053	0.009
Schistosoma mansoni	hypothetical protein	0.0205	0.1623	0.295
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0209	0.1657	0.1612
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0294	0.1475
Plasmodium falciparum	flap endonuclease 1	0.0025	0.0142	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0068	0.0157
Loa Loa (eye worm)	hypothetical protein	0.002	0.0097	0.0229
Onchocerca volvulus		0.0107	0.0817	0.1936
Trichomonas vaginalis	D-aminoacylase, putative	0.0107	0.0817	0.4167
Brugia malayi	Flap endonuclease-1	0.0025	0.0142	0.0312
Trypanosoma cruzi	hypothetical protein, conserved	0.0107	0.0817	0.0768
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0817	0.2033
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0044	0.0294	0.0525
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0127	0.0615
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0291	0.0528
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.0294	0.0695
Schistosoma mansoni	axis inhibition protein axin	0.002	0.0097	0.0176
Trichomonas vaginalis	set domain proteins, putative	0.0244	0.1949	1
Echinococcus multilocularis	axis inhibition protein axin	0.002	0.0097	0.0169
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0097	0.0458
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.0417	0.2645
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.0496	0.1202
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0044	0.0294	0.0242
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0021	0.0103	0.005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0201	0.0996
Echinococcus granulosus	cpg binding protein	0.0032	0.0197	0.035
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0146	0.0712
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0053	0.0233
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0389	0.3151	0.5674
Echinococcus multilocularis	cpg binding protein	0.0032	0.0197	0.035
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0031	0.019	0.0337
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0015	0.0053	0.009
Brugia malayi	hypothetical protein	0.0245	0.1955	0.4869
Mycobacterium ulcerans	hypothetical protein	0.0641	0.5235	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0193	0.0342
Leishmania major	hypothetical protein, conserved	0.0107	0.0817	0.0768
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0031	0.019	0.0462
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0031	0.019	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0053	0.012
Echinococcus granulosus	regulator of G protein signaling 3	0.002	0.0097	0.0169
Schistosoma mansoni	regulator of G protein signaling	0.002	0.0097	0.0176
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0576	0.4697	0.4668
Loa Loa (eye worm)	beta-lactamase	0.0107	0.0817	0.2033
Loa Loa (eye worm)	hypothetical protein	0.0031	0.019	0.0462
Echinococcus granulosus	ecdysone induced protein 78C	0.0031	0.019	0.0337
Brugia malayi	beta-lactamase family protein	0.0107	0.0817	0.2008
Echinococcus granulosus	tumor protein p63	0.068	0.555	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.022	0.1093
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.019	0.118
Entamoeba histolytica	hypothetical protein	0.0043	0.0291	0.9819
Echinococcus multilocularis	Regulator of G protein signaling 20	0.002	0.0097	0.0169
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.002	0.0097	0.0458
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0344	0.0821
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0031	0.019	0.0337
Echinococcus multilocularis	regulator of G protein signaling 7	0.002	0.0097	0.0169
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.019	0.0346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.022	0.1093
Brugia malayi	ecdysone receptor	0.0015	0.0053	0.009
Echinococcus granulosus	nuclear receptor nhr 48	0.0015	0.0053	0.009
Brugia malayi	Regulator of G protein signaling domain containing protein	0.002	0.0097	0.0199
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.019	0.0346
Giardia lamblia	GTOR	0.0044	0.0294	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0031	0.019	0.0337
Brugia malayi	Pre-SET motif family protein	0.0031	0.019	0.0435
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.1218	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0097	0.0458
Schistosoma mansoni	retinoic acid receptor RXR	0.0031	0.019	0.0345
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0421	0.3409	0.614
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0214	0.1705	0.4257
Brugia malayi	hypothetical protein	0.0043	0.0291	0.0686
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0044	0.0294	0.0242
Onchocerca volvulus		0.005	0.0344	0.0737
Schistosoma mansoni	thyroid hormone receptor	0.0421	0.3409	0.6197
Brugia malayi	Steroid receptor seven-up type 2	0.0031	0.019	0.0433
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0053	0.0233
Echinococcus multilocularis	nuclear receptor nhr 48	0.0015	0.0053	0.009
Brugia malayi	A-kinase anchor protein 10, precursor	0.002	0.0097	0.0199
Onchocerca volvulus	Bile acid receptor homolog	0.0031	0.019	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0031	0.019	0.0462
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0127	0.0615
Echinococcus granulosus	regulator of G protein signaling 3	0.002	0.0097	0.0169
Onchocerca volvulus		0.003	0.0183	0.0328
Schistosoma mansoni	survival motor neuron protein	0.005	0.0344	0.0626
Schistosoma mansoni	hypothetical protein	0.0032	0.0193	0.035
Echinococcus multilocularis	expressed protein	0.002	0.0097	0.0169
