Detailed information for compound 693540

Basic information

Technical information
  • TDR Targets ID: 693540
  • Name: N-[2-(2,3-dihydroindol-1-yl)-2-thiophen-2-yle thyl]-4-methoxybenzamide
  • MW: 378.487 | Formula: C22H22N2O2S
  • H donors: 1 H acceptors: 1 LogP: 4.27 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)NCC(N1CCc2c1cccc2)c1cccs1
  • InChi: 1S/C22H22N2O2S/c1-26-18-10-8-17(9-11-18)22(25)23-15-20(21-7-4-14-27-21)24-13-12-16-5-2-3-6-19(16)24/h2-11,14,20H,12-13,15H2,1H3,(H,23,25)
  • InChiKey: XROIIHLDOSYGNX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-indolin-1-yl-2-(2-thienyl)ethyl]-4-methoxy-benzamide
  • N-[2-(1-indolinyl)-2-(2-thienyl)ethyl]-4-methoxybenzamide
  • N-[2-(2,3-dihydroindol-1-yl)-2-thiophen-2-yl-ethyl]-4-methoxy-benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.8358 0.8808
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0388 0.0792
Echinococcus multilocularis importin subunit beta 1 0.003 0.0757 0.0727
Trypanosoma brucei unspecified product 0.0014 0.0242 0.2267
Schistosoma mansoni hypothetical protein 0.0012 0.0176 0.0144
Loa Loa (eye worm) hypothetical protein 0.001 0.013 0.0098
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.9485 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0505 0.0401
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0388 0.384
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0441 0.0973
Brugia malayi beta-NAC-like protein 0.0036 0.096 0.1114
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.1399 0.1642
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0587 0.1233
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0587 0.0587
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0757 0.7811
Echinococcus multilocularis geminin 0.0174 0.5416 0.5401
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0587 0.1233
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0637 0.6516
Loa Loa (eye worm) hypothetical protein 0.0024 0.0587 0.0557
Echinococcus granulosus importin subunit beta 1 0.003 0.0757 0.0727
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0032 0.0071
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0388 0.5
Trypanosoma brucei unspecified product 0.002 0.0441 0.4406
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0505 0.5093
Trypanosoma brucei transcription factor BTF3, putative 0.0036 0.096 1
Brugia malayi Importin beta-1 subunit 0.003 0.0757 0.087
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.8358 0.8808
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0441 0.4406
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0441 0.4406
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0032 0.0071
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0339 0.3311
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0441 0.4406
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0441 0.4406
Schistosoma mansoni hypothetical protein 0.0174 0.5416 0.5401
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0576 0.0576
Entamoeba histolytica Ran family GTPase 0.0022 0.0505 0.05
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0637 0.6516
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0441 0.0432
Onchocerca volvulus Glucosylceramidase homolog 0.0174 0.5415 1
Schistosoma mansoni transcription factor btf3 0.0036 0.096 0.0931
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0032 0.0071
Leishmania major DNA polymerase kappa, putative 0.002 0.0441 0.4406
Loa Loa (eye worm) hypothetical protein 0.002 0.0441 0.041
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0587 0.5981
Brugia malayi RNA, U transporter 1 0.0084 0.2518 0.2986
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.013 0.0117
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0587 0.1233
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.9485 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0032 0.0071
Brugia malayi hypothetical protein 0.0026 0.0637 0.0726
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.096 0.0981
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0032 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0242 0.2267
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0587 0.0666
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0032 0.0071
Giardia lamblia DINP protein human, muc B family 0.002 0.0441 0.0333
Giardia lamblia Fructose-bisphosphate aldolase 0.0301 0.9485 1
Schistosoma mansoni DNA polymerase eta 0.002 0.0441 0.041
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0032 0.0071
Entamoeba histolytica hypothetical protein 0.0024 0.0576 0.0576
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.8358 0.8808
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0505 0.5093
Loa Loa (eye worm) hypothetical protein 0.0018 0.0388 0.0357
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0242 0.2267
Plasmodium falciparum basic transcription factor 3b, putative 0.0036 0.096 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0441 0.4406
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0505 0.0474
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.013 0.0098
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0388 0.384
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0441 0.4406
Loa Loa (eye worm) ICD-1 protein 0.0036 0.096 0.0931
Leishmania major hypothetical protein, conserved 0.0026 0.0637 0.6516
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.5415 0.5695
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0597 0.0567
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.9485 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.9485 1
Echinococcus multilocularis snurportin 1 0.0317 1 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0576 0.5864
Plasmodium vivax basic transcription factor 3b, putative 0.0036 0.096 1
Brugia malayi hypothetical protein 0.0017 0.0341 0.0371
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0576 0.0576
Schistosoma mansoni ran 0.0022 0.0505 0.0474
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.013 0.1053
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0505 0.0474
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0441 0.0491
Mycobacterium ulcerans hypothetical protein 0.0024 0.0587 0.1233
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0587 0.0666
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0032 0.0071
Onchocerca volvulus 0.0024 0.0587 0.1031
Echinococcus granulosus dna polymerase eta 0.002 0.0441 0.041
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0032 0.0071
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0441 0.0973
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0266 0.8358 0.8352
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0226 0.2094
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0505 0.5093
Loa Loa (eye worm) hypothetical protein 0.0024 0.0587 0.0557
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0226 0.0206
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0441 0.4406
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.013 0.1053
Leishmania major DNA polymerase eta, putative 0.002 0.0441 0.4406
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0637 0.6516
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.8358 0.8808
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0441 0.0432
Schistosoma mansoni hypothetical protein 0.0317 1 1
Leishmania major basic transcription factor 3a, putative 0.0036 0.096 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.0018 0.0388 0.0357
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0587 0.1233
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.5718 0.6015
Loa Loa (eye worm) hypothetical protein 0.0243 0.7636 0.7628
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0441 0.4406
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.4532 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0441 0.4406
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0333 0.3242
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0356 0.0786
