TDR Targets

Basic information

Technical information

TDR Targets ID: 695000
Name: 2-amino-N-(2-fluorophenyl)-3-(4-methylbenzoyl )indolizine-1-carboxamide
MW: 387.406 | Formula: C23H18FN3O2
H donors: 2 H acceptors: 2 LogP: 5.34 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)C(=O)c1n2ccccc2c(c1N)C(=O)Nc1ccccc1F
InChi: 1S/C23H18FN3O2/c1-14-9-11-15(12-10-14)22(28)21-20(25)19(18-8-4-5-13-27(18)21)23(29)26-17-7-3-2-6-16(17)24/h2-13H,25H2,1H3,(H,26,29)
InChiKey: VLWNJVFOILHQKR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-amino-N-(2-fluorophenyl)-3-[(4-methylphenyl)-oxomethyl]-1-indolizinecarboxamide
2-amino-N-(2-fluorophenyl)-3-(4-methylphenyl)carbonyl-indolizine-1-carboxamide
ZINC04585244

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0364	0.4464
Echinococcus granulosus	intermediate filament protein	0.0059	0.1458	0.1446
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0798	0.0857
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0162	0.5127	0.5587
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0264	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0037	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0364	0.0351
Brugia malayi	RNA binding protein	0.0124	0.3802	0.414
Echinococcus granulosus	lamin	0.0059	0.1458	0.1446
Trichomonas vaginalis	glucosylceramidase, putative	0.0275	0.9169	1
Echinococcus granulosus	lysosomal alpha glucosidase	0.0181	0.5827	0.5822
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0037	0.0023
Echinococcus granulosus	lamin dm0	0.0059	0.1458	0.1446
Brugia malayi	hypothetical protein	0.0028	0.0364	0.0387
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0264	0.3191
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0181	0.5827	0.5822
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0264	1
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0097	0.2383
Echinococcus granulosus	GPCR family 2	0.0051	0.1188	0.1175
Echinococcus multilocularis	lamin dm0	0.0059	0.1458	0.1446
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0014	0.5
Trypanosoma brucei	glucosidase, putative	0.004	0.0798	1
Brugia malayi	Latrophilin receptor protein 2	0.0051	0.1188	0.1286
Brugia malayi	Importin beta-1 subunit	0.0028	0.036	0.0383
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0051	0.1188	0.1175
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0097	0.1064
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0264	0.5
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0097	0.1064
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0051	0.1188	0.1286
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0336	0.0323
Brugia malayi	Intermediate filament tail domain containing protein	0.0059	0.1458	0.1581
Schistosoma mansoni	alpha-glucosidase	0.0156	0.4927	0.492
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0097	0.0084
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0162	0.5127	0.512
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.004	0.0798	0.0785
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0264	0.3191
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0097	1
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0275	0.9169	1
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0097	0.0084
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0364	0.4464
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0124	0.3802	0.3793
Schistosoma mansoni	hypothetical protein	0.0051	0.1188	0.1175
Trichomonas vaginalis	glucosylceramidase, putative	0.019	0.6144	0.6696
Loa Loa (eye worm)	hypothetical protein	0.0028	0.036	0.0347
Brugia malayi	TAR-binding protein	0.0124	0.3802	0.414
Trypanosoma brucei	PAB1-binding protein , putative	0.0028	0.0364	0.4464
Echinococcus granulosus	tar DNA binding protein	0.0124	0.3802	0.3793
Schistosoma mansoni	hypothetical protein	0.0051	0.1188	0.1175
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0181	0.5827	0.6352
Trichomonas vaginalis	glucosylceramidase, putative	0.0275	0.9169	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0037	0.5
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0364	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.1188	0.1175
Onchocerca volvulus		0.0059	0.1458	0.2157
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0172	0.2015
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0014	0.053
Schistosoma mansoni	importin beta-1	0.0028	0.036	0.0347
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0264	1
Schistosoma mansoni	lamin	0.0059	0.1458	0.1446
Brugia malayi	Glycosyl hydrolases family 31 protein	0.004	0.0798	0.0861
Trichomonas vaginalis	glucosylceramidase, putative	0.018	0.5797	0.6317
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0798	0.0857
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.036	0.4417
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0298	1	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0097	0.1064
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0028	0.0375	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0264	0.0251
Schistosoma mansoni	hypothetical protein	0.011	0.3304	0.3294
Schistosoma mansoni	hypothetical protein	0.0298	1	1
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.036	0.0347
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0798	0.0857
Echinococcus granulosus	neutral alpha glucosidase AB	0.004	0.0798	0.0785
Trichomonas vaginalis	maltase-glucoamylase, putative	0.004	0.0798	0.0857
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0014	0.5
Echinococcus multilocularis	snurportin 1	0.0298	1	1
Loa Loa (eye worm)	intermediate filament protein	0.0059	0.1458	0.1446
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0051	0.1188	0.1175
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0264	1
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0097	0.0084
Onchocerca volvulus	Glucosylceramidase homolog	0.018	0.5797	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0336	0.0323
Echinococcus granulosus	geminin	0.018	0.5797	0.5791
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0264	1
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0798	1
Entamoeba histolytica	Ran family GTPase	0.0021	0.0097	0.1064
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0798	0.0857
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0172	0.0173
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0264	0.3191
Onchocerca volvulus		0.0105	0.3102	0.5129
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0097	0.0096
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0037	0.0649
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.3802	0.3793
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0264	0.3191
Trichomonas vaginalis	glucosylceramidase, putative	0.019	0.6144	0.6696