Entamoeba histolytica	hypothetical protein	0.0043	0.0291	0.9819
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0015	0.0053	0.009
Onchocerca volvulus		0.0107	0.0817	0.1936
Echinococcus multilocularis	regulator of G protein signaling 3	0.002	0.0097	0.0169
Brugia malayi	Nuclear hormone receptor E75	0.0015	0.0053	0.009
Mycobacterium leprae	Probable lipase LipE	0.0107	0.0817	0.5
Brugia malayi	ecdysteroid receptor	0.0031	0.019	0.0433
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0025	0.0142	0.0089
Echinococcus granulosus	regulator of G protein signaling 7	0.002	0.0097	0.0169
Schistosoma mansoni	cpg binding protein	0.003	0.0183	0.0332
Brugia malayi	nuclear hormone receptor	0.0031	0.019	0.0433
Echinococcus multilocularis	survival motor neuron protein 1	0.0245	0.1955	0.3519
Schistosoma mansoni	nuclear hormone receptor	0.0015	0.0053	0.0097
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0031	0.019	0.0337
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0294	0.1475
Echinococcus multilocularis	geminin	0.0205	0.1623	0.292
Schistosoma mansoni	nuclear hormone receptor	0.0031	0.019	0.0345
Schistosoma mansoni	regulator of G protein signaling	0.002	0.0097	0.0176
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0031	0.019	0.0433
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.0757	0.1884
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0193	0.0342
Brugia malayi	nuclear receptor NHR-67	0.0015	0.0053	0.009
Brugia malayi	nuclear receptor RXR	0.0015	0.0053	0.009
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0031	0.019	0.0433
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0015	0.0053	0.0097
Trichomonas vaginalis	D-aminoacylase, putative	0.0107	0.0817	0.4167
Brugia malayi	beta-lactamase	0.0107	0.0817	0.2008
Echinococcus granulosus	microtubule associated protein 2	0.0674	0.5502	0.9912
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0031	0.019	0.0345
Schistosoma mansoni	hypothetical protein	0.0032	0.0193	0.035
Echinococcus granulosus	regulator of G protein signaling 7	0.002	0.0097	0.0169
Loa Loa (eye worm)	flap endonuclease-1	0.0025	0.0142	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0245	0.1955	0.4884
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0017	0.0068	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0068	0.0157
Toxoplasma gondii	ABC1 family protein	0.0107	0.0817	0.5227
Brugia malayi	Nuclear hormone receptor-like 1	0.0031	0.019	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0031	0.019	0.0462
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.002	0.0097	0.0176
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0146	0.0712
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0044	0.0294	0.0242
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0171	0.1347	0.1301
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0015	0.0053	0.009
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0031	0.019	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0053	0.012
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0201	0.0996
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0241	0.1202
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0031	0.019	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0492	0.3997	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0388	0.0959
Brugia malayi	nuclear hormone receptor	0.0015	0.0053	0.009
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0031	0.019	0.0462
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0193	0.044
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0053	0.012
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0496	0.1229
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0025	0.0142	0.0864
Trichomonas vaginalis	esterase, putative	0.0107	0.0817	0.4167
Echinococcus multilocularis	flap endonuclease 1	0.0025	0.0142	0.025
Brugia malayi	Nuclear hormone receptor E75	0.0015	0.0053	0.009
Schistosoma mansoni	thyroid hormone receptor	0.0421	0.3409	0.6197
Echinococcus multilocularis	microtubule associated protein 2	0.0674	0.5502	0.9912
Loa Loa (eye worm)	hypothetical protein	0.0031	0.019	0.0462
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.002	0.0097	0.0176
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0193	0.044
Brugia malayi	Regulator of G protein signaling domain containing protein	0.002	0.0097	0.0199
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0171	0.1347	0.1301
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0201	0.0996
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0053	0.012
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.022	0.1093
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0031	0.019	0.0345
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0193	0.1529	0.2751
Echinococcus granulosus	geminin	0.0205	0.1623	0.292
Loa Loa (eye worm)	phosphatidylinositol 3	0.0015	0.0053	0.012
Onchocerca volvulus		0.0031	0.019	0.0346
Schistosoma mansoni	lozenge	0.0062	0.0441	0.0802
Brugia malayi	PXA domain containing protein	0.002	0.0097	0.0199
Echinococcus granulosus	axis inhibition protein axin	0.002	0.0097	0.0169
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0388	0.0705
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.0757	0.1859
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0201	0.0996
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0015	0.0053	0.009
Loa Loa (eye worm)	hypothetical protein	0.0031	0.019	0.0462
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0003	0.0006
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0031	0.019	0.0345