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0587 0.0587
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.9485 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0226 0.2094
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0356 0.0786
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0242 0.2267
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.013 0.0098
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0441 0.4406
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0441 0.0491
Echinococcus granulosus transcription factor btf3 0.0036 0.096 0.0931
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0176 0.0144
Loa Loa (eye worm) hypothetical protein 0.0124 0.3805 0.3785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0356 0.0786
Schistosoma mansoni importin beta-1 0.003 0.0757 0.0727
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0441 0.4406
Onchocerca volvulus 0.005 0.1399 0.254
Schistosoma mansoni DNA helicase recq5 0.001 0.013 0.0098
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.096 1
Toxoplasma gondii NAC domain-containing protein 0.0036 0.096 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0441 0.4406
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.5415 0.5695
Echinococcus multilocularis dna polymerase eta 0.002 0.0441 0.041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.9485 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0388 0.0357
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.05 0.5046
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0587 0.1233
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0441 0.4406
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.8358 0.8808
Schistosoma mansoni ran 0.0022 0.0505 0.0474
Plasmodium vivax importin-beta 2, putative 0.003 0.0757 0.7811
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0441 0.041
Echinococcus granulosus geminin 0.0174 0.5416 0.5401
Plasmodium falciparum importin beta, putative 0.003 0.0757 0.7811
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0441 0.4406
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.5415 0.5695
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0441 0.0908
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0441 0.4406
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.013 0.0098
Loa Loa (eye worm) hypothetical protein 0.0018 0.0388 0.0357
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0388 0.0857
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0441 0.4406
Treponema pallidum fructose-bisphosphate aldolase 0.0301 0.9485 0.5
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0757 0.7811
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0757 0.7811
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0441 0.4406
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.9485 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.9485 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0505 0.5093
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0356 0.0786
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.013 0.1053
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0441 0.4406
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0587 0.5981
Schistosoma mansoni hypothetical protein 0.005 0.1399 0.1372
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.096 0.0981
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0441 0.041
Entamoeba histolytica transcription factor BTF3, putative 0.0036 0.096 0.0981
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0576 0.0576
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.7636 0.7628
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0441 0.4406
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0587 0.1233
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0587 0.1233
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.5718 0.6015
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0587 0.5981
Echinococcus multilocularis dna polymerase kappa 0.002 0.0441 0.041
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.096 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0637 0.0606
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0597 0.0678
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0505 0.0567
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0637 0.6516
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0587 0.1295
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.013 0.0098
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.5415 0.5695
Schistosoma mansoni survival motor neuron protein 0.005 0.1399 0.1372
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0176 0.0144
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.013 0.0117
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0597 0.0597
Trypanosoma brucei unspecified product 0.0014 0.0242 0.2267
Schistosoma mansoni hypothetical protein 0.0174 0.5416 0.5401
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0441 0.0908
Leishmania major importin beta-1 subunit, putative 0.0024 0.0576 0.5864
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.4532 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0441 0.0432
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0587 0.0587
Trichomonas vaginalis ran, putative 0.0022 0.0505 0.05
Loa Loa (eye worm) hypothetical protein 0.0024 0.0587 0.0557
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.4532 1
Loa Loa (eye worm) RecQ helicase 0.0025 0.0597 0.0567
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0505 0.0474
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0637 0.6516
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0441 0.041
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.013 0.0098
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0226 0.0206
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0505 0.5093
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.9485 1
Schistosoma mansoni DNA helicase recq1 0.001 0.013 0.0098
Echinococcus multilocularis transcription factor btf3 0.0036 0.096 0.0931
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0587 0.1233
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.7636 0.7628
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0032 0.0071
Entamoeba histolytica hypothetical protein 0.0036 0.096 0.0981
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0505 0.5093
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.5415 0.5695
Echinococcus granulosus bloom syndrome protein 0.0025 0.0597 0.0567
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.9485 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0757 0.0727
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0587 0.1295
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0226 0.2094
Echinococcus granulosus dna polymerase kappa 0.002 0.0441 0.041
Brugia malayi hypothetical protein 0.0243 0.7636 0.9133
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.5415 0.5695
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.5415 0.5695
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0441 0.041
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0441 0.4406
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0587 0.0666
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0266 0.8358 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0388 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.096 0.0981
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0441 0.041
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0637 0.6516
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0637 0.6516
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0429 0.0399
Leishmania major GTP-binding protein, putative 0.0022 0.0505 0.5093
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0032 0.0071
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0587 0.1233
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.8358 0.8808

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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