Echinococcus multilocularis	neutral alpha glucosidase AB	0.004	0.0798	0.0785
Schistosoma mansoni	hypothetical protein	0.018	0.5797	0.5791
Trichomonas vaginalis	glucosylceramidase, putative	0.018	0.5797	0.6317
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0275	0.9169	0.9168
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0264	0.0278
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0014	0.0005
Schistosoma mansoni	alpha-glucosidase	0.0156	0.4927	0.492
Entamoeba histolytica	hypothetical protein	0.0023	0.0172	0.2015
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.004	0.0798	1
Plasmodium vivax	importin-beta 2, putative	0.0028	0.036	0.9896
Echinococcus multilocularis	musashi	0.0059	0.1458	0.1446
Brugia malayi	RNA, U transporter 1	0.0079	0.2197	0.2388
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0264	1
Brugia malayi	RNA recognition motif domain containing protein	0.0124	0.3802	0.414
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.3802	0.3793
Schistosoma mansoni	lamin	0.0059	0.1458	0.1446
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0172	0.2015
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0264	0.3191
Loa Loa (eye worm)	hypothetical protein	0.0058	0.142	0.1407
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0051	0.1188	0.1175
Trichomonas vaginalis	glucosylceramidase, putative	0.0275	0.9169	1
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0264	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0037	0.0023
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0264	0.0278
Schistosoma mansoni	ran	0.0021	0.0097	0.0084
Trichomonas vaginalis	glucosylceramidase, putative	0.0275	0.9169	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0037	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0037	0.0023
Brugia malayi	intermediate filament protein	0.0059	0.1458	0.1581
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.3802	0.3793
Leishmania major	hypothetical protein, conserved	0.0028	0.0364	0.4464
Trichomonas vaginalis	glucosylceramidase, putative	0.018	0.5797	0.6317
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0162	0.5127	0.5587
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0097	0.2383
Schistosoma mansoni	intermediate filament proteins	0.0059	0.1458	0.1446
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0264	1
Echinococcus multilocularis	tar DNA binding protein	0.0124	0.3802	0.3793
Plasmodium falciparum	importin beta, putative	0.0028	0.036	0.9896
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0264	0.0251
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0181	0.5827	0.5822
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.036	0.4417
Loa Loa (eye worm)	MH2 domain-containing protein	0.0124	0.3793	0.3785
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0028	0.0375	0.0361
Echinococcus multilocularis	GPCR, family 2	0.0051	0.1188	0.1175
Loa Loa (eye worm)	TAR-binding protein	0.0124	0.3802	0.3793
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0264	0.5
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0051	0.1188	0.1175
Echinococcus multilocularis	lamin	0.0059	0.1458	0.1446
Echinococcus multilocularis	geminin	0.018	0.5797	0.5791
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0364	1
Schistosoma mansoni	alpha glucosidase	0.004	0.0798	0.0785
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.004	0.0798	0.0857
Trichomonas vaginalis	glucosylceramidase, putative	0.018	0.5797	0.6317
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0037	0.0023
Leishmania major	alpha glucosidase II subunit, putative	0.004	0.0798	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0059	0.1458	0.1446
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.004	0.0798	0.0857
Brugia malayi	latrophilin 2 splice variant baaae	0.011	0.3304	0.3596
Trichomonas vaginalis	ran, putative	0.0021	0.0097	0.0091
Loa Loa (eye worm)	RNA binding protein	0.0124	0.3802	0.3793
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0031	0.0486	0.0472
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0264	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0798	0.0857
Brugia malayi	cytoplasmic intermediate filament protein	0.0031	0.0486	0.052
Toxoplasma gondii	LsmAD domain-containing protein	0.0028	0.0364	0.4464
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.3802	0.3793
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0172	0.0173
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.3802	0.3793
Echinococcus granulosus	importin subunit beta 1	0.0028	0.036	0.0347
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0037	0.139
Trichomonas vaginalis	sucrase-isomaltase, putative	0.004	0.0798	0.0857
Trichomonas vaginalis	glucosylceramidase, putative	0.0275	0.9169	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0264	1
Schistosoma mansoni	hypothetical protein	0.0051	0.1188	0.1175
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0264	0.3191
Trichomonas vaginalis	glucosylceramidase, putative	0.018	0.5797	0.6317
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0375	0.0361
Leishmania major	GTP-binding protein, putative	0.0021	0.0097	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1458	0.1446
Schistosoma mansoni	hypothetical protein	0.018	0.5797	0.5791
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.0364	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0275	0.9169	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0124	0.3793	0.3785
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.004	0.0798	1
Brugia malayi	MH2 domain containing protein	0.0124	0.3793	0.4131
Trichomonas vaginalis	glucosylceramidase, putative	0.018	0.5797	0.6317
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.004	0.0798	1
Onchocerca volvulus		0.0059	0.1458	0.2157
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0798	1
Trichomonas vaginalis	glucosylceramidase, putative	0.018	0.5797	0.6317
Schistosoma mansoni	hypothetical protein	0.0051	0.1188	0.1175
Schistosoma mansoni	ran	0.0021	0.0097	0.0084
Loa Loa (eye worm)	hypothetical protein	0.011	0.3304	0.3294
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0097	0.1064
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0051	0.1188	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0264	0.0251
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.0037	0.0908
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0264	1
Loa Loa (eye worm)	hypothetical protein	0.0162	0.5127	0.512
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0172	0.0173
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0181	0.5827	0.5822
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.036	0.4417

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 695000