Detailed information for compound 69478

Basic information

Technical information
  • TDR Targets ID: 69478
  • Name: 6-amino-1-cyclopropyl-7-(4-hydroxypiperidin-1 -yl)-4-oxoquinoline-3-carboxylic acid
  • MW: 343.377 | Formula: C18H21N3O4
  • H donors: 3 H acceptors: 4 LogP: 1.85 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC1CCN(CC1)c1cc2c(cc1N)c(=O)c(cn2C1CC1)C(=O)O
  • InChi: 1S/C18H21N3O4/c19-14-7-12-15(8-16(14)20-5-3-11(22)4-6-20)21(10-1-2-10)9-13(17(12)23)18(24)25/h7-11,22H,1-6,19H2,(H,24,25)
  • InChiKey: ZPLRPUJYZRRTQK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-amino-1-cyclopropyl-7-(4-hydroxy-1-piperidyl)-4-oxo-quinoline-3-carboxylic acid
  • 6-amino-1-cyclopropyl-7-(4-hydroxy-1-piperidinyl)-4-oxo-3-quinolinecarboxylic acid
  • 6-azanyl-1-cyclopropyl-7-(4-hydroxypiperidin-1-yl)-4-oxo-quinoline-3-carboxylic acid
  • 6-amino-1-cyclopropyl-7-(4-hydroxypiperidino)-4-keto-quinoline-3-carboxylic acid
  • 6-amino-1-cyclopropyl-7-(4-hydroxy-1-piperidyl)-4-keto-quinoline-3-carboxylic acid
  • 6-amino-1-cyclopropyl-7-(4-hydroxypiperidin-1-yl)-4-oxo-quinoline-3-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0047 0.0105
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0039 0.0309 0.0309
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.058 0.058
Schistosoma mansoni hypothetical protein 0.0166 0.1459 0.1678
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0446 0.3989 1
Schistosoma mansoni inositol transporter 0.0039 0.0309 0.0355
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0105
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0172 0.0358
Echinococcus granulosus sodium:glucose cotransporter 0.0039 0.0309 0.0309
Schistosoma mansoni lipoxygenase 0.0022 0.016 0.0184
Echinococcus multilocularis dihydrofolate reductase 0.0443 0.3965 0.3965
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0047 0.0047
Brugia malayi Cytochrome P450 family protein 0.0018 0.012 0.0267
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0106
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0446 0.3989 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0907 1
Loa Loa (eye worm) cytochrome P450 0.0008 0.003 0.0067
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0047 0.0047
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0047 0.0054
Plasmodium falciparum kinesin-5 0.0144 0.1262 0.2879
Echinococcus granulosus RUN 0.0022 0.016 0.016
Schistosoma mansoni cytochrome P450 0.0008 0.003 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0047 0.0105
Echinococcus multilocularis transient receptor potential cation channel 0.0322 0.2867 0.2867
Brugia malayi hypothetical protein 0.0005 0.0005 0.0011
Echinococcus multilocularis ankyrin repeat protein 0.0318 0.2836 0.2836
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0047 0.0105
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0047 0.0054
Loa Loa (eye worm) dihydrofolate reductase 0.0443 0.3965 0.8812
Brugia malayi GH02984p 0.0039 0.0309 0.0687
Brugia malayi Cytochrome P450 family protein 0.003 0.0226 0.0502
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0047 0.0105
Schistosoma mansoni nuclear hormone receptor 0.001 0.0047 0.0054
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0047 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0047 0.0105
Schistosoma mansoni lipoxygenase 0.0063 0.0524 0.0602
Giardia lamblia Kinesin-5 0.0144 0.1262 1
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.012 0.0227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0047 0.0105
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0172 0.0383
Brugia malayi dihydrofolate reductase family protein 0.0443 0.3965 0.8812
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0047 0.0105
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0005 0.0011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.058 0.1398
Schistosoma mansoni hypothetical protein 0.0967 0.8695 1
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0047 0.0105
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0105
Schistosoma mansoni kinesin eg-5 0.0144 0.1262 0.1452
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0047 0.0054
Loa Loa (eye worm) hypothetical protein 0.0039 0.0309 0.0687
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.058 0.1398
Loa Loa (eye worm) hypothetical protein 0.0503 0.45 1
Brugia malayi Dihydrofolate reductase 0.0443 0.3965 0.8812
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0039 0.0309 0.0309
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0172 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0047 0.0105
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0047 0.0105
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.058 0.1389
Brugia malayi hypothetical protein 0.0105 0.0907 0.2017
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0047 0.0105
Echinococcus granulosus sodium:myo inositol cotransporter 0.0039 0.0309 0.0309
Echinococcus granulosus geminin 0.0166 0.1459 0.1459