Echinococcus multilocularis	ecdysone induced protein 78C	0.0031	0.019	0.0337
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0107	0.0817	0.2033
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0053	0.012
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.022	0.1093
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0176	0.0311
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0127	0.0614
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0015	0.0053	0.0089
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0193	0.0342
Schistosoma mansoni	cpg binding protein	0.0032	0.0197	0.0358
Schistosoma mansoni	regulator of G protein signaling	0.002	0.0097	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0817	0.2033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0294	0.1475
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0015	0.0053	0.009
Onchocerca volvulus		0.0244	0.1949	0.4807
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0053	0.012
Echinococcus granulosus	expressed protein	0.002	0.0097	0.0169
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0107	0.0817	0.2008
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0097	0.0458
Schistosoma mansoni	flap endonuclease-1	0.0023	0.0121	0.0221
Brugia malayi	tailless protein	0.0015	0.0053	0.009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0175	0.086
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0167	0.0819
Loa Loa (eye worm)	hypothetical protein	0.01	0.0757	0.1884
Schistosoma mansoni	nuclear receptor	0.0015	0.0053	0.0097
Schistosoma mansoni	serine/threonine protein kinase	0.0193	0.1529	0.2779
Trichomonas vaginalis	penicillin-binding protein, putative	0.0107	0.0817	0.4167
Echinococcus multilocularis	Protein lozenge	0.0062	0.0441	0.079
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0148	0.0723
Schistosoma mansoni	nuclear receptor nhr-48	0.0015	0.0053	0.0097
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0015	0.0053	0.009
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0031	0.019	0.0337
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0015	0.0053	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0754	0.1875
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0097	0.0458
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0031	0.019	0.0433
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0684	0.5587	1
Schistosoma mansoni	serine/threonine protein kinase	0.0193	0.1529	0.2779
Schistosoma mansoni	nuclear hormone receptor	0.0015	0.0053	0.0097
Onchocerca volvulus		0.0492	0.3997	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0193	0.035
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0127	0.0614
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0127	0.0615
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0388	0.0705
Brugia malayi	nuclear receptor RXR	0.0017	0.0068	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0817	0.2033
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0015	0.0053	0.009
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0107	0.0817	0.1484
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0193	0.0469
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0031	0.019	0.0337
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.002	0.0101	0.0209
Brugia malayi	steroid hormone receptor	0.0031	0.019	0.0433
Echinococcus multilocularis	tumor protein p63	0.068	0.555	1
Loa Loa (eye worm)	hypothetical protein	0.0492	0.3997	1
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0576	0.4697	0.4668
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0031	0.019	0.0462
Echinococcus granulosus	GPCR family 2	0.0032	0.0193	0.0342
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0193	0.1529	0.2751
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0053	0.012
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0031	0.019	0.0433
Echinococcus multilocularis	regulator of G protein signaling 7	0.002	0.0097	0.0169
Brugia malayi	hypothetical protein	0.0017	0.0068	0.0127
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0148	0.0723
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0107	0.0817	0.1484
Schistosoma mansoni	hypothetical protein	0.0043	0.0291	0.0528
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.022	0.1093
Brugia malayi	CXXC zinc finger family protein	0.003	0.0183	0.0415
Echinococcus granulosus	Regulator of G protein signaling 20	0.002	0.0097	0.0169
Trichomonas vaginalis	flap endonuclease-1, putative	0.0025	0.0142	0.0689
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0148	0.0723
Schistosoma mansoni	cpg binding protein	0.0032	0.0197	0.0358
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0031	0.019	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0068	0.0157
Brugia malayi	photoreceptor-specific nuclear receptor	0.0031	0.019	0.0433
Brugia malayi	Pre-SET motif family protein	0.0214	0.1705	0.424
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0031	0.019	0.0462
Echinococcus granulosus	survival motor neuron protein 1	0.0245	0.1955	0.3519
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0017	0.0068	0.0117
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0388	0.0694
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0031	0.019	0.0346
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.002	0.0097	0.0169
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.002	0.0097	0.0169
Brugia malayi	hypothetical protein	0.0017	0.0068	0.0127
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0201	0.0996
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0031	0.019	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0817	0.2033
Schistosoma mansoni	RAR-like nuclear receptor	0.0031	0.019	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0053	0.012
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0017	0.0068	0.0123
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.0757	0.1859
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0044	0.0294	0.0242
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0171	0.1347	0.1301
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.019	0.0338
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0044	0.0294	0.0525
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0015	0.0053	0.009
Schistosoma mansoni	regulator of G protein signaling	0.002	0.0097	0.0176
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0015	0.0053	0.009
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.002	0.0101	0.0239
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0044	0.0294	0.0242
Schistosoma mansoni	hypothetical protein	0.0205	0.1623	0.295
Echinococcus granulosus	FTZ F1 alpha	0.0031	0.019	0.0337
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0017	0.0068	0.0157
Brugia malayi	hypothetical protein	0.0015	0.0053	0.009
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0193	0.0342
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0193	0.1529	0.3817
Loa Loa (eye worm)	hypothetical protein	0.0031	0.019	0.0462
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0031	0.019	0.0433
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0097	0.0458
Echinococcus granulosus	flap endonuclease 1	0.0025	0.0142	0.025
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.002	0.0097	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0068	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0053	0.012
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0031	0.019	0.0337
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0097	0.0458
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0044	0.0294	0.0535
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0033	0.0201	0.1249
Loa Loa (eye worm)	hypothetical protein	0.0031	0.019	0.0462
Entamoeba histolytica	hypothetical protein	0.0043	0.0291	0.9819
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0031	0.019	0.0345
Brugia malayi	orphan nuclear receptor NR2E1	0.0015	0.0053	0.009
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0291	0.0518
Plasmodium vivax	hypothetical protein, conserved	0.0107	0.0817	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0031	0.019	0.0433
Brugia malayi	regulator of G-protein signaling rgs-7	0.002	0.0097	0.0199
Trypanosoma brucei	hypothetical protein, conserved	0.0107	0.0817	0.0768
Onchocerca volvulus		0.0099	0.0754	0.1776
Schistosoma mansoni	z-protein (S1r protein)	0.002	0.0097	0.0176
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.002	0.0097	0.0229
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0388	0.0694
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0031	0.019	0.0337
Loa Loa (eye worm)	hypothetical protein	0.002	0.0097	0.0229
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.0068	0.0127
Brugia malayi	hypothetical protein	0.002	0.0097	0.0199
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0388	0.0694
Schistosoma mansoni	hypothetical protein	0.0389	0.3151	0.5727
Loa Loa (eye worm)	PXA domain-containing protein	0.002	0.0097	0.0229
Loa Loa (eye worm)	phosphatidylinositol 3	0.0044	0.0294	0.0724
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0031	0.019	0.0433
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0576	0.4697	0.4668
Entamoeba histolytica	hypothetical protein	0.0043	0.0291	0.9819
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0053	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0817	0.2033
Schistosoma mansoni	axis inhibition protein axin	0.002	0.0097	0.0176
Toxoplasma gondii	hypothetical protein	0.0196	0.1555	1
Brugia malayi	hypothetical protein	0.002	0.0097	0.0199
Echinococcus granulosus	thyroid hormone receptor alpha	0.0015	0.0053	0.009
Echinococcus multilocularis	regulator of G protein signaling 3	0.002	0.0097	0.0169
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0101	0.0183
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0015	0.0053	0.012
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0389	0.3151	0.5674
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0015	0.0053	0.012
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0017	0.0068	0.0117
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.019	0.0338
Loa Loa (eye worm)	DR-78	0.0015	0.0053	0.012
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0183	0.0445
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0201	0.0996
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0025	0.0142	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0053	0.012
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0031	0.019	0.0337
Brugia malayi	regulator of G-protein signaling egl-10	0.002	0.0097	0.0199
Loa Loa (eye worm)	RGS-3 protein	0.002	0.0097	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0031	0.019	0.0464
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.019	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0031	0.019	0.0462
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0035	0.022	0.0168
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0171	0.1347	0.1301
Brugia malayi	hypothetical protein	0.0015	0.0053	0.009
Brugia malayi	nuclear hormone receptor family member odr-7	0.0015	0.0053	0.009