Brugia malayi steroid hormone receptor 0.001 0.0047 0.0105
Brugia malayi hypothetical protein 0.0022 0.016 0.0355
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0011
Brugia malayi thymidylate synthase 0.0221 0.1954 0.4343
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0172 0.0358
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0047 0.0105
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.016 0.016
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0047 0.0105
Loa Loa (eye worm) hypothetical protein 0.0039 0.0309 0.0687
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.058 0.1398
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0172 0.0358
Brugia malayi Cytochrome P450 family protein 0.0008 0.003 0.0067
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0047 0.0047
Schistosoma mansoni loxhd1 0.0022 0.016 0.0184
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0005 0.0006
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0172 0.0198
Echinococcus multilocularis high affinity choline transporter 1 0.0039 0.0309 0.0309
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.012 0.0267
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0105
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0047 0.0047
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0047 0.0047
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0047 0.0105
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0221 0.1954 0.4889
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0047 0.0047
Brugia malayi hypothetical protein 0.0022 0.016 0.0355
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0047 0.0047
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0446 0.3989 1
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0172 0.0032
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0105 0.0907 0.2216
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0047 0.0054
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0039 0.0309 0.0309
Entamoeba histolytica kinesin, putative 0.0144 0.1262 1
Onchocerca volvulus 0.0503 0.45 1
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0446 0.3989 1
Echinococcus multilocularis 0.0008 0.003 0.003
Loa Loa (eye worm) kinesin-like protein KLP2 0.0144 0.1262 0.2805
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0063 0.0524 0.0524
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0011
Schistosoma mansoni inositol transporter 0.0039 0.0309 0.0355
Brugia malayi Sodium:solute symporter family protein 0.0039 0.0309 0.0687
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0172 0.0172
Schistosoma mansoni lozenge 0.0063 0.0528 0.0607
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0011
Plasmodium vivax kinesin-5 0.0144 0.1262 0.2879
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0172 0.0383
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.058 0.1389
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0172 0.0032
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0172 0.0198
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0047 0.0047
Loa Loa (eye worm) CYP4Cod1 0.0018 0.012 0.0267
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0795 0.7141 0.7141
Loa Loa (eye worm) runx1 0.0063 0.0528 0.1172
Brugia malayi nuclear hormone receptor 0.001 0.0047 0.0105
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0047 0.0054
Echinococcus multilocularis Protein lozenge 0.0063 0.0528 0.0528
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0047 0.0047
Echinococcus multilocularis geminin 0.0166 0.1459 0.1459
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0047 0.0054
Schistosoma mansoni thyroid hormone receptor 0.001 0.0047 0.0054
Brugia malayi nuclear receptor NHR-88 0.001 0.0047 0.0105
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0443 0.3965 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0047 0.0054
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0047 0.0047
Echinococcus granulosus sodium:glucose cotransporter 2 0.0039 0.0309 0.0309
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.058 0.1398
Echinococcus granulosus high affinity choline transporter 1 0.0039 0.0309 0.0309
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.058 0.058
Schistosoma mansoni rab6-interacting 0.0022 0.016 0.0184
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.016 0.016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0047 0.0105
Schistosoma mansoni rab6-interacting 0.0022 0.016 0.0184
Trypanosoma brucei cytochrome P450, putative 0.0018 0.012 0.0227
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0221 0.1954 0.2247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0047 0.0105
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0011
Onchocerca volvulus 0.0022 0.016 0.0355
Onchocerca volvulus 0.001 0.0047 0.0105
Toxoplasma gondii kinesin motor domain-containing protein 0.0144 0.1262 0.3112
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0105
Schistosoma mansoni polycystin 1-related 0.0022 0.016 0.0184