Mycobacterium leprae	conserved hypothetical protein	0.0107	0.0817	0.5
Loa Loa (eye worm)	nuclear hormone receptor	0.0015	0.0053	0.012
Brugia malayi	hypothetical protein	0.0492	0.3997	1
Schistosoma mansoni	coup transcription factor	0.0031	0.019	0.0345
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.0068	0.0127
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0107	0.0817	0.1466
Echinococcus multilocularis	axis inhibition protein axin	0.002	0.0097	0.0169
Brugia malayi	nuclear receptor NHR-88	0.0015	0.0053	0.009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0053	0.0233
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0015	0.0053	0.009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0029	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0008	0.0006
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.1218	1	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0031	0.019	0.0337
Echinococcus granulosus	beta LACTamase domain containing family member	0.0107	0.0817	0.1466
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0031	0.019	0.0462
Schistosoma mansoni	hypothetical protein	0.0068	0.0496	0.0901
Trypanosoma cruzi	hypothetical protein, conserved	0.0107	0.0817	0.0768
Loa Loa (eye worm)	hypothetical protein	0.002	0.0097	0.0229
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0044	0.0294	0.0242
Brugia malayi	conserved hypotetical protein	0.0015	0.0053	0.009
Trichomonas vaginalis	D-aminoacylase, putative	0.0107	0.0817	0.4167
Plasmodium vivax	SET domain protein, putative	0.0031	0.019	0.0723
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0019	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0817	0.2033
Loa Loa (eye worm)	steroid hormone receptor	0.0031	0.019	0.0462
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0388	0.0931
Schistosoma mansoni	zinc finger protein	0.0015	0.0053	0.0097
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0044	0.0294	1
Schistosoma mansoni	regulator of G protein signaling	0.002	0.0097	0.0176
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0388	0.0705
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0031	0.019	0.0462
Trypanosoma cruzi	target of rapamycin kinase 3	0.0035	0.022	0.0168
Onchocerca volvulus	Protein ultraspiracle homolog	0.0031	0.019	0.0346
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0019	0.0028
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0044	0.0294	1
Schistosoma mansoni	cellular tumor antigen P53	0.0099	0.0754	0.137
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0068	0.0157
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0127	0.0614
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0019	0.0033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0201	0.0996
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0193	0.0342
Loa Loa (eye worm)	hypothetical protein	0.002	0.0097	0.0229
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.0474	0.0862
Schistosoma mansoni	microtubule-associated protein tau	0.0674	0.5502	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0018	0.0082	0.0029
Echinococcus granulosus	axis inhibition protein axin	0.002	0.0097	0.0169
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0031	0.019	0.0462
Loa Loa (eye worm)	hypothetical protein	0.002	0.0097	0.0229
Brugia malayi	PXA domain containing protein	0.002	0.0097	0.0199
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0031	0.019	0.0345
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0053	0.0233
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0035	0.022	0.0168
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0031	0.019	0.0337
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0127	0.0615
Brugia malayi	beta-lactamase family protein	0.0107	0.0817	0.2008
Echinococcus multilocularis	FTZ F1 alpha	0.0031	0.019	0.0337
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.0173	0.1364	0.2453
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0053	0.012
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0015	0.0053	0.009
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0388	0.0694
Onchocerca volvulus		0.0107	0.0817	0.1936
Onchocerca volvulus		0.0031	0.019	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0053	0.012
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0031	0.019	0.0337
Entamoeba histolytica	Flap nuclease, putative	0.0025	0.0142	0.2274
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0015	0.0053	0.0096
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0025	0.0142	0.0089
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0641	0.5235	0.9261
Echinococcus granulosus	G protein coupled receptor kinase 1	0.0173	0.1364	0.2453

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	155.089 uM	PubChem BioAssay. Absorbance-based biochemical high throughput dose response assay to identify inhibitors of Methionine sulfoxide reductase A (MsrA). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.4611 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.0119 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.5821 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	14.7157 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813]	ChEMBL.	No reference
Potency (functional)	32.6294 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (binding)	39.8107 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	63.0957 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	= 100 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1491734
Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 693328