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0446 0.3989 1
Echinococcus multilocularis thymidylate synthase 0.0221 0.1954 0.1954
Loa Loa (eye worm) thymidylate synthase 0.0221 0.1954 0.4343
Brugia malayi hypothetical protein 0.0503 0.45 1
Echinococcus granulosus dihydrofolate reductase 0.0443 0.3965 0.3965
Schistosoma mansoni hypothetical protein 0.0008 0.003 0.0035
Echinococcus granulosus solute carrier family 5 0.0039 0.0309 0.0309
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0047 0.0047
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0105
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0047 0.0105
Onchocerca volvulus 0.0221 0.1954 0.4343
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.016 0.016
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0226 0.0502
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0172 0.0383
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0047 0.0105
Echinococcus granulosus FTZ F1 alpha 0.001 0.0047 0.0047
Chlamydia trachomatis dihydrofolate reductase 0.0443 0.3965 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0047 0.0105
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.058 0.0668
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0047 0.0105
Mycobacterium tuberculosis Hypothetical protein 0.0105 0.0907 0.2229
Brugia malayi cytochrome P450 0.0008 0.003 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0047 0.0105
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0047 0.0047
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0005 0.0011
Echinococcus multilocularis solute carrier family 5 0.0039 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0503 0.45 1
Onchocerca volvulus 0.0039 0.0309 0.0687
Echinococcus granulosus transient receptor potential cation channel 0.0322 0.2865 0.2865
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0047 0.0047
Brugia malayi hypothetical protein 0.0005 0.0005 0.0011
Schistosoma mansoni dihydrofolate reductase 0.0443 0.3965 0.456
Brugia malayi ecdysteroid receptor 0.001 0.0047 0.0105
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0446 0.3989 1
Echinococcus granulosus ankyrin repeat protein 0.0318 0.2836 0.2836
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0047 0.0054
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0039 0.0309 0.0309
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0047 0.0105
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0172 0.0172
Echinococcus multilocularis kinesin family 1 0.1111 1 1
Brugia malayi Doublecortin family protein 0.0022 0.016 0.0355
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0105
Loa Loa (eye worm) hypothetical protein 0.0022 0.016 0.0355
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0221 0.1954 0.4889
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0443 0.3965 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0011
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.016 0.016
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0018 0.012 0.0228
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0047 0.0047
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0005 0.0011
Brugia malayi Kinesin motor domain containing protein 0.0144 0.1262 0.2805
Onchocerca volvulus 0.0022 0.016 0.0355
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.016 0.016
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0047 0.0047
Echinococcus granulosus cytochrome P450 2K1 0.0008 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0105
Schistosoma mansoni hypothetical protein 0.0166 0.1459 0.1678
Echinococcus granulosus thymidylate synthase 0.0221 0.1954 0.1954
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0047 0.0105
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.012 0.0267
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.016 0.016
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0005 0.0006
Schistosoma mansoni hypothetical protein 0.0022 0.016 0.0184
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0443 0.3965 1
Schistosoma mansoni coup transcription factor 0.001 0.0047 0.0054
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.012 0.0227
Leishmania major cytochrome p450-like protein 0.0018 0.012 0.0227
Brugia malayi Cytochrome P450 family protein 0.0018 0.012 0.0267
Schistosoma mansoni sodium/solute symporter 0.0039 0.0309 0.0355
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.058 0.0668
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0063 0.0524 0.0524
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0047 0.0105
Brugia malayi nuclear receptor RXR 0.0005 0.0005 0.0011
Echinococcus multilocularis RUN 0.0022 0.016 0.016
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0047 0.0105
Loa Loa (eye worm) doublecortin family protein 0.0022 0.016 0.0355
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0047 0.0105
Schistosoma mansoni thyroid hormone receptor 0.001 0.0047 0.0054
Loa Loa (eye worm) hypothetical protein 0.0022 0.016 0.0355
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0047 0.0047
Mycobacterium ulcerans thymidylate synthase 0.0221 0.1954 0.4889
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0039 0.0309 0.0704
Schistosoma mansoni high-affinity choline transporter 0.0039 0.0309 0.0355
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0005 0.0005
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0318 0.2836 0.3261
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0105
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0047 0.0105
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0172 0.0358

Activities

Activity type Activity value Assay description Source Reference
ln MIC (functional) = 4 Antibacterial activity against Providencia stuartii CNUR 5(Gram negative) strain. ChEMBL. 9171879
ln MIC (functional) = 4 Antibacterial activity against Pseudomonas aeruginosa ATCC 9027(Gram negative) strain. ChEMBL. 9171879
ln MIC (functional) = 4 Antibacterial activity against Streptococcus faecalis LEP Br (Gram positive) strain. ChEMBL. 9171879
ln MIC (functional) = 5 Antibacterial activity against Staphylococcus aureus MPR 5 (Gram positive) strain. ChEMBL. 9171879
ln MIC (functional) = 5 Antibacterial activity against Staphylococcus aureus ATCC 6538 (Gram positive) strain. ChEMBL. 9171879
ln MIC (functional) = 5 Antibacterial activity against Staphylococcus epidermidis HCF Berset C (Gram positive) strain. ChEMBL. 9171879
ln MIC (functional) = 6 Antibacterial activity against Enterobacter cloacae OMNFI 174 (Gram negative) strain. ChEMBL. 9171879
ln MIC (functional) = 6 Antibacterial activity against Acinetobacter calcoloaceticus OSMPV 113 (Gram negative) strain. ChEMBL. 9171879
ln MIC (functional) = 6 Antibacterial activity against Shigella enteritidis (Gram negative) strain. ChEMBL. 9171879
ln MIC (functional) = 6 Antibacterial activity against Staphylococcus epidermidis CPHL A2 (Gram positive) strain, activity is expressed as log2MIC. ChEMBL. 9171879
ln MIC (functional) = 12 Antibacterial activity against Escherichia coli ATCC 8739(Gram negative) strain. ChEMBL. 9171879
ln MIC (functional) = 12 Antibacterial activity against Escherichia coli ISF 432(Gram negative) strain. ChEMBL. 9171879
ln MIC (functional) = 12 Antibacterial activity against Klebsiella pneumoniae ATCC 10031 (Gram negative) strain. ChEMBL. 9171879
Log2 MIC (functional) = 12 Antibacterial activity against Escherichia coli ISF 432(Gram negative) strain. ChEMBL. 9171879
Log2 MIC (functional) = 12 Antibacterial activity against Escherichia coli ATCC 8739(Gram negative) strain. ChEMBL. 9171879
MIC (functional) = 0.03 ug ml-1 Tested in vitro for inhibitory activity against gram negative bacteria E. coli ATCC 8739 strain ChEMBL. 7699714
MIC (functional) = 0.03 ug ml-1 Tested in vitro for inhibitory activity against gram negative bacteria E. coli ISF 432 strain. ChEMBL. 7699714
MIC (functional) = 0.03 ug ml-1 Tested in vitro for inhibitory activity against gram negative bacteria Klebsiella pneumoniae ATCC 10031 strain ChEMBL. 7699714
MIC (functional) = 0.03 ug ml-1 Tested in vitro for inhibitory activity against gram negative bacteria E. coli ATCC 8739 strain ChEMBL. 7699714
MIC (functional) = 0.03 ug ml-1 Tested in vitro for inhibitory activity against gram negative bacteria E. coli ISF 432 strain. ChEMBL. 7699714
MIC (functional) = 2 ug ml-1 Tested in vitro for inhibitory activity against gram negative bacteria Enterobacter cloacae OMNFI 174 strain. ChEMBL. 7699714
MIC (functional) = 2 ug ml-1 Tested in vitro for inhibitory activity against gram negative bacteria Acinetobacter calcoaceticus OSMPV 113 strain. ChEMBL. 7699714
MIC (functional) = 2 ug ml-1 Tested in vitro for inhibitory activity against gram negative bacteria Shigella enteritidis ChEMBL. 7699714
MIC (functional) = 2 ug ml-1 Tested in vitro for inhibitory activity against gram positive bacteria Staphylococcus epidermidis CPHL A2 strain ChEMBL. 7699714
MIC (functional) = 4 ug ml-1 Tested in vitro for inhibitory activity against gram positive bacteria Staphylococcus aureus MPR 5 strain ChEMBL. 7699714
MIC (functional) = 4 ug ml-1 Tested in vitro for inhibitory activity against gram positive bacteria Staphylococcus aureus ATCC 6538 strain ChEMBL. 7699714
MIC (functional) = 4 ug ml-1 Tested in vitro for inhibitory activity against gram positive bacteria Staphylococcus epidermidis HCF berset C strain ChEMBL. 7699714
MIC (functional) = 8 ug ml-1 Tested in vitro for inhibitory activity against gram negative bacteria Providencia stuartii CNUR 5 strain ChEMBL. 7699714
MIC (functional) = 8 ug ml-1 Tested in vitro for inhibitory activity against gram negative bacteria Pseudomonas aeruginosa ATCC 9027 strain ChEMBL. 7699714
MIC (functional) = 8 ug ml-1 Tested in vitro for inhibitory activity against gram positive bacteria Streptococcus faecalis LEP Br strain ChEMBL. 7699714

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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